Back to resultsA Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
Primary Purpose
Neoplasms
Status
Recruiting
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Encorafenib
Cetuximab
Oxaliplatin
Irinotecan
Leucovorin
5-FU
Capecitabine
Bevacizumab
Sponsored by
About this trial
This is an interventional treatment trial for Neoplasms focused on measuring Colorectal cancer, Colon cancer, Rectal cancer, Colorectal Neoplasms, Intestinal cancer, Intestinal Neoplasms, Gastrointestinal cancer, Gastrointestinal Neoplasms, Digestive system cancer, Digestive System Neoplasms, Digestive System Diseases, Gastrointestinal Diseases, Colonic Diseases, Intestinal Diseases, Rectal Diseases, BREAKWATER Study
Eligibility Criteria
Inclusion Criteria:
- Safety Lead-In = Male/female ≥ 18 years old
- Phase 3: Male/female ≥ 16 years old (where permitted locally)
- Histologically or cytologically confirmed Stage IV CRC that contains BRAF V600E mutation
- Prior systemic treatment in metastatic setting
- SLI: 0-1 regimens
- Phase 3: None
- Prior adjuvant or neoadjuvant therapy considered metastatic treatment if relapse/metastasis < 6 month from end of adj/neoadjuvant treatment
- Measurable disease (Phase 3)/ Measurable or evaluable disease (Safety Lead-in)
- ECOG PS 0-1
- Adequate organ function
Exclusion Criteria:
- Tumors that are locally confirmed or unknown MSI-H or dMMR unless participant is ineligible to receive immune checkpoint inhibitors due to a pre-existing medical condition
- Active bacterial or viral infections in 2 weeks prior to starting dosing
- Symptomatic brain metastases
Sites / Locations
- Mayo Clinic - Phoenix Oncology PharmacyRecruiting
- Mayo Clinic HospitalRecruiting
- Mayo Clinic in Arizona - ScottsdaleRecruiting
- Tower Hematology Oncology Medical Group (THO)Recruiting
- Keck Hospital of USCRecruiting
- LAC & USC Medical CenterRecruiting
- USC / Norris Comprehensive Cancer CenterRecruiting
- USC/Norris Comprehensive Cancer Center / Investigational Drug ServicesRecruiting
- USC/Norris Comprehensive Cancer CenterRecruiting
- Cedars- Sinai Medical CenterRecruiting
- Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer InstituteRecruiting
- Cedars-Sinai Medical CenterRecruiting
- Keck Hospital of USC PasadenaRecruiting
- Torrance Memorial Medical Center (TMMC)Recruiting
- Georgetown University Medical CenterRecruiting
- Medstar Georgetown University HospitalRecruiting
- Mount Sinai Comprehensive Cancer Center, AventuraRecruiting
- Sylvester Comprehensive Cancer Center- The Lennar Foundation Medical CenterRecruiting
- Holy Cross Hospital - Michael and Dianne Bienes Comprehensive Cancer CenterRecruiting
- Mayo Clinic FloridaRecruiting
- Mount Sinai Comprehensive Cancer CenterRecruiting
- Mount Sinai Medical CenterRecruiting
- Sylvester Comprehensive Cancer CenterRecruiting
- Baptist Hospital of MiamiRecruiting
- Miami Cancer InstituteRecruiting
- Orlando Health Cancer InstituteRecruiting
- Orlando Health, Inc.Recruiting
- Orlando Health, IncRecruiting
- BRCR GlobalRecruiting
- BRCR Medical Center Inc.Recruiting
- Lewis Cancer & Research Pavilion at St Joseph's/Candler Health SystemRecruiting
- Lewis Cancer & Research Pavilion PharmacyRecruiting
- St. Joseph's/Candler Health System, Inc.Recruiting
- Summit Cancer Care, P.C.Recruiting
- Summit Cancer CareRecruiting
- St. Joseph's/Candler Health System, Inc.Recruiting
- UChicago Medicine - River EastRecruiting
- The University of Chicago Medical Center, CCD - Investigational Drug Service PharmacyRecruiting
- University of Chicago Medical CenterRecruiting
- UChicago Medicine at Ingalls - FlossmoorRecruiting
- UChicago Medicine Ingalls MemorialRecruiting
- University of Chicago Comprehensive Cancer Center at Silver Cross HospitalRecruiting
- The University of Chicago Medicine Center for Advanced Care Orland ParkRecruiting
- UChicago Medicine at Ingalls - Tinley ParkRecruiting
- Ochsner Clinic Foundation Research PharmacyRecruiting
- Ochsner Clinic FoundationRecruiting
- University of Michigan HospitalsRecruiting
- University of MichiganRecruiting
- Mayo Clinic in Rochester, MinnesotaRecruiting
- Mayo Clinic RochesterRecruiting
- Mayo ClinicRecruiting
- Siteman Cancer Center - West CountyRecruiting
- Siteman Cancer Center - North CountyRecruiting
- Barnes- Jewish HospitalRecruiting
- Washington University School of MedicineRecruiting
- Siteman Cancer Center - South CountyRecruiting
- Siteman Cancer Center - St PetersRecruiting
- St Vincent HealthcareRecruiting
- St. Vincent Frontier Cancer CenterRecruiting
- Oncology Hematology West PC dba Nebraska Cancer SpecialistsRecruiting
- Oncology Hematology West PC dba Nebraska Cancer SpecialistsRecruiting
- Oncology Hematology West PC dba Nebraska Cancer SpecialistsRecruiting
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - IP StorageRecruiting
- Oncology Hematology West PC dba Nebraska Cancer SpecialistsRecruiting
- Memorial Sloan Kettering Cancer Center - Basking RidgeRecruiting
- Summit Medical GroupRecruiting
- Summit Medical GroupRecruiting
- Memorial Sloan Kettering Cancer Center- MonmouthRecruiting
- Memorial Sloan Kettering Cancer Center- BergenRecruiting
- North Shore Hematology Oncology Assoc. P.C. DBA NY Cancer and Blood SpecialistsRecruiting
- North Shore Hematology Oncology Assoc. P.C. DBA NY Cancer and Blood SpecialistsRecruiting
- Memorial Sloan Kettering Cancer Center CommackRecruiting
- Memorial Sloan Kettering Cancer Center - WestchesterRecruiting
- Memorial Sloan Kettering Cancer CenterRecruiting
- North Shore Hematology Oncology Assoc. P.C. DBA NY Cancer and Blood SpecialistsRecruiting
- Memorial Sloan Kettering Cancer Center - Main CampusRecruiting
- North Shore Hematology Oncology Assoc. P.C. DBA NY Cancer and Blood SpecialistsRecruiting
- North Shore Hematology Oncology Assoc. P.C. DBA NY Cancer and Blood SpecialistsRecruiting
- North Shore Hematology Oncology Assoc. P.C. DBA NY Cancer and Blood SpecialistsRecruiting
- Memorial Sloan Kettering Cancer Center- NassauRecruiting
- Carolinas Medical CenterRecruiting
- Carolinas Medical Center Investigational Drug ServicesRecruiting
- Levine Cancer InstituteRecruiting
- Atrium Health MercyRecruiting
- Atrium Health PinevilleRecruiting
- Levine Cancer Institute - SouthparkRecruiting
- Atrium Health University CityRecruiting
- Levine Cancer Institute University CityRecruiting
- Atrium Health CabarrusRecruiting
- Levine Cancer Institute - ConcordRecruiting
- Atrium Health UnionRecruiting
- Cleveland Clinic Taussig Cancer Center Investigational PharmacyRecruiting
- Cleveland ClinicRecruiting
- Investigational Drug Service, The Ohio State University Wexner Medical CenterRecruiting
- The Ohio State University James Cancer Hospital and Solove Research InstituteRecruiting
- Stefanie Spielman Comprehensive Breast CancerRecruiting
- Martha Morehouse Medical PlazaRecruiting
- The James Outpatient Care West CampusRecruiting
- University of Oklahoma Health Sciences Center, OU Health Stephenson Cancer CenterRecruiting
- Providence Cancer Institute Franz ClinicRecruiting
- Providence Portland Medical CenterRecruiting
- Providence Onc and Heme Care Clinic - WestsideRecruiting
- Providence Oncology and Hematology Care Clinic - WestsideRecruiting
- Providence St Vincent Medical CenterRecruiting
- Providence St. Vincent Medical CenterRecruiting
- AHN Cancer Institute at Jefferson HospitalRecruiting
- AHN Cancer Institute Forbes HospitalRecruiting
- AHN Cancer Institute - Allegheny General HospitalRecruiting
- AHN Cancer Institute PharmacyRecruiting
- AHN Cancer Institute West Penn HospitalRecruiting
