Axillary Management After Neoadjuvant Chemotherapy
Breast Cancer, Breast Neoplasms, Breast Cancer Female
About this trial
This is an interventional diagnostic trial for Breast Cancer focused on measuring locally advanced breast cancer, axillary involvement, neoadjuvant chemotherapy, axillary biopsy
Eligibility Criteria
Inclusion Criteria: 18-65 years-old female patients Clinical stage T1-3 and biopsy-proven N1 breast cancer Axillary nodal involvement Volunteer to participate in to study Exclusion Criteria: A history of axillary surgery or SLNB, prior axillary excisional lymph node surgery, N2-3 disease with a decision for initial axillary lymph node dissection (ALND), Diagnosis of inflammatory breast cancer, Presence of distant metastasis Incomplete chemotherapy, pregnancy, and lactation T4 tumors Refusal to participate in to study
Sites / Locations
- Istanbul Medipol University Hospital
- Istanbul Gaziosmanpasa Training and Research Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Group 1 = Fine needle aspiration biopsy
Group 2 = Core biopsy
In Group A, patients with axillary metastasis identified by FNAB were subjected to repeat ultrasound-guided FNAB after completion of neoadjuvant treatment, The obtained biopsies were sent for histopathological evaluation without revealing patient names to avoid influencing the research results, and the surgical team was not informed of the biopsy results. During surgery, both dyed lymph nodes and clipped lymph nodes were excised for SLNB and assessed by frozen section evaluation.
in Group B, patients with axillary metastasis identified by CNB underwent repeat biopsy using the same method after completing neoadjuvant treatment.The obtained biopsies were sent for histopathological evaluation without revealing patient names to avoid influencing the research results, and the surgical team was not informed of the biopsy results. During surgery, both dyed lymph nodes and clipped lymph nodes were excised for SLNB and assessed by frozen section evaluation.