Mechanisms of Treatment Effects Using Cultured, Allogeneic Mesenchymal Stromal Stem Cells (MSCs) in Knee Osteoarthritis
Osteoarthritis, Knee
About this trial
This is an interventional treatment trial for Osteoarthritis, Knee focused on measuring Knee, Osteoarthritis, Mesenchymal stem cells, Allogeneic
Eligibility Criteria
Inclusion Criteria: Patients with end-stage (Kellgren-Lawrence) knee osteoarthritis scheduled for knee arthroplasty Osteoarthritis of primary or post-traumatic etiology Exclusion Criteria: Secondary arthritis of other etiology Rheumatic diseases Uncontrolled metabolic disorders Crystalopathies Coagulopathy Anticoagulant therapy Heart failure Renal failure Other conditions that may affect immune response or pose additional risk during cell application
Sites / Locations
- University medical centre LjubljanaRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Intervention group
Control group
Knee aspiration and the application of UCB-MSCs
Only knee aspiration, without the application of UCB-MSCs