A Cognitive Training Tool Based on Life-logging in Mild Cognitive Impairment (ReMemory-MCI) (ReMemory-MCI)

Background: Mild Cognitive Impairment (MCI) is a risk factor for dementia and represents a critical window of opportunity to intervene and alter the trajectory of both cognitive and functional decline. Emerging life-logging technologies has shown a tremendous potential to increase autobiographical memory. Objective: The main goal of the present study is to develop a Cognitive Training program (CT) for MCI based on life-logging captured by a Wearable Camera (WeC) recording specific autobiographical episodes for stimulating posteriorly episodic memory. The challenge is to create an application to manage this large collection of images, which can be easily retrieved as events by users in a therapeutic context as a multimodal cognitive stimulation. The investigators will conduct a quasi-experimental design with non-equivalent control group, evaluating the effectiveness of the life-logging re-experiencing program immediately and 3-month follow-up period. Methodology: The design is a pretest, posttest and follow-up design, where 30 adults with MCI were sequentially allocated to one of two conditions: intervention or control group. All subjects wore a lifelogging WeC during two weeks, and subsequently they were generated several videos with the most relevant information of each event. Subjects in the Intervention Group will attend 1-hour individual training sessions 2 times per week for 14 8 weeks. Main outcomes measures will be cognitive, functional, emotional and quality of life measures, as well as biochemical measures (BDNF). Expected results: The investigators expect the outcomes to provide preliminary evidence that autobiographical experimentation CT programs can positively impact cognitive functioning and may represent an effective strategy to improve memory and functionality in those who begun to experience cognitive decline.

Life-logging, Cognitive Training, Mild Cognitive Impairment, Memory, Information and communications technology (ICT) in healthcare, Portable camera

Memory was measured using the Logical Memory Test from the Wechsler Memory Scale, IV version (WMS-IV, Spanish version); the International Shopping List Task and the One Card Learning Task from the computerized neurocognitive battery Cogstate.

Attention was measured using the Identification Task from the computerized neurocognitive battery Cogstate and the Forward Digit Span from the Wechsler Adult Intelligence Scale, fourth edition (WAIS-IV)

orking memory was measured using the One Back Task from the computerized neurocognitive battery Cogstate and the Backward Digit Span from the Wechsler Adult Intelligence Scale, fourth edition (WAIS-IV).

erbal Fluency was measured using the Controlled Oral Word Association Test, spanish adaptation, and semantic fluency test using the category Animals

Processing speed was measured using the Detection Task from the computerized neurocognitive battery Cogstate battery

Functional capacity was measured using Functional Assessment Questionnaire (FAQ) and the UCSD Performance-Based Skills Assessment (UPSA).

Inclusion Criteria: 65-90 years of age Meet definition criteria for MCI (Petersen, 2004) Be receiving CT at least three month in Day Hospital during three months or more; c) having memory complaint, usually verified by an informant Having memory complaint, usually verified by an informant Memory performance below the mean score for the corresponding age and education group Having normal general cognitive functioning as determined by a Mini-Mental State Examination (MMSE) score > o = 24 Having a reliable caregiver who can supervise the patient's daily activities Having Global clinical dementia rating scale score of 0.5 Granted written informed consent accepting to participate in the study Exclusion Criteria: Neurological, psychiatric or unstable medical disorders Intellectual deficiency (Premorbid Intellectual Quotient (IQ) -Vocabulary- less 85) Relevant hearing, vision, motor or language deficits Less than 4 years of education e) acquisition of Catalonian or Spanish languages after 15 years old