A Study of Co-infections of HIV-1 and Schistosoma Mansoni and Its Impact on Praziquantel Treatment Outcomes
Anemia, Intestinal Helminthiasis, Intestinal Schistosomiasis
About this trial
This is an interventional prevention trial for Anemia focused on measuring Human Immunodeficiency Virus-1, Schistosoma mansoni, Anemia, Immune response, Opportunistic infections, Tanzania
Eligibility Criteria
Inclusion Criteria:
- Permanent residents and those who have lived in the village for more than 2 years.
- HIV-1 positive individuals only those with CD4+ ≥ 400 cells/μl
Exclusion Criteria:
- HIV-1 positive individuals with CD4+ < 350 cells/μl,
- Those who are on antiretroviral therapy (ARV)
- Pregnant women are excluded.
- Participants with chronic diseases such as leukemia, tuberculosis and viral hepatitis
Sites / Locations
- Ilemela District
- National Institute for Medical Research, Mwanza
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
No Intervention
Experimental
No Intervention
HIV-1 co-infected with schistosoma mansoni
HIV-1 positive individuals with negative S. mansoni
Schistosoma mansoni positive but HIV-1 negative
HIV-1 and Schistosoma mansoni negative
HIV-1 patients co-infected with Schistosoma mansoni
HIV-1 positive individuals with negative Schistosoma mansoni
Schistosoma mansoni positive individuals but HIV-1 negative to be compared with HIV-1 co-infected with Schistosoma mansoni individuals
Individuals with no HIV-1 and S. mansoni infections