Back to resultsA Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone In Patients With Operable Triple-Negative Breast Cancer (IMpassion030)
Primary Purpose
Triple Negative Breast Cancer
Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Atezolizumab
Paclitaxel
Dose-dense Doxorubicin or dose-dense Epirubicin
Cyclophosphamide
Sponsored by
About this trial
This is an interventional treatment trial for Triple Negative Breast Cancer
Eligibility Criteria
Inclusion Criteria:
- Non-metastatic operable Stage II-III breast cancer
- Histologically documented TNBC (Triple Negative Breast Cancer)
- Confirmed tumor PD-L1 evaluation as documented through central testing of a representative tumor tissue specimen
- Adequately excised: Patients must have undergone either breast-conserving surgery or mastectomy/nipple- or skin-sparing mastectomy
- Adequate hematologic and end-organ function
- For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures
- For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures and agreement to refrain from donating sperm.
- No more than 8 weeks (56 days) may elapse between definitive breast surgery and randomization.
- Representative formalin-fixed, paraffin embedded (FFPE) tumor specimen from surgical resection in paraffin blocks (preferred) or at least 25 unstained slides.
Exclusion Criteria
- Prior history of invasive breast cancer
- For the currently diagnosed breast cancer, any previous systemic anti-cancer treatment (e.g., neoadjuvant or adjuvant), including, but not limited to, chemotherapy, anti-HER2 therapy.
- Previous therapy with anthracyclines or taxanes for any malignancy
- Cardiopulmonary dysfunction
- Prior malignancies within 5 years prior to randomization, with the exception of those with a negligible risk of metastasis or death and treated with expected curative outcome
- Active or history of autoimmune disease or immune deficiency
- History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening chest computed tomography (CT) scan
- Urinary outflow obstruction
- Active tuberculosis
- Major surgical procedure other than for diagnosis within 4 weeks prior to initiation of study treatment or anticipation of need for a major surgical procedure during study treatment or within 5 months following the last dose of Atezolizumab (for patients randomized to Atezolizumab)
- Prior allogeneic stem cell or solid organ transplant
- Treatment with systemic immunosuppressive medications within 2 weeks prior to initiation of study treatment or anticipation of need for systemic immunosuppressive medication during the study
Sites / Locations
- John Muir Health Clinical Research Center
- Cedars-Sinai Medical Center
- Martin-O?Neil Cancer Center
- Baptist - MD Anderson Cancer Center
- Advocate Illinois Masonic Outpatient Center for Advanced Care
- Des Moines Oncology Research Association
- Cancer Center of Kansas
- University of Maryland Greenebaum Comprehensive Cancer Center
- Fairview Southdale Medical Oncology Clinic
- HCA Midwest Division
- New Hampshire Hematology Oncology
- Monter Cancer Center
- Memorial Sloan Kettering Cancer Center
- Rochester General Hospital; Lipson Cancer and Blood Center
- SCRI
- Intermountain Precision Genomics Cancer Research Clinic-Dixie
- St. Mary's Medical Center
- Centro de Oncologia e; Investigacion Buenos Aires - COIBA
- INSTITUTO DE INVESTIGACIONES METABOLICAS (IDIM); Oncology
- Hospital Britanico de Buenos Aires
- Clinica Universitaria Reina Fabiola
- Fundación Ars Medica
- Centro Oncologico Riojano Integral (CORI)
- Instituto de Oncología de Rosario
- Centro Medico San Roque
- Centro de Investigacion Clinica - Clinica Viedma S.A.; Oncology Department
- St Vincent's Hospital Sydney
- Lismore Base Hospital
- Macquarie University Hospital
- Tweed Hospital
- Sydney Adventist Hospital
- Icon Cancer Care Wesley
- Icon Cancer Foundation; Icon Cancer Care Chermside
- Icon Cancer Care South Brisbane
- Mater Hospital; Cancer Services
- Icon Cancer Foundation; Icon Cancer Care Southport
- Princess Alexandra Hospital; Cancer Trials Unit
- Royal Adelaide Hospital; Cancer Centre
- Ashford Cancer Center Research
- Box Hill Hospital; Eastern Clinical Research Unit
- Monash Medical Centre
- Austin Hospital Olivia Newton John Cancer Centre
- Maroondah Hospital; Breast Clinic
- Lkh-Univ. Klinikum Graz; Klinik Für Gynäkologie
- Medical University Innsbruck; Frauenklinik Innsbruck, Dept Gyn
- Ordensklinikum Linz Barmherzige Schwestern; Interne 1 - Hämato-Onkologie
- Uniklinikum Salzburg, LKH; Univ.Klinik f. Innere Medizin III der PMU
- AKH - Medizinische Universität Wien; Department of Oncology
- General Hospital Hietzing, KLI; Dept. Obstet&Gynecol
- Salzkammergut-Klinikum Voecklabruck
- Klinikum Kreuzschwestern Wels; Iv. Interne Abt.
- Medizinische Universität Wien; Univ.Klinik für Frauenheilkunde - Klinik für Gynäkologie
- AZ KLINA
- Institut Jules Bordet
- UZ Leuven Gasthuisberg
- CHC MontLégia
- Chr de La Citadelle
- CHU Ambroise Paré
- Clinique Sainte-Elisabeth; Oncologie
- Vitaz
- Nucleo de Oncologia da Bahia - NOB
- Crio - Centro Regional Integrado de Oncologia
- Instituto Nacional de Cancer - INCa; Oncologia
- Hospital Jardim Amália
- Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda
- Hospital Moinhos de Vento
- Hospital das Clinicas - UFRGS
- Hospital Mae de Deus
- Hospital Sao Lucas - PUCRS
- Clinica de Neoplasias Litoral
- Hospital de Cancer de Barretos
- Hospital Amaral Carvalho
- Faculdade de Medicina do ABC - FMABC
- Instituto Brasileiro de Controle Do Câncer ? São Camilo Oncologia
- Instituto Do Câncer Do Estado de São Paulo Octávio Frias de Oliveira
- Peking University People's Hospital
- Beijing Hospital; Internal Medicine-Oncology
- Beijing Union Hospital
- The First Hospital of Jilin University
- Jilin Cancer Hospital
- West China Hospital, Sichuan University
- Chongqing Cancer Hospital
- Fujian Medical University Union Hospital
- The 900th Hospital of PLA joint service support force
- Sun yat-sen University Cancer Center; Internal Medicine of Oncology
- Guangdong General Hospital
- Sun Yat-Sen University Cancer Center - Huangpu Campus
- The First Affiliated Hospital of College of Medicine, Zhejiang University
- The Second Affiliated Hospital of Zhejiang University College
- Harbin Medical University Cancer Hospital
- Shandong Cancer Hospital
- Luoyang Central Hospital
- Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
- The Affiliated Hospital of Medical College Qingdao University
- Fudan University Shanghai Cancer Center
- Shanghai Jiao Tong University School of Medicine (SJTUSM) - Ruijin Hospital (GuangCi Hospital)
- Zhongshan Hospital Fudan University
- The University of Hong Kong-Shenzhen Hospital; Local Ethic Committee
- Hebei Medical University Fourth Hospital;(Tumor Hospital of Hebei Province)
- Wuhan Union Hospital Tongji Medical College, Huazhong University of Science and Technology
- Hubei Cancer Hospital
- The First Affiliated Hospital of Xian Jiao Tong University
- Zhejiang Cancer Hospital
- Henan Cancer Hospital
- Nemocnice Horovice, NH Hospital a.s.; Oncology Department
- Fakultni Poliklinika Vseobecne Fakultni Niemocnice; Onkologicka Klinika
- Krajska nemocnice T. Bati, a.s.
