A Pilot Study on Effect of add-on Sulforaphane to SSRIs and Application of Niacin Skin Flush Response Test in Major Depressive Disorder
Major Depressive Disorder
About this trial
This is an interventional treatment trial for Major Depressive Disorder focused on measuring Major Depressive Disorder, Sulforaphane, Niacin skin flush response, Marker, Add-on
Eligibility Criteria
Inclusion Criteria:
- aged 18-60 years;
- diagnosed with moderate or severe depressive disorder according to the criteria of the DSM-5;
- total score of 17-HDRS≥17;
- never receiving electroconvulsive therapy (ECT)/modified ECT (MECT)/rTMS or other treatments in the past month;
- having sufficient audio-visual ability and comprehension;
- signed informed consent statements.
Exclusion Criteria:
- serious or active somatic illness (abnormal index values were more than twice the limit of normal);
- a history of mania/hypomania;
- current high risk of suicide (score of item 3 of 17-HDRS ≥ 3);
- pregnant or lactating women, or planning pregnant women;
- taking immunosuppressants or vitamins recently.
Sites / Locations
- Shanghai Mental Health CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
No Intervention
SSRI group
SSRI plus Sulforaphane group
Healthy control group
One SSRI is prescribed based on treatment guidelines for major depressive disorder and drug prescription manual. The dose is 20-60mg/day for fluoxetine, 20-40mg/day for paroxetine, 100-300mg/day for fluvoxamine, 50-200mg/day for sertraline, 20-40mg/day for citalopram, 10-20mg/day for escitalopram, respectively.
One SSRI is prescribed based on treatment guidelines for major depressive disorder and drug prescription manual. The dose is 20-60mg/day for fluoxetine, 20-40mg/day for paroxetine, 100-300mg/day for fluvoxamine, 50-200mg/day for sertraline, 20-40mg/day for citalopram, 10-20mg/day for escitalopram, respectively. The oral dose of SFN is based on weight. The usage and dosage are as follows: 40-70kg, 4 tablets/day (containing 274μmol of glucosinolates); 70-90kg, 6 tablets/day (containing 411μmol of glucosinolates). Take it once in the morning and evening.
No intervention is given.