Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls
Folate Deficiency, Vitamin B 12 Deficiency, Anemia, Megaloblastic
About this trial
This is an interventional prevention trial for Folate Deficiency focused on measuring Small scale fortification, Folic acid, Vitamin B12, Anemia, Cognitive development, Teenage girls
Eligibility Criteria
Inclusion Criteria: Teenage girls between 13 and 19 years of age who live in households at Arba Minch Health and Demographic Surveillance Sites (AM-HDSS) are eligible to participate in the study if: One or both of their parents signed an informed consent form and the girl's agreement. Their parents and the girl planned to stay in the study area during the period of the study (minimum 6 months) in the kebele. Both parents and girls accept the intervention packages including blood draws and home visits. Exclusion Criteria: Chronically ill girls diagnosed with diabetes and asthma; Severely undernourished girls (defined as body mass index z score < -3 standard deviations of the median World Health Organization reference population); Severely anaemic girls (Hb concentration <80g/L); Teenage girls who are pregnant, lactating or taking IFA/B12 supplements; Diagnosed hemoglobinopathy (sickle cell or thalassemia); Diagnosed liver diseases like acute hepatitis, cirrhosis, hepatocellular carcinoma, and metastatic liver disease
Sites / Locations
- Arba Minch University
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Experimental
Control group
folic acid & vit B12 fortified flour
Teenage girls randomly assigned to the control group will receive a standard bag of unfortified cereal flours every week for six months.
Teenage girls randomly assigned to the control group will receive a standard bag of cereal flours fortified with folic acid and Vit B12 every week for six months.