- Herlev Hospital; Afdeling for Kræftbehandling
- Odense Universitetshospital, Onkologisk Afdeling, Klinisk Forsknings Enhed
- Sygehus Lillebælt, Vejle
- Centre Hospitalier Regional Metz-Thionville - Hopital de Mercy
- Institut Sainte Catherine
- CH de Beauvais
- CHU Jean Minjoz
- Clinique Tivoli; Sce Radiotherapie
- Polyclinique Bordeaux Nord Aquitaine
- Centre Hospitalier Fleyriat
- CHRU De Brest - Hopital Morvan - Institut De Cancerologie Et D'Hematologie
- CRLCC-Francois Baclesse; Oncologie Médicale
- CH de Cholet; oncologie
- Centre Hospitalier de Compiegne
- Centre Hospitalier Alpes Leman
- Centre Georges Francois Leclerc
- Centre Hospitalier Departemental de Vendee
- Clinique Chenieux; Oncology
- Centre Hospitalier Bretagne Sud
- Hopital Prive Jean Mermoz
- Hôpital Saint Joseph
- Clinique Clémentville
- Institut régional du Cancer Montpellier
- l'Hôpital privé du Confluent SAS
- Centre Antoine Lacassagne
- CH Annecy Genevois site Annecy; Oncologie
- Chi De Cornouaille; Oncologie Hospitalisation
- Institut Jean Godinot
- Institut du Cancer Coulancy Reims
- Centre Henri Becquerel
- Institut De Cancerologie Lucien Newrth
- Centre Paul Strauss
- Hopitaux Du Leman - Site Georges Pianta
- Institut Claudius Régaud
- CHU Tours - Hôpital Bretonneau
- Hopital Prive Drome Ardeche; Hopital De Jour
- Institut de Cancérologie de Lorraine
- Institut Gustave Roussy; Departement Oncologie Medicale
- Studienzentrum Berlin City
- St. Johannes-Hospital
- Onkozentrum Dres. Göhler
- BAG Freiberg-Richter, Jacobasch, Illmer, Wolf; Gemeinschaftspraxis Hämatologie-Onkologie
- Praxis für Hamatologie und Onkologie
- Onkodok GmbH
- Albertinen-Krankenhaus Klinik f.Gynäkologie und Geburtshilfe
- Ärztehaus am Bahnhofsplatz; Praxis Uleer/Pourfard
- ViDia Christliche Kliniken Karlsruhe, Vincentius-Diakonissen-Kliniken gAG; Frauenklinik
- St. Elisabeth-Krankenhaus
- Klinikum Ludwigsburg; Studiensekretariat
- St. Vincenz-Elisabeth-Hospital; Katholisches Klinikum Mainz
- Universitätsmedizin Mainz; Klinik u. Poliklinik f. Geburtshilfe u. Frauenheilkunde
- Dres. Michael Maasberg Marion Schmitz und Maria Theresia Keller
- Klinikum Memmingen; Abt.Gynäkologie
- Johannes Wesling Klinikum Minden; Hämatologie, Onkologie, Hämostaseologie und Palliativmedizin
- Brustzentrum Rhein-Ruhr Servicegesellschaft mbH
- Klinikum der Universität München; Frauenklinik - Onkologie II
- Klinikum Neumarkt; Frauenklinik
- Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe
- Johanniter Frauenklinik Stendal Germany
- Gynäkologie Kompetenzzentrum; Praxis Dr. med. Carsten Hielscher
- Universitätsklinik Tübingen; Frauenklinik
- GRN-Klinik Weinheim; Abt.Gynäkologie und Geburtshilfe
- Marien-Hospital Witten, MVZ Witten
- Klinikum Worms; Frauenklinik; Klinik für Gynäkologie und Geburtshilfe
- Pamela Youde Nethersole Eastern Hospital; Clinical Oncology
- Queen Mary Hospital
- Queen Elizabeth Hospital Department of Clinical Oncology
- National Institute of Oncology, A Dept of Internal Medicine
- Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház
- Pécsi Tudományegyetem; Klinikai Központ Onkoterápiás Intézet
- Mater Misecordiae University Hospital
- Beaumont Hospital; Cancer Clinical Trials Unit
- Shaare Zedek Medical Center
- Hadassah Med Org Kiryat; Oncology Institute
- Meir Medical center, Pediatrics
- Rabin MC; Davidof Center - Oncology Institute
- The Chaim Sheba Medical Center
- Azienda Ospedaliera Papa Giovanni XXIII
- Azienda Ospedaliero Universitaria Di Bologna - Policlinico S.Orsola Malpighi; UO Farmacia Clinica
- U.O Medicina Oncologica Ospedale di Carpi
- Ospedale Degli Infermi - Faenza; Oncologia Medica
- Azienda Ospedaliero - Universitaria di Modena Policlinico
- Azienda Ospedaliero Universitaria di Parma
- Ospedale degli Infermi
- A.O. Universitaria S. Maria Della Misericordia Di Udine; Oncologia
- Policlinico Universitario Campus Biomedico Di Roma
- Azienda Ospedaliero Universitaria San Martino
- ASST DI LECCO; Oncologia Medica
- Ospedale Mater Salutis
- Istituto Europeo Di Oncologia
- Fondazione Salvatore Maugeri
- Policlinico San Mattea
- Istituto Clinico Humanitas
- Azienda Ospedaliera SS. Antonio E. Biagio E. Cesare Arrigo di Alessandria
- Ospedale Degli Infermi Di Biella; Reparto Oncologia Medica
- Ospedale Santa Maria Annunziata; Oncologia
- Azienda Usl 7; Dept. Oncologico
- Nuovo Ospedale Di Prato
- Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia
- Aichi Cancer Center Hospital
- Chiba Cancer Center
- Shikoku Cancer Center
- National Hospital Organization Kyushu Cancer Center
- Fukushima Medical University Hospital
- Hiroshima City Hiroshima Citizens Hospital
- National Hospital Organization Hokkaido Cancer Center
- Hyogo Medical University Hospital
- University of Tsukuba Hospital
- Sagara Hospital
- Kanagawa Cancer Center
- Tokai University Hospital
- Kyoto University Hospital
- Okayama University Hospital
- Naha-nishi Clinic
- National Hospital Organization Osaka National Hospital
- Osaka International Cancer Institute
- Saitama Medical University International Medical Center
- Saitama Cancer Center
- Shizuoka Cancer Center
- St. Luke's Internat. Hospital, Breast Surgical Oncology
- The Cancer Institute Hospital of JFCR
- Chungbuk National University Hospital
- Soon Chun Hyang University Cheonan Hospital
- National Cancer Center
- CHA Bundang Medical Center
- Gachon University Gil Medical Center
- Inha University Hospital
- Seoul National University Bundang Hospital
- Seoul National University Hospital
- Severance Hospital; Yonsei University Health System
- Asan Medical Center
- Gangnam Severance Hospital
- Samsung Medical Center
- Seoul St Mary's Hospital
- Ewha Womans University Mokdong Hospital
- Ajou University Hospital
- Ulsan University Hosiptal
- Wonju Christian Hospital
- Health Pharma Professional Research
- Iem-Fucam
- Instituto Nacional De Cancerologia; Oncology; Tumores Mamarios
- Centro Médico Zambrano Hellion
- Centro de Investigacion Clinica de Oaxaca
- Oncologico Potosino
- Merida | Investigacion Clinica
- CENEIT Oncologicos; DENTRO DE CONDOMINIO SAN FRANCISCO
- Centro Medico Dalinde
- Hospital Nacional Carlos Alberto Seguin Escobedo-Essalud; Oncology & Haemathology
- Oncosalud Sac; Oncología
- Instituto Nacional de Enfermedades Neoplasicas
- Instytut MSF Sp. z o.o.
- MedPolonia
- Wielkopolskie Centrum Onkologi
- Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy; Klinika Onkologii
- "Filantropia" Clinical Hospital; Gynecological Oncology
- Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca; Oncologie Medicala
- Centrul de Oncologie Sfantul Nectarie
- Medsi Clinic
- Arkhangelsk Regional Clinical Oncology Dispensary
- Bashkirian Republican Clinical Oncology Dispensary
- Regional Clinical Oncology Hospital
- Oncologica Dispensary #2
- Evimed
- Mordovia State University
- Moscow Clinical Scientific Center
- FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF
- P.A. Herzen Oncological Inst. ; Oncology
- Nizhny Novgorod Regional Clinical Oncology Center
- National Medical Research Center for Oncology
- S-Pb clinical scientific practical center of specialized kinds of medical care (oncological)
- FBI "Scientific Research Institute of Oncology n. a. N. N. Petrov"
- LLC Strategic Medical Systems
- EosMed LLC
- LCC Center of Palliative Medicine - Devita
- Private Healthcare Institution Clinical Hospital RZhD Medicine
- Pyatigorsky Oncologic Dispensary
- Regional Oncology Hospital
- Ivanovo Regional Oncology Dispensary
- Regional Oncology Dispensary; Dept of Chemotherapy
- BIH at Omsk Region "Clinical Oncology Dispensary", Outpatient clinic
- Multidisciplinary clinic Reaviz
- Samara Regional Oncology Dispensary
- Regional Clinical Hospital
- SHI Volgograd Regional Clinical Oncological Dispensary#1
- National University Hospital; Medical Oncology
- National Cancer Centre
- Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia
- Hospital General De Catalunya; Servicio de Oncologia
- Hospital Mutua de Terrassa; Servicio de Oncologia
- Consorci Hospitalari de Terrassa
- Hospital de Jerez
- Hospital Provincial Castellón
- Hospital Son Llatzer
- Centro Oncologico de Galicia COG; Medical Oncology
- Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia
- Hospital Universitario Puerta de Hierro - Majadahonda
- Hospital Infanta Sofia; Servico de Oncologia
- Complexo Hospitalario de Vigo. Hospital Álvaro Cunqueiro; Servicio de Oncología
- Hospital Universitari Sant Joan de Reus; Planta baja, color lila
- Hospital Universitario de Canarias;servicio de Oncologia
- Hospital Universitario de Burgos
- Hospital San Pedro De Alcantara; Servicio de Oncologia
- Complejo Hospitalario de Jaen
- Complejo Asistencial Universitario de Leon; Servicio de Oncologia
- Hospital General Universitario Gregorio Marañon; Servicio de Oncologia
- Hospital Universitario Ramón y Cajal
- Hospital Universitario 12 de Octubre; Servicio de Oncologia
- Centro Integral Oncológico Clara Campal Ensayos Clínicos START
- Hosp Univ Fundacion Alcorcon
- Hospital Universitario de Fuenlabrada; Servicio de Oncologia
- Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia
- Hospital Universitario Virgen de Arrixaca; Servicio de Oncologia
- Hospital Quirón Sagrado Corazón
- Instituto Valenciano Oncologia; Oncologia Medica
- Hospital Clinico Universitario de Valencia
- Hospital General Universitario de Valencia; Servicio de oncologia
- Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia
- Hirslanden Medical Center - Tumorzentrum
- Centre Hospitalier Universitaire Vaudois - Lausanne
- Brust-Zentrum Zürich AG Seefeldstrasse 214 Zürich
- Chunghua Christian hospital
- Kaohsiung Medical University Hospital; Chung-Ho Memorial Hospital
- E-Da Cancer Hospital; Hematology- Oncology Department
- Chi Mei Medical Center Liou Ying Campus
- National Cheng Kung University Hospital
- Taipei Veterans General Hospital
- National Taiwan University Hospital
- Mackay Memorial Hospital - Taipei Branch
- Tri-Service General Hospital
- Chang Gung Medical Foundation Linkou Branch
- Rajavithi Hospital; Division of Medical Oncology
- Ramathibodi Hospital; Medicine/Oncology
- Siriraj Hospital; Clinical Research Center, Pharmacy Department
- Songklanagarind Hospital
- Srinagarind Hospital, Khon Kaen University
- Lampang Cancer Hospital
- King Chulalongkorn Memorial Hospital; Faculty of Medicine Chulalongkorn University
- Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma Merkezi
- Uludag Universitesi - Saglik Uygulama ve Arastirrma Merkezi
- Ege Universitesi Hastanesi (Saglik Uygulama ve Arastirma Merkezi)
- Izmir Ekonomi Universitesi Medical Park Hastanesi
- Mersin Universitesi Tip Fakultesi Hastanesi; Tibbi Onkoloji Birimi
- Medikal Park Samsun
- Yulis Medical and Diagnostic Center
- Municipal Noncommercial Institution Regional Center of Oncology
- MI "Clinical Oncological Dispensary" of Dnipro Reg Council; chemotherapy department
- Municipal Institution Odesa Regional Oncology Dispensary
- Vinnytsya Regional Clinical Oncology Dispensary
- Regional Oncology Center; Department of Mammology
- Chernivtsi Regional Clinical Oncology Dispensary
- City Clinical Hospital #4
- Municipal Institution Kirovograd Regional Oncology Dispensary
- ME Kryviy Rih Oncology Dispensary of Dnipropetrovs?k Regional Council; Chemotherapy Department
- Volyn Regional Oncology Dispensary
- Lviv State Oncological Regional Treatment and Diagnostic Center
- Municipal Institution Odesa Regional Clinical Hospital
- Sumy Reg. Clin. Oncological Dispensary; Thoracall Department
- CCCH City Oncological Center SHEI Uzhgorod NU
- Transkarpathian Regional Oncology Clinic; Chemotherapy
- Zaporizhzhia Regional Clinical Oncology Dispensary; Zaporizhzhya State Medical University
- NHS Lothian - Western General Hospital; NHS Lothian - Western General Hospital
- Calderdale and Huddersfield NHS Foundation Trust
- Leeds Teaching Hosp NHS Trust;St James's Institute of Onc
- Guys and St Thomas NHS Foundation Trust, Guys Hospital
- The Christie NHS Foundation Trust
- Nottingham University Hospitals NHS Trust - City Hospital
- University Hospitals of North Midlands NHS Trust-Royal Stoke University Hospital
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
Atezolizumab + Chemotherapy
Chemotherapy
Arm Description
Participants will receive atezolizumab (in combination with chemotherapy as described below) every 2 weeks for 10 doses, followed by atezolizumab maintenance therapy every 3 weeks to complete 1 year of treatment from the first dose Chemotherapy will consist of paclitaxel every week for 12 weeks, followed by dose-dense doxorubicin +cyclophosphamide or dose-dense epirubicin + cyclophosphamide every 2 weeks, for 4 doses supported with Granulocyte Colony-Stimulating Factor (G-CSF) or Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)
Chemotherapy will consist of paclitaxel every week for 12 weeks, followed by dose-dense doxorubicin +cyclophosphamide or dose-dense epirubicin + cyclophosphamide every 2 weeks, for 4 doses supported with Granulocyte Colony-Stimulating Factor (G-CSF) or Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)
Outcomes
Primary Outcome Measures
Invasive Disease-Free Survival (iDFS)
iDFS events are defined as follows:
Ipsilateral invasive breast tumor recurrence
Ipsilateral local-regional invasive breast cancer recurrence
Ipsilateral second primary invasive breast cancer
Contralateral invasive breast cancer
Distant recurrence
Death attributable to any cause
Secondary Outcome Measures
Overall Survival (OS)
Disease-Free Survival (DFS)
DFS is defined as any event of the primary endpoint and new diagnosis of an ipsilateral or contralateral non-invasive breast cancer.
