Back to results

A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease (FLOW)

Primary Purpose

Diabetes Mellitus, Type 2

Status

Active

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Semaglutide

Placebo (semaglutide)

About this trial

This is an interventional treatment trial for Diabetes Mellitus, Type 2

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Male or female, age above or equal to 18 years at the time of signing informed consent. Japan: Male or female, age above or equal to 20 years at the time of signing informed consent
Diagnosed with type 2 diabetes mellitus
HbA1c less than or equal to 10% (less than or equal to 86 mmol/mol)
Renal impairment defined either by:
1. serum creatinine-based eGFR greater than or equal to 50 and less than or equal to 75 mL/min/1.73 m^2 (CKD-EPI) and UACR greater than 300 and less than 5000 mg/g or
2. serum creatinine-based eGFR greater than or equal to 25 and less than 50 mL/min/1.73 m^2 (CKD-EPI) and UACR greater than 100 and less than 5000 mg/g
Treatment with maximum labelled or tolerated dose of a renin-angiotensin-aldosterone system (RAAS) blocking agent including an angiotensin converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB), unless such treatment is contraindicated or not tolerated. Treatment dose must be stable for at least 4 weeks prior to the date of the laboratory assessments used for determination of the inclusion criteria for renal impairment and kept stable until screening

Exclusion Criteria:

Congenital or hereditary kidney diseases including polycystic kidney disease, autoimmune kidney diseases including glomerulonephritis or congenital urinary tract malformations
Use of any glucagon-like peptide-1 (GLP-1) receptor agonist within 30 days prior to screening
Myocardial infarction, stroke, hospitalisation for unstable angina pectoris or transient ischaemic attack within 60 days prior to the day of screening
Presently classified as being in New York Heart Association (NYHA) Class IV heart failure
Planned coronary, carotid or peripheral artery revascularisation
Current (or within 90 days) chronic or intermittent haemodialysis or peritoneal dialysis
Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within the past 90 days prior to screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

Semaglutide

Placebo

Arm Description

Participants are to receive semglutide for up to 5 years or more (event driven). The trial is event driven with a pre-defined minimum number of renal endpoint events for the primary endpoint.

Participants are to receive placebo (semglutide) for up to 5 years or more (event driven). The trial is event driven with a pre-defined minimum number of renal endpoint events for the primary endpoint.

Outcomes

Primary Outcome Measures

Time to first occurrence of a composite primary outcome event defined as persistent eGFR decline of greater than or equal to 50 percentage from trial start, reaching ESRD, death from kidney disease or death from cardiovascular disease

Measured in month(s). End Stage Renal Disease (ESRD) is defined as the following individual components: Persistent estimated glomerular filtration rate (eGFR) less than 15 mL/min/1.73m^2 or, Chronic dialysis treatment or receiving a kidney transplantation.

Secondary Outcome Measures

Annual rate of change in eGFR (chronic kidney disease - epidemiology collaboration (CKD-EPI)) (total eGFR slope)

Measured in (mL/min/1.73 m^2)/year.

Time to first occurrence of a composite cardiovascular major adverse cardiovascular event (MACE) endpoint consisting of: Non-fatal myocardial infarction, non-fatal stroke, and cardiovascular (CV) death

Measured in month(s).

Time to occurrence of all-cause death

Measured in month(s).

Time to occurrence of each of the individual components of the primary composite endpoint and of the confirmatory secondary MACE endpoint

Measured in month(s).

Time to first occurrence of major adverse limb events (MALE), a composite endpoint consisting of: Acute limb ischemia hospitalisation and chronic limb ischemia hospitalisation

Measured in month(s).

Annual rate of change in eGFR (CKD-EPI) (chronic eGFR slope)

Measured in (mL/min/1.73 m^2)/year.

Change in eGFR (CKD-EPI)

Measured in mL/min/1.73 m^2.

Change in eGFR (cystatin C CKD-EPI)

Measured in mL/min/1.73 m^2.

Relative change in urinary albumin-to-creatinine ratio (UACR)

Measured in percentage.

Change in body weight

Measured in kilogram.

Change in glycosylated haemoglobin (HbA1c)

Measured in percentage point.

Change in systolic blood pressure

Measured in mmHg.

Change in diastolic blood pressure

Measured in mmHg.

Number of severe hypoglycaemic episodes

Number of events.

Full Information

NCT ID

NCT03819153

First Posted

January 18, 2019

Last Updated

September 14, 2023

Sponsor

Novo Nordisk A/S

1. Study Identification

Unique Protocol Identification Number

NCT03819153

Brief Title

A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease

Acronym

FLOW

Official Title

Effect of Semaglutide Versus Placebo on the Progression of Renal Impairment in Subjects With Type 2 Diabetes and Chronic Kidney Disease

Study Type

Interventional

2. Study Status

Record Verification Date

September 2023

Overall Recruitment Status

Active, not recruiting

Study Start Date

June 17, 2019 (Actual)

Primary Completion Date

August 19, 2024 (Anticipated)

Study Completion Date

August 19, 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Novo Nordisk A/S

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Yes

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

The researchers are doing this study to see if semaglutide can slow down the growth and worsening of chronic kidney disease in people with type 2 diabetes. Participants will get semaglutide (active medicine) or placebo ('dummy medicine'). This is known as participants' study medicine - which treatment participants get is decided by chance. Semaglutide is a medicine, doctors can prescribe in some countries for the treatment of type 2 diabetes. Participants will get the study medicine in a pen. Participants will use the pen to inject the medicine in a skin fold once a week. The study will close when there is enough information collected to show clear result of the study. The total time participants will be in this study is about 3 to 5 years, but it could be longer.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Diabetes Mellitus, Type 2

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

ParticipantCare ProviderInvestigatorOutcomes Assessor

Masking Description

Sponsor staff involved in the clinical trial is masked according to company standard procedures

Allocation

Randomized

Enrollment

3508 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

Semaglutide

Arm Type

Experimental

Arm Description

Participants are to receive semglutide for up to 5 years or more (event driven). The trial is event driven with a pre-defined minimum number of renal endpoint events for the primary endpoint.

Arm Title

Placebo

Arm Type

Placebo Comparator

Arm Description

Intervention Type

Drug

Intervention Name(s)

Semaglutide

Intervention Description

Participants are to inject semaglutide with a needle in the stomach, thigh or upper arm. Participants will use a pen to inject semaglutide under their skin. Participants will inject semaglutide 1 time a week on the same day of the week. Participants' dose of semaglutide will be changed over time. Participants start by taking a smaller amount (0.25 mg). After 4 weeks the dose will be increased to 0.5 mg. It will be increased more (to 1 mg) at 8 weeks. Participants will then stay on the same dose for the rest of the study.

