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A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis (MAESTRO-NASH)

Primary Purpose

NASH - Nonalcoholic Steatohepatitis

Status
Active
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
MGL-3196
Placebo
Sponsored by
Madrigal Pharmaceuticals, Inc.
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for NASH - Nonalcoholic Steatohepatitis

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Prescreening Criteria:

  • At least 3 metabolic risk factors
  • No history of significant alcohol consumption
  • Meet AST and FibroScan requirements OR have a historic liver biopsy < 2 years old demonstrating Fibrosis stage 1B, 2 or 3 with NASH [AST > 17 IU (females) or > 20 IU (males)]

Inclusion Criteria:

  1. Must be willing to participate in the study and provide written informed consent.
  2. Male and female adults ≥ 18 years of age.
  3. Female patients of child-bearing potential who agree to use study-required contraceptive measures and have a negative pregnancy test
  4. Males must agree to use one of the study-required contraceptive measures or be sterile.

5 Suspected or confirmed diagnosis of NASH suggested by historical data must meet one of the following:

  1. Biochemical test for fibrosis OR
  2. FibroScan test OR c Historical liver biopsy obtained < 2 years before expected randomization showing Stage 1B, 2 or 3 fibrosis with NASH 6. MRI-PDFF fat fraction ≥ 8% 7. Biopsy-proven NASH (Baseline liver biopsy) based on a liver biopsy obtained 6 months before anticipated date of randomization (if the biopsy is deemed acceptable for interpretation by the central reader) with fibrosis stage 1A, 1B, 2, or 3 on liver biopsy and NAS of ≥ 4 with a score of at least 1 in each of the following NAS components:

a. Steatosis (scored 0 to 3) b. Ballooning degeneration (scored 0 to 2) c. Lobular inflammation (scored 0 to 3) 8. Estimated GFR ≥45

Key Exclusion Criteria:

  1. History of significant alcohol consumption for a period of more than 3 consecutive months within 1 year prior to Screening.
  2. Regular use of drugs historically associated with NAFLD
  3. Active hyperthyroidism, untreated clinical hypothyroidism, or have had a thyroidectomy and are on replacement thyroxine
  4. History of bariatric surgery or intestinal bypass surgery within the 5 years prior to randomization or planned during the conduct of the study.
  5. Weight gain or loss ≥ 5% total body weight within 12 weeks prior to randomization
  6. HbA1c ≥ 9.0%.
  7. Glucagon-like peptide 1 [GLP-1] agonist therapy
  8. Use of high dose Vitamin E (> 400 IU/day) unless stable for ≥24 weeks prior to screening biopsy.
  9. Presence of cirrhosis on liver biopsy defined as stage 4 fibrosis.
  10. Diagnosis of hepatocellular carcinoma (HCC).
  11. MELD score ≥12, as determined at Screening, unless due to therapeutic anti coagulation.
  12. Hepatic decompensation or impairment as defined in protocol
  13. Chronic liver diseases other than NASH
  14. Active autoimmune disease
  15. Serum ALT > 250 U/L.
  16. Statins and/or other lipid-lowering therapies unless dose is stable for ≥30 days prior to randomization
  17. Fenofibrate unless dose is stable for at least 6 weeks prior to randomization