Recurrence-Free Interval (RFI)
Distant RFI
Percentage of participants with adverse events
Safety Objective
Serum concentration of Atezolizumab
Invasive Disease-Free Survival (iDFS) in PDL1- Selected Patients
Invasive Disease-Free Survival (iDFS) in Node- Positive Disease
Invasive Disease Free Survival (iDFS) including second primary non-breast invasive cancer
Percentage of Participants with Anti-Drug Antibodies (ADAs) to Atezolizumab
Mean changes from baseline in patient-reported function (role, physical)
Mean changes from baseline score in role, physical function will be assessed using the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire - Core 30 (EORTC QLQ-C30)
Mean changes from baseline in patient-reported health-related quality of life (HRQoL)
Mean changes from baseline score in HRQoL will be assessed using the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire - Core 30 (EORTC QLQ-C30).
Full Information
NCT ID
NCT03498716
First Posted
February 28, 2018
Last Updated
September 14, 2023
Sponsor
Hoffmann-La Roche
Collaborators
Breast International Group, Alliance Foundation Trials (AFT), Institut Jules Bordet/Clinical Trials Support Unit (IJB/CTSU), Frontier Science & Technology Research Foundation, Inc.
1. Study Identification
Unique Protocol Identification Number
NCT03498716
Brief Title
A Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone In Patients With Operable Triple-Negative Breast Cancer
Acronym
IMpassion030
Official Title
A Phase III, Multicenter, Randomized, Open-Label Study Comparing Atezolizumab (Anti PD-L1 Antibody) in Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone in Patients With Operable Triple Negative Breast Cancer
Study Type
Interventional
2. Study Status
Record Verification Date
September 2023
Overall Recruitment Status
Completed
Study Start Date
August 2, 2018 (Actual)
Primary Completion Date
August 14, 2023 (Actual)
Study Completion Date
August 14, 2023 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Hoffmann-La Roche
Collaborators
Breast International Group, Alliance Foundation Trials (AFT), Institut Jules Bordet/Clinical Trials Support Unit (IJB/CTSU), Frontier Science & Technology Research Foundation, Inc.
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
This study will evaluate the efficacy, safety, and pharmacokinetics of adjuvant atezolizumab in combination with paclitaxel, followed by atezolizumab, dose-dense doxorubicin or epirubicin (investigator's choice), and cyclophosphamide, compared with paclitaxel followed by dose-dense doxorubicin or epirubicin (investigator's choice) and cyclophosphamide alone in patients with Stage II-III TNBC (Triple Negative Breast Cancer)
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Triple Negative Breast Cancer
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
2203 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Atezolizumab + Chemotherapy
Arm Type
Experimental
Arm Description
Participants will receive atezolizumab (in combination with chemotherapy as described below) every 2 weeks for 10 doses, followed by atezolizumab maintenance therapy every 3 weeks to complete 1 year of treatment from the first dose
Chemotherapy will consist of paclitaxel every week for 12 weeks, followed by dose-dense doxorubicin +cyclophosphamide or dose-dense epirubicin + cyclophosphamide every 2 weeks, for 4 doses supported with Granulocyte Colony-Stimulating Factor (G-CSF) or Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)
Arm Title
Chemotherapy
Arm Type
Active Comparator
Arm Description
Chemotherapy will consist of paclitaxel every week for 12 weeks, followed by dose-dense doxorubicin +cyclophosphamide or dose-dense epirubicin + cyclophosphamide every 2 weeks, for 4 doses supported with Granulocyte Colony-Stimulating Factor (G-CSF) or Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)
Intervention Type
Drug
Intervention Name(s)
Atezolizumab
Intervention Description
Atezolizumab will be administered by IV, 840 mg every 2 weeks, for 10 doses.
Atezolizumab maintenance will be administered by IV, 1200 mg every 3 weeks to complete 1 year
Intervention Type
Drug
Intervention Name(s)
Paclitaxel
Intervention Description
Paclitaxel will be administered by IV, 80 mg/m^2 every week for 12 weeks.
Intervention Type
Drug
Intervention Name(s)
Dose-dense Doxorubicin or dose-dense Epirubicin
Intervention Description
Dose-dense doxorubicin will be administered by IV, 60 mg/m^2 every 2 weeks for a total of 4 doses.
Or
Dose-dense epirubicin will be administered by IV, (90 mg/m^2) every 2 weeks for a total of 4 doses
Intervention Type
Drug
Intervention Name(s)
Cyclophosphamide
Intervention Description
Cyclophosphamide will be administered by IV, 600 mg/m^2 every 2 weeks for 4 doses
Primary Outcome Measure Information:
Title
Invasive Disease-Free Survival (iDFS)
Description
iDFS events are defined as follows:
Ipsilateral invasive breast tumor recurrence
Ipsilateral local-regional invasive breast cancer recurrence
Ipsilateral second primary invasive breast cancer
Contralateral invasive breast cancer
Distant recurrence
Death attributable to any cause
Time Frame
Randomization until the first occurrence of iDFS event or death, through the end of study (approximately 7 years).
Secondary Outcome Measure Information:
Title
Overall Survival (OS)
Time Frame
Randomization to death from any cause through the end of study (approximately 7 years)
Title
Disease-Free Survival (DFS)
Description
DFS is defined as any event of the primary endpoint and new diagnosis of an ipsilateral or contralateral non-invasive breast cancer.
Time Frame
Randomization until the first occurrence of an DFS event, through the end of study (approximately 7 years)
Title
Recurrence-Free Interval (RFI)
Time Frame
Randomization until local, regional, or distant disease recurrence of breast cancer, through the end of study (approximately 7 years)
Title
Distant RFI
Time Frame
Randomization until distant disease recurrence, through the end of study (approximately 7 years)
Title
Percentage of participants with adverse events
Description
Safety Objective
Time Frame
Baseline to end of study (approximately 7 years)
Title
Serum concentration of Atezolizumab
Time Frame
Pre-infusion (0 hour), 30 minutes post-infusion on Week 1 Day 1 (infusion length = 60 minutes); pre-infusion on Day 1 of Weeks 5, 9, 13, 21, 33 and 45; at treatment discontinuation (up to approximately 1 year), 120 days after last dose
Title
Invasive Disease-Free Survival (iDFS) in PDL1- Selected Patients
Time Frame
Randomization until the first occurrence of iDFS event or death, through the end of study (approximately 7 years)
Title
Invasive Disease-Free Survival (iDFS) in Node- Positive Disease
Time Frame
Randomization until the first occurrence of iDFS event or death, through the end of study (approximately 7 years)
Title
Invasive Disease Free Survival (iDFS) including second primary non-breast invasive cancer
Time Frame
Randomization until the first occurrence of iDFS event or death, through the end of study (approximately 7 years)
Title
Percentage of Participants with Anti-Drug Antibodies (ADAs) to Atezolizumab
Time Frame
Updated: Pre-infusion (0 hour) on Day 1 of Weeks 1, 5, 9, 13, 21, 33 and 45; at treatment discontinuation (up to Week 51), 120 days after last dose
Title
Mean changes from baseline in patient-reported function (role, physical)
Description
Mean changes from baseline score in role, physical function will be assessed using the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire - Core 30 (EORTC QLQ-C30)
Time Frame
Baseline, Cycle 4 Day 1, Day 1 of every other cycle until Cycle 16 (cycle = 21 days), at the end of treatment/discontinuation visit ((up to approximately 1 year), and during Study Follow-up (up to approximately 7 years).
Title
Mean changes from baseline in patient-reported health-related quality of life (HRQoL)
Description
Mean changes from baseline score in HRQoL will be assessed using the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire - Core 30 (EORTC QLQ-C30).
Time Frame
Time Frame: Baseline, Cycle 4 Day 1, Day 1 of every other cycle until Cycle 16 (cycle = 21 days), at the end of treatment/discontinuation visit (up to approximately 1 year), and during Study Follow-up (up to approximately 7 years).
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Non-metastatic operable Stage II-III breast cancer
Histologically documented TNBC (Triple Negative Breast Cancer)
Confirmed tumor PD-L1 evaluation as documented through central testing of a representative tumor tissue specimen
Adequately excised: Patients must have undergone either breast-conserving surgery or mastectomy/nipple- or skin-sparing mastectomy
Adequate hematologic and end-organ function
For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures
For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures and agreement to refrain from donating sperm.
No more than 8 weeks (56 days) may elapse between definitive breast surgery and randomization.
Representative formalin-fixed, paraffin embedded (FFPE) tumor specimen from surgical resection in paraffin blocks (preferred) or at least 25 unstained slides.
Exclusion Criteria
Prior history of invasive breast cancer
For the currently diagnosed breast cancer, any previous systemic anti-cancer treatment (e.g., neoadjuvant or adjuvant), including, but not limited to, chemotherapy, anti-HER2 therapy.