Intervention Type

Drug

Intervention Name(s)

Placebo (semaglutide)

Intervention Description

Participants are to inject placebo (semaglutide) with a needle in the stomach, thigh or upper arm. Participants will use a pen to inject placebo (semaglutide) under their skin. Participants will inject placebo (semaglutide) 1 time a week on the same day of the week. Participants' dose of placebo (semaglutide) will be changed over time. Participants start by taking a smaller amount (0.25 mg). After 4 weeks the dose will be increased to 0.5 mg. It will be increased more (to 1 mg) at 8 weeks. Participants will then stay on the same dose for the rest of the study.

Primary Outcome Measure Information:

Title

Description

Time Frame

Week 0 to month 61

Secondary Outcome Measure Information:

Title

Annual rate of change in eGFR (chronic kidney disease - epidemiology collaboration (CKD-EPI)) (total eGFR slope)

Description

Measured in (mL/min/1.73 m^2)/year.

Time Frame

Week 0 to month 61

Title

Description

Measured in month(s).

Time Frame

Week 0 to month 61

Title

Time to occurrence of all-cause death

Description

Measured in month(s).

Time Frame

Week 0 to month 61

Title

Time to occurrence of each of the individual components of the primary composite endpoint and of the confirmatory secondary MACE endpoint

Description

Measured in month(s).

Time Frame

Week 0 to month 61

Title

Time to first occurrence of major adverse limb events (MALE), a composite endpoint consisting of: Acute limb ischemia hospitalisation and chronic limb ischemia hospitalisation

Description

Measured in month(s).

Time Frame

Week 0 to month 61

Title

Annual rate of change in eGFR (CKD-EPI) (chronic eGFR slope)

Description

Measured in (mL/min/1.73 m^2)/year.

Time Frame

Week 12 to month 61

Title

Change in eGFR (CKD-EPI)

Description

Measured in mL/min/1.73 m^2.

Time Frame

Week 0, Week 12

Title

Change in eGFR (cystatin C CKD-EPI)

Description

Measured in mL/min/1.73 m^2.

Time Frame

Week 0, Year 3

Title

Relative change in urinary albumin-to-creatinine ratio (UACR)

Description

Measured in percentage.

Time Frame

Week 0, Year 3

Title

Change in body weight

Description

Measured in kilogram.

Time Frame

Week 0, Year 3

Title

Change in glycosylated haemoglobin (HbA1c)

Description

Measured in percentage point.

Time Frame

Week 0, Year 3

Title

Change in systolic blood pressure

Description

Measured in mmHg.

Time Frame

Week 0, Year 3

Title

Change in diastolic blood pressure

Description

Measured in mmHg.

Time Frame

Week 0, Year 3

Title

Number of severe hypoglycaemic episodes

Description

Number of events.

Time Frame

Week 0 to month 61

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Male or female, age above or equal to 18 years at the time of signing informed consent. Japan: Male or female, age above or equal to 20 years at the time of signing informed consent Diagnosed with type 2 diabetes mellitus HbA1c less than or equal to 10% (less than or equal to 86 mmol/mol) Renal impairment defined either by: serum creatinine-based eGFR greater than or equal to 50 and less than or equal to 75 mL/min/1.73 m^2 (CKD-EPI) and UACR greater than 300 and less than 5000 mg/g or serum creatinine-based eGFR greater than or equal to 25 and less than 50 mL/min/1.73 m^2 (CKD-EPI) and UACR greater than 100 and less than 5000 mg/g Treatment with maximum labelled or tolerated dose of a renin-angiotensin-aldosterone system (RAAS) blocking agent including an angiotensin converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB), unless such treatment is contraindicated or not tolerated. Treatment dose must be stable for at least 4 weeks prior to the date of the laboratory assessments used for determination of the inclusion criteria for renal impairment and kept stable until screening Exclusion Criteria: Congenital or hereditary kidney diseases including polycystic kidney disease, autoimmune kidney diseases including glomerulonephritis or congenital urinary tract malformations Use of any glucagon-like peptide-1 (GLP-1) receptor agonist within 30 days prior to screening Myocardial infarction, stroke, hospitalisation for unstable angina pectoris or transient ischaemic attack within 60 days prior to the day of screening Presently classified as being in New York Heart Association (NYHA) Class IV heart failure Planned coronary, carotid or peripheral artery revascularisation Current (or within 90 days) chronic or intermittent haemodialysis or peritoneal dialysis Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within the past 90 days prior to screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Clinical Transparency (dept. 1452)

Organizational Affiliation

Novo Nordisk A/S

Official's Role

Study Director

Facility Information:

