A Clinical Trial of Gargling Agents in Reducing Intraoral Viral Load Among COVID-19 Patients (GARGLES)
Covid-19
About this trial
This is an interventional supportive care trial for Covid-19 focused on measuring Covid-19;, coronavirus disease, povidone, hydrogen peroxide, neem extracts, topical therapy, gargle
Eligibility Criteria
Inclusion Criteria:
- The inclusion criteria are laboratory confirmed Covid-19 positive male or female subjects in the age range of 18-65 years, within seven days of the onset of mild to moderate symptoms of viral infection, already admitted in the hospital.
Exclusion Criteria:
- Edentulous patients, patients with low Glasgow coma score, intubated, immune-compromised, history of radiotherapy or chemotherapy will be excluded. Patients with known pre-existing chronic mucosal lesions such as lichen planus will also be excluded.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Active Comparator
Active Comparator
Placebo Comparator
Povidone-Iodine 0.2% (BETADINE®)
Hydrogen peroxide 1% (ActiveOxy)
Neem extract (Azadirachta indicia)
Hypertonic saline (2%NaCl)
Positive controls
0.2% Povidone-Iodine (BETADINE®) 10 ml gargle and nasal lavage for 20-30 seconds, thrice daily for 6 days.
ActiveOxy (1% Hydrogen peroxide) 10 ml gargle and nasal lavage for 20-30 seconds, thrice daily for 6 days.
Neem extract (Azadirachta indicia) gargle will be prepared by chemistry laboratory. patients will do 10ml gargle and nasal lavage for 20-30 seconds, thrice daily for 6 days.
10 ml gargle and nasal lavage using Hypertonic saline for 20-30 seconds, thrice daily for 6 days.
10 ml gargle and nasal lavage using distilled water for 20-30 seconds, thrice daily for 6 days.