Previous therapy with anthracyclines or taxanes for any malignancy
Cardiopulmonary dysfunction
Prior malignancies within 5 years prior to randomization, with the exception of those with a negligible risk of metastasis or death and treated with expected curative outcome
Active or history of autoimmune disease or immune deficiency
History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening chest computed tomography (CT) scan
Urinary outflow obstruction
Active tuberculosis
Major surgical procedure other than for diagnosis within 4 weeks prior to initiation of study treatment or anticipation of need for a major surgical procedure during study treatment or within 5 months following the last dose of Atezolizumab (for patients randomized to Atezolizumab)
Prior allogeneic stem cell or solid organ transplant
Treatment with systemic immunosuppressive medications within 2 weeks prior to initiation of study treatment or anticipation of need for systemic immunosuppressive medication during the study
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Clinical Trials
Organizational Affiliation
Hoffmann-La Roche
Official's Role
Study Director
Facility Information:
Facility Name
John Muir Health Clinical Research Center
City
Concord
State/Province
California
ZIP/Postal Code
94520
Country
United States
Facility Name
Cedars-Sinai Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
Martin-O?Neil Cancer Center
City
Saint Helena
State/Province
California
ZIP/Postal Code
94574
Country
United States
Facility Name
Baptist - MD Anderson Cancer Center
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32207
Country
United States
Facility Name
Advocate Illinois Masonic Outpatient Center for Advanced Care
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60657
Country
United States
Facility Name
Des Moines Oncology Research Association
City
Des Moines
State/Province
Iowa
ZIP/Postal Code
50309
Country
United States
Facility Name
Cancer Center of Kansas
City
Wichita
State/Province
Kansas
ZIP/Postal Code
67214-3728
Country
United States
Facility Name
University of Maryland Greenebaum Comprehensive Cancer Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21201
Country
United States
Facility Name
Fairview Southdale Medical Oncology Clinic
City
Edina
State/Province
Minnesota
ZIP/Postal Code
55435
Country
United States
Facility Name
HCA Midwest Division
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64132
Country
United States
Facility Name
New Hampshire Hematology Oncology
City
Manchester
State/Province
New Hampshire
ZIP/Postal Code
03103
Country
United States
Facility Name
Monter Cancer Center
City
Lake Success
State/Province
New York
ZIP/Postal Code
11042
Country
United States
Facility Name
Memorial Sloan Kettering Cancer Center
City
New York
State/Province
New York
ZIP/Postal Code
11101
Country
United States
Facility Name
Rochester General Hospital; Lipson Cancer and Blood Center
City
Rochester
State/Province
New York
ZIP/Postal Code
14621
Country
United States
Facility Name
SCRI
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Facility Name
Intermountain Precision Genomics Cancer Research Clinic-Dixie
City
Saint George
State/Province
Utah
ZIP/Postal Code
84770
Country
United States
Facility Name
St. Mary's Medical Center
City
Huntington
State/Province
West Virginia
ZIP/Postal Code
25702
Country
United States
Facility Name
Centro de Oncologia e; Investigacion Buenos Aires - COIBA
City
Berazategui
ZIP/Postal Code
B1880BBF
Country
Argentina
Facility Name
INSTITUTO DE INVESTIGACIONES METABOLICAS (IDIM); Oncology
City
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
C1012AAR
Country
Argentina
Facility Name
Hospital Britanico de Buenos Aires
City
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
C1284AEB
Country
Argentina
Facility Name
Clinica Universitaria Reina Fabiola
City
Cordoba
ZIP/Postal Code
X5004FHP
Country
Argentina
Facility Name
Fundación Ars Medica
City
Jujuy
Country
Argentina
Facility Name
Centro Oncologico Riojano Integral (CORI)
City
La Rioja
ZIP/Postal Code
F5300COE
Country
Argentina
Facility Name
Instituto de Oncología de Rosario
City
Rosario
ZIP/Postal Code
S2000KZE
Country
Argentina
Facility Name
Centro Medico San Roque
City
San Miguel de Tucuman
ZIP/Postal Code
T4000IAK
Country
Argentina
Facility Name
Centro de Investigacion Clinica - Clinica Viedma S.A.; Oncology Department
City
Viedma
ZIP/Postal Code
R8500ACE
Country
Argentina
Facility Name
St Vincent's Hospital Sydney
City
Darlinghurst
State/Province
New South Wales
ZIP/Postal Code
2010
Country
Australia
Facility Name
Lismore Base Hospital
City
Lismore
State/Province
New South Wales
ZIP/Postal Code
2480
Country
Australia
Facility Name
Macquarie University Hospital
City
Macquarie Park
State/Province
New South Wales
ZIP/Postal Code
2109
Country
Australia
Facility Name
Tweed Hospital
City
Tweed Heads
State/Province
New South Wales
ZIP/Postal Code
2485
Country
Australia
Facility Name
Sydney Adventist Hospital
City
Wahroonga
State/Province
New South Wales
ZIP/Postal Code
2076
Country
Australia
Facility Name
Icon Cancer Care Wesley
City
Auchenflower
State/Province
Queensland
ZIP/Postal Code
4066
Country
Australia
Facility Name
Icon Cancer Foundation; Icon Cancer Care Chermside
City
Chermside
State/Province
Queensland
ZIP/Postal Code
4032
Country
Australia
Facility Name
Icon Cancer Care South Brisbane
City
South Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Facility Name
Mater Hospital; Cancer Services
City
South Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Facility Name
Icon Cancer Foundation; Icon Cancer Care Southport
City
Southport
State/Province
Queensland
ZIP/Postal Code
4215
Country
Australia
Facility Name
Princess Alexandra Hospital; Cancer Trials Unit
City
Woolloongabba
State/Province
Queensland
ZIP/Postal Code
4102
Country
Australia
Facility Name
Royal Adelaide Hospital; Cancer Centre
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Ashford Cancer Center Research
City
Kurralta Park
State/Province
South Australia
ZIP/Postal Code
5037
Country
Australia
Facility Name
Box Hill Hospital; Eastern Clinical Research Unit
City
Box Hill
State/Province
Victoria
ZIP/Postal Code
3128
Country
Australia
Facility Name
Monash Medical Centre
City
Clayton
State/Province
Victoria
ZIP/Postal Code
3168
Country
Australia
Facility Name
Austin Hospital Olivia Newton John Cancer Centre
City
Heidelberg
State/Province
Victoria
ZIP/Postal Code
3084
Country
Australia
Facility Name
Maroondah Hospital; Breast Clinic
City
Ringwood East
State/Province
Victoria
ZIP/Postal Code
3135
Country
Australia
Facility Name
Lkh-Univ. Klinikum Graz; Klinik Für Gynäkologie
City
Graz
ZIP/Postal Code
8036
Country
Austria
Facility Name
Medical University Innsbruck; Frauenklinik Innsbruck, Dept Gyn
City
Innsbruck
ZIP/Postal Code
6020
Country
Austria
Facility Name
Ordensklinikum Linz Barmherzige Schwestern; Interne 1 - Hämato-Onkologie
City
Linz
ZIP/Postal Code
4010
Country
Austria
Facility Name
Uniklinikum Salzburg, LKH; Univ.Klinik f. Innere Medizin III der PMU
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
Facility Name
AKH - Medizinische Universität Wien; Department of Oncology
City
Vienna
ZIP/Postal Code
1090
Country
Austria
Facility Name
General Hospital Hietzing, KLI; Dept. Obstet&Gynecol
City
Vienna
ZIP/Postal Code
1130
Country
Austria
Facility Name
Salzkammergut-Klinikum Voecklabruck
City
Vöcklabruck
ZIP/Postal Code
4840
Country
Austria
Facility Name
Klinikum Kreuzschwestern Wels; Iv. Interne Abt.
City
Wels
ZIP/Postal Code
4600
Country
Austria
Facility Name
Medizinische Universität Wien; Univ.Klinik für Frauenheilkunde - Klinik für Gynäkologie
City
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
AZ KLINA
City
Brasschaat
ZIP/Postal Code
2930
Country
Belgium
Facility Name
Institut Jules Bordet
City
Bruxelles
ZIP/Postal Code
1000
Country
Belgium
Facility Name
UZ Leuven Gasthuisberg
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
CHC MontLégia
City
Liege
ZIP/Postal Code
4000
Country
Belgium
Facility Name
Chr de La Citadelle
City
Liège
ZIP/Postal Code
4000
Country
Belgium
Facility Name
CHU Ambroise Paré
City
Mons
ZIP/Postal Code
7000
Country
Belgium
Facility Name
Clinique Sainte-Elisabeth; Oncologie
City
Namur
ZIP/Postal Code
5000
Country
Belgium
Facility Name
Vitaz
City
Sint Niklaas
ZIP/Postal Code
9100
Country
Belgium
Facility Name
Nucleo de Oncologia da Bahia - NOB
City
Salvador, Bahia
State/Province
BA
ZIP/Postal Code
40170-380
Country
Brazil
Facility Name
Crio - Centro Regional Integrado de Oncologia
City
Fortaleza
State/Province
CE
ZIP/Postal Code
60336-232
Country
Brazil
Facility Name
Instituto Nacional de Cancer - INCa; Oncologia
City
Rio de Janeiro
State/Province
RJ
ZIP/Postal Code
20560-120
Country
Brazil
Facility Name
Hospital Jardim Amália
City
Volta Redonda
State/Province
RJ
ZIP/Postal Code
27251-260
Country
Brazil
Facility Name
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda
City
Ijui
State/Province
RS
ZIP/Postal Code
98700-000
Country
Brazil
Facility Name
Hospital Moinhos de Vento
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90035-000
Country
Brazil
Facility Name
Hospital das Clinicas - UFRGS
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90035-903
Country
Brazil
Facility Name
Hospital Mae de Deus
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90110-000
Country
Brazil
Facility Name
Hospital Sao Lucas - PUCRS
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90610-000
Country
Brazil
Facility Name
Clinica de Neoplasias Litoral
City
Itajai
State/Province
SC
ZIP/Postal Code
88301-220
Country
Brazil
Facility Name
Hospital de Cancer de Barretos
City
Barretos
State/Province
SP
ZIP/Postal Code
14784-400
Country
Brazil
Facility Name
Hospital Amaral Carvalho
City
Jau
State/Province
SP
ZIP/Postal Code
17210-120
Country
Brazil
Facility Name
Faculdade de Medicina do ABC - FMABC
City
Santo Andre
State/Province
SP
ZIP/Postal Code
09060-650
