Leiden Thrombosis Recurrence Risk Prevention (L-TRRiP)
Venous Thromboembolism, Venous Thromboses, Pulmonary Embolism
About this trial
This is an interventional other trial for Venous Thromboembolism
Eligibility Criteria
Inclusion Criteria: Provision of informed consent prior to any study specific procedures. Be diagnosed with a first confirmed symptomatic deep vein thrombosis (including distal vein thrombosis, in Dutch: 'kuitvenetrombose') or pulmonary embolism with an indication for treatment with anticoagulant therapy for at least 3 months as prescribed by their treating physician. Be aged 18 years or above. Exclusion Criteria: Patients with active cancer (i.e. cancer diagnosis within six months before VTE (excluding basal-cell or squamous-cell carcinoma of the skin), recently recurrent or progressive cancer or any cancer that required anti-cancer treatment within six months before the venous thromboembolism was diagnosed) or antiphospholipid syndrome Patients who need to continue anticoagulant treatment for another indication (e.g. atrial fibrillation). Patients with a strong indication for long-term antiplatelet therapy despite oral anticoagulation (e.g. those with recent STEMI) Patients with COVID-19 associated VTE (hospital admission because of COVID-19 <3 months before the VTE) or vaccine-induced immune thrombotic thrombocytopenia (VITT) Patients in whom the risk of bleeding is deemed extremely high by the treating physician, necessitating discontinuation of anticoagulant treatment for the first VTE after the initial 3 months or even during the initial 3 months.
Sites / Locations
- Leiden University Medical CenterRecruiting
- Amsterdam Medical Center, location AMCRecruiting
- Wilhelmina ZiekenhuisRecruiting
- Rode Kruis ZiekenhuisRecruiting
- Amphia ZiekenhuisRecruiting
- Haaglanden Medisch CentrumRecruiting
- HagaZiekenhuisRecruiting
- Nij Smellinghe ZiekenhuisRecruiting
- Ziekenhuis Gelderse ValleiRecruiting
- Admiraal de Ruyter ZiekenhuisRecruiting
- Groene Hart ZiekenhuisRecruiting
- Martini ZiekenhuisRecruiting
- University Medical Center GroningenRecruiting
- Radboud University Medical CenterRecruiting
- Ikazia ZiekenhuisRecruiting
- DiakonessenhuisRecruiting
- Isala KliniekenRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Other
Other
Other
Other
Continue anticoagulation
Discontinue anticoagulation
Randomised to continue anticoagulation
Randomised to discontinue anticoagulation
Patients with high recurrent VTE risk and low major bleeding risks are advised to continue anticoagulant therapy.
Patients with low recurrent VTE risk are advised to discontinue anticoagulant therapy.
Patients with intermediate recurrent VTE risk or high recurrent VTE risk and high major bleeding risk are randomised to continue or discontinue anticoagulant therapy.
Patients with intermediate recurrent VTE risk or high recurrent VTE risk and high major bleeding risk are randomised to continue or discontinue anticoagulant therapy.