- UPMC Hillman Cancer Center Investigational Drug ServiceRecruiting
- UPMC Hillman Cancer CenterRecruiting
- Wexford Health and Wellness PavilionRecruiting
- Vanderbilt Health Clinic at Walgreens ClarksvilleRecruiting
- Vanderbilt Health Clinic at Walgreens Cool SpringsRecruiting
- Vanderbilt Health Clinic at Walgreens GallatinRecruiting
- The West Clinic. PLLC. dba West Cancer CenterRecruiting
- Vanderbilt Health Clinic at Walgreens HendersonvilleRecruiting
- Vanderbilt Health Clinic at Walgreens HermitageRecruiting
- Vanderbilt Health Clinic at Walgreens La VergneRecruiting
- Vanderbilt Health Clinic at Walgreens LebanonRecruiting
- The West Clinic PLLC dba West Cancer CenterRecruiting
- Vanderbilt Health Clinic at Walgreens MurfreesboroRecruiting
- Vanderbilt Health Clinic at Walgreens Belle MeadeRecruiting
- Vanderbilt Health Clinic at Walgreens Nippers CornerRecruiting
- Vanderbilt Health Clinic at Walgreens DonelsonRecruiting
- Vanderbilt Health Clinic at Walgreens Hart LaneRecruiting
- Vanderbilt Health Clinic at Walgreens BellevueRecruiting
- Vanderbilt-Ingram Cancer CenterRecruiting
- Henry-Joyce Cancer CenterRecruiting
- Vanderbilt Oncology IDS PharmacyRecruiting
- Vanderbilt Health Clinic at Walgreens SmyrnaRecruiting
- The University of Texas MD Anderson Cancer CenterRecruiting
- The University of Texas MD Anderson Cancer CenterRecruiting
- VCU Health System, Investigational Drug Service PharmacyRecruiting
- Virginia Commonwealth University Massey Cancer CenterRecruiting
- Seattle Cancer Care AllianceRecruiting
- University of Washington Medical CenterRecruiting
- University of Wisconsin Clinical Science CenterRecruiting
- Froedtert Hospital and the Medical College of WisconsinRecruiting
- Centro Medico San RoqueRecruiting
- Centro Medico San RoqueRecruiting
- Instituto Médico Especializado Alexander FlemingRecruiting
- Clinica Universitaria Reina FabiolaRecruiting
- Hospital Privado Centro Médico de CórdobaRecruiting
- Hospital Privado Centro Médico de CórdobaRecruiting
- Chris O'Brien LifehouseRecruiting
- Liverpool HospitalRecruiting
- Slade PharmacyRecruiting
- GenesisCare - North ShoreRecruiting
- GenesisCare North ShoreRecruiting
- Royal Brisbane & Women's HospitalRecruiting
- Princess Alexandra HospitalRecruiting
- The Queen Elizabeth HospitalRecruiting
- Monash HealthRecruiting
- Austin HealthRecruiting
- Peter MacCallum Cancer CentreRecruiting
- Alfred HealthRecruiting
- Université Libre de Bruxelles - Hôpital ErasmeRecruiting
- Cliniques universitaires Saint-LucRecruiting
- Grand Hôpital de CharleroiRecruiting
- CHR Verviers East BelgiumRecruiting
- AZ Groeninge Campus KennedylaanRecruiting
- ZNA MiddelheimRecruiting
- UZ LeuvenRecruiting
- Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart TilmanRecruiting
- Hospital Bruno BornRecruiting
- Hospital Bruno BornRecruiting
- Hospital Bruno BornRecruiting
- Hospital de Clinicas de Porto AlegreRecruiting
- INCARecruiting
- Instituto Nacional de Câncer José Alencar Gomes da Silva - INCARecruiting
- Reichow - Centro de Ensino e PesquisaRecruiting
- Clínica de Neoplasias LitoralRecruiting
- Hospital do Cancer de Barretos - Fundacao Pio XIIRecruiting
- CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - Faculdade de Medicina do ABCRecruiting
- Fundacao do ABC-Faculdade de Medicina do ABCRecruiting
- FUNDAÇÃO DO ABC - Faculdade de Medicina do ABC - Centro de Estudos e Pesquisas de Hematologia e OnRecruiting
- CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - Faculdade de Medicina do ABCRecruiting
- Instituto do Cancer do Estado de Sao Paulo, ICESPRecruiting
- Fundação Pio XII - Hospital de Câncer de BarretosRecruiting
- Medical School Famerp-HB-FUNFARME_Do not use - Duplicate facilityRecruiting
- Fundação Faculdade Regional de Medicina de São José do Rio PretoRecruiting
- MHAT Uni Hospital OODRecruiting
- MHAT "Dr. Tota Venkova" ADRecruiting
- Complex Oncology Center - Plovdiv EOODRecruiting
- MHAT Central Onco Hospital OODRecruiting
- Complex Oncology Center - Plovdiv EOODRecruiting
- Medical Center Nadezhda Clinical EOODRecruiting
- Acibadem City Clinic MHAT TokudaRecruiting
- University Multiprofile Hospital for Active Treatment SofiamedRecruiting
- Tom Baker Cancer CentreRecruiting
- Cross Cancer InstituteRecruiting
- Kingston Health Sciences Centre-Kingston General Hospital SiteRecruiting
- London Regional Cancer Program, London Health Sciences CentreRecruiting
- Sunnybrook Health Sciences CentreRecruiting
- Centre Intégré de Santé et de Services Sociaux (CISSS) de Laval / Hôpital de la Cité-de-la-SantRecruiting
- Jewish General HospitalRecruiting
- Anhui Provincial Cancer Hospital
- The First Affiliated Hospital of Anhui Medical UniversityRecruiting
- Cancer Hospital Chinese Academy of Medical ScienceRecruiting
- Beijing Cancer hospitalRecruiting
- Beijing HospitalRecruiting
- Chongqing University Cancer HospitalRecruiting
- Fujian Medical University Union Hospital-1 BingfanglouRecruiting
- Guangdong Provincial People's Hospital
- Guangdong Provincial People's HospitalRecruiting
- The Sixth Affiliated Hospital of Sun Yat-sen University
- Affiliated Tumor Hospital of Guangxi Medical UniversityRecruiting
- Henan provincial people's hospitalRecruiting
- Tongji Hospital, Tongji Medical College, Huazhong University of Science & TechnologyRecruiting
- The Second Xiangya Hospital of Central South UniversityRecruiting
- The Third Xiangya Hospital of Central South UniversityRecruiting
- Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical SchoolRecruiting
- Shengjing Hospital Of China Medical UniversityRecruiting
- Jinan Central HospitalRecruiting
- Shandong province cancer hospitalRecruiting
- The Affiliated Hospital of Qingdao UniversityRecruiting
- Shanghai Jiaotong University School of Medicine Ruijin HospitalRecruiting
- Shanghai General HospitalRecruiting
- Sichuan Province Cancer HospitalRecruiting
- Yunnan Cancer Hospital(The Third Affiliated Hospital of Kunming Medical University)Recruiting
- The second Affiliated Hospital of College of Medicine, Zhejiang UniversityRecruiting
- Peking University First HospitalRecruiting
- Fudan University Shanghai Cancer CenterRecruiting
- Tianjin Union Medical CenterRecruiting
- Fakultní nemocnice Brno BohuniceRecruiting
- Fakultni nemocnice Hradec KraloveRecruiting
- Fakultni Thomayerova nemocniceRecruiting
- Fakultni nemocnice OlomoucRecruiting
- Fakultni nemocnice v MotoleRecruiting
- Fakultni nemocnice BulovkaRecruiting
- Aalborg Universitetshospital, SydRecruiting
- Vejle Hospital-Sygehus LillebaeltRecruiting
- Vejle SygehusRecruiting
- Aalborg UniversitetshospitalRecruiting
- RigshospitaletRecruiting
- Herlev and Gentofte HospitalRecruiting
- Odense University HospitalRecruiting
- Docrates SyöpäsairaalaRecruiting
- Tampereen yliopistollinen sairaalaRecruiting
- Helsinki University Central HospitalRecruiting
- Oulu University HospitalRecruiting
- Satakunnan KeskussairaalaRecruiting
- Tampereen yliopistollinen sairaalaRecruiting
- Turku University HospitalRecruiting
- Muenchen Klinik Neuperlach, Klinik fuer Haematologie und OnkologieRecruiting
- Institut für Klinisch Onkologische ForschungRecruiting
- Medizinische Hochschule HannoverRecruiting
- Medizinische Hochschule HannoverRecruiting
- Universitätsklinikum LeipzigRecruiting
- Radiologie BerlinRecruiting
- Onkologische Schwerpunktpraxis KurfuerstendammRecruiting
- Waage ApothekeRecruiting
- HELIOS Klinikum Berlin Buch GmbHRecruiting
- Helios Klinikum Berlin-BuchRecruiting
- Technische Universität Dresden, Medizinische Fakultät Carl Gustav CarusRecruiting
- Universitätsklinikum Carl Gustav Carus DresdenRecruiting