Facility Name

Novo Nordisk Investigational Site

City

Tuscumbia

State/Province

Alabama

ZIP/Postal Code

35674

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Chula Vista

State/Province

California

ZIP/Postal Code

91910

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Concord

State/Province

California

ZIP/Postal Code

94520

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Fresno

State/Province

California

ZIP/Postal Code

93720

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

La Mesa

State/Province

California

ZIP/Postal Code

91942

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Lancaster

State/Province

California

ZIP/Postal Code

93534

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Lincoln

State/Province

California

ZIP/Postal Code

95648

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Loma Linda

State/Province

California

ZIP/Postal Code

92357

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Long Beach

State/Province

California

ZIP/Postal Code

90807

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Long Beach

State/Province

California

ZIP/Postal Code

90822

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Los Angeles

State/Province

California

ZIP/Postal Code

90022

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Northridge

State/Province

California

ZIP/Postal Code

91324

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Palm Springs

State/Province

California

ZIP/Postal Code

92262

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Port Hueneme

State/Province

California

ZIP/Postal Code

93041

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Rialto

State/Province

California

ZIP/Postal Code

92377

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Roseville

State/Province

California

ZIP/Postal Code

95661

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

San Diego

State/Province

California

ZIP/Postal Code

92123

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

San Dimas

State/Province

California

ZIP/Postal Code

91773

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

San Ramon

State/Province

California

ZIP/Postal Code

94583

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Torrance

State/Province

California

ZIP/Postal Code

90502

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

West Hills

State/Province

California

ZIP/Postal Code

91304

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Aurora

State/Province

Colorado

ZIP/Postal Code

80045

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Denver

State/Province

Colorado

ZIP/Postal Code

80246

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Clearwater

State/Province

Florida

ZIP/Postal Code

33756

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Coral Gables

State/Province

Florida

ZIP/Postal Code

33134

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Delray Beach

State/Province

Florida

ZIP/Postal Code

33445

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Fleming Island

State/Province

Florida

ZIP/Postal Code

32003

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Hialeah

State/Province

Florida

ZIP/Postal Code

33016

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Hollywood

State/Province

Florida

ZIP/Postal Code

33021

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Homestead

State/Province

Florida

ZIP/Postal Code

33032

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Miami Lakes

State/Province

Florida

ZIP/Postal Code

33014

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Miami Lakes

State/Province

Florida

ZIP/Postal Code

33016

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33130

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33144

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33173

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

New Port Richey

State/Province

Florida

ZIP/Postal Code

34652

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Pembroke Pines

State/Province

Florida

ZIP/Postal Code

33027

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Port Charlotte

State/Province

Florida

ZIP/Postal Code

33952

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Saint Augustine

State/Province

Florida

ZIP/Postal Code

32080

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Sarasota

State/Province

Florida

ZIP/Postal Code

34239

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Winter Haven

State/Province

Florida

ZIP/Postal Code

33880

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Alpharetta

State/Province

Georgia

ZIP/Postal Code

30022

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Augusta

State/Province

Georgia

ZIP/Postal Code

30904

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Roswell

State/Province

Georgia

ZIP/Postal Code

30076

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Meridian

State/Province

Idaho

ZIP/Postal Code

83646

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Nampa

State/Province

Idaho

ZIP/Postal Code

83686-6011

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60607

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Gurnee

State/Province

Illinois

ZIP/Postal Code

60031

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Skokie

State/Province

Illinois

ZIP/Postal Code

60077

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Valparaiso

State/Province

Indiana

ZIP/Postal Code

46383

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Council Bluffs

State/Province

Iowa

ZIP/Postal Code

51501

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Manhattan

State/Province

Kansas

ZIP/Postal Code

66502

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Paducah

State/Province

Kentucky

ZIP/Postal Code

42001

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Beltsville

State/Province

Maryland

ZIP/Postal Code

20705

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02115-5804

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Buckley

State/Province

Michigan

ZIP/Postal Code

49620

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Flint

State/Province

Michigan

ZIP/Postal Code

48504

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Flint

State/Province

Michigan

ZIP/Postal Code

48532

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Rochester

State/Province

Minnesota

ZIP/Postal Code

55905-0001

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64111

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63110

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Omaha

State/Province

Nebraska

ZIP/Postal Code

68198

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87109

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Albany

State/Province

New York

ZIP/Postal Code

12203

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Mineola

State/Province

New York

ZIP/Postal Code

11501

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

New York

State/Province

New York

ZIP/Postal Code

10016

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

West Seneca

State/Province

New York

ZIP/Postal Code

14224

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Chapel Hill

State/Province

North Carolina

ZIP/Postal Code

27514

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Morehead City

State/Province

North Carolina

ZIP/Postal Code

28557

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Morganton

State/Province

North Carolina

ZIP/Postal Code

28655

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

New Bern

State/Province

North Carolina

ZIP/Postal Code

28562

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Whiteville

State/Province

North Carolina

