A Four-way Crossover, Single and Repeat Dose Study to Determine the Dose Proportionality and Absolute Bioavailability of Fluticasone Furoate Inhalation Powder Administered by Novel Dry Powder Inhaler (NDPI)

This is an interventional treatment trial for Asthma focused on measuring bioavailability, Fluticasone Furoate, pharmacokinetics, dose proportionality Read More

Inclusion Criteria:

• Healthy male or female subjects between 18 and 65 years of age and body mass index (BMI) within the range 18.5 to 29.0 kilogram/meter squared.
• Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and bilirubin < or =1.5x upper limit of normal (ULN).
• Female subjects of child bearing potential are eligible to enter if they are not pregnant and willing to use protocol-specified methods of contraception to prevent pregnancy during the study.
• Average QT duration corrected for heart rate by Fridericia's formula (QTcF) <450 millisecond.
• Forced Expiratory Volume in 1 Second (FEV1) > or = 85% predicted at screening.
• Current non-smokers
• Able to satisfactorily use the NDPI.

Exclusion Criteria:

• Subjects must not have a systolic blood pressure above 145 milimeter(mm) of mercury(Hg) or a diastolic pressure above 85 mmHg at the screening visit.
• History of breathing problems in adult life confirmed by normal lung function parameters (≥85% predicted).
• Donation of more than 500 mL blood within a 56 day period.
• Subjects who have suffered a lower respiratory tract infection within 4 weeks of the screening visit.
• Current or chronic history of liver disease, or known hepatic or biliary abnormalities.
• The subject treated for or diagnosed with depression within six months of screening or has a history of significant psychiatric illness.
• The subject has a positive: drug/alcohol, Hepatitis, HIV screen.
• Abuse of alcohol.
• Subject having positive cotinine and urine alcohol test.
• Participated in >3 clinical trials in the previous 10 months (if male), or >2 clinical trials in the previous 10 months (if female), or the subject has participated in a study (including follow up) within 60 days prior to the first dosing day in the current study.
• Exposure to more than four new chemical entities within 12 months prior to the first dosing day.
• Taken systemic, oral or depot corticosteroids less than 12 weeks or inhaled, intranasal or topical steroids less than 4 weeks before the screening visit.
• Use of prescription or non-prescription drugs.
• History of severe milk protein allergy, sensitivity to any of the study medications, including immediate or delayed hypersensitivity to any intranasal, inhaled or systemic corticosteroid therapy.
• Pregnant or lactating females.
• Unwillingness or inability to follow the procedures outlined in the protocol.
• Subject is mentally or legally incapacitated.