A New Scoring System Improves Diagnostic Accuracy of Intestinal Dysganglionosis --a Prospective Study
Hirschsprung Disease
About this trial
This is an interventional diagnostic trial for Hirschsprung Disease focused on measuring Intestinal dysganglinosis, Hirschsprung disease, Hirschsprung disease allied disorders, diagnostic scoring system, Prospective study
Eligibility Criteria
Inclusion Criteria:
- Hard or firm stools for 2 or less per week
- Age are from newborn to 3 years old
Exclusion Criteria:
- Children>3 years of age
- Patients presented severe inflammation or malnutrition, unconsciousness or perforation of intestine
Sites / Locations
- Tongji HospitalRecruiting
Arms of the Study
Arm 1
Other
surgery treatment
The patients with a predicting score of more than 5 are diagnosed with HD, and are performed surgery to remove the aganglionic bowel. The patients with a score less than 5 are mostly indicative of HAD, and receive conservative treatments that included colonic irrigation, enema, high dose lactulose, and oral paraffin oil for at least 6 months. When there is no clinical improvement, patients are consented for surgical procedures to remove the dysganglionic bowel segments. one stage pull through procedure to remove the dysganglionic bowel segments.