- Facharztzentrum EppendorfRecruiting
- ZytoService Deutschland GmbH, Standort-Hamburg-JenfeldRecruiting
- Radiologie im Israelitischen KrankenhausRecruiting
- Klinikum Oldenburg AöRRecruiting
- Klinikum Oldenburg AöRRecruiting
- Rajiv Gandhi Cancer Institute And Research CentreRecruiting
- Rajiv Gandhi Cancer Institute And Research CentreRecruiting
- Tata Memorial HospitalRecruiting
- Deenanath Mangeshkar Hospital & Research CentreRecruiting
- Sahyadri Speciality HospitalRecruiting
- Bhakti Vedanta Hospital and Research InstituteRecruiting
- R K Birla Cancer Center, SMS HospitalRecruiting
- Sawai Man Singh Medical College Hospital (SMS Hospital)Recruiting
- Azienda Ospedaliera Universitaria di Cagliari - Presidio Policlinico Universitario "D.Casula"Recruiting
- IRCCS Casa Sollievo della SofferenzaRecruiting
- ASST Grande Ospedale Metropolitano NiguardaRecruiting
- Fondazione del Piemonte per l'Oncologia - Istituto di Candiolo IRCCSRecruiting
- Azienda Ospedaliero Universitaria San Luigi GonzagaRecruiting
- Fondazione Poliambulanza Istituto OspedalieroRecruiting
- Istituto Europeo di Oncologia IRCCSRecruiting
- Azienda Ospedaliera Universitaria dell'Università "Luigi Vanvitelli" di NapoliRecruiting
- IRCCS Istituto Oncologico Veneto (IOV)Recruiting
- Azienda USL - IRCCS di Reggio Emilia - Arcispedale Santa Maria NuovaRecruiting
- Chiba cancer centerRecruiting
- National Cancer Center Hospital EastRecruiting
- National Hospital Organization Shikoku Cancer CenterRecruiting
- Hokkaido University HospitalRecruiting
- Kanazawa University HospitalRecruiting
- St. Marianna University HospitalRecruiting
- Kanagawa cancer centerRecruiting
- Aichi Cancer Center HospitalRecruiting
- Osaka Prefectural Hospital Organization Osaka International Cancer InstituteRecruiting
- Kindai University HospitalRecruiting
- Osaka University HospitalRecruiting
- Osaka Medical and Pharmaceutical University HospitalRecruiting
- Saitama Medical University International Medical CenterRecruiting
- Saitama Prefectural Cancer CenterRecruiting
- Shizuoka Cancer CenterRecruiting
- National Cancer Center HospitalRecruiting
- Japanese Foundation for Cancer ResearchRecruiting
- National Hospital Organization Kyushu Cancer CenterRecruiting
- National Hospital Organization - Osaka National Hospital - Institute For Clinical ResearchRecruiting
- Keio University HospitalRecruiting
- National Cancer CenterRecruiting
- Kyungpook National University HospitalRecruiting
- Dong-A University HospitalRecruiting
- Kyungpook National University Chilgok HospitalRecruiting
- Gachon University Gil Medical CenterRecruiting
- Chonnam National University Hwasun Hospital PharmacyRecruiting
- Chonnam National University Hwasun HospitalRecruiting
- Korea University Anam HospitalRecruiting
- Seoul National University HospitalRecruiting
- Severance Hospital, Yonsei University Health SystemRecruiting
- Asan Medical CenterRecruiting
- Samsung Medical CenterRecruiting
- Accelerium, S. de R.L. de C.V.Recruiting
- Centro de Investigacion Clinica de OaxacaRecruiting
- Maastricht UMC+Recruiting
- Catharina ZiekenhuisRecruiting
- Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL)Recruiting
- Haaglanden Medisch CentrumRecruiting
- Amsterdam UMC, location VUMcRecruiting
- Maastricht University Medical CenterRecruiting
- Universitair Medisch Centrum UtrechtRecruiting
- Tauranga HospitalRecruiting
- Auckland City HospitalRecruiting
- Auckland District Health Board Charitable TrustRecruiting
- Haukeland University HospitalRecruiting
- Stavanger UniversitetssykehusRecruiting
- St. Olavs hospitalRecruiting
- Sørlandet Sykehus KristiansandRecruiting
- Oslo universitetssykehus, RadiumhospitaletRecruiting
- Oslo Universitetssykehus UllevålRecruiting
- Przychodnia Lekarska KOMEDRecruiting
- Szpital Specjalistyczny W Brzozowie, Podkarpacki Osrodek Onkologiczny Im.Ks.B.MarkiewiczaRecruiting
- Wojewodzki Szpital Specjalistyczny Nr 4 w Bytomiu Oddzial OnkologiiRecruiting
- COPERNICUS PL sp. z. o. o. Wojewodzkie Centrum Onkologii w Gdansku AmbulatoryjnaRecruiting
- COPERNICUS Podmiot Leczniczy Sp. z o.o. Wojewodzkie Centrum OnkologiiRecruiting
- Przychodnia Lekarska KOMEDRecruiting
- Private Medical Institution "Euromedservice"
- Private Medical Institution "Euromedservice"
- GBUZ
- Kaluga Regional Clinical Oncology Center
- FSAEI HE I.M Sechenov First MSMU MoH Russia (Sechenovskiy University),
- BHI of Omsk Region "Clinical Oncology Dispensary"
- BHI of Omsk Region "Clinical Oncology Dispensary"
- LLC "EuroCityClinic"
- LLC "Medicina Severnoy Stolitsy"
- LLC "Severo-Zapadny Medical Center"
- Private Healthcare Institution "Clinical Hospital "RZD-Medicine" of St. Petersburg
- FSBI "Russian Scientific Center For Radiology and Surgical Technologies n.a. Academician A.M. Granov
- SHI YR Regional Clinical Oncology Hospital
- SHI YR Regional Clinical Oncology Hospital
- SHI YR Regional Clinical Oncology Hospital
- Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska BystricaRecruiting
- Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska BystricaRecruiting
- Onkologicky ustav sv. Alzbety s.r.o.Recruiting
- Narodny Onkologicky UstavRecruiting
- Vychodoslovensky onkologicky ustav, a.s.Recruiting
- POKO Poprad s.r.o.Recruiting
- Cancercare Rondebosch OncologyRecruiting
- Cancercare Langenhoven Drive Oncology CentreRecruiting
- Charlotte Maxeke Johannesburg Academic HospitalRecruiting
- Wits Clinical ResearchRecruiting
- Cape Town Oncology Trials
- Mary Potter Oncology CentreRecruiting
- Complejo Hospitalario Universitario Santiago de CompostelaRecruiting
- Hospital General Universitario de ElcheRecruiting
- ICO L'Hospitalet (Hospital Duran i Reynals)Recruiting
- Hospital Universitario Vall d'HebronRecruiting
- Hospital Clinic BarcelonaRecruiting
- Hospital General Universitario Gregorio MarañonRecruiting
- Hospital Universitario Ramon Y CajalRecruiting
- Hospital Universitario 12 de octubreRecruiting
- Hospital Universitario Virgen Del RocioRecruiting
- Hospital Clinico Universitario de ValenciaRecruiting
- Hospital General Universitario de ValenciaRecruiting
- Hospital Universitario Miguel ServetRecruiting
- Karolinska Universitetssjukhuset SolnaRecruiting
- Akademiska sjukhusetRecruiting
- Norrlands universitetssjukhusRecruiting
- Sahlgrenska UniversitetssjukhusetRecruiting
- Kaohsiung Medical University Chung-Ho Memorial HospitalRecruiting
- China Medical University HospitalRecruiting
- China Medical University HospitalRecruiting
- National Cheng-Kung University HospitalRecruiting
- Chi Mei Hospital, LiouyingRecruiting
- National Taiwan University HospitalRecruiting
- National Taiwan University HospitalRecruiting
- Taipei Medical University HospitalRecruiting
- Taipei Veterans General HospitalRecruiting
- Taipei Veterans General HospitalRecruiting
- Chang Gung Medical Foundation-Linkou BranchRecruiting
- Medical and diagnostic center of MediX-Ray International Group LLC Israeli Oncology Hospital "LISOD"
- Municipal Non-profit Enterprise "City Clinical Hospital #4" of Dnipro City Council
- PRECARPATHIAN NUCLEAR MEDICINE CENTER, Limited Liability Company
- Ivano-Frankivsk National Medical University
- MNPE "Prykarpatski Clinical Oncological Center" of Ivano-Frankivsk Regional Council"
- Municipal non-profit enterprise "City clinical hospital #2 named after O.O.Shalimov"
- Communal Non-Profit Enterprise "Regional Center of Oncology"
- Communal enterprise "Kryvyi Rih Oncology Dispensary" of Dnipropetrovsk Regional Council
- SI "Insitute of Neurosurgery n.a.acad. A.P.
- SI "Insitute of Neurosurgery n.a.acad. A.P.
- Municipal non-profit enterprise of Kyiv regional council "Kyiv regional clinical hospital"
- Municipal non-profit enterprise "Zaporizhzhia Regional Antitumor Center" Zaporizhzhia RegionalRecruiting
- Freeman HospitalRecruiting
- Royal Marsden NHS Foundation TrustRecruiting
- Heartlands HospitalRecruiting
- Royal Marsden NHS Foundation TrustRecruiting
- Hammersmith Hospital, Imperial College Healthcare NHS TrustRecruiting
- Charing Cross Hospital, Imperial College Healthcare NHS TrustRecruiting
- Churchill Hospital - OncologyRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm Type
Experimental
Experimental
Experimental
Experimental
Active Comparator
Experimental
Active Comparator
Arm Label
Safety Lead-in Cohort 1
Safety Lead-in Cohort 2
Phase 3 Arm A
Phase 3 Arm B
Phase 3 Arm C
Cohort 3 Arm D
Cohort 3 Arm E
Arm Description
Encorafenib 300 mg orally once daily Cetuximab 500 mg/m2 (120-minute IV infusion) every two weeks Irinotecan 180 mg/m2 (90-minute IV infusion) every two weeks Leucovorin 400 mg/m2 (120-minute IV infusion) every two weeks 5-FU 400 mg/m2 IV bolus, then 5-FU 2400 mg/m2 continuous IV infusion over 46-48 hours every two weeks
Encorafenib 300 mg orally once daily Cetuximab 500 mg/m2 (120 minute IV infusion) every two weeks Oxaliplatin 85 mg/m2 (120-minute IV infusion) every two weeks Leucovorin 400 mg/m2 (120-minute IV infusion) every two weeks 5-FU 400 mg/m2 IV bolus, then 5-FU 2400 mg/m2 continuous IV infusion over 46-48 hours every two weeks
Encorafenib 300 mg orally once daily Cetuximab 500 mg/m2 (120-minute IV infusion) every two weeks
Encorafenib 300 mg orally once daily Cetuximab 500 mg/m2 (120 minute IV infusion) every two weeks Oxaliplatin 85 mg/m2 (120-minute IV infusion) every two weeks Leucovorin 400 mg/m2 (120-minute IV infusion) every two weeks 5-FU 400 mg/m2 IV bolus, then 5-FU 2400 mg/m2 continuous IV infusion over 46-48 hours every two weeks
Every two weeks: Oxaliplatin 85 mg/m2 (120-minute IV infusion) Leucovorin 400 mg/m2 (120-minute IV infusion) 5-FU 400 mg/m2 IV bolus, then 5-FU 2400 mg/m2 continuous IV infusion over 46-48 hours Bevacizumab (optional; given per prescribing instructions) -OR- Every two weeks: Irinotecan 165 mg/m2 (90-minute IV infusion) Oxaliplatin 85 mg/m2 (120-minute IV infusion) Leucovorin 400 mg/m2 (120-minute IV infusion) 5-FU 2400 or 3200 mg/m2 continuous IV infusion over 46 48 hours Bevacizumab (optional; given per prescribing instructions) -OR- Oxaliplatin 130 mg/m2 (120-minute IV infusion) every 3 weeks Capecitabine 1000 mg/m2 oral tablet twice daily on Days 1-14 Bevacizumab (optional; given per prescribing instructions)
Encorafenib 300 mg orally once daily Cetuximab 500 mg/m2 (120-minute IV infusion) every two weeks Irinotecan 180 mg/m2 (90-minute IV infusion) every two weeks Leucovorin 400 mg/m2 (120-minute IV infusion) every two weeks 5-FU 400 mg/m2 IV bolus, then 5-FU 2400 mg/m2 continuous IV infusion over 46-48 hours every two weeks
Irinotecan 180 mg/m2 (90-minute IV infusion) every 2 weeks, Leucovorin 400 mg/m2 (120-minute IV infusion) every 2 weeks, 5-FU 400 mg/m2 IV bolus, then 5-FU 2400 mg/m2 continuous IV infusion over 46-48 hours every two weeks, Bevacizumab (optional; given per prescribing instructions)
Outcomes
Primary Outcome Measures
Safety Lead-in Study: Incidence of Dose Limiting Toxicities (DLTs)
Incidence of dose limiting toxicity defined as any adverse event (AE) or abnormal laboratory value assessed as unrelated to disease, disease progression, intercurrent illness or concomitant medications/therapies occurring during the first 28 days of treatment
Phase 3: Progression free survival, by blinded independent review
Progression free survival, defined as the time from the date of randomization to the earliest documented disease progression or death due to any cause: encorafenib and cetuximab + mFOLFOX6 (Arm B) vs the Control Arm (Arm C)
Phase 3: Objective response rate by blinded independent review
Objective response defined as complete response (CR), or partial response (PR) according to RECIST v1.1 based on BICR assessment, from the date of randomization until the date of the first documentation of progression of disease (PD)
Cohort 3: Objective response rate by blinded independent review
Defined as CR, or PR according to RECIST v1.1 based on BICR assessment, from the date of randomization until the date of the first documentation of PD, death or start of new anticancer therapy
Secondary Outcome Measures
Safety Lead-in: Incidence of adverse events
An adverse event is any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship as assessed by CTCAE 4.03
Safety Lead-in: Incidence of abnormal clinical laboratory parameters, abnormal vital signs and abnormal electrocardiograms
Changes in clinical laboratory parameters, vital signs and electrocardiograms determined clinically significant at the investigator's discretion.
Safety Lead-in: Incidence of dose interruptions, dose modifications and discontinuations due to adverse events
Safety Lead-in: Overall response rate by investigator
Overall response rate, defined as the proportion of participants who have achieved a confirmed best overall response per RECIST v1.1: encorafenib and cetuximab + mFOLFOX6 or FOLFIRI
Safety Lead-in: Duration of response by Investigator
Duration of response, defined as the time from the date of first radiographic evidence of response to the earliest documented disease progression per RECIST v1.1, or death due to any cause: encorafenib and cetuximab + mFOLFOX6 or FOLFIRI
Safety Lead-in:Progression free survival by Investigator
Progression free survival, defined as the time from the first dose to the earliest documented disease progression per RECIST v1.1, or death due to any cause: encorafenib and cetuximab + mFOLFOX6 or FOLFIRI
Safety Lead-in: Time to response by Investigator
Time to response, defined as the time from first dose to first radiographic evidence of response per RECIST v1.1: encorafenib and cetuximab + mFOLFOX6 or FOLFIRI
Safety Lead-in: Overall survival
Overall survival defined as the time from the first dose to death due to any cause: encorafenib and cetuximab + mFOLFOX6 or FOLFIRI
Phase 3: Overall survival
Overall survival, defined as the time from the date of randomization to death due to any cause: encorafenib + cetuximab (Arm A) vs Control Arm (Arm C) and encorafenib + cetuximab +mFOLFOX6 (Arm B) vs Control Arm (Arm C) and encorafenib + cetuximab (Arm A) vs encorafenib + cetuximab +mFOLFOX6 (Arm B)
Phase 3: Overall response rate by Investigator and by blinded independent review
Overall response rate, defined as the proportion of participants who have achieved a confirmed best overall response per RECIST v1.1: encorafenib + cetuximab (Arm A) vs Control Arm (Arm C) and encorafenib + cetuximab +mFOLFOX6 (Arm B) vs Control Arm (Arm C) and encorafenib + cetuximab (Arm A) vs encorafenib + cetuximab +mFOLFOX6 (Arm B)
Phase 3: Duration of response by Investigator and blinded independent review
Duration of response, defined as the time from the date of first radiographic evidence of response to the earliest documented disease progression per RECIST v1.1, or death due to any cause: encorafenib + cetuximab (Arm A) vs Control Arm (Arm C) and encorafenib + cetuximab +mFOLFOX6 (Arm B) vs Control Arm (Arm C) and encorafenib + cetuximab (Arm A) vs encorafenib + cetuximab +mFOLFOX6 (Arm B)
Phase 3: Time to response by blinded independent review and by Investigator
Time to response, defined as the time from first dose to first radiographic evidence of response per RECIST v1.1: encorafenib + cetuximab (Arm A) vs Control Arm (Arm C) and encorafenib + cetuximab +mFOLFOX6 (Arm B) vs Control Arm (Arm C) and encorafenib + cetuximab (Arm A) vs encorafenib + cetuximab +mFOLFOX6 (Arm B)
Phase 3: Progression free survival by Investigator and by blinded independent review
Progression free survival, defined as the time from the first dose to the earliest documented disease progression per RECIST v1.1, or death due to any cause:: encorafenib + cetuximab (Arm A) vs Control Arm (Arm C) and encorafenib + cetuximab +mFOLFOX6 (Arm B) vs Control Arm (Arm C) and encorafenib + cetuximab (Arm A) vs encorafenib + cetuximab +mFOLFOX6 (Arm B)
Phase 3: Progression free survival 2 by Investigator
Progression free survival 2, defined as the time from the date of randomization to the second objective disease progression per RECIST v1.1, or death from any cause, whichever occurs first: encorafenib + cetuximab (Arm A) vs Control Arm (Arm C) and encorafenib + cetuximab +mFOLFOX6 (Arm B) vs Control Arm (Arm C) and encorafenib + cetuximab (Arm A) vs encorafenib + cetuximab +mFOLFOX6
Phase 3: Incidence of adverse events
An adverse event was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship: encorafenib + cetuximab (Arm A) and encorafenib + cetuximab +mFOLFOX6 (Arm B)
Phase 3: Incidence of abnormal clinical laboratory parameters, abnormal vital signs and abnormal electrocardiograms
Changes in clinical laboratory parameters, vital signs and electrocardiograms determined clinically significant at the investigator's discretion: encorafenib + cetuximab (Arm A) and encorafenib + cetuximab +mFOLFOX6 (Arm B)
Phase 3: Change from Baseline in the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (EORTC QLQ-C30)
EORTC QLQ-C30: included functional scales (physical, role, cognitive, emotional, and social), global health status, symptom scales (fatigue, pain, nausea/vomiting) and single items (dyspnoea, appetite loss, insomnia, constipation/diarrhea and financial difficulties). Most questions used 4 point scale (1 'Not at all' to 4 'Very much'; 2 questions used 7-point scale (1 'very poor' to 7 'Excellent'). Scores averaged, transformed to 0-100 scale; higher score=better level of functioning or greater degree of symptoms.
Phase 3: Change from Baseline in the EuroQol-5D-5L (EQ-5D-5L) Questionnaire
The EQ-5D-5L is a standardized measure of health utility that provides a single index value for the participant's health status. It is frequently used for economic evaluations of health care and has been shown to be a valid and reliable instrument, and comprises a short descriptive system questionnaire and a visual analogue scale (EQ VAS) that are cognitively undemanding, taking about 2 minutes to complete
Phase 3: Change from Baseline in the Patient Global Impression of Severity (PGIS)
The PGIS is a single-item questionnaire designed to assess participant's overall impression of disease severity at a given point in time.
Phase 3: Change from Baseline in the Patient Global Impression of Change (PGIC) questionnaires
The PGIC is a single-item questionnaire designed to assess the participant's overall sense of whether there has been a change in symptoms or quality of life since starting treatment.
Phase 3: Confirm the MSI-status in tumor tissue
Summarize MSI-status as determined by retrospective central testing of baseline tumor tissue
Phase 3: Determine the correlation between cfDNA genetic alterations and clinical outcome
BRAF V600E variant allele fraction (VAF) and/or overall mean VAF from cfDNA analysis of plasma samples collected at baseline and on treatment
Safety Lead-in: Maximum plasma concentration of encorafenib, LHY746, irinotecan and SN-38
Safety Lead-in: Area under the plasma concentration time curve of encorafenib, LHY746, irinotecan and SN-38
Safety Lead-in: Time to maximim plasma concentration time curve of encorafenib, LHY746, irinotecan and SN-38
Safety Lead-in: Maximum plasma concentration of encorafenib, LHY746 and oxaliplatin
Safety Lead-in: Area under the plasma concentration time curve of encorafenib, LHY746 and oxaliplatin
Safety Lead-in: Clearance of irinotecan, SN-38 and oxaliplatin
Changes in exposures of irinotecan and its metabolite (SN-38) on Cycle 1 Day 15 compared to Cycle 1 Day 1 in Cohort 1 (encorafenib and cetuximab + FOLFIRI) Changes in exposures of oxaliplatin on Cycle 1 Day 15 compared to Cycle 1 Day 1 in Cohort 2 (encorafenib and cetuximab + mFOLFOX6)
Safety Lead-in: Time to maximim plasma concentration time curve of encorafenib, LHY746 and oxaliplatin
Phase 3: Trough concentrations of encorafenib and its metabolite LHY746
Trough plasma concentrations in all patients in Arm A and Arm B
Cohort 3: Progression free survival by Investigator and by blinded independent review
Progression free survival, defined as the time from the first dose to the earliest documented disease progression per RECIST v1.1, or death due to any cause.
Cohort 3: Overall response rate by investigator
Overall response rate, defined as the proportion of participants who have achieved a confirmed best overall response per RECIST v 1.1
Cohort 3: Duration of response by Investigator and by blinded independent review
Duration of response, defined as the time from the date of first radiographic evidence of response to the earliest documented disease progression per RECIST v1.1, or death due to any cause
Cohort 3: Time to response by Investigator and by blinded independent review
Time to response, defined as the time from the date of randomization to first radiographic evidence of response per RECIST v1.1
Cohort 3: Overall survival
Overall survival, defined as the time from the date of randomization to death due to any cause
Cohort 3: Incidence of adverse events
An adverse event was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship: encorafenib + cetuximab (Arm A) and encorafenib + cetuximab +mFOLFOX6 (Arm B)
Cohort 3: Incidence of abnormal clinical laboratory parameters, abnormal vital signs and abnormal electrocardiograms
Changes in clinical laboratory parameters, vital signs and electrocardiograms determined clinically significant at the investigator's discretion: encorafenib + cetuximab (Arm A) and encorafenib + cetuximab +mFOLFOX6 (Arm B)
Cohort 3: Change from Baseline in the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (EORTC QLQ-C30)
EORTC QLQ-C30: included functional scales (physical, role, cognitive, emotional, and social), global health status, symptom scales (fatigue, pain, nausea/vomiting) and single items (dyspnoea, appetite loss, insomnia, constipation/diarrhea and financial difficulties). Most questions used 4 point scale (1 'Not at all' to 4 'Very much'; 2 questions used 7-point scale (1 'very poor' to 7 'Excellent'). Scores averaged, transformed to 0-100 scale; higher score=better level of functioning or greater degree of symptoms.
Cohort 3: Change from Baseline in the EuroQol-5D-5L (EQ-5D-5L) Questionnaire
The EQ-5D-5L is a standardized measure of health utility that provides a single index value for the participant's health status. It is frequently used for economic evaluations of health care and has been shown to be a valid and reliable instrument, and comprises a short descriptive system questionnaire and a visual analogue scale (EQ VAS) that are cognitively undemanding, taking about 2 minutes to complete
Cohort 3: Change from Baseline in the Patient Global Impression of Severity (PGIS)
The PGIS is a single-item questionnaire designed to assess participant's overall impression of disease severity at a given point in time.
Cohort 3: Change from Baseline in the Patient Global Impression of Change (PGIC) questionnaires
The PGIC is a single-item questionnaire designed to assess the participant's overall sense of whether there has been a change in symptoms or quality of life since starting treatment.
Cohort 3: Confirm the MSI-status in tumor tissue
Summarize MSI-status as determined by retrospective central testing of baseline tumor tissue
Cohort 3: Determine the correlation between cfDNA genetic alterations and clinical outcome
BRAF V600E variant allele fraction (VAF) and/or overall mean VAF from cfDNA analysis of plasma samples collected at baseline and on treatment
Cohort 3: Trough concentrations of encorafenib and its metabolite LHY746
Trough plasma concentrations in all patients in Arm D
Full Information
NCT ID
NCT04607421
First Posted
October 5, 2020
Last Updated
September 7, 2023
Sponsor
Pfizer
Collaborators
Ono Pharmaceutical Co. Ltd, Merck KGaA, Darmstadt, Germany, Eli Lilly and Company
1. Study Identification
Unique Protocol Identification Number
NCT04607421
Brief Title
A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
Official Title
AN OPEN-LABEL, MULTICENTER, RANDOMIZED PHASE 3 STUDY OF FIRST-LINE ENCORAFENIB PLUS CETUXIMAB WITH OR WITHOUT CHEMOTHERAPY VERSUS STANDARD OF CARE THERAPY WITH A SAFETY LEAD-IN OF ENCORAFENIB AND CETUXIMAB PLUS CHEMOTHERAPY IN PARTICIPANTS WITH METASTATIC BRAF V600E-MUTANT COLORECTAL CANCER
Study Type
Interventional
2. Study Status
Record Verification Date
September 2023
Overall Recruitment Status
Recruiting
Study Start Date
December 21, 2020 (Actual)
Primary Completion Date
November 16, 2024 (Anticipated)
Study Completion Date
November 15, 2026 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Pfizer
Collaborators
Ono Pharmaceutical Co. Ltd, Merck KGaA, Darmstadt, Germany, Eli Lilly and Company
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The purpose of this study is to evaluate two study medicines (encorafenib plus cetuximab) taken alone or together with standard chemotherapy for the potential treatment of colorectal cancer that:
has spread to other parts of the body (metastatic);
has a certain type of abnormal gene called "BRAF"; and
has not received prior treatment.
Participants in this study will receive one of the following study treatments:
Encorafenib plus cetuximab: These participants will receive encorafenib by mouth at home every day and cetuximab once every two weeks by intravenous (IV) infusion (an injection into the vein) at the study clinic.
Encorafenib plus cetuximab with chemotherapy: These participants will receive encorafenib and cetuximab in the way described in the bullet above. Additionally, they will receive standard chemotherapy by IV infusion and oral treatment at home.
Chemotherapy alone: These participants will receive chemotherapy, the standard treatment for this condition, by IV infusion at the study clinics and oral treatment at home.
The study team will monitor how each participant responds to the study treatment for up to about 3 years.
Detailed Description
The purpose of the study is to evaluate whether encorafenib plus cetuximab (EC), alone or in combination with chemotherapy, can improve clinical outcomes relative to current standard of-care chemotherapy in participants with previously untreated BRAF V600E-mutant mCRC. Since encorafenib has not previously been combined with chemotherapy, the tolerability and PK of EC in combination with mFOLFOX6 and in combination with FOLFIRI will be evaluated in separate cohorts in the safety lead-in portion of the trial in order to identify which chemotherapy combination is to be used in the Phase 3 portion of the study.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Neoplasms
Keywords
Colorectal cancer, Colon cancer, Rectal cancer, Colorectal Neoplasms, Intestinal cancer, Intestinal Neoplasms, Gastrointestinal cancer, Gastrointestinal Neoplasms, Digestive system cancer, Digestive System Neoplasms, Digestive System Diseases, Gastrointestinal Diseases, Colonic Diseases, Intestinal Diseases, Rectal Diseases, BREAKWATER Study
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
Outcomes Assessor
Allocation
Randomized
Enrollment
815 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Safety Lead-in Cohort 1
Arm Type
Experimental
Arm Description
Encorafenib 300 mg orally once daily Cetuximab 500 mg/m2 (120-minute IV infusion) every two weeks Irinotecan 180 mg/m2 (90-minute IV infusion) every two weeks Leucovorin 400 mg/m2 (120-minute IV infusion) every two weeks 5-FU 400 mg/m2 IV bolus, then 5-FU 2400 mg/m2 continuous IV infusion over 46-48 hours every two weeks
Arm Title
Safety Lead-in Cohort 2
Arm Type
Experimental
Arm Description
Encorafenib 300 mg orally once daily Cetuximab 500 mg/m2 (120 minute IV infusion) every two weeks Oxaliplatin 85 mg/m2 (120-minute IV infusion) every two weeks Leucovorin 400 mg/m2 (120-minute IV infusion) every two weeks 5-FU 400 mg/m2 IV bolus, then 5-FU 2400 mg/m2 continuous IV infusion over 46-48 hours every two weeks
Arm Title
Phase 3 Arm A
Arm Type
Experimental
Arm Description
Encorafenib 300 mg orally once daily Cetuximab 500 mg/m2 (120-minute IV infusion) every two weeks
Arm Title
Phase 3 Arm B
Arm Type
Experimental
Arm Description
Encorafenib 300 mg orally once daily Cetuximab 500 mg/m2 (120 minute IV infusion) every two weeks Oxaliplatin 85 mg/m2 (120-minute IV infusion) every two weeks Leucovorin 400 mg/m2 (120-minute IV infusion) every two weeks 5-FU 400 mg/m2 IV bolus, then 5-FU 2400 mg/m2 continuous IV infusion over 46-48 hours every two weeks
Arm Title
Phase 3 Arm C
Arm Type
Active Comparator
Arm Description
Every two weeks: Oxaliplatin 85 mg/m2 (120-minute IV infusion) Leucovorin 400 mg/m2 (120-minute IV infusion) 5-FU 400 mg/m2 IV bolus, then 5-FU 2400 mg/m2 continuous IV infusion over 46-48 hours Bevacizumab (optional; given per prescribing instructions) -OR- Every two weeks: Irinotecan 165 mg/m2 (90-minute IV infusion) Oxaliplatin 85 mg/m2 (120-minute IV infusion) Leucovorin 400 mg/m2 (120-minute IV infusion) 5-FU 2400 or 3200 mg/m2 continuous IV infusion over 46 48 hours Bevacizumab (optional; given per prescribing instructions) -OR- Oxaliplatin 130 mg/m2 (120-minute IV infusion) every 3 weeks Capecitabine 1000 mg/m2 oral tablet twice daily on Days 1-14 Bevacizumab (optional; given per prescribing instructions)
Arm Title
Cohort 3 Arm D
Arm Type
Experimental
Arm Description
Encorafenib 300 mg orally once daily Cetuximab 500 mg/m2 (120-minute IV infusion) every two weeks Irinotecan 180 mg/m2 (90-minute IV infusion) every two weeks Leucovorin 400 mg/m2 (120-minute IV infusion) every two weeks 5-FU 400 mg/m2 IV bolus, then 5-FU 2400 mg/m2 continuous IV infusion over 46-48 hours every two weeks
Arm Title
Cohort 3 Arm E
Arm Type
Active Comparator
Arm Description
Irinotecan 180 mg/m2 (90-minute IV infusion) every 2 weeks, Leucovorin 400 mg/m2 (120-minute IV infusion) every 2 weeks, 5-FU 400 mg/m2 IV bolus, then 5-FU 2400 mg/m2 continuous IV infusion over 46-48 hours every two weeks, Bevacizumab (optional; given per prescribing instructions)
Intervention Type
Drug
Intervention Name(s)
Encorafenib
Other Intervention Name(s)
Braftovi, PF-07263896, LGX818, ONO-7702
Intervention Description
75 mg capsules
Intervention Type
Drug
Intervention Name(s)
Cetuximab
Other Intervention Name(s)
Erbitux
Intervention Description
Injection for intravenous use 100 mg/vial, 200 mg/vial, or 500 mg/vial
Intervention Type
Drug
Intervention Name(s)
Oxaliplatin
Other Intervention Name(s)
Eloxatin
Intervention Description
Powder for solution for intravenous use 50 mg/vial, 100 mg/vial, or 200 mg/vial
Intervention Type
Drug
Intervention Name(s)
Irinotecan
Other Intervention Name(s)
Campostar
Intervention Description
Solution for intravenous infusion 40 mg/vial, 100 mg/vial, or 300 mg/vial
Intervention Type
Drug
Intervention Name(s)
Leucovorin
Other Intervention Name(s)
Wellcovorin, Fusilev, Khapzory
Intervention Description
Injection 50 mg/vial, 100 mg/vial, 200 mg/vial, or 350 mg/vial
Intervention Type
Drug
Intervention Name(s)
5-FU
Other Intervention Name(s)
Fluorouracil
Intervention Description
Injection for intravenous use 250 mg/vial, 500 mg/vial, or 1000 mg/vial
Intervention Type
Drug
Intervention Name(s)
Capecitabine
Other Intervention Name(s)
Xeloda
Intervention Description
150 mg or 500 mg Tablet
Intervention Type
Drug
Intervention Name(s)
Bevacizumab
Other Intervention Name(s)
Zirabev
Intervention Description
Optional Injection for intravenous use 100 mg/vial or 400 mg/vial
Primary Outcome Measure Information:
Title
Safety Lead-in Study: Incidence of Dose Limiting Toxicities (DLTs)
Description
Incidence of dose limiting toxicity defined as any adverse event (AE) or abnormal laboratory value assessed as unrelated to disease, disease progression, intercurrent illness or concomitant medications/therapies occurring during the first 28 days of treatment
Time Frame
After 30 evaluable patients in each cohort complete 1 cycle (up to 28 days), approximately 12 months
Title
Phase 3: Progression free survival, by blinded independent review
Description
Progression free survival, defined as the time from the date of randomization to the earliest documented disease progression or death due to any cause: encorafenib and cetuximab + mFOLFOX6 (Arm B) vs the Control Arm (Arm C)
Time Frame
Duration of Phase 3, approximately 36 months
Title
Phase 3: Objective response rate by blinded independent review
Description
Objective response defined as complete response (CR), or partial response (PR) according to RECIST v1.1 based on BICR assessment, from the date of randomization until the date of the first documentation of progression of disease (PD)
Time Frame
Duration of Phase 3, approximately 23 months
Title
Cohort 3: Objective response rate by blinded independent review
Description
Defined as CR, or PR according to RECIST v1.1 based on BICR assessment, from the date of randomization until the date of the first documentation of PD, death or start of new anticancer therapy
Time Frame
Duration of Cohort 3, approximately 15 months.
Secondary Outcome Measure Information:
Title
Safety Lead-in: Incidence of adverse events
Description
An adverse event is any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship as assessed by CTCAE 4.03
Time Frame
After 30 evaluable patients in each cohort complete 1 cycle (up to 28 days), approximately 12 months
Title
Safety Lead-in: Incidence of abnormal clinical laboratory parameters, abnormal vital signs and abnormal electrocardiograms
Description
Changes in clinical laboratory parameters, vital signs and electrocardiograms determined clinically significant at the investigator's discretion.