Sites / Locations

  • University of Alabama at Birmingham
  • East Valley Family Physicians
  • The Institute for Liver Health - Chandler
  • The Institute for Liver Health - Glendale
  • Desert Clinical Research
  • Adobe Gastroenterology
  • The Institute for Liver Health - Tucson
  • Arkansas Gastroenterology
  • Fresno Clinical Research Center
  • National Research Institute - Huntington Park
  • University of California San Diego
  • Cedars-Sinai Medical Center
  • National Research Institute - Los Angeles
  • Ruane Clinical Research
  • Stanford University School of Medicine
  • National Research Institute - Panorama City
  • Alliance Clinical Research
  • San Fernando Valley Health Institute
  • Colorado Springs Family Practice
  • South Denver Gastroenterology - Swedish Medical Center Office
  • Excel Medical Clinical Trials
  • Covenant Metabolic Specialists - Fort Myers
  • University of Florida Hepatology Research at CTRB
  • Nature Coast Clinical Research
  • Florida Research Institute
  • University of Miami
  • Miami Dade Medical Research Institute
  • Bioclinica Research - Orlando
  • Progressive Medical Research
  • Covenant Research
  • Bioclinica Research - The Villages
  • GI Specialists of Georgia
  • Clinical Research - Chicago
  • Northwestern Medical Faculty Foundation
  • The University of Chicago Medicine
  • University of Kansas Medical Center Research Institute
  • Kansas Medical Clinic - Gastroenterology
  • Texas Digestive Disease Consultants - Gastroenterology Associates - Baton Rouge
  • Tandem Clinical Research
  • Tulane University School of Medicine
  • Ochsner Medical Center
  • Clinical Trials of America
  • Walter Reed National Military Medical Center
  • Beth Israel Deaconess Medical Center
  • Gastrointestinal Associates and Endoscopy Center - Madison
  • Southern Therapy and Advanced Research
  • Saint Luke's Hospital of Kansas City
  • Kansas City Research Institute
  • Saint Louis University
  • Clinical Research US - Henderson
  • Mt. Sinai Medical Center
  • New York Presbyterian Hospital
  • University of North Carolina Medical Center - Chapel Hill
  • Duke University Medical Center
  • Cumberland Research Associates
  • Lucas Research
  • Consultants for Clinical Research
  • Aventiv Research - Columbus
  • Awasty Research Network
  • Premier Medical Group - Clarksville
  • Gastro One - Germantown - Centre Oak Way
  • Associates in Gastroenterology
  • Gastrointestinal Associates - Knoxville
  • South Texas Research Institute - Brownsville
  • Dallas Research Center
  • Liver Center of Texas
  • Texas Digestive Disease Consultants - Dallas
  • The Liver Institute at Methodist Dallas Medical Center
  • South Texas Research Institute
  • Brooke Army Medical Center
  • Texas Digestive Disease Consultants - Fort Worth
  • Liver Associates of Texas
  • Doctor's Hospital at Renaissance
  • Plano Research Center
  • Pinnacle Clinical Research - Austin
  • Pinnacle Clinical Research
  • San Antonio Research Center
  • The Texas Liver Institute
  • Texas Digestive Disease Consultants - San Marcos
  • Impact Research Institute
  • Texas Digestive Disease Consultants - Bay Area Gastroenterology
  • Wasatch Peak Family Practice
  • Salt Lake City Research Center
  • University of Utah Hospital
  • University of Virginia Health System
  • Bon Secours St. Mary's Hospital of Richmond
  • Hunter Holmes McGuire Veterans Administration Medical Center
  • Virginia Commonwealth University
  • Liver Institute Northwest
  • Royal Prince Alfred Hospital
  • Saint Vincent's Hospital Sydney
  • Nepean Hospital
  • John Hunter Hospital
  • Westmead Hospital
  • Royal Brisbane and Women's Hospital
  • Mater Misericordiae
  • Royal Adelaide Hospital
  • Monash Medical Centre
  • Austin Health
  • The Alfred Hospital
  • The Royal Melbourne Hospital
  • Sir Charles Gairdner Hospital
  • Royal Perth Hospital
  • Klinikum Klagenfurt Am Wörthersee
  • Ordensklinikum Linz GmbH Barmherzige Schwestern
  • Krankenanstalt Rudolfstiftung
  • Landesklinik St. Veit
  • Universitätsklinikum St. Pölten
  • Medizinische Universität Wien
  • Klinikum Wels-Grieskirchen
  • Universitair Ziekenhuis Antwerpen
  • Hôpital Erasme
  • Universitair Ziekenhuis Leuven
  • Ziekenhuis Oost-Limburg'
  • Algemeen Ziekenhuis Maria Middelares
  • Universitair Ziekenhuis Gent
  • AZ Delta Campus Wilgenstraat
  • Cliniques Universitaires Saint-Luc
  • Universitair Ziekenhuis Brussel
  • Centre Hospitalier Universitaire Brugmann
  • Universitair Ziekenhuis Leuven
  • University of Calgary Liver Unit
  • University of Alberta
  • South Shore Medical Arts
  • LMC/ Manna Research - Brampton
  • William Osler Health System
  • McMaster University
  • Toronto General Hospital - Clinical Trials Pharmacy
  • Toronto Liver Center
  • Lair Centre
  • GI Research Institute
  • Nouvel Hôpital Civil
  • Les Hôpitaux Universitaires de Strasbourg - Hôpital Hautepierre
  • Centre Hospitalier Universitaire Estaing
  • Centre Hospitalier Universitaire de Rennes
  • Hôpital Jean-Minjoz
  • Hôpital Avicenne
  • Centre Hospitalier Universitaire Henri Mondor
  • Assistance Publique-Hôpitaux de Paris Hôpital Cochin
  • Centre Hospitalier Universitaire de Montpellier
  • Hôpital Dupuytren
  • Centre Hospitalier Universitaire de Toulouse - Hôpital Rangueil
  • Centre Hospitalier Régional Universitaire de Lille
  • Center Hospitalier Universitaire d'Angers
  • Centre Hospitalier Universitaire de Nice Hôpital l'Archet
  • Hôpital de la Croix Rousse
  • Centre Hospitalier Universitaire Amiens-Picardie
  • Hôpital Beaujon
  • Hôpital Universitaire Pitié Salpêtrière
  • Centre Hospitalier Universitaire de Nancy - Hôpital de Brabois
  • Berlin Clinical Research Center
  • Charité Universitätsmedizin Berlin - Campus Mitte
  • Charité Universitätsmedizin Berlin
  • EPIMED
  • Zentrum für Infektiologie Berlin Prenzlauer Berg
  • Frankfurt Clinical Research Center
  • Universitätsklinikum Frankfurt
  • Universitätsklinikum des Saarlandes
  • EUGASTRO
  • Leipzig Research Center
  • SIBAmed Studienzentrum
  • Universitätsmedizin der Johannes Gutenberg Universität Mainz
  • Universitätsklinikum Würzburg
  • Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház
  • Magyarország Egészségügyi Szolgáltató - Gyula
  • Debreceni Egyetem Kenézy Gyula Egyetemi Kórház
  • Magyarország Research Center
  • Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház
  • Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet
  • Magyarország Research Center
  • The Chaim Sheba Medical Center
  • Emek Medical Center
  • Soroka University Medical Center
  • Rambam Health Care Campus - Rambam Medical Center
  • The Lady Davis Carmel Medical Center
  • Hadassah University Hospital Ein Kerem
  • Shaare Zedek Medical Center
  • Western Galilee Hospital-Nahariya
  • Holy Family Hospital
  • Rabin Medical Center
  • Tel Aviv Sourasky Medical Center
  • Azienda Ospedaliera Papa Giovanni XXIII
  • Azienda Ospedaliero - Universitaria Careggi
  • Azienda Ospedaliera Universitaria Policlinico Gaetano Martino
  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
  • Polo Universitario - L'Azienda Ospedaliera Luigi Sacco
  • Azienda Ospedaliera Universitaria-Maggiore della Carità di Novara
  • Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
  • Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT)
  • Azienda Ospedaliero-Universitaria Pisana Ospedale Cisanello
  • Fondazione Policlinico Universitario Agostino Gemelli
  • Universita degli Studi di Roma La Sapienza - Umberto I Policlinico di Roma
  • Ospedale Casa Sollievo della Sofferenza
  • Centro Mexicano de Desarrollo de Estudios Clínicos
  • Centro de Investigacion y Gastroenterologia
  • Centro Integral en Reumatología
  • JM Research
  • Investigaciones Médicas Cisneros
  • Polska Oddział w Częstochowie
  • Polska Oddział w Gdansk
  • Polska Oddział w Gdyni
  • Polska Oddział w Katowicach
  • Polska Oddział w Poznaniu
  • Centrum Medyczne Pratia Poznan
  • Polska Oddział w Warszawie
  • Polska Oddział w Wrocław
  • Polska Oddział w Łodz
  • Fundación De Investigación De Diego
  • Hospital Universitario Puerta de Hierro - Majadahonda
  • Complejo Hospitalario Torrecárdenas
  • Hospital de la Santa Creu i de Sant Pau
  • Hospital del Mar - Parc de Salut Mar
  • Hospital Universitari Vall d'Hebrón
  • Hospital General Universitario Gregorio Marañón
  • Hospital Universitario Ramón Y Cajal
  • Complejo Hospitalario de Pontevedra
  • Hospital Universitario Marqués de Valdecilla
  • Hospital Universitario Virgen del Rocio
  • Consorci Hospital General Universitari de València
  • Hospital Universitari i Politecnic La Fe de Valencia
  • Universitatsspital Bern
  • Fondazione Epatocentro Ticino
  • Universitatsspital Zurich
  • Midlands Clinical Research Centre
  • University Hospitals Birmingham NHS Foundation Trust
  • Cambridge University Hospitals NHS Foundation Trust
  • Lancashire Clinical Research Centre
  • North Teesside Clinical Research Centre
  • Merseyside Clinical Research Centre
  • Barts Health NHS Trust
  • Chelsea and Westminster Hospital NHS Foundation Trust
  • Imperial College Healthcare NHS Trust
  • Royal Free London NHS Foundation Trust
  • Manchester Clinical Research Centre
  • The Newcastle Upon Tyne Hospitals NHS Foundation Trust
  • Norfolk and Norwich University Hospital
  • Nottingham University Hospitals NHS Trust
  • Thames Valley Dedicated Research Centre
  • Belfast Health and Social Care Trust
  • The Hexham Clinic
  • The Wales Clinic
  • Abertawe Bro Morgannwg University Health Board
  • Aintree University Hospitals NHS Foundation Trust
  • Saint George's University Hospitals NHS Foundation Trust
  • Plymouth Hospitals NHS Trust
  • Portsmouth Hospitals NHS Trust