Country
Brazil
Facility Name
Instituto Brasileiro de Controle Do Câncer ? São Camilo Oncologia
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
04014-002
Country
Brazil
Facility Name
Instituto Do Câncer Do Estado de São Paulo Octávio Frias de Oliveira
City
São Paulo
State/Province
SP
ZIP/Postal Code
01246 000
Country
Brazil
Facility Name
Peking University People's Hospital
City
Beijing
ZIP/Postal Code
100044
Country
China
Facility Name
Beijing Hospital; Internal Medicine-Oncology
City
Beijing
ZIP/Postal Code
100730
Country
China
Facility Name
Beijing Union Hospital
City
Beijing
ZIP/Postal Code
100730
Country
China
Facility Name
The First Hospital of Jilin University
City
Changchun City
ZIP/Postal Code
130021
Country
China
Facility Name
Jilin Cancer Hospital
City
Changchun
ZIP/Postal Code
132013
Country
China
Facility Name
West China Hospital, Sichuan University
City
Chengdu
ZIP/Postal Code
610041
Country
China
Facility Name
Chongqing Cancer Hospital
City
Chongqing
ZIP/Postal Code
400030
Country
China
Facility Name
Fujian Medical University Union Hospital
City
Fuzhou City
ZIP/Postal Code
350001
Country
China
Facility Name
The 900th Hospital of PLA joint service support force
City
Fuzhou
ZIP/Postal Code
110016
Country
China
Facility Name
Sun yat-sen University Cancer Center; Internal Medicine of Oncology
City
Guangzhou
ZIP/Postal Code
510060
Country
China
Facility Name
Guangdong General Hospital
City
Guangzhou
ZIP/Postal Code
510080
Country
China
Facility Name
Sun Yat-Sen University Cancer Center - Huangpu Campus
City
Guangzhou
Country
China
Facility Name
The First Affiliated Hospital of College of Medicine, Zhejiang University
City
Hangzhou
ZIP/Postal Code
310003
Country
China
Facility Name
The Second Affiliated Hospital of Zhejiang University College
City
Hangzhou
ZIP/Postal Code
310009
Country
China
Facility Name
Harbin Medical University Cancer Hospital
City
Harbin
ZIP/Postal Code
150081
Country
China
Facility Name
Shandong Cancer Hospital
City
Jinan
ZIP/Postal Code
250117
Country
China
Facility Name
Luoyang Central Hospital
City
Luoyang City
ZIP/Postal Code
471000
Country
China
Facility Name
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
City
Nanjing City
ZIP/Postal Code
210008
Country
China
Facility Name
The Affiliated Hospital of Medical College Qingdao University
City
Qingdao
ZIP/Postal Code
266003
Country
China
Facility Name
Fudan University Shanghai Cancer Center
City
Shanghai City
ZIP/Postal Code
200120
Country
China
Facility Name
Shanghai Jiao Tong University School of Medicine (SJTUSM) - Ruijin Hospital (GuangCi Hospital)
City
Shanghai
ZIP/Postal Code
200025
Country
China
Facility Name
Zhongshan Hospital Fudan University
City
Shanghai
ZIP/Postal Code
200032
Country
China
Facility Name
The University of Hong Kong-Shenzhen Hospital; Local Ethic Committee
City
Shenzhen City
ZIP/Postal Code
518053
Country
China
Facility Name
Hebei Medical University Fourth Hospital;(Tumor Hospital of Hebei Province)
City
Shijiazhuang
ZIP/Postal Code
050035
Country
China
Facility Name
Wuhan Union Hospital Tongji Medical College, Huazhong University of Science and Technology
City
Wuhan City
ZIP/Postal Code
430022
Country
China
Facility Name
Hubei Cancer Hospital
City
Wuhan
ZIP/Postal Code
430079
Country
China
Facility Name
The First Affiliated Hospital of Xian Jiao Tong University
City
Xi'an City
ZIP/Postal Code
710061
Country
China
Facility Name
Zhejiang Cancer Hospital
City
Zhejiang
ZIP/Postal Code
310022
Country
China
Facility Name
Henan Cancer Hospital
City
Zhengzhou
ZIP/Postal Code
450008
Country
China
Facility Name
Nemocnice Horovice, NH Hospital a.s.; Oncology Department
City
Horovice
ZIP/Postal Code
26831
Country
Czechia
Facility Name
Fakultni Poliklinika Vseobecne Fakultni Niemocnice; Onkologicka Klinika
City
Praha 2
ZIP/Postal Code
128 08
Country
Czechia
Facility Name
Krajska nemocnice T. Bati, a.s.
City
Zlin
ZIP/Postal Code
76001
Country
Czechia
Facility Name
Herlev Hospital; Afdeling for Kræftbehandling
City
Herlev
ZIP/Postal Code
2730
Country
Denmark
Facility Name
Odense Universitetshospital, Onkologisk Afdeling, Klinisk Forsknings Enhed
City
Odense C
ZIP/Postal Code
5000
Country
Denmark
Facility Name
Sygehus Lillebælt, Vejle
City
Vejle
ZIP/Postal Code
7100
Country
Denmark
Facility Name
Centre Hospitalier Regional Metz-Thionville - Hopital de Mercy
City
Ars-Laquenexy
ZIP/Postal Code
57530
Country
France
Facility Name
Institut Sainte Catherine
City
Avignon
ZIP/Postal Code
84082
Country
France
Facility Name
CH de Beauvais
City
Beauvais
ZIP/Postal Code
60000
Country
France
Facility Name
CHU Jean Minjoz
City
Besançon
ZIP/Postal Code
25030
Country
France
Facility Name
Clinique Tivoli; Sce Radiotherapie
City
Bordeaux
ZIP/Postal Code
33000
Country
France
Facility Name
Polyclinique Bordeaux Nord Aquitaine
City
Bordeaux
ZIP/Postal Code
33300
Country
France
Facility Name
Centre Hospitalier Fleyriat
City
Bourg-en- Bresse Cedex
ZIP/Postal Code
01012
Country
France
Facility Name
CHRU De Brest - Hopital Morvan - Institut De Cancerologie Et D'Hematologie
City
Brest
ZIP/Postal Code
29609
Country
France
Facility Name
CRLCC-Francois Baclesse; Oncologie Médicale
City
Caen
ZIP/Postal Code
14076
Country
France
Facility Name
CH de Cholet; oncologie
City
Cholet
ZIP/Postal Code
49325
Country
France
Facility Name
Centre Hospitalier de Compiegne
City
Compiegne
ZIP/Postal Code
60321
Country
France
Facility Name
Centre Hospitalier Alpes Leman
City
Contamine Sur Arve
ZIP/Postal Code
74130
Country
France
Facility Name
Centre Georges Francois Leclerc
City
Dijon
ZIP/Postal Code
21000
Country
France
Facility Name
Centre Hospitalier Departemental de Vendee
City
La Roche Sur Yon
ZIP/Postal Code
85925
Country
France
Facility Name
Clinique Chenieux; Oncology
City
Limoges
ZIP/Postal Code
87039
Country
France
Facility Name
Centre Hospitalier Bretagne Sud
City
Lorient
ZIP/Postal Code
56100
Country
France
Facility Name
Hopital Prive Jean Mermoz
City
Lyon
ZIP/Postal Code
69008
Country
France
Facility Name
Hôpital Saint Joseph
City
Marseille
ZIP/Postal Code
13008
Country
France
Facility Name
Clinique Clémentville
City
Montpellier
ZIP/Postal Code
34070
Country
France
Facility Name
Institut régional du Cancer Montpellier
City
Montpellier
ZIP/Postal Code
34298
Country
France
Facility Name
l'Hôpital privé du Confluent SAS
City
Nantes
ZIP/Postal Code
44202
Country
France
Facility Name
Centre Antoine Lacassagne
City
Nice
ZIP/Postal Code
06189
Country
France
Facility Name
CH Annecy Genevois site Annecy; Oncologie
City
Pringy
ZIP/Postal Code
74374
Country
France
Facility Name
Chi De Cornouaille; Oncologie Hospitalisation
City
Quimper
ZIP/Postal Code
29107
Country
France
Facility Name
Institut Jean Godinot
City
Reims
ZIP/Postal Code
51056
Country
France
Facility Name
Institut du Cancer Coulancy Reims
City
Reims
ZIP/Postal Code
51100
Country
France
Facility Name
Centre Henri Becquerel
City
Rouen
ZIP/Postal Code
76038
Country
France
Facility Name
Institut De Cancerologie Lucien Newrth
City
St Priest en Jarez CEDEX
ZIP/Postal Code
42271
Country
France
Facility Name
Centre Paul Strauss
City
Strasbourg
ZIP/Postal Code
67000
Country
France
Facility Name
Hopitaux Du Leman - Site Georges Pianta
City
Thonon Les Bains
ZIP/Postal Code
74200
Country
France
Facility Name
Institut Claudius Régaud
City
Toulouse
ZIP/Postal Code
31059
Country
France
Facility Name
CHU Tours - Hôpital Bretonneau
City
Tours
ZIP/Postal Code
37044
Country
France
Facility Name
Hopital Prive Drome Ardeche; Hopital De Jour
City
Valence
ZIP/Postal Code
26000
Country
France
Facility Name
Institut de Cancérologie de Lorraine
City
Vandoeuvre-Les-Nancy
ZIP/Postal Code
54519
Country
France
Facility Name
Institut Gustave Roussy; Departement Oncologie Medicale
City
Villejuif
ZIP/Postal Code
94805
Country
France
Facility Name
Studienzentrum Berlin City
City
Berlin
ZIP/Postal Code
14169
Country
Germany
Facility Name
St. Johannes-Hospital
City
Dortmund
ZIP/Postal Code
44137
Country
Germany
Facility Name
Onkozentrum Dres. Göhler
City
Dresden
ZIP/Postal Code
01127
Country
Germany
Facility Name
BAG Freiberg-Richter, Jacobasch, Illmer, Wolf; Gemeinschaftspraxis Hämatologie-Onkologie
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
Praxis für Hamatologie und Onkologie
City
Erfurt
ZIP/Postal Code
99085
Country
Germany
Facility Name
Onkodok GmbH
City
Gütersloh
ZIP/Postal Code
33332
Country
Germany
Facility Name
Albertinen-Krankenhaus Klinik f.Gynäkologie und Geburtshilfe
City
Hamburg
ZIP/Postal Code
22457
Country
Germany
Facility Name
Ärztehaus am Bahnhofsplatz; Praxis Uleer/Pourfard
City
Hildesheim
ZIP/Postal Code
31134
Country
Germany
Facility Name
ViDia Christliche Kliniken Karlsruhe, Vincentius-Diakonissen-Kliniken gAG; Frauenklinik
City
Karlsruhe
ZIP/Postal Code
76135
Country
Germany
Facility Name
St. Elisabeth-Krankenhaus
City
Köln
ZIP/Postal Code
50935
Country
Germany
Facility Name
Klinikum Ludwigsburg; Studiensekretariat
City
Ludwigsburg
ZIP/Postal Code
71640
Country
Germany
Facility Name
St. Vincenz-Elisabeth-Hospital; Katholisches Klinikum Mainz
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Universitätsmedizin Mainz; Klinik u. Poliklinik f. Geburtshilfe u. Frauenheilkunde
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Dres. Michael Maasberg Marion Schmitz und Maria Theresia Keller
City
Mayen
ZIP/Postal Code
56727
Country
Germany
Facility Name
Klinikum Memmingen; Abt.Gynäkologie
City
Memmingen
ZIP/Postal Code
87700
Country
Germany
Facility Name
Johannes Wesling Klinikum Minden; Hämatologie, Onkologie, Hämostaseologie und Palliativmedizin
City
Minden
ZIP/Postal Code
32429
Country
Germany
Facility Name
Brustzentrum Rhein-Ruhr Servicegesellschaft mbH
City
Mönchengladbach
ZIP/Postal Code
41061
Country
Germany
Facility Name
Klinikum der Universität München; Frauenklinik - Onkologie II
City
München
ZIP/Postal Code
80336
Country
Germany
Facility Name
Klinikum Neumarkt; Frauenklinik
City
Neumarkt i.d.OPf.
