Arsenic Trioxide Combined With Chemotherapy for the Treatment of p53-mutated Pediatric Cancer
Pediatric Cancer, Li-Fraumeni Syndrome, p53 Mutations
About this trial
This is an interventional treatment trial for Pediatric Cancer focused on measuring Arsenic Trioxide
Eligibility Criteria
Inclusion Criteria: Pathological diagnosis basis of malignant tumor; Patients not more than 18 years old; Patient has either germline or somatic p53 mutations, which was shown to be partially/completely restored to function by ATO in in vitro experiments (http://www.rescuep53.net); There are measurable lesions; Guardians agreed and signed informed consent. Exclusion Criteria: Patients with one or more critical organs failure such as heart, brain, kidney failure.
Sites / Locations
- Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Arms of the Study
Arm 1
Experimental
Arsenic trioxide combined chemotherapy
Patients with p53-mutated pediatric cancer should initially undergo the corresponding first-line chemotherapy regimen. If the patient is evaluated as PD/SD, arsenic trioxide (ATO) will be administered in conjunction with previous conventional chemotherapy on the third day of each treatment cycle.