ZIP/Postal Code

28472

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Wilmington

State/Province

North Carolina

ZIP/Postal Code

28401

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Winston-Salem

State/Province

North Carolina

ZIP/Postal Code

27103

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45220-2213

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Maumee

State/Province

Ohio

ZIP/Postal Code

43537

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Norman

State/Province

Oklahoma

ZIP/Postal Code

73069

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Beaver

State/Province

Pennsylvania

ZIP/Postal Code

15009

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Jersey Shore

State/Province

Pennsylvania

ZIP/Postal Code

17740

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19114

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Little River

State/Province

South Carolina

ZIP/Postal Code

29566

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Murrells Inlet

State/Province

South Carolina

ZIP/Postal Code

29576

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Orangeburg

State/Province

South Carolina

ZIP/Postal Code

29118

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Bartlett

State/Province

Tennessee

ZIP/Postal Code

38133

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Chattanooga

State/Province

Tennessee

ZIP/Postal Code

37411

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37232

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Austin

State/Province

Texas

ZIP/Postal Code

78705

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Austin

State/Province

Texas

ZIP/Postal Code

78731

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Austin

State/Province

Texas

ZIP/Postal Code

78751

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Corpus Christi

State/Province

Texas

ZIP/Postal Code

78414

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75226

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75231

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75390-9302

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

El Paso

State/Province

Texas

ZIP/Postal Code

79902

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

El Paso

State/Province

Texas

ZIP/Postal Code

79935

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77074

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77081

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77099

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Rockwall

State/Province

Texas

ZIP/Postal Code

75032

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78207

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78215

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78224

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78230

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78233

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Sugar Land

State/Province

Texas

ZIP/Postal Code

77478

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84108

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

South Burlington

State/Province

Vermont

ZIP/Postal Code

05403

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Norfolk

State/Province

Virginia

ZIP/Postal Code

23504

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Richmond

State/Province

Virginia

ZIP/Postal Code

23249

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Salem

State/Province

Virginia

ZIP/Postal Code

24153-6404

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Winchester

State/Province

Virginia

ZIP/Postal Code

22601

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Olympia

State/Province

Washington

ZIP/Postal Code

98502

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Spokane

State/Province

Washington

ZIP/Postal Code

99202

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98405

Country

United States

Facility Name

Novo Nordisk Investigational Site

City

Villa Dominico

State/Province

Buenos Aires

ZIP/Postal Code

B1872EEA

Country

Argentina

Facility Name

Novo Nordisk Investigational Site

City

Buenos Aires

ZIP/Postal Code

C1250AAN

Country

Argentina

Facility Name

Novo Nordisk Investigational Site

City

Buenos Aires

ZIP/Postal Code

C1425AGC

Country

Argentina

Facility Name

Novo Nordisk Investigational Site

City

Caba

ZIP/Postal Code

1429

Country

Argentina

Facility Name

Novo Nordisk Investigational Site

City

Caba

ZIP/Postal Code

C1060ABA

Country

Argentina

Facility Name

Novo Nordisk Investigational Site

City

Caba

ZIP/Postal Code

C1430CKE

Country

Argentina

Facility Name

Novo Nordisk Investigational Site

City

Caba

ZIP/Postal Code

C1440AAD

Country

Argentina

Facility Name

Novo Nordisk Investigational Site

City

Gosford

State/Province

New South Wales

ZIP/Postal Code

2250

Country

Australia

Facility Name

Novo Nordisk Investigational Site

City

St Leonards

State/Province

New South Wales

ZIP/Postal Code

2065

Country

Australia

Facility Name

Novo Nordisk Investigational Site

City

Westmead

State/Province

New South Wales

ZIP/Postal Code

2145

Country

Australia

Facility Name

Novo Nordisk Investigational Site

City

Milton

State/Province

Queensland

ZIP/Postal Code

4064

Country

Australia

Facility Name

Novo Nordisk Investigational Site

City

Clayton

State/Province

Victoria

ZIP/Postal Code

3168

Country

Australia

Facility Name

Novo Nordisk Investigational Site

City

Fitzroy

State/Province

Victoria

ZIP/Postal Code

3065

Country

Australia

Facility Name

Novo Nordisk Investigational Site

City

Melbourne

State/Province

Victoria

ZIP/Postal Code

3004

Country

Australia

Facility Name

Novo Nordisk Investigational Site

City

Parkville

State/Province

Victoria

ZIP/Postal Code

3050

Country

Australia

Facility Name

Novo Nordisk Investigational Site

City

Bonheiden

ZIP/Postal Code

2820

Country

Belgium

Facility Name

Novo Nordisk Investigational Site

City

Brussel

ZIP/Postal Code

1090

Country

Belgium

Facility Name

Novo Nordisk Investigational Site

City

Bruxelles

ZIP/Postal Code

1200

Country

Belgium

Facility Name

Novo Nordisk Investigational Site

City

Edegem

ZIP/Postal Code

2650

Country

Belgium

Facility Name

Novo Nordisk Investigational Site

City

Gent

ZIP/Postal Code

9000

Country

Belgium

Facility Name

Novo Nordisk Investigational Site

City

Leuven

ZIP/Postal Code

3000

Country

Belgium

Facility Name

Novo Nordisk Investigational Site

City

Liège

ZIP/Postal Code

4000

Country

Belgium

Facility Name

Novo Nordisk Investigational Site

City

Roeselare

ZIP/Postal Code

8800

Country

Belgium

Facility Name

Novo Nordisk Investigational Site

City

Fortaleza

State/Province

Ceara

ZIP/Postal Code

60170-195

Country

Brazil

Facility Name

Novo Nordisk Investigational Site

City

Curitiba

State/Province

Parana

ZIP/Postal Code

80440-020

Country

Brazil

Facility Name

Novo Nordisk Investigational Site

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90430-001

Country

Brazil

Facility Name

Novo Nordisk Investigational Site

City

Santo André

State/Province

Sao Paulo

ZIP/Postal Code

09030-010

Country

Brazil

Facility Name

Novo Nordisk Investigational Site

City

São Paulo

State/Province

Sao Paulo

ZIP/Postal Code

01223-001

Country

Brazil

Facility Name

Novo Nordisk Investigational Site

City

São Paulo

State/Province

Sao Paulo

ZIP/Postal Code

01228-000

Country

Brazil

Facility Name

Novo Nordisk Investigational Site

City

São Paulo

State/Province

Sao Paulo

ZIP/Postal Code

01228-200

Country

Brazil

Facility Name

Novo Nordisk Investigational Site

City

Bahia

ZIP/Postal Code

41810-011

Country

Brazil

