A Multicenter, Prospective, Randomized, Double-Blind Clinical Trial Comparing Itraconazole Oral Solution in Cyclodextrin to Placebo in the Treatment of Aspergilloma

Inclusion Criteria: You may be eligible for this study if you: Are 18 years of age or older. Have been diagnosed with aspergilloma within the last month. Have (or have a history of) at least one of the following: positive test for Aspergillus species. presence of antibodies to Aspergillus. Are willing to participate in the study for 2 full years. Are female and not pregnant. Are not breast-feeding. Agree to use barrier methods of birth control / contraception during the study and for 30 days after. Exclusion Criteria: You will not be eligible for this study if you: Have a history of allergy to triazole or imidazole drugs. Are unable to take oral medication. Are not expected to live for more than a month. Have had a lung biopsy indicating Aspergillus infection. Have had radiation therapy within the last 6 months. Require treatment with certain medications. Received amphotericin, amphotericin lipid formulation, fluconazole, or itraconazole in the two weeks prior to study entry. Received chemotherapy within the last 6 months.