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Placebo Comparator

Active Comparator

Active Comparator

Arm Label

Matching Placebo

80 mg MGL-3196

100 mg MGL-3196

Arm Description

Placebo Daily

80 mg daily

100 mg daily

Outcomes

Primary Outcome Measures

Week 52 Dual Primary Objectives: To determine the effect of 80 or 100 mg MGL-3196 vs matching placebo on liver biopsy (NASH CRN score) at Week 52 compared with Baseline
Proportion with resolution of NASH (ballooning 0, inflammation 0,1) associated with at least 2-point reduction in NAFLD Activity Score (NAS) without worsening of fibrosis stage OR Proportion with at least a 1-point improvement in fibrosis stage with no worsening of NAS
Month 54 Primary Objective: Time to experiencing an adjudicated Composite Clinical Outcome event (Final Primary Endpoint, at 54 months)
The Composite Clinical Outcome is composed of all-cause mortality, liver transplant, and significant hepatic events (including hepatic decompensation events [ascites, encephalopathy, or gastroesophageal variceal hemorrhage], histological progression to cirrhosis, and a confirmed increase of MELD score from <12 to ≥15).

Secondary Outcome Measures

Week 52 Key Secondary Objective: To determine the effect of once-daily, oral administration of MGL-3196 80 or 100 mg versus matching placebo on the percent change from Baseline at 24 weeks in directly measured low-density lipoprotein cholesterol (LDL-C)
Assess the effect of MGL-3196 80 mg or 100 mg compared to placebo on LDL-C measured by percent change from Baseline at 24 weeks.

Full Information

First Posted
March 26, 2019
Last Updated
October 11, 2023
Sponsor
Madrigal Pharmaceuticals, Inc.
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1. Study Identification

Unique Protocol Identification Number
NCT03900429
Brief Title
A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis
Acronym
MAESTRO-NASH
Official Title
A Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (Resmetirom) in Patients With Non-Alcoholic Steatohepatitis (NASH) and Fibrosis to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation
Study Type
Interventional

2. Study Status

Record Verification Date
October 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
March 28, 2019 (Actual)
Primary Completion Date
December 19, 2022 (Actual)
Study Completion Date
January 2028 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Madrigal Pharmaceuticals, Inc.

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
A double-blind placebo controlled randomized Phase 3 study to determine if 80 or 100 mg of MGL-3196 as compared with placebo resolves NASH and/or reduces fibrosis on liver biopsy and prevents progression to cirrhosis and/or advanced liver disease
Detailed Description
Primary and secondary endpoint population at Week 52 will be at least 900 patients, more than half F3, the remainder F2 and <10% F1B based on final liver biopsy baseline fibrosis score.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
NASH - Nonalcoholic Steatohepatitis

