A Novel Positron Emission Tomography (PET) Approach to Measuring Myocardial Metabolism
Type 2 Diabetes Mellitus
About this trial
This is an interventional basic science trial for Type 2 Diabetes Mellitus
Eligibility Criteria
Inclusion Criteria:
Lean:
- BMI<25 kg/m2
- normal glucose tolerance by 75g oral glucose tolerance test
Type 2 diabetes mellitus:
- BMI >25 kg/m2
- previously diagnosed type 2 diabetes mellitus
- on oral and/or injected insulin treatment.
Exclusion Criteria:
Lean:
*Use of any chronic medications
Type 2 diabetes mellitus
- known microvascular disease
- known coronary or other macro vascular disease
- use of PPARgamma class antidiabetic agents within 6 months
Sites / Locations
- Indiana University Hospital GCRC
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Saline
Insulin Clamp
Studies will be performed on one day under fasting conditions, using a saline infusion. All subjects will receive infusions of radiolabeled acetate and radiolabeled thiapalmitate tracer (16-18-F-fluoro-4-thiapalmitate).
Studies will be performed on a separate day under fasting conditions, using an insulin infusion to achieve steady state insulin/glucose clamp conditions. Studies will be performed on one day under fasting conditions, using a saline infusion. All subjects will receive infusions of radiolabeled acetate and radiolabeled thiapalmitate tracer (16-18-F-fluoro-4-thiapalmitate).