Facility Name

Novo Nordisk Investigational Site

City

Kozloduy

ZIP/Postal Code

3320

Country

Bulgaria

Facility Name

Novo Nordisk Investigational Site

City

Plovdiv

ZIP/Postal Code

4001

Country

Bulgaria

Facility Name

Novo Nordisk Investigational Site

City

Sliven

ZIP/Postal Code

8800

Country

Bulgaria

Facility Name

Novo Nordisk Investigational Site

City

Smolyan

ZIP/Postal Code

4700

Country

Bulgaria

Facility Name

Novo Nordisk Investigational Site

City

Sofia

ZIP/Postal Code

1431

Country

Bulgaria

Facility Name

Novo Nordisk Investigational Site

City

Sofia

ZIP/Postal Code

1784

Country

Bulgaria

Facility Name

Novo Nordisk Investigational Site

City

Stara Zagora

ZIP/Postal Code

6001

Country

Bulgaria

Facility Name

Novo Nordisk Investigational Site

City

Calgary

State/Province

Alberta

ZIP/Postal Code

T2H 2G4

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Red Deer

State/Province

Alberta

ZIP/Postal Code

T4N 6V7

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Vancouver

State/Province

British Columbia

ZIP/Postal Code

V5Y 3W2

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Mount Pearl

State/Province

Newfoundland and Labrador

ZIP/Postal Code

A1N 1W7

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

St. Johns

State/Province

Newfoundland and Labrador

ZIP/Postal Code

A1B 3V6

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Halifax

State/Province

Nova Scotia

ZIP/Postal Code

B3H 1V8

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Brampton

State/Province

Ontario

ZIP/Postal Code

L6S 0C6

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Brampton

State/Province

Ontario

ZIP/Postal Code

L6T 0G1

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Burlington

State/Province

Ontario

ZIP/Postal Code

L7M 4Y1

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Concord

State/Province

Ontario

ZIP/Postal Code

L4K 4M2

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Etobicoke

State/Province

Ontario

ZIP/Postal Code

M9R 4E1

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Hamilton

State/Province

Ontario

ZIP/Postal Code

L8M 1K7

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

London

State/Province

Ontario

ZIP/Postal Code

N5W 6A2

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Nepean

State/Province

Ontario

ZIP/Postal Code

K2J 0V2

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Oshawa

State/Province

Ontario

ZIP/Postal Code

L1G 2B9

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Oshawa

State/Province

Ontario

ZIP/Postal Code

L1J 2K1

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Sarnia

State/Province

Ontario

ZIP/Postal Code

N7T 4X3

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Stoney Creek

State/Province

Ontario

ZIP/Postal Code

L8J 0B6

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M4G 3E8

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M5G 2N2

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M5T 3L9

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M9V 4B4

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Laval

State/Province

Quebec

ZIP/Postal Code

H7T 2P5

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H2K 1H2

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H4A 3T2

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H4N 2W2

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Quebec

ZIP/Postal Code

G1W 4R4

Country

Canada

Facility Name

Novo Nordisk Investigational Site

City

Beijing

State/Province

Beijing

ZIP/Postal Code

100044

Country

China

Facility Name

Novo Nordisk Investigational Site

City

Beijing

State/Province

Beijing

ZIP/Postal Code

101200

Country

China

Facility Name

Novo Nordisk Investigational Site

City

Zhenjiang

State/Province

Jiangsu

ZIP/Postal Code

212001

Country

China

Facility Name

Novo Nordisk Investigational Site

City

Jin'an

State/Province

Shandong

ZIP/Postal Code

250013

Country

China

Facility Name

Novo Nordisk Investigational Site

City

Annonay

ZIP/Postal Code

07100

Country

France

Facility Name

Novo Nordisk Investigational Site

City

BRON cedex

ZIP/Postal Code

69677

Country

France

Facility Name

Novo Nordisk Investigational Site

City

Caen

ZIP/Postal Code

14033

Country

France

Facility Name

Novo Nordisk Investigational Site

City

Grenoble - Cédex 09

ZIP/Postal Code

38043

Country

France

Facility Name

Novo Nordisk Investigational Site

City

La Roche-sur-yon

ZIP/Postal Code

85925

Country

France

Facility Name

Novo Nordisk Investigational Site

City

Le Coudray

ZIP/Postal Code

28630

Country

France

Facility Name

Novo Nordisk Investigational Site

City

Le Creusot

ZIP/Postal Code

71200

Country

France

Facility Name

Novo Nordisk Investigational Site

City

Paris

ZIP/Postal Code

75019

Country

France

Facility Name

Novo Nordisk Investigational Site

City

Reims

ZIP/Postal Code

51092

Country

France

Facility Name

Novo Nordisk Investigational Site

City

Saint Herblain

ZIP/Postal Code

44800

Country

France

Facility Name

Novo Nordisk Investigational Site

City

TOULOUSE cedex

ZIP/Postal Code

31054

Country

France

Facility Name

Novo Nordisk Investigational Site

City

Venissieux

ZIP/Postal Code

69200

Country

France

Facility Name

Novo Nordisk Investigational Site

City

Bad Mergentheim

ZIP/Postal Code

97980

Country

Germany

Facility Name

Novo Nordisk Investigational Site

City

Bad Oeynhausen

ZIP/Postal Code

32545

Country

Germany

Facility Name

Novo Nordisk Investigational Site

City

Düsseldorf

ZIP/Postal Code

40210

Country

Germany

Facility Name

Novo Nordisk Investigational Site

City

Erlangen

ZIP/Postal Code

91054

Country

Germany

Facility Name

Novo Nordisk Investigational Site

City

Essen

ZIP/Postal Code

45136

Country

Germany

Facility Name

Novo Nordisk Investigational Site

City

Essen

ZIP/Postal Code

45219

Country

Germany

Facility Name

Novo Nordisk Investigational Site

City

Hamburg

ZIP/Postal Code

22607

Country

Germany

Facility Name

Novo Nordisk Investigational Site

City

Münster

ZIP/Postal Code

48145

Country

Germany

Facility Name

Novo Nordisk Investigational Site

City

Saint Ingbert-Oberwürzbach

ZIP/Postal Code

66386

Country

Germany

Facility Name

Novo Nordisk Investigational Site

City

Athens

ZIP/Postal Code

115 25

Country

Greece

Facility Name

Novo Nordisk Investigational Site

City

Athens

ZIP/Postal Code

GR-11527

Country

Greece

Facility Name

Novo Nordisk Investigational Site

City

Athens

ZIP/Postal Code

GR-151 23

Country

Greece

Facility Name

Novo Nordisk Investigational Site

City

Athens

ZIP/Postal Code

GR-17562

Country

Greece

Facility Name

Novo Nordisk Investigational Site

City

Haidari-Athens

ZIP/Postal Code

GR-12462

Country

Greece

Facility Name

Novo Nordisk Investigational Site

City

Lamia

ZIP/Postal Code

GR35100

Country

Greece

Facility Name

Novo Nordisk Investigational Site

City

Patra

ZIP/Postal Code

GR-26504

Country

Greece

Facility Name

Novo Nordisk Investigational Site

City

Thessaloniki

ZIP/Postal Code

GR-54636

Country

Greece

Facility Name

Novo Nordisk Investigational Site

City

Thessaloniki

ZIP/Postal Code

GR-54642

Country

Greece

Facility Name

Novo Nordisk Investigational Site

City

Thessaloniki

ZIP/Postal Code

GR-54643

Country

Greece

Facility Name

Novo Nordisk Investigational Site

City

Thessaloniki

ZIP/Postal Code

GR-564 29

Country

Greece

Facility Name

Novo Nordisk Investigational Site

City

Thessaloniki

ZIP/Postal Code

GR-57001

Country

Greece

Facility Name

Novo Nordisk Investigational Site

City

Baja

State/Province

Bács-Kiskun

ZIP/Postal Code

6500

Country

Hungary

Facility Name

Novo Nordisk Investigational Site