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
1759 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Matching Placebo
Arm Type
Placebo Comparator
Arm Description
Placebo Daily
Arm Title
80 mg MGL-3196
Arm Type
Active Comparator
Arm Description
80 mg daily
Arm Title
100 mg MGL-3196
Arm Type
Active Comparator
Arm Description
100 mg daily
Intervention Type
Drug
Intervention Name(s)
MGL-3196
Other Intervention Name(s)
Resmetirom
Intervention Description
Tablet
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Matching Tablets
Primary Outcome Measure Information:
Title
Week 52 Dual Primary Objectives: To determine the effect of 80 or 100 mg MGL-3196 vs matching placebo on liver biopsy (NASH CRN score) at Week 52 compared with Baseline
Description
Proportion with resolution of NASH (ballooning 0, inflammation 0,1) associated with at least 2-point reduction in NAFLD Activity Score (NAS) without worsening of fibrosis stage OR Proportion with at least a 1-point improvement in fibrosis stage with no worsening of NAS
Time Frame
52 weeks
Title
Month 54 Primary Objective: Time to experiencing an adjudicated Composite Clinical Outcome event (Final Primary Endpoint, at 54 months)
Description
The Composite Clinical Outcome is composed of all-cause mortality, liver transplant, and significant hepatic events (including hepatic decompensation events [ascites, encephalopathy, or gastroesophageal variceal hemorrhage], histological progression to cirrhosis, and a confirmed increase of MELD score from <12 to ≥15).
Time Frame
up to 54 months
Secondary Outcome Measure Information:
Title
Week 52 Key Secondary Objective: To determine the effect of once-daily, oral administration of MGL-3196 80 or 100 mg versus matching placebo on the percent change from Baseline at 24 weeks in directly measured low-density lipoprotein cholesterol (LDL-C)
Description
Assess the effect of MGL-3196 80 mg or 100 mg compared to placebo on LDL-C measured by percent change from Baseline at 24 weeks.
Time Frame
24 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Must be willing to participate in the study and provide written informed consent. Male and female adults ≥ 18 years of age. Suspected or confirmed diagnosis of NASH fibrosis suggested by the historical data. Meet one of the following criteria that is consistent with NASH liver fibrosis: Historical biochemical test for fibrosis: PRO-C3 >14 ng/mL or ELF ≥9 FibroScan with transient elastography ≥8.5 kPa and controlled attenuation parameter ≥280 dB.m-1 Historical liver biopsy obtained <2 years before expected randomization showing Stage 1B, 2 or 3 fibrosis with NASH based on existing pathology review, with no significant change in body weight >5% or medication that might affect NAS or fibrosis stage. MRI-PDFF fat fraction ≥8% obtained during the screening period Biopsy-proven NASH (baseline liver biopsy) based on a liver biopsy obtained ≤6 months before anticipated date of randomization (if the biopsy is deemed acceptable for interpretation by the central reader) with fibrosis stage 1A/1C, 1B, 2, or 3 on liver biopsy and NAS of ≥4 with a score of at least 1 in each of the following NAS components: Steatosis (scored 0 to 3) Ballooning degeneration (scored 0 to 2) Lobular inflammation (scored 0 to 3) Exclusion Criteria: History of significant alcohol consumption for a period of more than 3 consecutive months within 1 year prior to Screening. Regular use of drugs historically associated with NAFLD Thyroid diseases: Active hyperthyroidism. Untreated clinical hypothyroidism defined by thyroid stimulating hormone (TSH) >7 IU/L with symptoms of hypothyroidism or >10 IU/L without symptoms. Patients who have had a thyroidectomy and are on replacement thyroxine doses >75 µg per day are allowed. History of bariatric surgery or intestinal bypass surgery within the 5 years prior to randomization or planned during the conduct of the study. Recent significant weight gain or loss HbA1c ≥ 9.0%. Glucagon-like peptide 1 [GLP-1] agonist, high dose Vitamin E (> 400 IU/day), or pioglitazone therapy unless stable dose for 24 weeks prior to biopsy. Presence of cirrhosis on liver biopsy defined as stage 4 fibrosis. Diagnosis of hepatocellular carcinoma (HCC). MELD score ≥12, as determined at Screening, unless due to therapeutic anti coagulation. Hepatic decompensation Chronic liver diseases other than NASH Active autoimmune disease Serum ALT > 250 U/L. Active, serious medical disease with a likely life expectancy < 2 years. Participation in an investigational new drug trial in the 60 days or 5 half-lives, whichever is longer. Any other condition which, in the opinion of the Investigator, would impede compliance, hinder completion of the study, compromise the well-being of the patient, or interfere with the study outcomes.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Rebecca Taub, MD
Organizational Affiliation
Madrigal Pharmaceuticals, Inc.
Official's Role
Study Director
Facility Information:
Facility Name
University of Alabama at Birmingham
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35249
Country
United States
Facility Name
East Valley Family Physicians
City
Chandler
State/Province
Arizona
ZIP/Postal Code
85224
Country
United States
Facility Name
The Institute for Liver Health - Chandler
City
Chandler
State/Province
Arizona
ZIP/Postal Code
85224
Country
United States
Facility Name
The Institute for Liver Health - Glendale
City
Glendale
State/Province
Arizona
ZIP/Postal Code
85306
Country
United States
Facility Name
Desert Clinical Research
City
Mesa
State/Province
Arizona
ZIP/Postal Code
85213
Country
United States
Facility Name
Adobe Gastroenterology
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85712
Country
United States
Facility Name
The Institute for Liver Health - Tucson
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85712
Country
United States
Facility Name
Arkansas Gastroenterology
City
North Little Rock
State/Province
Arkansas
ZIP/Postal Code
72117
Country
United States
Facility Name
Fresno Clinical Research Center
City
Fresno
State/Province
California
ZIP/Postal Code
93720
Country
United States
Facility Name
National Research Institute - Huntington Park
City
Huntington Park
State/Province
California
ZIP/Postal Code
90255
Country
United States
Facility Name
University of California San Diego