ZIP/Postal Code
92318
Country
Germany
Facility Name
Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe
City
Offenbach
ZIP/Postal Code
63069
Country
Germany
Facility Name
Johanniter Frauenklinik Stendal Germany
City
Stendal
ZIP/Postal Code
39676
Country
Germany
Facility Name
Gynäkologie Kompetenzzentrum; Praxis Dr. med. Carsten Hielscher
City
Stralsund
ZIP/Postal Code
18439
Country
Germany
Facility Name
Universitätsklinik Tübingen; Frauenklinik
City
Tübingen
ZIP/Postal Code
72076
Country
Germany
Facility Name
GRN-Klinik Weinheim; Abt.Gynäkologie und Geburtshilfe
City
Weinheim
ZIP/Postal Code
69469
Country
Germany
Facility Name
Marien-Hospital Witten, MVZ Witten
City
Witten
ZIP/Postal Code
58452
Country
Germany
Facility Name
Klinikum Worms; Frauenklinik; Klinik für Gynäkologie und Geburtshilfe
City
Worms
ZIP/Postal Code
67550
Country
Germany
Facility Name
Pamela Youde Nethersole Eastern Hospital; Clinical Oncology
City
Hong Kong
Country
Hong Kong
Facility Name
Queen Mary Hospital
City
Hong Kong
Country
Hong Kong
Facility Name
Queen Elizabeth Hospital Department of Clinical Oncology
City
Kowloon
Country
Hong Kong
Facility Name
National Institute of Oncology, A Dept of Internal Medicine
City
Budapest
ZIP/Postal Code
1122
Country
Hungary
Facility Name
Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház
City
Miskolc
ZIP/Postal Code
3526
Country
Hungary
Facility Name
Pécsi Tudományegyetem; Klinikai Központ Onkoterápiás Intézet
City
Pécs
ZIP/Postal Code
7623
Country
Hungary
Facility Name
Mater Misecordiae University Hospital
City
Dublin
ZIP/Postal Code
7
Country
Ireland
Facility Name
Beaumont Hospital; Cancer Clinical Trials Unit
City
Dublin
ZIP/Postal Code
9
Country
Ireland
Facility Name
Shaare Zedek Medical Center
City
Jerusalem
ZIP/Postal Code
9103102
Country
Israel
Facility Name
Hadassah Med Org Kiryat; Oncology Institute
City
Jerusalem
ZIP/Postal Code
9112000
Country
Israel
Facility Name
Meir Medical center, Pediatrics
City
Kfar Sava
ZIP/Postal Code
4428164
Country
Israel
Facility Name
Rabin MC; Davidof Center - Oncology Institute
City
Petach Tikva
ZIP/Postal Code
4941492
Country
Israel
Facility Name
The Chaim Sheba Medical Center
City
Ramat Gan
ZIP/Postal Code
5211401
Country
Israel
Facility Name
Azienda Ospedaliera Papa Giovanni XXIII
City
Bergamo
State/Province
Abruzzo
ZIP/Postal Code
24060
Country
Italy
Facility Name
Azienda Ospedaliero Universitaria Di Bologna - Policlinico S.Orsola Malpighi; UO Farmacia Clinica
City
Bologna
State/Province
Emilia-Romagna
ZIP/Postal Code
40138
Country
Italy
Facility Name
U.O Medicina Oncologica Ospedale di Carpi
City
Carpi
State/Province
Emilia-Romagna
ZIP/Postal Code
41012
Country
Italy
Facility Name
Ospedale Degli Infermi - Faenza; Oncologia Medica
City
Faenza
State/Province
Emilia-Romagna
ZIP/Postal Code
48018
Country
Italy
Facility Name
Azienda Ospedaliero - Universitaria di Modena Policlinico
City
Modena
State/Province
Emilia-Romagna
ZIP/Postal Code
41110
Country
Italy
Facility Name
Azienda Ospedaliero Universitaria di Parma
City
Parma
State/Province
Emilia-Romagna
ZIP/Postal Code
43126
Country
Italy
Facility Name
Ospedale degli Infermi
City
Rimini
State/Province
Emilia-Romagna
ZIP/Postal Code
47923
Country
Italy
Facility Name
A.O. Universitaria S. Maria Della Misericordia Di Udine; Oncologia
City
Udine
State/Province
Friuli-Venezia Giulia
ZIP/Postal Code
33100
Country
Italy
Facility Name
Policlinico Universitario Campus Biomedico Di Roma
City
Roma
State/Province
Lazio
ZIP/Postal Code
00128
Country
Italy
Facility Name
Azienda Ospedaliero Universitaria San Martino
City
Genova
State/Province
Liguria
ZIP/Postal Code
16132
Country
Italy
Facility Name
ASST DI LECCO; Oncologia Medica
City
Lecco
State/Province
Lombardia
ZIP/Postal Code
23900
Country
Italy
Facility Name
Ospedale Mater Salutis
City
Legnago (VR)
State/Province
Lombardia
ZIP/Postal Code
37045
Country
Italy
Facility Name
Istituto Europeo Di Oncologia
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20141
Country
Italy
Facility Name
Fondazione Salvatore Maugeri
City
Pavia
State/Province
Lombardia
ZIP/Postal Code
27100
Country
Italy
Facility Name
Policlinico San Mattea
City
Pavia
State/Province
Lombardia
ZIP/Postal Code
27100
Country
Italy
Facility Name
Istituto Clinico Humanitas
City
Rozzano (MI)
State/Province
Lombardia
ZIP/Postal Code
20089
Country
Italy
Facility Name
Azienda Ospedaliera SS. Antonio E. Biagio E. Cesare Arrigo di Alessandria
City
Alessandria
State/Province
Piemonte
ZIP/Postal Code
15121
Country
Italy
Facility Name
Ospedale Degli Infermi Di Biella; Reparto Oncologia Medica
City
Ponderano (BI)
State/Province
Piemonte
ZIP/Postal Code
13875
Country
Italy
Facility Name
Ospedale Santa Maria Annunziata; Oncologia
City
Bagno a Ripoli
State/Province
Toscana
ZIP/Postal Code
50012
Country
Italy
Facility Name
Azienda Usl 7; Dept. Oncologico
City
Poggibonsi
State/Province
Toscana
ZIP/Postal Code
53036
Country
Italy
Facility Name
Nuovo Ospedale Di Prato
City
Prato
State/Province
Toscana
ZIP/Postal Code
50047
Country
Italy
Facility Name
Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia
City
Perugia
State/Province
Umbria
ZIP/Postal Code
06100
Country
Italy
Facility Name
Aichi Cancer Center Hospital
City
Aichi
ZIP/Postal Code
464-8681
Country
Japan
Facility Name
Chiba Cancer Center
City
Chiba
ZIP/Postal Code
260-8717
Country
Japan
Facility Name
Shikoku Cancer Center
City
Ehime
ZIP/Postal Code
791-0280
Country
Japan
Facility Name
National Hospital Organization Kyushu Cancer Center
City
Fukuoka
ZIP/Postal Code
811-1395
Country
Japan
Facility Name
Fukushima Medical University Hospital
City
Fukushima
ZIP/Postal Code
960-1295
Country
Japan
Facility Name
Hiroshima City Hiroshima Citizens Hospital
City
Hiroshima
ZIP/Postal Code
730-8518
Country
Japan
Facility Name
National Hospital Organization Hokkaido Cancer Center
City
Hokkaido
ZIP/Postal Code
003-0804
Country
Japan
Facility Name
Hyogo Medical University Hospital
City
Hyogo
ZIP/Postal Code
663-8501
Country
Japan
Facility Name
University of Tsukuba Hospital
City
Ibaraki
ZIP/Postal Code
305-8576
Country
Japan
Facility Name
Sagara Hospital
City
Kagoshima
ZIP/Postal Code
892-0833
Country
Japan
Facility Name
Kanagawa Cancer Center
City
Kanagawa
ZIP/Postal Code
241-8515
Country
Japan
Facility Name
Tokai University Hospital
City
Kanagawa
ZIP/Postal Code
259-1193
Country
Japan
Facility Name
Kyoto University Hospital
City
Kyoto
ZIP/Postal Code
606-8507
Country
Japan
Facility Name
Okayama University Hospital
City
Okayama
ZIP/Postal Code
700-8558
Country
Japan
Facility Name
Naha-nishi Clinic
City
Okinawa
ZIP/Postal Code
901-0154
Country
Japan
Facility Name
National Hospital Organization Osaka National Hospital
City
Osaka
ZIP/Postal Code
540-0006
Country
Japan
Facility Name
Osaka International Cancer Institute
City
Osaka
ZIP/Postal Code
541-8567
Country
Japan
Facility Name
Saitama Medical University International Medical Center
City
Saitama
ZIP/Postal Code
350-1298
Country
Japan
Facility Name
Saitama Cancer Center
City
Saitama
ZIP/Postal Code
362-0806
Country
Japan
Facility Name
Shizuoka Cancer Center
City
Shizuoka
ZIP/Postal Code
411-8777
Country
Japan
Facility Name
St. Luke's Internat. Hospital, Breast Surgical Oncology
City
Tokyo
ZIP/Postal Code
104-8560
Country
Japan
Facility Name
The Cancer Institute Hospital of JFCR
City
Tokyo
ZIP/Postal Code
135-8550
Country
Japan
Facility Name
Chungbuk National University Hospital
City
Cheongju-si
ZIP/Postal Code
28644
Country
Korea, Republic of
Facility Name
Soon Chun Hyang University Cheonan Hospital
City
Dongnam-gu, Cheonan-si
ZIP/Postal Code
31151
Country
Korea, Republic of
Facility Name
National Cancer Center
City
Goyang-si
ZIP/Postal Code
10408
Country
Korea, Republic of
Facility Name
CHA Bundang Medical Center
City
Gyeonggi-do
ZIP/Postal Code
13496
Country
Korea, Republic of
Facility Name
Gachon University Gil Medical Center
City
Incheon
ZIP/Postal Code
21565
Country
Korea, Republic of
Facility Name
Inha University Hospital
City
Incheon
ZIP/Postal Code
22332
Country
Korea, Republic of
Facility Name
Seoul National University Bundang Hospital
City
Seongnam-si
ZIP/Postal Code
463-707
Country
Korea, Republic of
Facility Name
Seoul National University Hospital
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Facility Name
Severance Hospital; Yonsei University Health System
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Facility Name
Gangnam Severance Hospital
City
Seoul
ZIP/Postal Code
06273
Country
Korea, Republic of
Facility Name
Samsung Medical Center
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Facility Name
Seoul St Mary's Hospital
City
Seoul
ZIP/Postal Code
06591
Country
Korea, Republic of
Facility Name
Ewha Womans University Mokdong Hospital
City
Seoul
ZIP/Postal Code
07985
Country
Korea, Republic of
Facility Name
Ajou University Hospital
City
Suwon City
ZIP/Postal Code
443-721
Country
Korea, Republic of
Facility Name
Ulsan University Hosiptal
City
Ulsan
ZIP/Postal Code
44033
Country
Korea, Republic of
Facility Name
Wonju Christian Hospital
City
Wonju
ZIP/Postal Code
220-701
Country
Korea, Republic of
Facility Name
Health Pharma Professional Research
City
Cdmx
State/Province
Mexico CITY (federal District)
ZIP/Postal Code
03100
Country
Mexico
Facility Name
Iem-Fucam
City
D.f.