City

Budapest

ZIP/Postal Code

1076

Country

Hungary

Facility Name

Novo Nordisk Investigational Site

City

Budapest

ZIP/Postal Code

1132

Country

Hungary

Facility Name

Novo Nordisk Investigational Site

City

Debrecen

ZIP/Postal Code

4025

Country

Hungary

Facility Name

Novo Nordisk Investigational Site

City

Debrecen

ZIP/Postal Code

4043

Country

Hungary

Facility Name

Novo Nordisk Investigational Site

City

Debrecen

ZIP/Postal Code

H-4032

Country

Hungary

Facility Name

Novo Nordisk Investigational Site

City

Gyula

ZIP/Postal Code

H-5700

Country

Hungary

Facility Name

Novo Nordisk Investigational Site

City

Nyíregyháza

ZIP/Postal Code

4405

Country

Hungary

Facility Name

Novo Nordisk Investigational Site

City

Pécs

ZIP/Postal Code

7623

Country

Hungary

Facility Name

Novo Nordisk Investigational Site

City

Siófok

ZIP/Postal Code

8600

Country

Hungary

Facility Name

Novo Nordisk Investigational Site

City

Szombathely

ZIP/Postal Code

H-9700

Country

Hungary

Facility Name

Novo Nordisk Investigational Site

City

Guntur

State/Province

Andhra Pradesh

ZIP/Postal Code

522001

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Bangalore

State/Province

Karnataka

ZIP/Postal Code

560054

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Bangalore

State/Province

Karnataka

ZIP/Postal Code

560060

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Bangalore

State/Province

Karnataka

ZIP/Postal Code

560092

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Kochi

State/Province

Kerala

ZIP/Postal Code

682041

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Kozhikode

State/Province

Kerala

ZIP/Postal Code

673008

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Mumbai

State/Province

Maharashtra

ZIP/Postal Code

400012

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Pune

State/Province

Maharashtra

ZIP/Postal Code

411030

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Chennai

State/Province

Tamil Nadu

ZIP/Postal Code

600037

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Hyderbad

State/Province

Telengana

ZIP/Postal Code

500 012

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Lucknow

State/Province

Uttar Pradesh

ZIP/Postal Code

226003

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Lucknow

State/Province

Uttar Pradesh

ZIP/Postal Code

226005

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Lucknow

State/Province

Uttar Pradesh

ZIP/Postal Code

226014

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Kolkata

State/Province

West Bengal

ZIP/Postal Code

700054

Country

India

Facility Name

Novo Nordisk Investigational Site

City

New Delhi

ZIP/Postal Code

110017

Country

India

Facility Name

Novo Nordisk Investigational Site

City

New Delhi

ZIP/Postal Code

110060

Country

India

Facility Name

Novo Nordisk Investigational Site

City

Holon

ZIP/Postal Code

58100

Country

Israel

Facility Name

Novo Nordisk Investigational Site

City

Jerusalem

ZIP/Postal Code

91120

Country

Israel

Facility Name

Novo Nordisk Investigational Site

City

Kfar Saba

ZIP/Postal Code

4428164

Country

Israel

Facility Name

Novo Nordisk Investigational Site

City

Rehovot

ZIP/Postal Code

7661041

Country

Israel

Facility Name

Novo Nordisk Investigational Site

City

Milano

State/Province

ZIP/Postal Code

20132

Country

Italy

Facility Name

Novo Nordisk Investigational Site

City

Palermo

State/Province

ZIP/Postal Code

90127

Country

Italy

Facility Name

Novo Nordisk Investigational Site

City

Pisa

State/Province

ZIP/Postal Code

56124

Country

Italy

Facility Name

Novo Nordisk Investigational Site

City

Bergamo

ZIP/Postal Code

24127

Country

Italy

Facility Name

Novo Nordisk Investigational Site

City

Milano

ZIP/Postal Code

20122

Country

Italy

Facility Name

Novo Nordisk Investigational Site

City

Milano

ZIP/Postal Code

20157

Country

Italy

Facility Name

Novo Nordisk Investigational Site

City

Roma

ZIP/Postal Code

00161

Country

Italy

Facility Name

Novo Nordisk Investigational Site

City

Roma

ZIP/Postal Code

00189

Country

Italy

Facility Name

Novo Nordisk Investigational Site

City

Koriyama-shi

State/Province

Fukushima, Japan

ZIP/Postal Code

963-8851

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Sapporo-shi, Hokkaido

State/Province

Hokkaido, Japan

ZIP/Postal Code

060-0062

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Kumamoto-shi

State/Province

Kumamoto, Japan

ZIP/Postal Code

862-0976

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Miyazaki-shi

State/Province

Miyazaki, Japan

ZIP/Postal Code

880-0034

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Chiba

ZIP/Postal Code

271-0077

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Fukui

ZIP/Postal Code

910-8526

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Fukuoka

ZIP/Postal Code

816-0864

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Gunma

ZIP/Postal Code

373-0036

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Hokkaido

ZIP/Postal Code

062-0007

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Ibaraki,

ZIP/Postal Code

331-0133

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Ibaraki

ZIP/Postal Code

311-0113

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Ishikawa

ZIP/Postal Code

920-0293

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Kanagawa

ZIP/Postal Code

232-0064

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Kanagawa

ZIP/Postal Code

235-0045

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Kanagawa

ZIP/Postal Code

247-0055

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Kyoto

ZIP/Postal Code

611-0041

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Okayama

ZIP/Postal Code

701-0192

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Osaka

ZIP/Postal Code

569-1045

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Saitama

ZIP/Postal Code

336-0967

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Tochigi

ZIP/Postal Code

323-0022

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Tokyo

ZIP/Postal Code

103-0028

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Tokyo

ZIP/Postal Code

104-0031

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Tokyo

ZIP/Postal Code

113-8431

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Tokyo

ZIP/Postal Code

113-8655

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Tokyo

ZIP/Postal Code

125-0054

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Tokyo

ZIP/Postal Code

177-0041

Country

Japan

Facility Name

Novo Nordisk Investigational Site

City

Alor Setar

ZIP/Postal Code

05460

Country

Malaysia

Facility Name

Novo Nordisk Investigational Site

City

Ipoh, Perak

ZIP/Postal Code

30450

Country

Malaysia

Facility Name

Novo Nordisk Investigational Site

City

Kuala Lumpur

ZIP/Postal Code

59100

Country

Malaysia

Facility Name

Novo Nordisk Investigational Site

City

Kuching

ZIP/Postal Code

93586

Country

Malaysia

Facility Name

Novo Nordisk Investigational Site

City

Pulau Pinang

ZIP/Postal Code

10990

Country

Malaysia

Facility Name

Novo Nordisk Investigational Site

City

Serdang

ZIP/Postal Code

43000

Country

Malaysia

Facility Name

Novo Nordisk Investigational Site

City

Actopan

State/Province

Hidalgo

ZIP/Postal Code

42500

Country

Mexico

Facility Name

Novo Nordisk Investigational Site

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44600

Country

Mexico

Facility Name

Novo Nordisk Investigational Site

City

Distrito Federal

State/Province

México, D.F.

ZIP/Postal Code

14080

Country

Mexico

Facility Name

Novo Nordisk Investigational Site

City

Mexico City

State/Province

México, D.F.