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Cedars-Sinai Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
National Research Institute - Los Angeles
City
Los Angeles
State/Province
California
ZIP/Postal Code
90057
Country
United States
Facility Name
Ruane Clinical Research
City
Los Angeles
State/Province
California
ZIP/Postal Code
90057
Country
United States
Facility Name
Stanford University School of Medicine
City
Palo Alto
State/Province
California
ZIP/Postal Code
94304
Country
United States
Facility Name
National Research Institute - Panorama City
City
Panorama City
State/Province
California
ZIP/Postal Code
91402
Country
United States
Facility Name
Alliance Clinical Research
City
Poway
State/Province
California
ZIP/Postal Code
92064
Country
United States
Facility Name
San Fernando Valley Health Institute
City
Van Nuys
State/Province
California
ZIP/Postal Code
91405
Country
United States
Facility Name
Colorado Springs Family Practice
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80909
Country
United States
Facility Name
South Denver Gastroenterology - Swedish Medical Center Office
City
Englewood
State/Province
Colorado
ZIP/Postal Code
80113
Country
United States
Facility Name
Excel Medical Clinical Trials
City
Boca Raton
State/Province
Florida
ZIP/Postal Code
33434
Country
United States
Facility Name
Covenant Metabolic Specialists - Fort Myers
City
Fort Myers
State/Province
Florida
ZIP/Postal Code
33912
Country
United States
Facility Name
University of Florida Hepatology Research at CTRB
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32610
Country
United States
Facility Name
Nature Coast Clinical Research
City
Inverness
State/Province
Florida
ZIP/Postal Code
34452
Country
United States
Facility Name
Florida Research Institute
City
Lakewood Ranch
State/Province
Florida
ZIP/Postal Code
34211
Country
United States
Facility Name
University of Miami
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Facility Name
Miami Dade Medical Research Institute
City
Miami
State/Province
Florida
ZIP/Postal Code
33176
Country
United States
Facility Name
Bioclinica Research - Orlando
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Facility Name
Progressive Medical Research
City
Port Orange
State/Province
Florida
ZIP/Postal Code
32127
Country
United States
Facility Name
Covenant Research
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34240
Country
United States
Facility Name
Bioclinica Research - The Villages
City
The Villages
State/Province
Florida
ZIP/Postal Code
32162
Country
United States
Facility Name
GI Specialists of Georgia
City
Marietta
State/Province
Georgia
ZIP/Postal Code
30060
Country
United States
Facility Name
Clinical Research - Chicago
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60602
Country
United States
Facility Name
Northwestern Medical Faculty Foundation
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611
Country
United States
Facility Name
The University of Chicago Medicine
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
Facility Name
University of Kansas Medical Center Research Institute
City
Fairway
State/Province
Kansas
ZIP/Postal Code
66205
Country
United States
Facility Name
Kansas Medical Clinic - Gastroenterology
City
Topeka
State/Province
Kansas
ZIP/Postal Code
66606
Country
United States
Facility Name
Texas Digestive Disease Consultants - Gastroenterology Associates - Baton Rouge
City
Baton Rouge
State/Province
Louisiana
ZIP/Postal Code
70809
Country
United States
Facility Name
Tandem Clinical Research
City
Marrero
State/Province
Louisiana
ZIP/Postal Code
70072
Country
United States
Facility Name
Tulane University School of Medicine
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
Ochsner Medical Center
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Facility Name
Clinical Trials of America
City
West Monroe
State/Province
Louisiana
ZIP/Postal Code
71291
Country
United States
Facility Name
Walter Reed National Military Medical Center
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20889
Country
United States
Facility Name
Beth Israel Deaconess Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
Gastrointestinal Associates and Endoscopy Center - Madison
City
Flowood
State/Province
Mississippi
ZIP/Postal Code
39232
Country
United States
Facility Name
Southern Therapy and Advanced Research
City
Jackson
State/Province
Mississippi
ZIP/Postal Code
39216
Country
United States
Facility Name
Saint Luke's Hospital of Kansas City
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64111
Country
United States
Facility Name
Kansas City Research Institute
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64131
Country
United States
Facility Name
Saint Louis University
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63104
Country
United States
Facility Name
Clinical Research US - Henderson
City
Henderson
State/Province
Nevada
ZIP/Postal Code
89052
Country
United States
Facility Name
Mt. Sinai Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10029
Country
United States
Facility Name
New York Presbyterian Hospital
City
New York
State/Province
New York
ZIP/Postal Code
10065
Country
United States
Facility Name
University of North Carolina Medical Center - Chapel Hill
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
27599
Country
United States
Facility Name
Duke University Medical Center
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27705
Country
United States
Facility Name
Cumberland Research Associates
City
Fayetteville
State/Province
North Carolina
ZIP/Postal Code
28304
Country
United States
Facility Name
Lucas Research
City
Morehead City
State/Province
North Carolina
ZIP/Postal Code
28557
Country
United States
Facility Name
Consultants for Clinical Research
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45249
Country
United States
Facility Name
Aventiv Research - Columbus
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43213
Country
United States
Facility Name
Awasty Research Network
City
Marion
State/Province
Ohio
ZIP/Postal Code
43302
Country
United States
Facility Name
Premier Medical Group - Clarksville
City
Clarksville
State/Province
Tennessee
ZIP/Postal Code
37040
Country
United States
Facility Name
Gastro One - Germantown - Centre Oak Way
City
Germantown
State/Province
Tennessee
ZIP/Postal Code
38138
Country
United States
Facility Name
