Therapy With Paravertebral Oxygen-ozone Injections and Topical Cannabidiol and β-Caryophyllene Patch in Neck Pain
Neck Pain
About this trial
This is an interventional treatment trial for Neck Pain
Eligibility Criteria
Inclusion Criteria: Neck pain resulting from spinal pathology present for at least 1 month with or without brachial irradiation Cervical radiographic and/or MRI examination certifying the pathology of the spine Failure of previous conservative treatment (pharmacological or physiotherapy) Adults Signing of informed consent Exclusion Criteria: Specific causes of neck pain (trauma, spinal deformity, fracture, neoplasia) Central or peripheral neurological signs Rheumatic diseases: diagnosis of rheumatoid arthritis, Reiter's syndrome, psoriatic arthritis, gout, ankylosing spondylitis or arthritis secondary to other inflammatory diseases, chondrocalcinosis, Paget's disease or villonodular synovitis Neuromuscular disorders Presence of cognitive-behavioral deficit or psychiatric illness which, in the opinion of the investigator, could compromise patient safety or interfere with the evaluation of the effects of the treatment Surgery in the previous 6 months Cervical infiltrative treatments in the previous 4 months Use of orally administered systemic steroids within 2 weeks prior to screening Pregnant or breastfeeding women or women planning to become pregnant during the study participation period Known alcohol or drug dependence currently or within the past year
Sites / Locations
- Humanitas Clinical and Research Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Oxygen-Ozone Therapy plus Cannabidiol and ß-Caryophyllene Patch
Oxygen-Ozone Therapy
The patients will undergo 8 session of oxygen-ozone therapy, 2 per week. In each session 10 cc of a gaseous mixture of oxygen-ozone (at a concentration of 10 μg of ozone per ml of oxygen) will be injected with 6 paravertebral injections. For the fisrt 2 weeks of oxygen-ozone therapy patients will be asked to apply patches with local action based on Cannabidiol and ß-Caryophyllene for 8-24 hours/day for 5 days/week.
The patients will undergo 8 session of oxygen-ozone therapy, 2 per week. In each session 10 cc of a gaseous mixture of oxygen-ozone (at a concentration of 10 μg of ozone per ml of oxygen) will be injected with 6 paravertebral injections.