A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough (CALM-1)
Refractory Chronic Cough
About this trial
This is an interventional treatment trial for Refractory Chronic Cough
Eligibility Criteria
Inclusion Criteria: Capable of giving signed informed consent Refractory chronic cough (including unexplained chronic cough) for at least one year Women of child-bearing potential must use a highly effective contraception method during the study and for at least 14 days after the last dose Exclusion Criteria: Current smoker/vaper (all forms of smoking and inhaled substances, including , cannabis/tobacco smoke and nicotine vapors) or individuals who have given up smoking within the past 6 months, or those with >20 pack-year smoking history Diagnosis of Chronic Obstructive Pulmonary Disease (COPD), bronchiectasis, idiopathic pulmonary fibrosis or uncontrolled asthma Respiratory tract infection within 4 weeks before screening Laboratory confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection at screening History of malignancy in the last 5 years History of alcohol or drug abuse within the last 3 years Has a positive serologic test for human immunodeficiency virus (HIV), hepatitis B virus surface antigen, or hepatitis C virus. Previous participation in a BLU-5937 trial
Sites / Locations
- Jasper Summit Research, LLC
- Research Solutions of Arizona, PCRecruiting
- Medical Research of ArizonaRecruiting
- Little Rock Allergy & Asthma, P.A. Clinical Research CenterRecruiting
- Warren W. Pleskow, MD, 1071572Recruiting
- Allergy & Asthma Research of Southern CaliforniaRecruiting
- Center for Clinical Trials, LLCRecruiting
- Allergy Associates Medical Group, Inc.Recruiting
- Care Access ResearchRecruiting
- Innovative Research of West Florida, Inc.Recruiting
- Omega Research ConsultantsRecruiting
- North Florida Foundation for Research and Education, Inc.
- The Community Research of South FloridaRecruiting
- Sher Allergy
- Cordova Research Institute, LLCRecruiting
- Life Spring Research FoundationRecruiting
- Well Pharma Medical Research CorporationRecruiting
- Coral Research Clinic corpRecruiting
- Gwinnett Pulmonary Group P.C.Recruiting
- PMG Research of DuPage Medical GroupRecruiting
- Sneeze, Wheeze and Itch Associates, LLCRecruiting
- McFarland Clinic P.C.Recruiting
- University of Iowa Hospitals & Clinics
- University of Kansas Medical Center Research Institute, Inc.
- Cotton O'Neil Clinical Research CenterRecruiting
- University of Kansas Medical Center Research Institute, Inc.
- Avant Research Associates, LLCRecruiting
- Infinity Medical Research IncRecruiting
- Michigan Medicine Investigational Drug ServicesRecruiting
- The Curators of the University of Missouri on behalf of University of Missouri Health Care
- Montana Medical Research, Inc.Recruiting
- The Asthma and Allergy CenterRecruiting
- Montefiore Medical Center (MMC)
- American Health Research, Inc.Recruiting
- PMG Research of RaleighRecruiting
- PMG Research of Rocky Mount, LLCRecruiting
- PMG Research of Salisbury, LLCRecruiting
- Southeastern Research Center LLCRecruiting
- Remington-Davis, Inc.Recruiting
- University of Oklahoma Health Sciences Center
- Vital Prospects Clinical Research Institute, P.C.Recruiting
- Velocity Clinical ResearchRecruiting
- Allergy Associates Research CenterRecruiting
- Clinical Research Associates of Central PA, LLCRecruiting
- Temple Lung Center
- AAPRI Clinical Research InstituteRecruiting
- Lowcountry Lung and Critical Care, P.A.Recruiting
- Main Street Physician's Care - WaterwayRecruiting
- PMG Research of Charleston, LLCRecruiting
- Clinical Research of Rock HillRecruiting
- Accellacare BristolRecruiting
- PMG Research of KnoxvilleRecruiting
- Pharmaceutical Research & Consulting, Inc.Recruiting
- Clinical Trial Network LLCRecruiting
- University of Texas Health Science Center at HoustonRecruiting
- Metroplex Pulmonary and Sleep CenterRecruiting
- Diagnostics Research Group, LLCRecruiting
- Allergy Asthma Research InstituteRecruiting
- University of Utah Hospitals & Clinics
- Eastern Virginia Medical SchoolRecruiting
- TPMG Clinical Research WilliamsburgRecruiting
- Bellingham Asthma, Allergy & Immunology ClinicRecruiting
- Expertia S.A- Mautalen Salud e InvestigaciónRecruiting
- CINME - Centro De Investigaciones MetabolicasRecruiting
- Centro de Investigaciones Medicas Mar del PlataRecruiting
- CEMER - Centro Medico de Enfermedades Respiratorias
- APRILLUS Asistencia e InvestigacionRecruiting
- Instituto de Especialidades de la Salud Rosario
- Instituto Medico Fundación Grupo Colaborativo Rosario Investigación y Prevención MedicaRecruiting
- Instituto Medico de la Fundacion Estudios ClinicosRecruiting
- Hospital Italiano de Buenos Aires
- Instituto Medico DAMIC
- Fundacion ScherbovskyRecruiting
- Insares S.A.Recruiting
- Instituto del Buen Aire