Associates in Gastroenterology
City
Hermitage
State/Province
Tennessee
ZIP/Postal Code
37076
Country
United States
Facility Name
Gastrointestinal Associates - Knoxville
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37909
Country
United States
Facility Name
South Texas Research Institute - Brownsville
City
Brownsville
State/Province
Texas
ZIP/Postal Code
78520
Country
United States
Facility Name
Dallas Research Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75234
Country
United States
Facility Name
Liver Center of Texas
City
Dallas
State/Province
Texas
ZIP/Postal Code
75234
Country
United States
Facility Name
Texas Digestive Disease Consultants - Dallas
City
Dallas
State/Province
Texas
ZIP/Postal Code
75234
Country
United States
Facility Name
The Liver Institute at Methodist Dallas Medical Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75234
Country
United States
Facility Name
South Texas Research Institute
City
Edinburg
State/Province
Texas
ZIP/Postal Code
78539
Country
United States
Facility Name
Brooke Army Medical Center
City
Fort Sam Houston
State/Province
Texas
ZIP/Postal Code
78234
Country
United States
Facility Name
Texas Digestive Disease Consultants - Fort Worth
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
Liver Associates of Texas
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Doctor's Hospital at Renaissance
City
McAllen
State/Province
Texas
ZIP/Postal Code
78504
Country
United States
Facility Name
Plano Research Center
City
Plano
State/Province
Texas
ZIP/Postal Code
75093
Country
United States
Facility Name
Pinnacle Clinical Research - Austin
City
Rollingwood
State/Province
Texas
ZIP/Postal Code
78746
Country
United States
Facility Name
Pinnacle Clinical Research
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
San Antonio Research Center
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
The Texas Liver Institute
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Texas Digestive Disease Consultants - San Marcos
City
San Marcos
State/Province
Texas
ZIP/Postal Code
78666
Country
United States
Facility Name
Impact Research Institute
City
Waco
State/Province
Texas
ZIP/Postal Code
76710
Country
United States
Facility Name
Texas Digestive Disease Consultants - Bay Area Gastroenterology
City
Webster
State/Province
Texas
ZIP/Postal Code
77598
Country
United States
Facility Name
Wasatch Peak Family Practice
City
Layton
State/Province
Utah
ZIP/Postal Code
84041
Country
United States
Facility Name
Salt Lake City Research Center
City
Murray
State/Province
Utah
ZIP/Postal Code
84123
Country
United States
Facility Name
University of Utah Hospital
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84132
Country
United States
Facility Name
University of Virginia Health System
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22903
Country
United States
Facility Name
Bon Secours St. Mary's Hospital of Richmond
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23226
Country
United States
Facility Name
Hunter Holmes McGuire Veterans Administration Medical Center
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23249
Country
United States
Facility Name
Virginia Commonwealth University
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23249
Country
United States
Facility Name
Liver Institute Northwest
City
Seattle
State/Province
Washington
ZIP/Postal Code
98105
Country
United States
Facility Name
Royal Prince Alfred Hospital
City
Camperdown
State/Province
New South Wales
ZIP/Postal Code
2050
Country
Australia
Facility Name
Saint Vincent's Hospital Sydney
City
Darlinghurst
State/Province
New South Wales
ZIP/Postal Code
2010
Country
Australia
Facility Name
Nepean Hospital
City
Kingswood
State/Province
New South Wales
ZIP/Postal Code
2747
Country
Australia
Facility Name
John Hunter Hospital
City
New Lambton
State/Province
New South Wales
ZIP/Postal Code
2305
Country
Australia
Facility Name
Westmead Hospital
City
Westmead
State/Province
New South Wales
ZIP/Postal Code
2145
Country
Australia
Facility Name
Royal Brisbane and Women's Hospital
City
Herston
State/Province
Queensland
ZIP/Postal Code
4029
Country
Australia
Facility Name
Mater Misericordiae
City
South Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Facility Name
Royal Adelaide Hospital
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Monash Medical Centre
City
Clayton
State/Province
Victoria
ZIP/Postal Code
3168
Country
Australia
Facility Name
Austin Health
City
Heidelberg
State/Province
Victoria
ZIP/Postal Code
3084
Country
Australia
Facility Name
The Alfred Hospital
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3004
Country
Australia
Facility Name
The Royal Melbourne Hospital
City
Parkville
State/Province
Victoria
ZIP/Postal Code
3050
Country
Australia
Facility Name
Sir Charles Gairdner Hospital
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
Facility Name
Royal Perth Hospital
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6000
Country
Australia
Facility Name
Klinikum Klagenfurt Am Wörthersee
City
Klagenfurt
State/Province
Carinthia
Country
Austria
Facility Name
Ordensklinikum Linz GmbH Barmherzige Schwestern
City
Linz
State/Province
Upper Austria
Country
Austria
Facility Name
Krankenanstalt Rudolfstiftung
City
Wien
State/Province
Vienna
Country
Austria
Facility Name
Landesklinik St. Veit
City
Salzburg
Country
Austria
Facility Name
Universitätsklinikum St. Pölten
City
St. Pölten
ZIP/Postal Code
3100
Country
Austria
Facility Name
Medizinische Universität Wien
City
Vienna
Country
Austria
Facility Name
Klinikum Wels-Grieskirchen
City
Wels
Country
Austria
Facility Name
Universitair Ziekenhuis Antwerpen
City
Edegem
State/Province
Antwerpen
Country
Belgium
Facility Name
Hôpital Erasme
City
Bruxelles
State/Province
Brussels
Country
Belgium
Facility Name
Universitair Ziekenhuis Leuven
City
Leuven
State/Province
Flemish Brabant
Country
Belgium
Facility Name
Ziekenhuis Oost-Limburg'
City
Genk
State/Province
Limburg
Country
Belgium
Facility Name
Algemeen Ziekenhuis Maria Middelares
City
Gent
State/Province
Oost-Vlaanderen
Country
Belgium
Facility Name
Universitair Ziekenhuis Gent
City
Gent
State/Province
Oost-Vlaanderen
Country
Belgium
Facility Name
AZ Delta Campus Wilgenstraat
City
Roeselare
State/Province
West-Vlaanderen
Country
Belgium
Facility Name
Cliniques Universitaires Saint-Luc
City
Brussels
Country
Belgium
Facility Name
