A Comparative Study of a Combination of Zidovudine, Didanosine, and Double-Blinded Nevirapine Versus a Combination of Zidovudine and Didanosine
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Didanosine, Drug Therapy, Combination, Acquired Immunodeficiency Syndrome, AIDS-Related Complex, Zidovudine, Nevirapine
Eligibility Criteria
Inclusion Criteria Concurrent Medication: Required: PCP prophylaxis for patients with CD4 count < 200 cells/mm3 or a prior history of PCP. Allowed: Trimethoprim with sulfamethoxazole or dapsone, intravenous pentamidine, atovaquone, primaquine-clindamycin or trimetrexate for acute PCP. Topical antifungals, clotrimazole, ketoconazole, fluconazole, and amphotericin B for treatment of mucosal and esophageal candidiasis. Prophylaxis or therapy for opportunistic infections, as indicated, with other medications such as itraconazole, isoniazid, pyrazinamide, clofazimine, clarithromycin, azithromycin, ethambutol, amikacin, ciprofloxacin, ofloxacin, pyrimethamine, sulfadiazine, and clindamycin. Maintenance therapy for opportunistic infections as long as patients have been on a stable dosage regimen for 1 month prior to study entry. Ganciclovir for CMV retinitis or gastrointestinal disease as long as patients have been on a stable dose for at least 1 month prior to study entry with no grade 3 or 4 neutropenia or dependence on G-CSF. Acyclovir (<= 1000 mg/day) for maintenance of herpes simplex virus infections. Erythropoietin or G-CSF if clinically indicated. Antibiotics for bacterial infections unless specifically excluded. Rifampin or rifabutin. Symptomatic treatments such as antipyretics, analgesics, and antiemetics. Concurrent Treatment: Allowed: Local radiation therapy. Prior Medication: Required: At least 6 months of prior cumulative nucleoside therapy with AZT, ddI, or ddC, given as monotherapy or in combination. Patients must have: Prior or current documentation of HIV seropositivity by ELISA confirmed by Western blot, positive HIV antigen, or positive HIV culture, or a second antibody test by a method other than ELISA. CD4 count <= 350 cells/mm3. Prior cumulative nucleoside therapy of >= 6 months. Consent of parent or guardian if less than 18 years of age. Exclusion Criteria Concurrent Medication: Excluded: Antiretroviral therapies other than study medications. Systemic corticosteroids given consecutively for > 21 days. Induction or maintenance with foscarnet. Systemic cytotoxic chemotherapy for a malignancy. Erythromycin. Coumadin/warfarin. Phenytoin or phenobarbital. Amoxicillin/clavulanate acid (Augmentin) or ticarcillin/clavulanate acid (Timentin). Patients with the following prior conditions are excluded: History of pancreatitis. History of intolerance to 500 or 600 mg/day AZT or to 400 mg/day ddI tablets or 500 mg/day ddI sachets. History of grade 2 or worse peripheral neuropathy. Prior Medication: Excluded at any time: Prior non-nucleoside reverse transcriptase inhibitors (NVP; L697,611; TIBO; atevirdine). Excluded within 14 days prior to study entry: Acute treatment for a serious infection or any opportunistic infection. Biologic response modifiers such as interferon and IL-2. Erythromycin. Coumadin/warfarin. Phenytoin or phenobarbital. Ticarcillin/clavulanate acid (Timentin) or amoxicillin/clavulanate acid (Augmentin).
Sites / Locations
- Univ of Alabama at Birmingham
- Univ of Southern California / LA County USC Med Ctr
- Highland Gen Hosp / San Francisco Gen Hosp
- Summitt Med Ctr / San Francisco Gen Hosp
- Univ of California / San Diego Treatment Ctr
- San Francisco AIDS Clinic / San Francisco Gen Hosp
- San Francisco Gen Hosp
- Univ of Colorado Health Sciences Ctr
- Univ of Miami School of Medicine
- Northwestern Univ Med School
- Cook County Hosp
- Rush Presbyterian - Saint Luke's Med Ctr
- Indiana Univ Hosp
- Univ of Iowa Hosp and Clinic
- Harvard (Massachusetts Gen Hosp)
- Boston Med Ctr
- Beth Israel Deaconess - West Campus
- Beth Israel Deaconess Med Ctr
- Hennepin County Med Clinic
- Univ of Minnesota
- St Paul Ramsey Med Ctr
- Univ of Nebraska Med Ctr
- Bronx Municipal Hosp Ctr/Jacobi Med Ctr
- Comprehensive Health Care Ctr / Bronx Municipal Hosp
- Montefiore Drug Treatment Ctr / Bronx Municipal Hosp
- Montefiore Family Health Ctr / Bronx Municipal Hosp
- Samaritan Village Inc / Bronx Municipal Hosp
- Jack Weiler Hosp / Bronx Municipal Hosp
- Montefiore Med Ctr / Bronx Municipal Hosp
- North Central Bronx Hosp / Bronx Municipal Hosp
- City Hosp Ctr at Elmhurst / Mount Sinai Hosp
- Beth Israel Med Ctr
- Saint Clare's Hosp and Health Ctr
- Cornell Univ Med Ctr
- Mem Sloan - Kettering Cancer Ctr
- Mount Sinai Med Ctr
- Univ of North Carolina
- Carolinas Med Ctr
- Moses H Cone Memorial Hosp
- Wake County Dept of Health
- Univ of Cincinnati
- Girard Med Ctr
- Univ of Pennsylvania at Philadelphia
- Thomas Jefferson Univ Hosp