A Chinese Patent Medicine Yangzhengxiaoji Capsule to Improve the Nausea of Niraparib in the Maintenance Treatment in Ovarian Cancer
Ovarian Cancer
About this trial
This is an interventional treatment trial for Ovarian Cancer focused on measuring Niraparib, Ovarian Cancer,Nausea
Eligibility Criteria
Inclusion Criteria: Sign a written informed consent form before conducting any research-related procedures; Women aged 18 or above; Ovarian cancer, fallopian tube cancer or primary peritoneal cancer diagnosed histologically can be treated with Niraparib after evaluation by clinicians; Life expectancy > 3 months; Patients' ECOG physical condition score is 0-1, KPS score is ≥70; Patients received ≥ 3 cycles bevacizumab in combination within platinum-based chemotherapy Good organ function, including: Neutrophil count ≥ 1500/L Platelet ≥ 100,000/L Hemoglobin ≥10g/dL Serum creatinine ≤1.5 times the upper limit of normal value, or creatinine clearance ≥60mL/min (according to Cockcroft-Gault Formula calculation) Total bilirubin ≤1.5 times the upper limit of normal value or direct bilirubin ≤1.0 times the upper limit of normal value AST and ALT ≤2.5 times the upper limit of normal value, and liver metastasis must be ≤5 times the upper limit of normal value. 7. No serious abnormalities of heart, brain, lung, liver and kidney function; 8. No serious mental illness; 9. Ability to comply with the plan; 10. the toxic and side effects of any previous chemotherapy have recovered to ≤CTCAE 1 grade or baseline level, except for sensory neuropathy or alopecia with stable symptoms ≤CTCAE 2 grade. Exclusion Criteria: People who are allergic to the ingredients in Yangzhengxiaoji Capsule Have undergone major surgery within 3 weeks before the start of the study, or have not recovered any surgical effects after surgery, or have received chemotherapy. patients who are combined with other cancers; Patients with severe heart, liver, kidney and hematopoietic diseases; 5 Patients with poor compliance cannot take drugs according to regulations.
Sites / Locations
- Sicchuan cancer hospital
Arms of the Study
Arm 1
Experimental
Arm
Participants received Niraparib 200mg or 300mg QD PO continually combined with Yangzheng Xiaoji capsule, 0.36g*4 tid,28 days as one cycle,up to 3 cycles.