ZIP/Postal Code

14080

Country

Mexico

Facility Name

Novo Nordisk Investigational Site

City

Culiacán

State/Province

Sinaloa

ZIP/Postal Code

80230

Country

Mexico

Facility Name

Novo Nordisk Investigational Site

City

Ciudad Madero

State/Province

Tamaulipas

ZIP/Postal Code

89440

Country

Mexico

Facility Name

Novo Nordisk Investigational Site

City

Alkmaar

ZIP/Postal Code

1815 JD

Country

Netherlands

Facility Name

Novo Nordisk Investigational Site

City

Almelo

ZIP/Postal Code

7609 PP

Country

Netherlands

Facility Name

Novo Nordisk Investigational Site

City

Almere

ZIP/Postal Code

1311RL

Country

Netherlands

Facility Name

Novo Nordisk Investigational Site

City

Amersfoort

ZIP/Postal Code

3813 TZ

Country

Netherlands

Facility Name

Novo Nordisk Investigational Site

City

Amsterdam

ZIP/Postal Code

1061 AE

Country

Netherlands

Facility Name

Novo Nordisk Investigational Site

City

Amsterdam

ZIP/Postal Code

1081 HV

Country

Netherlands

Facility Name

Novo Nordisk Investigational Site

City

Arnhem

ZIP/Postal Code

6815 AD

Country

Netherlands

Facility Name

Novo Nordisk Investigational Site

City

Hilversum

ZIP/Postal Code

1213 XZ

Country

Netherlands

Facility Name

Novo Nordisk Investigational Site

City

Utrecht

ZIP/Postal Code

3584 CX

Country

Netherlands

Facility Name

Novo Nordisk Investigational Site

City

Bialystok

ZIP/Postal Code

15-351

Country

Poland

Facility Name

Novo Nordisk Investigational Site

City

Kielce

ZIP/Postal Code

25-035

Country

Poland

Facility Name

Novo Nordisk Investigational Site

City

Olsztyn

ZIP/Postal Code

10-561

Country

Poland

Facility Name

Novo Nordisk Investigational Site

City

Poznan

ZIP/Postal Code

60-355

Country

Poland

Facility Name

Novo Nordisk Investigational Site

City

Radom

ZIP/Postal Code

26-600

Country

Poland

Facility Name

Novo Nordisk Investigational Site

City

Szczecin

ZIP/Postal Code

70-111

Country

Poland

Facility Name

Novo Nordisk Investigational Site

City

Warszawa

ZIP/Postal Code

01-192

Country

Poland

Facility Name

Novo Nordisk Investigational Site

City

Warszawa

ZIP/Postal Code

04-749

Country

Poland

Facility Name

Novo Nordisk Investigational Site

City

Zabrze

ZIP/Postal Code

41-800

Country

Poland

Facility Name

Novo Nordisk Investigational Site

City

Barnaul

ZIP/Postal Code

656024

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Barnaul

ZIP/Postal Code

656045

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Chelyabinsk

ZIP/Postal Code

454048

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Kazan

ZIP/Postal Code

420061

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Kemerovo

ZIP/Postal Code

650066

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Moscow

ZIP/Postal Code

117292

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Novosibirsk

ZIP/Postal Code

630005

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Novosibirsk

ZIP/Postal Code

630099

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Penza

ZIP/Postal Code

440026

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Saint Petersburg

ZIP/Postal Code

194156

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Saint-Petersburg

ZIP/Postal Code

190121

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Saint-Petersburg

ZIP/Postal Code

194156

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Saint-Petersburg

ZIP/Postal Code

194356

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Samara

ZIP/Postal Code

443031

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Saratov

ZIP/Postal Code

410031

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Saratov

ZIP/Postal Code

410039

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Stavropol

ZIP/Postal Code

355035

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Ulianovsk

ZIP/Postal Code

432063

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Voronezh

ZIP/Postal Code

394018

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Yaroslavl

ZIP/Postal Code

150003

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Yoshkar-Ola

ZIP/Postal Code

424004

Country

Russian Federation

Facility Name

Novo Nordisk Investigational Site

City

Bratislava

ZIP/Postal Code

851 01

Country

Slovakia

Facility Name

Novo Nordisk Investigational Site

City

Kosice

ZIP/Postal Code

04011

Country

Slovakia

Facility Name

Novo Nordisk Investigational Site

City

Lubochna

ZIP/Postal Code

03491

Country

Slovakia

Facility Name

Novo Nordisk Investigational Site

City

Lucenec

ZIP/Postal Code

984 01

Country

Slovakia

Facility Name

Novo Nordisk Investigational Site

City

Nitra

ZIP/Postal Code

94901

Country

Slovakia

Facility Name

Novo Nordisk Investigational Site

City

Presov

ZIP/Postal Code

08001

Country

Slovakia

Facility Name

Novo Nordisk Investigational Site

City

Trebisov

ZIP/Postal Code

07501

Country

Slovakia

Facility Name

Novo Nordisk Investigational Site

City

Trstena

ZIP/Postal Code

02801

Country

Slovakia

Facility Name

Novo Nordisk Investigational Site

City

Zilina

ZIP/Postal Code

010 01

Country

Slovakia

Facility Name

Novo Nordisk Investigational Site

City

Zilina

ZIP/Postal Code

010 08

Country

Slovakia

Facility Name

Novo Nordisk Investigational Site

City

Zilina

ZIP/Postal Code

01001

Country

Slovakia

Facility Name

Novo Nordisk Investigational Site

City

Bloemfontein

State/Province

Free State

ZIP/Postal Code

9300

Country

South Africa

Facility Name

Novo Nordisk Investigational Site

City

Benoni

State/Province

Gauteng

ZIP/Postal Code

1501

Country

South Africa

Facility Name

Novo Nordisk Investigational Site

City

Cosmo City

State/Province

Gauteng

ZIP/Postal Code

2188

Country

South Africa

Facility Name

Novo Nordisk Investigational Site

City

Johannesburg

State/Province

Gauteng

ZIP/Postal Code

1818

Country

South Africa

Facility Name

Novo Nordisk Investigational Site

City

Johannesburg

State/Province

Gauteng

ZIP/Postal Code

1827

Country

South Africa

Facility Name

Novo Nordisk Investigational Site

City

Johannesburg

State/Province

Gauteng

ZIP/Postal Code

2013

Country

South Africa

Facility Name

