A Study Evaluating the Effects of Topical Clitoral Estradiol Cream in Post Menopausal Women
Hypoactive Sexual Desire Disorder
About this trial
This is an interventional other trial for Hypoactive Sexual Desire Disorder focused on measuring Arousal, Orgasm, Clitoral, Estradiol, Post Menopausal
Eligibility Criteria
Inclusion Criteria:
- Sexually active postmenopausal women of any age with complaint of vulvar and/or vaginal atrophy who also complain of bothersome decreased libido, and/or arousal, and/or orgasmic dysfunction
Exclusion Criteria:
- Not sexually active with a partner or an arousal device
- Uncontrolled diabetes as defined by having a consistent blood sugar level of over 100 mg/dL
- Uncontrolled hypertension as defined by an average systolic blood pressure ≥140 mmHg or an average diastolic blood pressure ≥90 mmHg, among those with hypertension
- Allergic to estradiol
- Contraindications to estradiol such as undiagnosed abnormal genital bleeding; known/suspected or history of breast cancer; known/suspected estrogen-dependent neoplasm; active deep vein thrombosis, pulmonary embolism; active or recent stroke or myocardial infarction; liver dysfunction or disease
- Spanish speaking
Sites / Locations
- Waukesa Memorial Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Estradiol vulvar cream
Placebo cream
The estradiol cream 0.5 grams will be placed on the clitoris/vestibule every night for 2 weeks, then 3 times a week thereafter on Monday, Wednesday, and Friday, for a total of 12 weeks. In addition estradiol 10mcg tablet will be placed in the vaginal every night for 2 weeks, then 2x a week on Tuesday and Thursday, for a total of 12 weeks.
The placebo cream 0.5 grams will be placed on the clitoris/vestibule every night for 2 weeks, then 3 times a week thereafter on Monday, Wednesday, and Friday, for a total of 12 weeks. In addition estradiol 10mcg tablet will be placed in the vaginal every night for 2 weeks, then 2x a week on Tuesday and Thursday, for a total of 12 weeks.