State/Province
Mexico CITY (federal District)
ZIP/Postal Code
04980
Country
Mexico
Facility Name
Instituto Nacional De Cancerologia; Oncology; Tumores Mamarios
City
Distrito Federal
State/Province
Mexico CITY (federal District)
ZIP/Postal Code
14000
Country
Mexico
Facility Name
Centro Médico Zambrano Hellion
City
Monterrey
State/Province
Nuevo LEON
ZIP/Postal Code
66278
Country
Mexico
Facility Name
Centro de Investigacion Clinica de Oaxaca
City
Oaxaca de Juárez
State/Province
Oaxaca
ZIP/Postal Code
68020
Country
Mexico
Facility Name
Oncologico Potosino
City
San Luis Potosí
State/Province
SAN LUIS Potosi
ZIP/Postal Code
78209
Country
Mexico
Facility Name
Merida | Investigacion Clinica
City
Mérida
State/Province
Yucatan
ZIP/Postal Code
97125
Country
Mexico
Facility Name
CENEIT Oncologicos; DENTRO DE CONDOMINIO SAN FRANCISCO
City
Mexico City
ZIP/Postal Code
03100
Country
Mexico
Facility Name
Centro Medico Dalinde
City
Mexico City
ZIP/Postal Code
06700
Country
Mexico
Facility Name
Hospital Nacional Carlos Alberto Seguin Escobedo-Essalud; Oncology & Haemathology
City
Arequipa
ZIP/Postal Code
04001
Country
Peru
Facility Name
Oncosalud Sac; Oncología
City
Lima
ZIP/Postal Code
41
Country
Peru
Facility Name
Instituto Nacional de Enfermedades Neoplasicas
City
Lima
ZIP/Postal Code
Lima 34
Country
Peru
Facility Name
Instytut MSF Sp. z o.o.
City
?ód?
ZIP/Postal Code
90-302
Country
Poland
Facility Name
MedPolonia
City
Poznan
ZIP/Postal Code
60-693
Country
Poland
Facility Name
Wielkopolskie Centrum Onkologi
City
Poznan
ZIP/Postal Code
61-866
Country
Poland
Facility Name
Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy; Klinika Onkologii
City
Warszawa
ZIP/Postal Code
00-909
Country
Poland
Facility Name
"Filantropia" Clinical Hospital; Gynecological Oncology
City
Bucharest
ZIP/Postal Code
011191
Country
Romania
Facility Name
Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca; Oncologie Medicala
City
Cluj Napoca
ZIP/Postal Code
400015
Country
Romania
Facility Name
Centrul de Oncologie Sfantul Nectarie
City
Craiova
ZIP/Postal Code
200347
Country
Romania
Facility Name
Medsi Clinic
City
Moscow
State/Province
Adygeja
ZIP/Postal Code
143442
Country
Russian Federation
Facility Name
Arkhangelsk Regional Clinical Oncology Dispensary
City
Arkhangelsk
State/Province
Arhangelsk
ZIP/Postal Code
163045
Country
Russian Federation
Facility Name
Bashkirian Republican Clinical Oncology Dispensary
City
UFA
State/Province
Baskortostan
ZIP/Postal Code
450054
Country
Russian Federation
Facility Name
Regional Clinical Oncology Hospital
City
Yaroslavl
State/Province
Jaroslavl
ZIP/Postal Code
150054
Country
Russian Federation
Facility Name
Oncologica Dispensary #2
City
Sochi
State/Province
Krasnodar
ZIP/Postal Code
354057
Country
Russian Federation
Facility Name
Evimed
City
Chelyabinsk
State/Province
Kurgan
Country
Russian Federation
Facility Name
Mordovia State University
City
Saransk
State/Province
Mordovija
ZIP/Postal Code
430032
Country
Russian Federation
Facility Name
Moscow Clinical Scientific Center
City
Moscow
State/Province
Moskovskaja Oblast
ZIP/Postal Code
111123
Country
Russian Federation
Facility Name
FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF
City
Moscow
State/Province
Moskovskaja Oblast
ZIP/Postal Code
115478
Country
Russian Federation
Facility Name
P.A. Herzen Oncological Inst. ; Oncology
City
Moscow
State/Province
Moskovskaja Oblast
ZIP/Postal Code
125248
Country
Russian Federation
Facility Name
Nizhny Novgorod Regional Clinical Oncology Center
City
Nizhny Novgorod
State/Province
Niznij Novgorod
ZIP/Postal Code
603126
Country
Russian Federation
Facility Name
National Medical Research Center for Oncology
City
Rostov-na-donu
State/Province
Rostov
ZIP/Postal Code
344037
Country
Russian Federation
Facility Name
S-Pb clinical scientific practical center of specialized kinds of medical care (oncological)
City
Saint-Petersburg
State/Province
Sankt Petersburg
ZIP/Postal Code
197758
Country
Russian Federation
Facility Name
FBI "Scientific Research Institute of Oncology n. a. N. N. Petrov"
City
Saint-Petersburg
State/Province
Sankt Petersburg
Country
Russian Federation
Facility Name
LLC Strategic Medical Systems
City
Sankt-peterburg
State/Province
Sankt Petersburg
ZIP/Postal Code
194291
Country
Russian Federation
Facility Name
EosMed LLC
City
Sankt-peterburg
State/Province
Sankt Petersburg
ZIP/Postal Code
195197
Country
Russian Federation
Facility Name
LCC Center of Palliative Medicine - Devita
City
Sankt-peterburg
State/Province
Sankt Petersburg
ZIP/Postal Code
197343
Country
Russian Federation
Facility Name
Private Healthcare Institution Clinical Hospital RZhD Medicine
City
St. Petersburg
State/Province
Sankt Petersburg
ZIP/Postal Code
195271
Country
Russian Federation
Facility Name
Pyatigorsky Oncologic Dispensary
City
Pyatigorsk
State/Province
Stavropol
ZIP/Postal Code
357524
Country
Russian Federation
Facility Name
Regional Oncology Hospital
City
Irkutsk
ZIP/Postal Code
664035
Country
Russian Federation
Facility Name
Ivanovo Regional Oncology Dispensary
City
Ivanovo
ZIP/Postal Code
153040
Country
Russian Federation
Facility Name
Regional Oncology Dispensary; Dept of Chemotherapy
City
Novgorod Veliky
ZIP/Postal Code
173016
Country
Russian Federation
Facility Name
BIH at Omsk Region "Clinical Oncology Dispensary", Outpatient clinic
City
Omsk
ZIP/Postal Code
644013
Country
Russian Federation
Facility Name
Multidisciplinary clinic Reaviz
City
Samara
ZIP/Postal Code
443011
Country
Russian Federation
Facility Name
Samara Regional Oncology Dispensary
City
Samara
ZIP/Postal Code
443031
Country
Russian Federation
Facility Name
Regional Clinical Hospital
City
Saratov
ZIP/Postal Code
410053
Country
Russian Federation
Facility Name
SHI Volgograd Regional Clinical Oncological Dispensary#1
City
Volgograd
ZIP/Postal Code
400138
Country
Russian Federation
Facility Name
National University Hospital; Medical Oncology
City
Singapore
ZIP/Postal Code
119074
Country
Singapore
Facility Name
National Cancer Centre
City
Singapore
ZIP/Postal Code
169610
Country
Singapore
Facility Name
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia
City
Badalona
State/Province
Barcelona
ZIP/Postal Code
08916
Country
Spain
Facility Name
Hospital General De Catalunya; Servicio de Oncologia
City
Sant Cugat Del Valles
State/Province
Barcelona
ZIP/Postal Code
28981
Country
Spain
Facility Name
Hospital Mutua de Terrassa; Servicio de Oncologia
City
Terrassa
State/Province
Barcelona
ZIP/Postal Code
08221
Country
Spain
Facility Name
Consorci Hospitalari de Terrassa
City
Terrassa
State/Province
Barcelona
ZIP/Postal Code
08227
Country
Spain
Facility Name
Hospital de Jerez
City
Jerez De La Frontera
State/Province
Cadiz
ZIP/Postal Code
11407
Country
Spain
Facility Name
Hospital Provincial Castellón
City
Castellon DE LA Plana/castello DE LA Plana
State/Province
Castellon
ZIP/Postal Code
12002
Country
Spain
Facility Name
Hospital Son Llatzer
City
Palma de Mallorca
State/Province
Islas Baleares
ZIP/Postal Code
07198
Country
Spain
Facility Name
Centro Oncologico de Galicia COG; Medical Oncology
City
A Coruna
State/Province
LA Coruña
ZIP/Postal Code
15009
Country
Spain
Facility Name
Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia
City
Santiago de Compostela
State/Province
LA Coruña
ZIP/Postal Code
15706
Country
Spain
Facility Name
Hospital Universitario Puerta de Hierro - Majadahonda
City
Majadahonda
State/Province
Madrid
ZIP/Postal Code
28220
Country
Spain
Facility Name
Hospital Infanta Sofia; Servico de Oncologia
City
San Sebastian de Los Reyes
State/Province
Madrid
ZIP/Postal Code
28702
Country
Spain
Facility Name
Complexo Hospitalario de Vigo. Hospital Álvaro Cunqueiro; Servicio de Oncología
City
Vigo
State/Province
Pontevedra
ZIP/Postal Code
36312
Country
Spain
Facility Name
Hospital Universitari Sant Joan de Reus; Planta baja, color lila
City
Reus
State/Province
Tarragona
ZIP/Postal Code
43204
Country
Spain
Facility Name
Hospital Universitario de Canarias;servicio de Oncologia
City
La Laguna
State/Province
Tenerife
ZIP/Postal Code
38320
Country
Spain
Facility Name
Hospital Universitario de Burgos
City
Burgos
ZIP/Postal Code
09006
Country
Spain
Facility Name
Hospital San Pedro De Alcantara; Servicio de Oncologia
City
Caceres
ZIP/Postal Code
10003
Country
Spain
Facility Name
Complejo Hospitalario de Jaen
