Behavioral Pharmacological Examination of a Novel Buprenorphine Induction Method Among Individuals Who Use Fentanyl (NBIM)
Opioid Use Disorder
About this trial
This is an interventional treatment trial for Opioid Use Disorder focused on measuring buprenorphine, fentanyl, initiation to treatment
Eligibility Criteria
Inclusion Criteria: 18 years or older Speak fluent English Medically cleared to take study medication Willing to comply with the study protocol Provides urine sample that tests positive for fentanyl Current moderate to severe opioid use disorder Exclusion Criteria: Significant cognitive impairment resulting in inability to provide informed consent (e.g., severe dementia or intellectual disability) Unable to read or understand study questions with assistance from the research staff Medical symptoms interfering with their ability to answer study questions Psychiatric symptoms interfering with their ability to answer survey questions Currently enrolled and taking medications for OUD Pregnant or Breastfeeding Taking medication contraindicated with study medication Deemed by the principal investigator or medical team to not be a good fit for the study protocol. Current or history of hypo/hypertension (i.e., no less than 90/60, no greater than 140/90) or adverse cardiovascular event in the past three years (e.g. significant cardiac arrhythmia, myocardiac infarction, endocarditis).
Sites / Locations
- Johns Hopkins School of Medicine
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
4mg buprenorphine
8mg buprenorphine
16mg buprenorphine
24mg buprenorphine
4mg of buprenorphine will be given to a subset of participants immediately after naloxone administration.
8mg of buprenorphine will be given to a subset of participants immediately after naloxone administration.
16mg of buprenorphine will be given to a subset of participants immediately after naloxone administration.
24mg of buprenorphine will be given to a subset of participants immediately after naloxone administration.