Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance (EX-MITO-DYS-IR)
Mitochondrial Myopathies, Mitochondrial Diseases, Mitochondrial Disorders
About this trial
This is an interventional basic science trial for Mitochondrial Myopathies focused on measuring Mitochondrial disease, Muscle metabolism, Insulin resistance, Exercise training, Mitochondrial dysfunction
Eligibility Criteria
Inclusion Criteria: Known m.3243A>G mutation in the MT-TL1 gene encoding the mitochondrial leucyl-tRNA 1 gene Other known mtDNA point mutations Exclusion Criteria: Use of antiarrhythmic medications or other medications which, in the opinion of the investigators, have the potential to affect outcome measures. Diagnosed severe heart disease, dysregulated thyroid gland conditions, or other dysregulated endocrinopathies, or other conditions which, in the opinion of the investigators, have the potential to affect outcome measures. Pregnancy
Sites / Locations
- RigshospitaletRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Exercise leg
Control leg
High-intensity exercise training for one leg
No exercise training for the controlateral leg