City
Jaen
ZIP/Postal Code
23007
Country
Spain
Facility Name
Complejo Asistencial Universitario de Leon; Servicio de Oncologia
City
Leon
ZIP/Postal Code
24071
Country
Spain
Facility Name
Hospital General Universitario Gregorio Marañon; Servicio de Oncologia
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Hospital Universitario Ramón y Cajal
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Facility Name
Hospital Universitario 12 de Octubre; Servicio de Oncologia
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Facility Name
Centro Integral Oncológico Clara Campal Ensayos Clínicos START
City
Madrid
ZIP/Postal Code
28050
Country
Spain
Facility Name
Hosp Univ Fundacion Alcorcon
City
Madrid
ZIP/Postal Code
28922
Country
Spain
Facility Name
Hospital Universitario de Fuenlabrada; Servicio de Oncologia
City
Madrid
ZIP/Postal Code
28943
Country
Spain
Facility Name
Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia
City
Malaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Hospital Universitario Virgen de Arrixaca; Servicio de Oncologia
City
Murcia
ZIP/Postal Code
30120
Country
Spain
Facility Name
Hospital Quirón Sagrado Corazón
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Facility Name
Instituto Valenciano Oncologia; Oncologia Medica
City
Valencia
ZIP/Postal Code
46009
Country
Spain
Facility Name
Hospital Clinico Universitario de Valencia
City
Valencia
ZIP/Postal Code
46010
Country
Spain
Facility Name
Hospital General Universitario de Valencia; Servicio de oncologia
City
Valencia
ZIP/Postal Code
46014
Country
Spain
Facility Name
Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Facility Name
Hirslanden Medical Center - Tumorzentrum
City
Aarau
ZIP/Postal Code
5000
Country
Switzerland
Facility Name
Centre Hospitalier Universitaire Vaudois - Lausanne
City
Lausanne
ZIP/Postal Code
1011
Country
Switzerland
Facility Name
Brust-Zentrum Zürich AG Seefeldstrasse 214 Zürich
City
Zürich
ZIP/Postal Code
8008
Country
Switzerland
Facility Name
Chunghua Christian hospital
City
Changhua
ZIP/Postal Code
500
Country
Taiwan
Facility Name
Kaohsiung Medical University Hospital; Chung-Ho Memorial Hospital
City
Kaoshiung City
ZIP/Postal Code
807
Country
Taiwan
Facility Name
E-Da Cancer Hospital; Hematology- Oncology Department
City
Kaoshiung
ZIP/Postal Code
824
Country
Taiwan
Facility Name
Chi Mei Medical Center Liou Ying Campus
City
Liuying Township
ZIP/Postal Code
736
Country
Taiwan
Facility Name
National Cheng Kung University Hospital
City
Tainan
ZIP/Postal Code
70457
Country
Taiwan
Facility Name
Taipei Veterans General Hospital
City
Taipei City
ZIP/Postal Code
112
Country
Taiwan
Facility Name
National Taiwan University Hospital
City
Taipei
ZIP/Postal Code
10002
Country
Taiwan
Facility Name
Mackay Memorial Hospital - Taipei Branch
City
Taipei
ZIP/Postal Code
104
Country
Taiwan
Facility Name
Tri-Service General Hospital
City
Taipei
ZIP/Postal Code
11490
Country
Taiwan
Facility Name
Chang Gung Medical Foundation Linkou Branch
City
Taoyuan City
ZIP/Postal Code
333
Country
Taiwan
Facility Name
Rajavithi Hospital; Division of Medical Oncology
City
Bangkok
ZIP/Postal Code
10400
Country
Thailand
Facility Name
Ramathibodi Hospital; Medicine/Oncology
City
Bangkok
ZIP/Postal Code
10400
Country
Thailand
Facility Name
Siriraj Hospital; Clinical Research Center, Pharmacy Department
City
Bangkok
ZIP/Postal Code
10700
Country
Thailand
Facility Name
Songklanagarind Hospital
City
Hat Yai
ZIP/Postal Code
90110
Country
Thailand
Facility Name
Srinagarind Hospital, Khon Kaen University
City
Khon Kaen
ZIP/Postal Code
40002
Country
Thailand
Facility Name
Lampang Cancer Hospital
City
Muang Lampang
ZIP/Postal Code
52000
Country
Thailand
Facility Name
King Chulalongkorn Memorial Hospital; Faculty of Medicine Chulalongkorn University
City
Patumwan
ZIP/Postal Code
10330
Country
Thailand
Facility Name
Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma Merkezi
City
Adana
ZIP/Postal Code
01240
Country
Turkey
Facility Name
Uludag Universitesi - Saglik Uygulama ve Arastirrma Merkezi
City
Bursa
ZIP/Postal Code
16059
Country
Turkey
Facility Name
Ege Universitesi Hastanesi (Saglik Uygulama ve Arastirma Merkezi)
City
Izmir
ZIP/Postal Code
35100
Country
Turkey
Facility Name
Izmir Ekonomi Universitesi Medical Park Hastanesi
City
Izmir
ZIP/Postal Code
35575
Country
Turkey
Facility Name
Mersin Universitesi Tip Fakultesi Hastanesi; Tibbi Onkoloji Birimi
City
Mersin
ZIP/Postal Code
33110
Country
Turkey
Facility Name
Medikal Park Samsun
City
Samsun
ZIP/Postal Code
55200
Country
Turkey
Facility Name
Yulis Medical and Diagnostic Center
City
Zaporizhzhia
State/Province
Katerynoslav Governorate
ZIP/Postal Code
69061
Country
Ukraine
Facility Name
Municipal Noncommercial Institution Regional Center of Oncology
City
Kharkiv
State/Province
Kharkiv Governorate
ZIP/Postal Code
61070
Country
Ukraine
Facility Name
MI "Clinical Oncological Dispensary" of Dnipro Reg Council; chemotherapy department
City
Dnipro
State/Province
KIEV Governorate
ZIP/Postal Code
49100
Country
Ukraine
Facility Name
Municipal Institution Odesa Regional Oncology Dispensary
City
Odesa
State/Province
KIEV Governorate
ZIP/Postal Code
65055
Country
Ukraine
Facility Name
Vinnytsya Regional Clinical Oncology Dispensary
City
Vinnytsya
State/Province
Podolia Governorate
ZIP/Postal Code
21029
Country
Ukraine
Facility Name
Regional Oncology Center; Department of Mammology
City
Chernigiv
ZIP/Postal Code
14029
Country
Ukraine
Facility Name
Chernivtsi Regional Clinical Oncology Dispensary
City
Chernivtsi
ZIP/Postal Code
58013
Country
Ukraine
Facility Name
City Clinical Hospital #4
City
Dnipropetrovsk
ZIP/Postal Code
49102
Country
Ukraine
Facility Name
Municipal Institution Kirovograd Regional Oncology Dispensary
City
Kirovograd
ZIP/Postal Code
25011
Country
Ukraine
Facility Name
ME Kryviy Rih Oncology Dispensary of Dnipropetrovs?k Regional Council; Chemotherapy Department
City
Kryvyi Rih
ZIP/Postal Code
50048
Country
Ukraine
Facility Name
Volyn Regional Oncology Dispensary
City
Lutsk
ZIP/Postal Code
43018
Country
Ukraine
Facility Name
Lviv State Oncological Regional Treatment and Diagnostic Center
City
Lviv
ZIP/Postal Code
79031
Country
Ukraine
Facility Name
Municipal Institution Odesa Regional Clinical Hospital
City
Odesa
ZIP/Postal Code
65025
Country
Ukraine
Facility Name
Sumy Reg. Clin. Oncological Dispensary; Thoracall Department
City
Sumy
ZIP/Postal Code
40005
Country
Ukraine
Facility Name
CCCH City Oncological Center SHEI Uzhgorod NU
City
Uzhgorod
ZIP/Postal Code
88000
Country
Ukraine
Facility Name
Transkarpathian Regional Oncology Clinic; Chemotherapy
City
Uzhgorod
ZIP/Postal Code
88000
Country
Ukraine
Facility Name
Zaporizhzhia Regional Clinical Oncology Dispensary; Zaporizhzhya State Medical University
City
Zaporizhzhya
ZIP/Postal Code
69040
Country
Ukraine
Facility Name
NHS Lothian - Western General Hospital; NHS Lothian - Western General Hospital
City
Edinburgh
ZIP/Postal Code
EH4 2XU
Country
United Kingdom
Facility Name
Calderdale and Huddersfield NHS Foundation Trust
City
Huddersfield
ZIP/Postal Code
HD3 3EA
Country
United Kingdom
Facility Name
Leeds Teaching Hosp NHS Trust;St James's Institute of Onc
City
Leeds
ZIP/Postal Code
LS9 7TF
Country
United Kingdom
Facility Name
Guys and St Thomas NHS Foundation Trust, Guys Hospital
City
London
ZIP/Postal Code
SE1 9RT
Country
United Kingdom
Facility Name
The Christie NHS Foundation Trust
City
Manchester
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Facility Name
Nottingham University Hospitals NHS Trust - City Hospital
City
Nottingham
ZIP/Postal Code
NG5 1PB
Country
United Kingdom
Facility Name
University Hospitals of North Midlands NHS Trust-Royal Stoke University Hospital
City
Stoke-On-Trent
ZIP/Postal Code
ST4 6QG
Country
United Kingdom
12. IPD Sharing Statement
Citations:
PubMed Identifier
32450725
Citation
Perez-Garcia J, Soberino J, Racca F, Gion M, Stradella A, Cortes J. Atezolizumab in the treatment of metastatic triple-negative breast cancer. Expert Opin Biol Ther. 2020 Sep;20(9):981-989. doi: 10.1080/14712598.2020.1769063. Epub 2020 May 25.
Results Reference
derived
Learn more about this trial
A Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone In Patients With Operable Triple-Negative Breast Cancer
We'll reach out to this number within 24 hrs