A Phase I Safety and Immunogenicity Trial of UBI HIV Lipopeptide Immunotherapeutic P3C541b in HIV-1 Seropositive Human Subjects

Inclusion Criteria Patients must have: HIV positivity. CD4 count >= 500 cells/mm3. No evidence of AIDS, persistent diarrhea, fever, oral hairy leukoplakia, herpes varicella-zoster (multidermatomal), oral candidiasis, opportunistic infections, severe cytomegalovirus infection, or disseminated or chronic herpes simplex. Successful establishment of EBV transformed B lymphoblastoid cell line. NOTE: Most patients in group 2 must possess one or more HLA types A33, B8, B27, or Bw62. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: Active syphilis. Positive circulating hepatitis B virus antigen. Active clinically significant medical problems. Evidence of psychiatric, medical, or substance abuse problems that would affect ability to participate on study. Occupational or other responsibilities that would prevent completion of study. Concurrent Medication: Excluded: Other HIV immunotherapeutic. Zidovudine or analog. Investigational therapies for HIV. Patients with the following prior conditions are excluded: History of cancer unless surgically excised with reasonable assurance of cure. History of anaphylaxis or other serious adverse reactions to vaccines. History of serious allergic reaction to any substance that required hospitalization or emergent medical care (e.g., Stevens-Johnson syndrome, bronchospasms, or hypotension). History of autoimmune disease or use of immunosuppressive medications. History of suicide attempts or past psychosis. Prior Medication: Excluded within the past 6 months: HIV immunotherapeutic. Zidovudine or analog. Investigational therapies for HIV. Illicit drug use within past 30 days.