- Cliniques Universitaires Saint-LucRecruiting
- Universitair Ziekenhuis GentRecruiting
- UZ Leuven
- C. H. R. de la CitadelleRecruiting
- AZ Sint-MaartenRecruiting
- University of Calgary - Health Sciences CentreRecruiting
- Peak Research Group
- Kelowna Respirology and Asthma ResearchRecruiting
- Dynamic Drug AdvancementRecruiting
- Burlington Lung ClinicRecruiting
- Hamilton Medical Research GroupRecruiting
- McMaster University Health Sciences CenterRecruiting
- Inspiration Research Limited
- Dr. Syed Anees Medicine Professional CorporationRecruiting
- CISSS de la Monteregie-Centre
- Montreal Chest Institute
- Institut Universitaire de Cardiologie et de Pneumologie de Quebec
- DIEX Recherche Quebec Inc.Recruiting
- Clinique Specialisee en Allergie de la CapitaleRecruiting
- Clinique de pneumologie et du sommeil de LanaudièreRecruiting
- CIC Mauricie Inc.Recruiting
- DIEX Recherche Victoriaville Inc.Recruiting
- Recherche GCP ResearchRecruiting
- Fundación Cardiovascular de Colombia - Instituto del Corazón Floridablanca
- Asociacion IPS Medicos Internistas de Caldas
- Clinica SOMER
- Fundacion Centro de Investigacion Clinica CIC
- Hospital Pablo Tobón Uribe
- CHU de Strasbourg - Nouvel Hôpital CivilRecruiting
- Hopital Européen de MarseilleRecruiting
- Hôpital Nord - CHU Marseille
- CHU de Dijon - Hôpital François MitterandRecruiting
- Hopital LarreyRecruiting
- Hopital Arnaud de VilleneuveRecruiting
- Hopital Albert Calmette CHU Lille
- Hôpital CochinRecruiting
- DRC Gyogyszervizsgalo Kozpont Kft.Recruiting
- Clinexpert Kft.Recruiting
- Omnimodus Elixir Kft.Recruiting
- Erzsebet Gondozohaz Kft.Recruiting
- Szalay Janos RendelointezetRecruiting
- Da Vinci MaganklinikaRecruiting
- Puspokladanyi Egeszsegugyi Szolgaltato Nonprofit Kft.Recruiting
- Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRecruiting
- Shetty HospitalRecruiting
- Siddhi HospitalRecruiting
- Suyog Multispeciality HospitalRecruiting
- Bhaktivedanta Hospital and Research InstituteRecruiting
- Aashirwad HospitalRecruiting
- ACE Hospital and Research CentreRecruiting
- Institute of Medical Sciences and SUM Hospital
- Asthma BhavanRecruiting
- Calcutta Medical Research InstituteRecruiting
- Indraprastha Apollo HospitalsRecruiting
- Hillel Yaffe Medical Center
- The Lady Davis Carmel Medical Center
- Hadassah University Hospital - Ein Kerem
- Mersin University Medical Faculty
- Rabin Medical Center-Beilinson Campus
- Sheba Medical Center
- Tel Aviv Sourasky Medical Center
- Noordwest ZiekenhuisgroepRecruiting
- RijnstateRecruiting
- Amphia Ziekenhuis, MolengrachtRecruiting
- Bernhoven UdenRecruiting
- Gelre Ziekenhuizen, ZutphenRecruiting
- Isala Klinieken, WeezenlandenRecruiting
- Prywatny Gabinet Internistyczno-AlergologicznyRecruiting
- Centrum Medyczne Pratia BydgoszczRecruiting
- Ostrowieckie Centrum Medyczne spółka cywilna Anna Olech-Cudzik, Krzysztof CudzikRecruiting
- Center of Innovative TherapiesRecruiting
- Prywatny Gabinet LekarskiRecruiting
- Alergo-Med Specjalistyczna Przychodnia Lekarska Sp. Z .O.O.Recruiting
- Centrum Medyczne Lucyna Andrzej Dymek s.c.Recruiting
- Uniwersytecki Szpital Kliniczny nr 1 im. Norberta BarlickiegoRecruiting
- Uniwersytecki Szpital Kliniczny nr 1 im. N. Barlickiego w LodziRecruiting
- Iatros InternationalRecruiting
- Worthwhile Clinical TrialsRecruiting
- Smith, C - Morningside HospitalRecruiting
- Global Clinical Trials
- Botho ke Bontle Health ServicesRecruiting
- Dr NK Gounden Medi-CentreRecruiting
- TASK EdenRecruiting
- Dr JM Engelbrecht Trial SiteRecruiting
- Complejo Hospitalario Universitario de SantiagoRecruiting
- Accellacare España SL
- Hospital Universitario Quironsalud MadridRecruiting
- Hospital de la Santa Creu i Sant PauRecruiting
- Hospital Clinic de BarcelonaRecruiting
- Hospital Universitario de La Princesa
- Hospital General Universitario Gregorio MarañonRecruiting
- Hospital Universitario Clinico San CarlosRecruiting
- Hospital Clinico Universitario Virgen de la VictoriaRecruiting
- Hospital Quironsalud MalagaRecruiting
- Yedikule Pulmonary Dis. and Surgery Edu. and Res. Hosp.
- Sureyyapasa Pulmonary Diseases and Cardiothoracic Surgery Education and Research Hospital
- Ege University Medical Faculty
- Kocaeli Universitesi - Kocaeli Universitesi Tip Fakultesi
- TC SBU Izmir Dr Suat Seren Gogus Hastaliklari ve Cerrahisi Egitim ve Arastirma
- Accellacare Yorkshire
- Holderness Health
- Royal Brompton Hospital
- Wythenshawe Hospital
- Accellacare South London
- Accellacare North London
- Norfolk and Norwich University Hospital
- Lakeside Healthcare
- Belfast City Hospital
- West Walk Surgery
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Placebo Comparator
BLU-5937 25 mg
BLU-5937 50 mg
Placebo
BLU-5937 oral dose 25 mg twice a day.
BLU-5937 oral dose 50 mg twice a day.
Matching Placebo for BLU-5937 oral dose twice a day.