The Incorporation of Dietary Protein-Derived Amino Acids in Duodenal Epithelium (GutFeeding)
Protein Malabsorption
About this trial
This is an interventional basic science trial for Protein Malabsorption focused on measuring Gastrointestinal tract, Intestinal mucosa, Protein, Digestion, Absorption, Aging, Muscle protein synthesis
Eligibility Criteria
Inclusion Criteria: Male sex Aged 18-35 years or 67+ years Body mass index (BMI) between 18.5 and 30 kg/m2 Exclusion Criteria: History of cardiovascular, respiratory, gastrointestinal, urogenital, neurological, psychiatric, dermatologic, musculoskeletal, metabolic, endocrine, haematological, immunologic disorders, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol, interfere with the execution of the experiment, or potential influence the study outcomes (to be decided by the principal investigator and responsible physician) Major abdominal surgery interfering with gastrointestinal function (upon judgement of the principal investigator and responsible physician) Use of medication which limit participation in or completion of the study protocol, interferes with the execution of the experiment, or potential influences the study outcomes (to be decided by the principal investigator and responsible physician) Use of supplementation (i.e. vitamin, pre- and probiotic supplementation) within 14 days prior to testing Administration of investigational drugs or participation in any scientific intervention study in the 14 days prior to the study, which may interfere with this study (upon judgement of the principal investigator and responsible physician) Specific diet (e.g. vegetarian, vegan, gluten free, no diary) within the study period Planning to lose weight during the study period Lactose intolerance Excessive alcohol consumption (defined as > 14 alcoholic consumptions per week) Smoking Drug use Donated blood two months prior to the test day Recent (<1 year) participation in amino acid tracer (L-[ring-2H5]-phenylalanine, L-[ring-2H3]-leucine, L-[ring-2H4]-lysine, L-[ring-2H2]-tyrosine) or intrinsically labelled protein ([1-13C]-phenylalanine, [1-13C]-leucine, [1-13C]-lysine) studies No given permission to register participation in electronic patient file at MUMC+ and to add records of gastroduodenoscopy
Sites / Locations
- Maastricht University Medical Center+Recruiting
Arms of the Study
Arm 1
Experimental
Intrinsically labelled milk protein
20 grams of protein dissolved in 500 mL of water