17AAG to Treat Kidney Tumors in Von Hippel-Lindau Disease

Inclusion Criteria: Patients must satisfy all of the following inclusion criteria to be eligible for study enrollment. Clinical diagnosis of von Hippel Lindau disease. Presence of one or more localized renal tumors for which surgical resection would be considered the standard approach. Age greater than or equal to 18 years. Because no dosing or adverse event data are currently available on the use of 17 AAG in patients less than 18 years of age, children are excluded from this study. Life expectancy less than 3 months. Performance status Eastern Cooperative Oncology Group (ECOG) 0-2. Patients must have normal organ and marrow function as defined below: white blood cells (WBC)count greater than or equal to 3,000/microliter, absolute neutrophil count greater than or equal to 1,500/microliter, platelet count greater than or equal to 100,000/microliter, Hgb greater than 10Gm/dl, serum creatinine less than or equal to 1.0 upper limit of normal (ULN) or measured 24 hour creatinine clearance greater than 60 ml/min,aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than 1.0 times the ULN, total bilirubin less than or equal to ULN(less than 3 times the normal limit (NL) in patients with Gilbert's disease). Negative hepatitis B surface antigen (HbsAg), human immunodeficiency virus type 1 (HIV-1) and nonreactive hepatitis C virus (HCV). No history of serious intercurrent illness. At least four weeks from completion of any surgical or investigational therapy for von Hippel Lindau disease. Willingness to undergo resection of renal tumor at the time point defined in the protocol. All men and women of childbearing potential must use effective contraception as determined by the principal investigator or protocol chair. Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: Prior or concomitant non-von Hippel Lindau associated malignancy with the exception of adequately treated basal or squamous cell carcinoma of the skin or any other malignancy from which the patient has remained disease free for more than five years. Any renal tumor greater than 4cm in size. Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events (to grade 1 or less toxicity according to Common Terminology Criteria for Adverse Events version 3.0 (CTCAE 3.0) due to agents administered more than 4 weeks earlier. Patients may not be receiving any other investigational agents. Patients with known metastatic renal cell cancer. Patients with a history of serious allergy to eggs. Concomitant therapy with cytochrome P450 3A4 (CYP3A4) potent inhibitors. Patients who are on CYP3A4 substrates and inducers qualify for enrollment for this study. Pregnant women are excluded from this study because 17 AAG has the potential for teratogenic or abortifacient effects, and no data regarding its safety in pregnant women is available. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with 17 AAG, breastfeeding should be discontinued if the mother is treated with 17 AAG. Human immunodeficiency virus (HIV)-positive patients are excluded from the study because of unknown but potential pharmacokinetic interactions of anti-retroviral drugs with 17 AAG. Use of any medications that prolong or may prolong corrected QT interval (QTc). Patients who have significant cardiac disease including heart failure that meets New York Heart Association (NYHA)class III and IV definitions, uncontrolled dysrhythmias requiring anti-arhythmic drugs, or patients with active ischemic heart disease including myocardial infarction and poorly controlled angina within 12 months of study entry. Patients who have a history of serious ventricular arrhythmia (ventricular tachycardia (VT) or ventricular fibrillation (VF),greater than or equal to 3 beats in a row), QTc greater than or equal to 450msec for men and 470msec for women, or left ventricular ejection fraction (LVEF) below lower limit of normal by multi gated acquisition scan(MUGA). Patients with a history of prior chest radiation or radiation that potentially included the heart in the treatment field. Patients with congenital long Q wave, T wave (QT) syndrome. Patients with left bundle branch block. Patients with symptomatic pulmonary disease requiring medication, including the following:dyspnea, dyspnea on exertion, paroxysmal nocturnal dyspnea, oxygen requirement and significant pulmonary disease, including chronic obstructive pulmonary disease, patients meeting Medicare criteria for home oxygen. Carbon monoxide diffusing capacity (DLCO) less than or equal to 80%. Patients with a prior history of cardiac or pulmonary toxicity after receiving anthracyclines, such as doxorubicin, daunorubicin, mitoxantrone, bleomycin, or carmustine (BCNU). Patients with greater than or equal to grade 2 baseline pulmonary or cardiac symptoms.