a Pilot Study of Pramipexole to Treat Extrapyramidal Symptoms Induced by Antipsychotics
Extrapyramidal Syndrome
About this trial
This is an interventional treatment trial for Extrapyramidal Syndrome focused on measuring Extrapyramidal syndromes praminpexole pilot study
Eligibility Criteria
Inclusion Criteria:
- Age from 18-65 years old, male or female
- Subjects who met DSM-IV-TR criteria for extrapyramidal symptoms
- Scored 1 (mild) on at least two SAS items or 2 (moderate) on one of the items Exclusion Criteria are considered as antipsychotic induced parkinson ; Scored at least 2 (mild) on the BARS global item are considered as antipsychotic induced akathisia
- Written informed consent provided by legal guardians or patients
- Understand and voluntarily participate in this trail
Exclusion Criteria:
1 A history of severe nervous system disease or nervous system injury 2 A history of severe or unstable heart, liver, kidney, endocrine (including thyroid function), hematological (such as those with hemorrhagic tendency) condition 3 Subjects who have an imminent risk of suicideor who can be a threat to himself others which judged by investigator 4 Substance or alcohol dependence at enrolment 5 Pregnancy or lactation or willing to pregnant during the trial 6 Low compliance to the doctor 7 Subjects who can't take drug in time according to doctors' advice 8 scored (mild) on at least two AIMS items or 3 (moderate) on one of the items are considered as tardive dyskesia Withdrawl Criteria
- An adverse sffecr or serious adverse effect occured so that the intervention needs to be stopped
- Subjects with poor compliance or who didn't take drugs for 4 days
- Obvious plan violation ,or the safety codition and symptoms of the patients are deteriorating
- scored (mild) on at least two AIMS items or 3 (moderate) on one of the items are considered as tardive dyskesia
- Researcher's decision of the withdrawl of the subjects -
Sites / Locations
- Shanghai Mental Health Center
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
pramipexole
Antan
pramipexole ,flexible dose (0.375mg/d-0.75mg/d)
Antan,flexible dose (2-4mg/d)