A D1 Agonist For Working Memory
Schizotypal Personality Disorder, SPD
About this trial
This is an interventional treatment trial for Schizotypal Personality Disorder focused on measuring schizotypal personality disorder, cognitive impairment, working memory, Dopamine Agonists, Cognition Disorders, Personality Disorders, Delirium, Dementia, Amnestic, Cognitive Disorders, Mental Disorders, Dihydrexidine, Dopamine A
Eligibility Criteria
Inclusion Criteria:
- Currently meeting DSM-IV-TR criteria for Schizotypal
- Personality Disorder
- Males and Females 18 ≤ age ≤ 65
- Medically and neurologically healthy
- Willing and having capacity to provide informed consent
Exclusion Criteria:
- Currently bipolar I disorder, schizophrenia or current psychosis
- Clinically significant cardiovascular or neurological conditions, uncontrolled hypertension, clinically significant EKG abnormalities, or serious general medical illness
- Clinical evidence of dehydration or significant hypotension
- Currently meeting DSM-IV-TR criteria for Major Depressive Disorder
- Current substance abuse or past dependence within the last six months (other than nicotine)
- Currently taking psychotropic medications
- Currently pregnant or lactating
- Non-English speaking
- Socio-economically disadvantaged people will be included in our research study.
Sites / Locations
- Icahn School of Medicine at Mount Sinai
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Placebo Comparator
No Intervention
DAR 0-100A then Placebo
Placebo then DAR 0-100A
Healthy Control
15 mg is dissolved in 150 cc NS administered over 30 minutes x 3 consecutive days. Subjects will return a minimum of two weeks later for Visit 5 to receive drug (if randomized initially to placebo) or placebo (if randomized to drug).
15 mg dissolved in 150 cc NS saline is administered over 30 minutes x 3 consecutive days. Subjects will return a minimum of two weeks later for Visit 5 to receive drug (if randomized initially to placebo) or placebo (if randomized to drug).
patients without diagnosis of SPD