Universitair Ziekenhuis Brussel
City
Brussel
ZIP/Postal Code
1090
Country
Belgium
Facility Name
Centre Hospitalier Universitaire Brugmann
City
Laeken
Country
Belgium
Facility Name
Universitair Ziekenhuis Leuven
City
Leuven
Country
Belgium
Facility Name
University of Calgary Liver Unit
City
Calgary
State/Province
Alberta
Country
Canada
Facility Name
University of Alberta
City
Edmonton
State/Province
Alberta
Country
Canada
Facility Name
South Shore Medical Arts
City
Bridgewater
State/Province
Nova Scotia
Country
Canada
Facility Name
LMC/ Manna Research - Brampton
City
Brampton
State/Province
Ontario
Country
Canada
Facility Name
William Osler Health System
City
Brampton
State/Province
Ontario
Country
Canada
Facility Name
McMaster University
City
Hamilton
State/Province
Ontario
Country
Canada
Facility Name
Toronto General Hospital - Clinical Trials Pharmacy
City
Toronto
State/Province
Ontario
Country
Canada
Facility Name
Toronto Liver Center
City
Toronto
State/Province
Ontario
Country
Canada
Facility Name
Lair Centre
City
Vancouver
ZIP/Postal Code
V5Z 1J4
Country
Canada
Facility Name
GI Research Institute
City
Vancouver
Country
Canada
Facility Name
Nouvel Hôpital Civil
City
Strasbourg Cedex
State/Province
Alsace
Country
France
Facility Name
Les Hôpitaux Universitaires de Strasbourg - Hôpital Hautepierre
City
Strasbourg
State/Province
Alsace
Country
France
Facility Name
Centre Hospitalier Universitaire Estaing
City
Clermont-Ferrand
State/Province
Auvergne
Country
France
Facility Name
Centre Hospitalier Universitaire de Rennes
City
Rennes Cedex 9
State/Province
Bretagne
Country
France
Facility Name
Hôpital Jean-Minjoz
City
Besançon
State/Province
Franche-Comte
Country
France
Facility Name
Hôpital Avicenne
City
Bobigny Cedex
State/Province
Ile-de-France
Country
France
Facility Name
Centre Hospitalier Universitaire Henri Mondor
City
Créteil Cedex
State/Province
Ile-de-France
Country
France
Facility Name
Assistance Publique-Hôpitaux de Paris Hôpital Cochin
City
Paris Cedex 14
State/Province
Ile-de-France
Country
France
Facility Name
Centre Hospitalier Universitaire de Montpellier
City
Montpellier Cedex 5
State/Province
Languedoc-Roussillon
Country
France
Facility Name
Hôpital Dupuytren
City
Limoges
State/Province
Limousin
Country
France
Facility Name
Centre Hospitalier Universitaire de Toulouse - Hôpital Rangueil
City
Toulouse Cedex
State/Province
Midi-Pyrenees
Country
France
Facility Name
Centre Hospitalier Régional Universitaire de Lille
City
Lille
State/Province
Nord Pas-de-Calais
Country
France
Facility Name
Center Hospitalier Universitaire d'Angers
City
Angers
State/Province
Pays De La Loire
Country
France
Facility Name
Centre Hospitalier Universitaire de Nice Hôpital l'Archet
City
Nice Cedex 3
State/Province
Provence Alpes Cote D'Azur
Country
France
Facility Name
Hôpital de la Croix Rousse
City
Lyon Cedex 04
State/Province
Rhone-Alpes
Country
France
Facility Name
Centre Hospitalier Universitaire Amiens-Picardie
City
Amiens
Country
France
Facility Name
Hôpital Beaujon
City
Clichy
Country
France
Facility Name
Hôpital Universitaire Pitié Salpêtrière
City
Paris Cedex 13
Country
France
Facility Name
Centre Hospitalier Universitaire de Nancy - Hôpital de Brabois
City
Vandœuvre-lès-Nancy
Country
France
Facility Name
Berlin Clinical Research Center
City
Berlin
Country
Germany
Facility Name
Charité Universitätsmedizin Berlin - Campus Mitte
City
Berlin
Country
Germany
Facility Name
Charité Universitätsmedizin Berlin
City
Berlin
Country
Germany
Facility Name
EPIMED
City
Berlin
Country
Germany
Facility Name
Zentrum für Infektiologie Berlin Prenzlauer Berg
City
Berlin
Country
Germany
Facility Name
Frankfurt Clinical Research Center
City
Frankfurt am main
Country
Germany
Facility Name
Universitätsklinikum Frankfurt
City
Frankfurt am main
Country
Germany
Facility Name
Universitätsklinikum des Saarlandes
City
Homburg
Country
Germany
Facility Name
EUGASTRO
City
Leipzig
Country
Germany
Facility Name
Leipzig Research Center
City
Leipzig
Country
Germany
Facility Name
SIBAmed Studienzentrum
City
Leipzig
Country
Germany
Facility Name
Universitätsmedizin der Johannes Gutenberg Universität Mainz
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Universitätsklinikum Würzburg
City
Würzburg
Country
Germany
Facility Name
Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház
City
Békéscsaba
State/Province
Bekes
Country
Hungary
Facility Name
Magyarország Egészségügyi Szolgáltató - Gyula
City
Gyula
State/Province
Bekes
Country
Hungary
Facility Name
Debreceni Egyetem Kenézy Gyula Egyetemi Kórház
City
Debrecen
State/Province
Hajdu-Bihar
Country
Hungary
Facility Name
Magyarország Research Center
City
Debrecen
State/Province
Hajdu-Bihar
Country
Hungary
Facility Name
Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház
City
Nyíregyháza
State/Province
Szabolcs-Szatmar-Bereg
Country
Hungary
Facility Name
Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet
City
Budapest
Country
Hungary
Facility Name
Magyarország Research Center
City
Budapest
Country
Hungary
Facility Name
The Chaim Sheba Medical Center
City
Ramat Gan
State/Province
Tel Aviv
Country
Israel
Facility Name
Emek Medical Center
City
Afula
Country
Israel
Facility Name
Soroka University Medical Center
City
Be'er Sheva
Country
Israel
Facility Name
Rambam Health Care Campus - Rambam Medical Center
City
Haifa
Country
Israel
Facility Name
The Lady Davis Carmel Medical Center
City
Haifa
Country
Israel
Facility Name
Hadassah University Hospital Ein Kerem
City
Jerusalem
Country
Israel
Facility Name
Shaare Zedek Medical Center
City
Jerusalem
Country
Israel
Facility Name
Western Galilee Hospital-Nahariya
City
Nahariya
Country
Israel
Facility Name
Holy Family Hospital
City
Nazareth
Country
Israel
Facility Name
Rabin Medical Center
City
Petah Tikva
Country
Israel
Facility Name
Tel Aviv Sourasky Medical Center
City
Tel Aviv
Country
Israel
Facility Name
Azienda Ospedaliera Papa Giovanni XXIII
City
Bergamo
Country
Italy
Facility Name
Azienda Ospedaliero - Universitaria Careggi
City
Firenze
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria Policlinico Gaetano Martino
City
Messina
Country
Italy
Facility Name
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
City
Milano
Country
Italy
Facility Name
Polo Universitario - L'Azienda Ospedaliera Luigi Sacco
City
Milano
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria-Maggiore della Carità di Novara