Novo Nordisk Investigational Site

City

Durban

State/Province

KwaZulu-Natal

ZIP/Postal Code

4092

Country

South Africa

Facility Name

Novo Nordisk Investigational Site

City

Cape Town

State/Province

Western Cape

ZIP/Postal Code

7925

Country

South Africa

Facility Name

Novo Nordisk Investigational Site

City

Cape Town

ZIP/Postal Code

7530

Country

South Africa

Facility Name

Novo Nordisk Investigational Site

City

Barcelona

ZIP/Postal Code

08003

Country

Spain

Facility Name

Novo Nordisk Investigational Site

City

Barcelona

ZIP/Postal Code

08035

Country

Spain

Facility Name

Novo Nordisk Investigational Site

City

Burela

ZIP/Postal Code

27880

Country

Spain

Facility Name

Novo Nordisk Investigational Site

City

Getafe

ZIP/Postal Code

28909

Country

Spain

Facility Name

Novo Nordisk Investigational Site

City

Lugo

ZIP/Postal Code

27004

Country

Spain

Facility Name

Novo Nordisk Investigational Site

City

Valencia

ZIP/Postal Code

46010

Country

Spain

Facility Name

Novo Nordisk Investigational Site

City

Valencia

ZIP/Postal Code

46017

Country

Spain

Facility Name

Novo Nordisk Investigational Site

City

Bangkoknoi, Bangkok

State/Province

Bangkok

ZIP/Postal Code

10700

Country

Thailand

Facility Name

Novo Nordisk Investigational Site

City

Chiang Mai

State/Province

Mueang Chiang Mai District

ZIP/Postal Code

50200

Country

Thailand

Facility Name

Novo Nordisk Investigational Site

City

Bangkok

ZIP/Postal Code

10330

Country

Thailand

Facility Name

Novo Nordisk Investigational Site

City

Bangkok

ZIP/Postal Code

10400

Country

Thailand

Facility Name

Novo Nordisk Investigational Site

City

Bangkok

ZIP/Postal Code

10700

Country

Thailand

Facility Name

Novo Nordisk Investigational Site

City

Ankara

ZIP/Postal Code

06100

Country

Turkey

Facility Name

Novo Nordisk Investigational Site

City

Ankara

ZIP/Postal Code

06230

Country

Turkey

Facility Name

Novo Nordisk Investigational Site

City

Ankara

ZIP/Postal Code

06500

Country

Turkey

Facility Name

Novo Nordisk Investigational Site

City

Antalya

ZIP/Postal Code

07058

Country

Turkey

Facility Name

Novo Nordisk Investigational Site

City

Aydin

ZIP/Postal Code

09100

Country

Turkey

Facility Name

Novo Nordisk Investigational Site

City

Istanbul

ZIP/Postal Code

34098

Country

Turkey

Facility Name

Novo Nordisk Investigational Site

City

Istanbul

ZIP/Postal Code

34390

Country

Turkey

Facility Name

Novo Nordisk Investigational Site

City

Istanbul

ZIP/Postal Code

34722

Country

Turkey

Facility Name

Novo Nordisk Investigational Site

City

Istanbul

ZIP/Postal Code

34899

Country

Turkey

Facility Name

Novo Nordisk Investigational Site

City

Izmir

ZIP/Postal Code

35100

Country

Turkey

Facility Name

Novo Nordisk Investigational Site

City

Kahramanmaras

ZIP/Postal Code

46040

Country

Turkey

Facility Name

Novo Nordisk Investigational Site

City

Kocaeli

ZIP/Postal Code

41380

Country

Turkey

Facility Name

Novo Nordisk Investigational Site

City

Dnipro

ZIP/Postal Code

49000

Country

Ukraine

Facility Name

Novo Nordisk Investigational Site

City

Ivano-Frankivsk

ZIP/Postal Code

76008

Country

Ukraine

Facility Name

Novo Nordisk Investigational Site

City

Kharkiv

ZIP/Postal Code

61002

Country

Ukraine

Facility Name

Novo Nordisk Investigational Site

City

Kharkiv

ZIP/Postal Code

61039

Country

Ukraine

Facility Name

Novo Nordisk Investigational Site

City

Kyiv

ZIP/Postal Code

04114

Country

Ukraine

Facility Name

Novo Nordisk Investigational Site

City

Poltava

ZIP/Postal Code

36039

Country

Ukraine

Facility Name

Novo Nordisk Investigational Site

City

Zaporizhia

ZIP/Postal Code

69001

Country

Ukraine

Facility Name

Novo Nordisk Investigational Site

City

Aberdeen

ZIP/Postal Code

AB25 2ZN

Country

United Kingdom

Facility Name

Novo Nordisk Investigational Site

City

Birmingham

ZIP/Postal Code

B9 5SS

Country

United Kingdom

Facility Name

Novo Nordisk Investigational Site

City

Cardiff

ZIP/Postal Code

CF5 4AD

Country

United Kingdom

Facility Name

Novo Nordisk Investigational Site

City

Dundee

ZIP/Postal Code

DD1 9SY

Country

United Kingdom

Facility Name

Novo Nordisk Investigational Site

City

Edinburgh

ZIP/Postal Code

EH4 2XU

Country

United Kingdom

Facility Name

Novo Nordisk Investigational Site

City

Glasgow

ZIP/Postal Code

G31 2ER

Country

United Kingdom

Facility Name

Novo Nordisk Investigational Site

City

Ipswich

ZIP/Postal Code

IP4 5PD

Country

United Kingdom

Facility Name

Novo Nordisk Investigational Site

City

London

ZIP/Postal Code

N18 1QX

Country

United Kingdom

Facility Name

Novo Nordisk Investigational Site

City

London

ZIP/Postal Code

NW3 2QG

Country

United Kingdom

Facility Name

Novo Nordisk Investigational Site

City

Stevenage

ZIP/Postal Code

SG1 4AB

Country

United Kingdom

Facility Name

Novo Nordisk Investigational Site

City

Tooting

ZIP/Postal Code

SW17 0RE

Country

United Kingdom

12. IPD Sharing Statement

Plan to Share IPD

Yes

IPD Sharing Plan Description

According to the Novo Nordisk disclosure commitment on novonordisk-trials.com

IPD Sharing URL

https://www.novonordisk-trials.com

Citations:

PubMed Identifier

36651820

Citation

Rossing P, Baeres FMM, Bakris G, Bosch-Traberg H, Gislum M, Gough SCL, Idorn T, Lawson J, Mahaffey KW, Mann JFE, Mersebach H, Perkovic V, Tuttle K, Pratley R. The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease. Nephrol Dial Transplant. 2023 Aug 31;38(9):2041-2051. doi: 10.1093/ndt/gfad009.

Results Reference

background

PubMed Identifier

35441935

Citation

Cohen S, Sternlicht H, Bakris GL. Mineralocorticoid Receptor Antagonists in the Treatment of Diabetic Kidney Disease: Their Application in the Era of SGLT2 Inhibitors and GLP-1 Receptor Agonists. Curr Diab Rep. 2022 May;22(5):213-218. doi: 10.1007/s11892-022-01461-4. Epub 2022 Apr 20.

Results Reference

derived

Learn more about this trial

A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease

We'll reach out to this number within 24 hrs

A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease (FLOW)

Diabetes Mellitus, Type 2

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial