A Study of Dideoxycytidine in HIV-Infected Patients
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Zalcitabine, Drug Evaluation, Acquired Immunodeficiency Syndrome, AIDS-Related Complex, Biological Availability
Eligibility Criteria
Inclusion Criteria Prior Medication: Allowed: Oral nonabsorbable antifungal agents. Exclusion Criteria Active drug or alcohol abuse. Co-existing Condition: Patients with fever > 102 degrees F at study entry will be excluded. Patients with fever > 102 degrees F at study entry will be excluded. Prior Medication: Excluded: Chronic systemic medications. Any other experimental drug within 2 weeks of study entry. Drugs with known nephrotoxic or hepatotoxic effects within 2 weeks of study entry. Drugs known to cause neutropenia within 2 weeks of study entry. Rifampin or rifampin derivatives, phenytoin, or barbiturates within 2 weeks of study entry. Any other medication except oral nonabsorbable antifungal agents within 72 hours of study entry. All medications, including aspirin, must be approved by investigator. All medications, including aspirin, must be approved by investigator. Patients must demonstrate the following clinical and laboratory findings: AIDS, AIDS related complex (ARC), or persistent generalized lymphadenopathy as defined by the CDC classification. No ascites. Off all medications except oral antifungal, nonabsorbable agents for 72 hours prior to study entry.
Sites / Locations
- Johns Hopkins Hosp