Supplementation for Male Subfertility (FertEnhancer)
Male Infertility
About this trial
This is an interventional treatment trial for Male Infertility focused on measuring Sub-fertility, Infertility, Antioxidants, Supplements, Creatine, Arginine, Vitamins, Aging, Oxidative stress, Inflammation, DNA, Mitochondria, Fragmentation, ATP
Eligibility Criteria
Inclusion Criteria: Males between the ages of 25-50 years diagnosed with subfertility through Ontario Networks of Experts in Fertility (ONE Fertility, Burlington, ON). For diagnosis of male subfertility, the 2010 and 2021 World Health Organization criteria will be used for sperm count, motility, morphology and vitality. Exclusion Criteria: Smoking, history and drug alcohol abuse, BMI > 30 kg/m2, genital disease (cryptorchidism, current genital inflammation, or varicocele), genital trauma or surgery to the male reproductive system, known Y chromosome microdeletions or karyotype abnormalities (if known prior), hepatobiliary disease, significant renal insufficiency, occupational exposures to reproductive toxins, endocrine abnormality, recent or current sexually transmitted infection, use of cytotoxic drugs, use of immunosuppressants, use of anticonvulsants, use of androgens or antiandrogens, history of central nervous system injury, neurological or psychiatric disease to potentially compromise study data collection, treatment of erectile dysfunction with any drugs during the past 4 weeks, history of cancer chemotherapy, current supplementation with ingredients being tested unless 1-month washout period
Sites / Locations
- Mark Tarnopololsky
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Active multi-ingredient supplement (Fertility Enhancer; FE)
Inactive placebo (Placebo; PLA)
Volunteers will be randomized in a double-blinded fashion into the experimental treatment group, which entails daily supplementation of an active multi-ingredient supplement designed to enhance fertility (Fertility Enhancer; FE) for 3 months.
Volunteers will be randomized in a double-blinded fashion into a placebo group, which entails daily supplementation of a calorie-matched, inactive placebo (Placebo; PLA) identical in flavor to the active supplement for 3 months.