Efficacy of Songling Xuemaikang Capsules on Grade 1 Hypertension: a Randomized Controlled Trial (ESCIHP)
Hypertension,Essential
About this trial
This is an interventional treatment trial for Hypertension,Essential focused on measuring Songling Xuemaikang Capsules, Vascular remodeling, Grade 1 hypertension, Mild hypertension
Eligibility Criteria
Inclusion Criteria: Age between 35-65 years old, male or female; Grade 1 essential hypertension; Taking no antihypertensive drugs or taking antihypertensive drugs irregularly in the past ; Sign the informed consent; Exclusion Criteria: Significant liver and kidney dysfunction, ALT and AST upper the twice of normal range, Scr≥2.0mg/dl, eGFR<60ml/(min·1. 73m2); Gastrointestinal diseases, which may affect drug absorption; Be allergic to the clinical trial medicine; Pregnant or breastfeeding women, men who plan to give birth within half a year; Combined with other serious primary diseases or malignant tumors; Hyperlipidemia with or without taking lipid-lowering drugs; Combined with left ventricular hypertrophy, ABI < 0.9, CIMT ≥ 0.9mm or atherosclerotic plaque; Hypertensive comorbidities (cerebrovascular disease, other cardiovascular diseases, renal disease, peripheral artery disease, retinopathy, diabetes); Other serious conditions in which is not fit for the study.
Sites / Locations
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
- Suzhou Hosptial of Traditional Chinese Medicine
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine
- China Academy of Chinese Medical Sciences Xiyuan Hospital Jining Hospital
- China Academy of Chinese Medical Sciences Xiyuan Hospital Shanxi Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Lifestyle intervention + Songling Xuemaikang Capsules
Lifestyle intervention + placebo
Therapeutic Hypertensive Lifestyle Modifications, everyday, duration: 12 weeks Songling Xuemaikang Capsules, 3 capsules at a time, three times a day, duration: 12 weeks
Therapeutic Hypertensive Lifestyle Modifications, everyday, duration: 12 weeks placebo, 3 capsules at a time, three times a day, duration: 12 weeks