City
Novara
Country
Italy
Facility Name
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
City
Palermo
Country
Italy
Facility Name
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT)
City
Palermo
Country
Italy
Facility Name
Azienda Ospedaliero-Universitaria Pisana Ospedale Cisanello
City
Pisa
ZIP/Postal Code
56124
Country
Italy
Facility Name
Fondazione Policlinico Universitario Agostino Gemelli
City
Roma
Country
Italy
Facility Name
Universita degli Studi di Roma La Sapienza - Umberto I Policlinico di Roma
City
Roma
Country
Italy
Facility Name
Ospedale Casa Sollievo della Sofferenza
City
San Giovanni Rotondo
Country
Italy
Facility Name
Centro Mexicano de Desarrollo de Estudios Clínicos
City
Ciudad de México
State/Province
Distrito Federal
ZIP/Postal Code
06100
Country
Mexico
Facility Name
Centro de Investigacion y Gastroenterologia
City
Ciudad de México
State/Province
Distrito Federal
ZIP/Postal Code
06700
Country
Mexico
Facility Name
Centro Integral en Reumatología
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44160
Country
Mexico
Facility Name
JM Research
City
Cuernavaca
State/Province
Morelos
ZIP/Postal Code
62290
Country
Mexico
Facility Name
Investigaciones Médicas Cisneros
City
Monterrey
State/Province
Nuevo Leon
ZIP/Postal Code
64000
Country
Mexico
Facility Name
Polska Oddział w Częstochowie
City
Częstochowa
Country
Poland
Facility Name
Polska Oddział w Gdansk
City
Gdańsk
Country
Poland
Facility Name
Polska Oddział w Gdyni
City
Gdynia
Country
Poland
Facility Name
Polska Oddział w Katowicach
City
Katowice
Country
Poland
Facility Name
Polska Oddział w Poznaniu
City
Poznań
Country
Poland
Facility Name
Centrum Medyczne Pratia Poznan
City
Skórzewo
ZIP/Postal Code
60-185
Country
Poland
Facility Name
Polska Oddział w Warszawie
City
Warszawa
Country
Poland
Facility Name
Polska Oddział w Wrocław
City
Wrocław
Country
Poland
Facility Name
Polska Oddział w Łodz
City
Łódź
Country
Poland
Facility Name
Fundación De Investigación De Diego
City
San Juan
Country
Puerto Rico
Facility Name
Hospital Universitario Puerta de Hierro - Majadahonda
City
Majadahonda
State/Province
Madrid
Country
Spain
Facility Name
Complejo Hospitalario Torrecárdenas
City
Almeria
Country
Spain
Facility Name
Hospital de la Santa Creu i de Sant Pau
City
Barcelona
Country
Spain
Facility Name
Hospital del Mar - Parc de Salut Mar
City
Barcelona
Country
Spain
Facility Name
Hospital Universitari Vall d'Hebrón
City
Barcelona
Country
Spain
Facility Name
Hospital General Universitario Gregorio Marañón
City
Madrid
Country
Spain
Facility Name
Hospital Universitario Ramón Y Cajal
City
Madrid
Country
Spain
Facility Name
Complejo Hospitalario de Pontevedra
City
Pontevedra
Country
Spain
Facility Name
Hospital Universitario Marqués de Valdecilla
City
Santander
Country
Spain
Facility Name
Hospital Universitario Virgen del Rocio
City
Sevilla
Country
Spain
Facility Name
Consorci Hospital General Universitari de València
City
Valencia
Country
Spain
Facility Name
Hospital Universitari i Politecnic La Fe de Valencia
City
Valencia
Country
Spain
Facility Name
Universitatsspital Bern
City
Bern
Country
Switzerland
Facility Name
Fondazione Epatocentro Ticino
City
Lugano
Country
Switzerland
Facility Name
Universitatsspital Zurich
City
Zürich
Country
Switzerland
Facility Name
Midlands Clinical Research Centre
City
Birmingham
State/Province
England
Country
United Kingdom
Facility Name
University Hospitals Birmingham NHS Foundation Trust
City
Birmingham
State/Province
England
Country
United Kingdom
Facility Name
Cambridge University Hospitals NHS Foundation Trust
City
Cambridge
State/Province
England
Country
United Kingdom
Facility Name
Lancashire Clinical Research Centre
City
Chorley
State/Province
England
Country
United Kingdom
Facility Name
North Teesside Clinical Research Centre
City
Hardwick
State/Province
England
Country
United Kingdom
Facility Name
Merseyside Clinical Research Centre
City
Liverpool
State/Province
England
Country
United Kingdom
Facility Name
Barts Health NHS Trust
City
London
State/Province
England
Country
United Kingdom
Facility Name
Chelsea and Westminster Hospital NHS Foundation Trust
City
London
State/Province
England
Country
United Kingdom
Facility Name
Imperial College Healthcare NHS Trust
City
London
State/Province
England
Country
United Kingdom
Facility Name
Royal Free London NHS Foundation Trust
City
London
State/Province
England
Country
United Kingdom
Facility Name
Manchester Clinical Research Centre
City
Manchester
State/Province
England
Country
United Kingdom
Facility Name
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
City
Newcastle Upon Tyne
State/Province
England
Country
United Kingdom
Facility Name
Norfolk and Norwich University Hospital
City
Norwich
State/Province
England
Country
United Kingdom
Facility Name
Nottingham University Hospitals NHS Trust
City
Nottingham
State/Province
England
Country
United Kingdom
Facility Name
Thames Valley Dedicated Research Centre
City
Reading
State/Province
England
Country
United Kingdom
Facility Name
Belfast Health and Social Care Trust
City
Belfast
State/Province
Northern Ireland
Country
United Kingdom
Facility Name
The Hexham Clinic
City
Hexham
State/Province
Northumberland, England
Country
United Kingdom
Facility Name
The Wales Clinic
City
Cardiff
State/Province
Wales
Country
United Kingdom
Facility Name
Abertawe Bro Morgannwg University Health Board
City
Swansea
State/Province
Wales
Country
United Kingdom
Facility Name
Aintree University Hospitals NHS Foundation Trust
City
Liverpool
Country
United Kingdom
Facility Name
Saint George's University Hospitals NHS Foundation Trust
City
London
Country
United Kingdom
Facility Name
Plymouth Hospitals NHS Trust
City
Plymouth
Country
United Kingdom
Facility Name
Portsmouth Hospitals NHS Trust
City
Portsmouth
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
33860116
Citation
Harrison SA, Bashir M, Moussa SE, McCarty K, Pablo Frias J, Taub R, Alkhouri N. Effects of Resmetirom on Noninvasive Endpoints in a 36-Week Phase 2 Active Treatment Extension Study in Patients With NASH. Hepatol Commun. 2021 Jan 4;5(4):573-588. doi: 10.1002/hep4.1657. eCollection 2021 Apr.
Results Reference
derived

Learn more about this trial

A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis

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