Study of Brain-Gut Function Reconstruction After Intersphincteric Resection for Ultra-Low Rectal Tumors
Rectal Neoplasms
About this trial
This is an interventional treatment trial for Rectal Neoplasms focused on measuring Ultra-low rectal tumors, Intersphincteric Resection, transcranial magnetic stimulation, fMRI
Eligibility Criteria
Inclusion Criteria: Primary ultra-low rectal tumor patient who is received intersphincteric resection and preventive ileostomy was performed. Patient who is willing to participate in the study, and voluntarily sign informed consent. Exclusion Criteria: Anastomotic leakage or other serious complications occur after surgery. Advanced tumor, tumor recurrence or metastasis. Patients with contraindications of fMRI scanning, such as history of metal implants in the body, claustrophobia, etc. Patients with contraindications for TMS treatment, such as intracranial metal implants, epilepsy history, heart disease with unstable heart function, retinal detachment, etc. Combined with organic brain disease and drug abuse history. Combined with other mental diseases. Pregnant or lactating women.
Sites / Locations
- Huashan Hospital Affiliated to Fudan UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Sham Comparator
Active Comparator
Active Comparator
Sham Stimultion Group
Pre-ileostomy-closure Stimultion Group
Post-ileostomy-closure Stimultion Group
Patients on the Sham stimulation group will be interfered with the stimulation coil perpendicular to the skull, so that they will hear the sound of machine without having therapeutic effects. The parameters will be the same as those in the stimulation group.
Patients on the Pre-ileostomy-closure group will be interfered with stimulation 3 weeks before the procedure of ileostomy closure.
Patients on the Post-ileostomy-closure group will be interfered with stimulation 3 weeks after the procedure of ileostomy closure.