A Multicenter Study to Assess the Tolerability of Once Daily Lopinavir/Ritonavir (LPV/r) Liquid Versus Capsules

Inclusion Criteria: Ability and willingness of subject or legal guardian/representative to give written informed consent. HIV-1 infected. At least 18 years of age Have the last two HIV-1 RNA measurements performed prior to screening be <50 or 75 copies/mL within the last 180 days, as well as at the time of screening. No evidence of primary PI mutations (defined by IAS-USA) documented on previous resistance testing, if ever performed and available, or suggested to be present by previous treatment history. Laboratory values: Absolute neutrophil count (ANC) >500/mm3. -Hemoglobin >7.0 g/dL. platelet count >50,000/mm3. AST (SGOT), ALT (SGPT), and alkaline phosphatase <5 X ULN. Total bilirubin <2.5 x ULN, unless on IDV or ATV in which case must be <1.5 x ULN of direct bilirubin. Calculated creatinine clearance >50 mL/min as estimated by the Cockcroft-Gault equation For women of reproductive potential, negative serum or urine pregnancy test within 7 days prior to initiating study medications. If participating in sexual activity that could lead to pregnancy, female study subjects must use two forms of contraception, one of which must be a barrier method. All subjects must continue to use contraception for 6 weeks after stopping the study medications. Willingness to take an alcohol containing product. Karnofsky performance score >70. Exclusion Criteria: Pregnancy or breast-feeding Greater than Grade 1 diarrhea or nausea (as defined by protocol) Use of a NNRTI within 12 weeks of screening Use of antimotility or antiemetics during the 14 days prior to screening Use of any of the prohibited medications (defined by protocol) within 30 days of study entry. Need to continue the use of prohibited or select precautionary medications (defined by protocol) Known hypersensitivity to lopinavir/ritonavir Active drug or alcohol use or dependence which, in the Investigator's opinion, may interfere with adherence to study requirements or endanger subject's health while on the study Serious illness requiring systemic treatment and/or hospitalization until subject either completes therapy or is clinically stable on therapy, in the opinion of the investigator, for at least 30 days prior to study entry. Acute therapy for serious infection or other serious medical illnesses (in the judgment of the site investigator) requiring systemic treatment and/or hospitalization within 14 days prior to study entry. Use of immunomodulators (e.g., interleukins, interferons, cyclosporine), HIV-1 vaccine, systemic cytotoxic chemotherapy, or investigational therapy within 30 days prior to study entry