A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection
Craniopharyngioma
About this trial
This is an interventional treatment trial for Craniopharyngioma focused on measuring Brain tumor, Pediatrics, Radiation therapy, Proton therapy, Surgery
Eligibility Criteria
Inclusion Criteria:
- Craniopharyngioma diagnosed by histology, cytology or neuroimaging or intra-operative assessment
- Patients ages 0-21 years at the time of diagnosis
Exclusion Criteria:
- Prior history of fractionated radiation therapy
- Prior treatment with intracystic P-32 or intracystic bleomycin
- Pregnant females are excluded. Radiation has teratogenic or abortifacient effects
Sites / Locations
- St. Jude Children's Research HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Tumor-Surgery
Tumor-No Surgery
Participants who are eligible to undergo surgery to remove the tumor will proceed to surgery. If all tumor is removed, they will be followed over 5 years for outcome comparison to the other participant groups. If the entire tumor is not removed by surgery, participants will receive 6 weeks of proton therapy. They will then be followed for 5 years to collect outcome data for comparison to the other participant groups.
Participants whose tumor cannot be resected through surgery will receive 6 weeks of proton therapy. They will then be followed over 5 years for outcome comparison to the other participant groups.