Time Frame
After 30 evaluable patients in each cohort complete 1 cycle (up to 28 days), approximately 12 months
Title
Safety Lead-in: Incidence of dose interruptions, dose modifications and discontinuations due to adverse events
Time Frame
After 30 evaluable patients in each cohort complete 1 cycle (up to 28 days), approximately 12 months
Title
Safety Lead-in: Overall response rate by investigator
Description
Overall response rate, defined as the proportion of participants who have achieved a confirmed best overall response per RECIST v1.1: encorafenib and cetuximab + mFOLFOX6 or FOLFIRI
Time Frame
After 30 evaluable patients in each cohort complete 1 cycle (up to 28 days), approximately 12 months
Title
Safety Lead-in: Duration of response by Investigator
Description
Duration of response, defined as the time from the date of first radiographic evidence of response to the earliest documented disease progression per RECIST v1.1, or death due to any cause: encorafenib and cetuximab + mFOLFOX6 or FOLFIRI
Time Frame
After 30 evaluable patients in each cohort complete 1 cycle (up to 28 days), approximately 12 months
Title
Safety Lead-in:Progression free survival by Investigator
Description
Progression free survival, defined as the time from the first dose to the earliest documented disease progression per RECIST v1.1, or death due to any cause: encorafenib and cetuximab + mFOLFOX6 or FOLFIRI
Time Frame
After 30 evaluable patients in each cohort complete 1 cycle (up to 28 days), approximately 12 months
Title
Safety Lead-in: Time to response by Investigator
Description
Time to response, defined as the time from first dose to first radiographic evidence of response per RECIST v1.1: encorafenib and cetuximab + mFOLFOX6 or FOLFIRI
Time Frame
After 30 evaluable patients in each cohort complete 1 cycle (up to 28 days), approximately 12 months
Title
Safety Lead-in: Overall survival
Description
Overall survival defined as the time from the first dose to death due to any cause: encorafenib and cetuximab + mFOLFOX6 or FOLFIRI
Time Frame
After 30 evaluable patients in each cohort complete 1 cycle (up to 28 days), approximately 36 months
Title
Phase 3: Overall survival
Description
Overall survival, defined as the time from the date of randomization to death due to any cause: encorafenib + cetuximab (Arm A) vs Control Arm (Arm C) and encorafenib + cetuximab +mFOLFOX6 (Arm B) vs Control Arm (Arm C) and encorafenib + cetuximab (Arm A) vs encorafenib + cetuximab +mFOLFOX6 (Arm B)
Time Frame
Duration of Phase 3, approximately 50 months
Title
Phase 3: Overall response rate by Investigator and by blinded independent review
Description
Overall response rate, defined as the proportion of participants who have achieved a confirmed best overall response per RECIST v1.1: encorafenib + cetuximab (Arm A) vs Control Arm (Arm C) and encorafenib + cetuximab +mFOLFOX6 (Arm B) vs Control Arm (Arm C) and encorafenib + cetuximab (Arm A) vs encorafenib + cetuximab +mFOLFOX6 (Arm B)
Time Frame
Duration of Phase 3, approximately 36 months
Title
Phase 3: Duration of response by Investigator and blinded independent review
Description
Duration of response, defined as the time from the date of first radiographic evidence of response to the earliest documented disease progression per RECIST v1.1, or death due to any cause: encorafenib + cetuximab (Arm A) vs Control Arm (Arm C) and encorafenib + cetuximab +mFOLFOX6 (Arm B) vs Control Arm (Arm C) and encorafenib + cetuximab (Arm A) vs encorafenib + cetuximab +mFOLFOX6 (Arm B)
Time Frame
Duration of Phase 3, approximately 36 months
Title
Phase 3: Time to response by blinded independent review and by Investigator
Description
Time to response, defined as the time from first dose to first radiographic evidence of response per RECIST v1.1: encorafenib + cetuximab (Arm A) vs Control Arm (Arm C) and encorafenib + cetuximab +mFOLFOX6 (Arm B) vs Control Arm (Arm C) and encorafenib + cetuximab (Arm A) vs encorafenib + cetuximab +mFOLFOX6 (Arm B)
Time Frame
Duration of Phase 3, approximately 36 months
Title
Phase 3: Progression free survival by Investigator and by blinded independent review
Description
Progression free survival, defined as the time from the first dose to the earliest documented disease progression per RECIST v1.1, or death due to any cause:: encorafenib + cetuximab (Arm A) vs Control Arm (Arm C) and encorafenib + cetuximab +mFOLFOX6 (Arm B) vs Control Arm (Arm C) and encorafenib + cetuximab (Arm A) vs encorafenib + cetuximab +mFOLFOX6 (Arm B)
Time Frame
Duration of Phase 3, approximately 36 months
Title
Phase 3: Progression free survival 2 by Investigator
Description
Progression free survival 2, defined as the time from the date of randomization to the second objective disease progression per RECIST v1.1, or death from any cause, whichever occurs first: encorafenib + cetuximab (Arm A) vs Control Arm (Arm C) and encorafenib + cetuximab +mFOLFOX6 (Arm B) vs Control Arm (Arm C) and encorafenib + cetuximab (Arm A) vs encorafenib + cetuximab +mFOLFOX6
Time Frame
Duration of Phase 3, approximately 36 months
Title
Phase 3: Incidence of adverse events
Description
An adverse event was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship: encorafenib + cetuximab (Arm A) and encorafenib + cetuximab +mFOLFOX6 (Arm B)
Time Frame
Duration of Phase 3, approximately 36 months
Title
Phase 3: Incidence of abnormal clinical laboratory parameters, abnormal vital signs and abnormal electrocardiograms
Description
Changes in clinical laboratory parameters, vital signs and electrocardiograms determined clinically significant at the investigator's discretion: encorafenib + cetuximab (Arm A) and encorafenib + cetuximab +mFOLFOX6 (Arm B)
Time Frame
Duration of Phase 3, approximately 36 months
Title
Phase 3: Change from Baseline in the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (EORTC QLQ-C30)
Description
EORTC QLQ-C30: included functional scales (physical, role, cognitive, emotional, and social), global health status, symptom scales (fatigue, pain, nausea/vomiting) and single items (dyspnoea, appetite loss, insomnia, constipation/diarrhea and financial difficulties). Most questions used 4 point scale (1 'Not at all' to 4 'Very much'; 2 questions used 7-point scale (1 'very poor' to 7 'Excellent'). Scores averaged, transformed to 0-100 scale; higher score=better level of functioning or greater degree of symptoms.
Time Frame
Duration of Phase 3, approximately 36 months
Title
Phase 3: Change from Baseline in the EuroQol-5D-5L (EQ-5D-5L) Questionnaire
Description
The EQ-5D-5L is a standardized measure of health utility that provides a single index value for the participant's health status. It is frequently used for economic evaluations of health care and has been shown to be a valid and reliable instrument, and comprises a short descriptive system questionnaire and a visual analogue scale (EQ VAS) that are cognitively undemanding, taking about 2 minutes to complete
Time Frame
Duration of Phase 3, approximately 36 months
Title
Phase 3: Change from Baseline in the Patient Global Impression of Severity (PGIS)
Description
The PGIS is a single-item questionnaire designed to assess participant's overall impression of disease severity at a given point in time.
Time Frame
Duration of Phase 3, approximately 36 months
Title
Phase 3: Change from Baseline in the Patient Global Impression of Change (PGIC) questionnaires
Description
The PGIC is a single-item questionnaire designed to assess the participant's overall sense of whether there has been a change in symptoms or quality of life since starting treatment.
Time Frame
Duration of Phase 3, approximately 36 months
Title
Phase 3: Confirm the MSI-status in tumor tissue
Description
Summarize MSI-status as determined by retrospective central testing of baseline tumor tissue
Time Frame
Once, pre-treatment
Title
Phase 3: Determine the correlation between cfDNA genetic alterations and clinical outcome
Description
BRAF V600E variant allele fraction (VAF) and/or overall mean VAF from cfDNA analysis of plasma samples collected at baseline and on treatment
Time Frame
Predose on Cycle 1 Day 1, 15, Cycle 2 Day 15, Cycle 7 Day 1 and EOT. Arm C sampling on Day 1 of Cycles 1-3, 9 and EOT. EOT is approx 36 months.
Title
Safety Lead-in: Maximum plasma concentration of encorafenib, LHY746, irinotecan and SN-38
Time Frame
Cycle 1 Day 1 and Day 15: predose, and 0.75, 1.5, 2.5, 3.5, 5.5 and 7.5 hours after dosing, Cycle 1 Day 3 and Day 17:predose and Cycle 2 through Cycle 6: Day 1 predose. Each cycle is 28 days
Title
Safety Lead-in: Area under the plasma concentration time curve of encorafenib, LHY746, irinotecan and SN-38
Time Frame
Cycle 1 Day 1 and Day 15: predose, and 0.75, 1.5, 2.5, 3.5, 5.5 and 7.5 hours after dosing, Cycle 1 Day 3 and Day 17:predose and Cycle 2 through Cycle 6: Day 1 predose. Each cycle is 28 days.
Title
Safety Lead-in: Time to maximim plasma concentration time curve of encorafenib, LHY746, irinotecan and SN-38
Time Frame
Cycle 1 Day 1 and Day 15: predose, and 0.75, 1.5, 2.5, 3.5, 5.5 and 7.5 hours after dosing, Cycle 1 Day 3 and Day 17:predose and Cycle 2 through Cycle 6: Day 1 predose. Each cycle is 28 days
Title
Safety Lead-in: Maximum plasma concentration of encorafenib, LHY746 and oxaliplatin
Time Frame
Cycle 1 Day 1 and Day 15: predose, and 1, 2, 3, 4, 6 and 8 hours after dosing, Cycle 1 Day 3 and Day 17: predose and Cycle 2 through Cycle 6: Day 1 predose. Each cycle is 28 days
Title
Safety Lead-in: Area under the plasma concentration time curve of encorafenib, LHY746 and oxaliplatin
Time Frame
Cycle 1 Day 1 and Day 15: predose, and 1, 2, 3, 4, 6 and 8 hours after dosing, Cycle 1 Day 3 and Day 17: predose and Cycle 2 through Cycle 6: Day 1 predose. Each cycle is 28 days
Title
Safety Lead-in: Clearance of irinotecan, SN-38 and oxaliplatin
Description
Changes in exposures of irinotecan and its metabolite (SN-38) on Cycle 1 Day 15 compared to Cycle 1 Day 1 in Cohort 1 (encorafenib and cetuximab + FOLFIRI) Changes in exposures of oxaliplatin on Cycle 1 Day 15 compared to Cycle 1 Day 1 in Cohort 2 (encorafenib and cetuximab + mFOLFOX6)
Time Frame
Cycle 1 Day 1 and Day 15: predose, and 0.75, 1.5, 2.5, 3.5, 5.5 and 7.5 hours after dosing, Cycle 1 Day 3 and Day 17:predose and Cycle 2 through Cycle 6: Day 1 predose. Each cycle is 28 days
Title
Safety Lead-in: Time to maximim plasma concentration time curve of encorafenib, LHY746 and oxaliplatin
Time Frame
Cycle 1 Day 1 and Day 15: predose, and 1, 2, 3, 4, 6 and 8 hours after dosing, Cycle 1 Day 3 and Day 17: predose and Cycle 2 through Cycle 6: Day 1 predose. Each cycle is 28 days
Title
Phase 3: Trough concentrations of encorafenib and its metabolite LHY746
Description
Trough plasma concentrations in all patients in Arm A and Arm B
Time Frame
Predose on Cycle 1 through Cycle 6. Each cycle is 28 days
Title
Cohort 3: Progression free survival by Investigator and by blinded independent review
Description
Progression free survival, defined as the time from the first dose to the earliest documented disease progression per RECIST v1.1, or death due to any cause.
Time Frame
Duration of Cohort 3, approximately 21 months
Title
Cohort 3: Overall response rate by investigator
Description
Overall response rate, defined as the proportion of participants who have achieved a confirmed best overall response per RECIST v 1.1
Time Frame
Duration of Cohort 3, approximately 21 months
Title
Cohort 3: Duration of response by Investigator and by blinded independent review
Description
Duration of response, defined as the time from the date of first radiographic evidence of response to the earliest documented disease progression per RECIST v1.1, or death due to any cause
Time Frame
Duration of Cohort 3, approximately 21 months
Title
Cohort 3: Time to response by Investigator and by blinded independent review
Description
Time to response, defined as the time from the date of randomization to first radiographic evidence of response per RECIST v1.1
Time Frame
Duration of Cohort 3, approximately 21 months
Title
Cohort 3: Overall survival
Description
Overall survival, defined as the time from the date of randomization to death due to any cause
Time Frame
Duration of Cohort 3, approximately 36 months
Title
Cohort 3: Incidence of adverse events
Description
An adverse event was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship: encorafenib + cetuximab (Arm A) and encorafenib + cetuximab +mFOLFOX6 (Arm B)
Time Frame
Duration of Cohort 3, approximately 21 months
Title
Cohort 3: Incidence of abnormal clinical laboratory parameters, abnormal vital signs and abnormal electrocardiograms
Description
Changes in clinical laboratory parameters, vital signs and electrocardiograms determined clinically significant at the investigator's discretion: encorafenib + cetuximab (Arm A) and encorafenib + cetuximab +mFOLFOX6 (Arm B)
Time Frame
Duration of Cohort 3, approximately 21 months
Title
Cohort 3: Change from Baseline in the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (EORTC QLQ-C30)
Description
EORTC QLQ-C30: included functional scales (physical, role, cognitive, emotional, and social), global health status, symptom scales (fatigue, pain, nausea/vomiting) and single items (dyspnoea, appetite loss, insomnia, constipation/diarrhea and financial difficulties). Most questions used 4 point scale (1 'Not at all' to 4 'Very much'; 2 questions used 7-point scale (1 'very poor' to 7 'Excellent'). Scores averaged, transformed to 0-100 scale; higher score=better level of functioning or greater degree of symptoms.
Time Frame
Duration of Cohort 3, approximately 21 months
Title
Cohort 3: Change from Baseline in the EuroQol-5D-5L (EQ-5D-5L) Questionnaire
Description
The EQ-5D-5L is a standardized measure of health utility that provides a single index value for the participant's health status. It is frequently used for economic evaluations of health care and has been shown to be a valid and reliable instrument, and comprises a short descriptive system questionnaire and a visual analogue scale (EQ VAS) that are cognitively undemanding, taking about 2 minutes to complete
Time Frame
Duration of Cohort 3, approximately 21 months
Title
Cohort 3: Change from Baseline in the Patient Global Impression of Severity (PGIS)
Description
The PGIS is a single-item questionnaire designed to assess participant's overall impression of disease severity at a given point in time.
Time Frame
Duration of Cohort 3, approximately 21 months
Title
Cohort 3: Change from Baseline in the Patient Global Impression of Change (PGIC) questionnaires
Description
The PGIC is a single-item questionnaire designed to assess the participant's overall sense of whether there has been a change in symptoms or quality of life since starting treatment.
Time Frame
Duration of Cohort 3, approximately 21 months
Title
Cohort 3: Confirm the MSI-status in tumor tissue
Description
Summarize MSI-status as determined by retrospective central testing of baseline tumor tissue
Time Frame
Once, pre-treatment
Title
Cohort 3: Determine the correlation between cfDNA genetic alterations and clinical outcome
Description
BRAF V600E variant allele fraction (VAF) and/or overall mean VAF from cfDNA analysis of plasma samples collected at baseline and on treatment
Time Frame
Predose on Cycle 1 Day 1, Cycle 1 Day 15, Cycle 2 Day 15, Cycle 7 Day 1 and End of Treatment (Duration of Cohort 3, approximately 21 months). Each cycle is 28 days.
Title
Cohort 3: Trough concentrations of encorafenib and its metabolite LHY746
Description
Trough plasma concentrations in all patients in Arm D
Time Frame
Predose on Cycle 1 through Cycle 6. Each cycle is 28 days
10. Eligibility
Sex
All
Minimum Age & Unit of Time
16 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Safety Lead-In = Male/female ≥ 18 years old
Phase 3 and Cohort 3: Male/female ≥ 16 years old (where permitted locally)
Histologically or cytologically confirmed Stage IV CRC that contains BRAF V600E mutation
Prior systemic treatment in metastatic setting: 0-1 regimens for Safety Lead In; none for Phase 3 and Cohort 3. (Note: Prior adjuvant or neoadjuvant therapy considered metastatic treatment if relapse/metastasis < 6 month from end of adj/neoadjuvant treatment )
Measurable disease (Phase 3 and Cohort 3)/ Measurable or evaluable disease (Safety Lead-in)
ECOG PS 0-1
Adequate organ function
Exclusion Criteria:
Tumors that are locally confirmed or unknown MSI-H or dMMR unless participant is ineligible to receive immune checkpoint inhibitors due to a pre-existing medical condition
Active bacterial or viral infections in 2 weeks prior to starting dosing
Symptomatic brain metastases
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Pfizer CT.gov Call Center
Phone
1-800-718-1021
Email
ClinicalTrials.gov_Inquiries@pfizer.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Pfizer CT.gov Call Center
Organizational Affiliation
Pfizer
Official's Role
Study Director
Facility Information:
Facility Name
Mayo Clinic - Phoenix Oncology Pharmacy
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85054
Country
United States
Individual Site Status
Recruiting
Facility Name
Mayo Clinic Hospital
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85054
Country
United States
Individual Site Status
Recruiting
Facility Name
Mayo Clinic in Arizona - Scottsdale
City
Scottsdale
State/Province
Arizona
ZIP/Postal Code
85259
Country
United States
Individual Site Status
Recruiting
Facility Name
Tower Hematology Oncology Medical Group (THO)
City
Beverly Hills
State/Province
California
ZIP/Postal Code
90211
Country
United States
Individual Site Status
Recruiting
Facility Name
Keck Hospital of USC
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Individual Site Status
Recruiting
Facility Name
LAC & USC Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Individual Site Status
Recruiting
Facility Name
USC / Norris Comprehensive Cancer Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Individual Site Status
Recruiting
Facility Name
USC/Norris Comprehensive Cancer Center / Investigational Drug Services
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Individual Site Status
Recruiting
Facility Name
USC/Norris Comprehensive Cancer Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Individual Site Status
Recruiting
Facility Name
Cedars- Sinai Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Individual Site Status
Recruiting
Facility Name
Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Individual Site Status
Recruiting
Facility Name
Cedars-Sinai Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Individual Site Status
Recruiting
Facility Name
Keck Hospital of USC Pasadena
City
Pasadena
State/Province
California
ZIP/Postal Code
91105
Country
United States
Individual Site Status
Recruiting
Facility Name
Torrance Memorial Medical Center (TMMC)
City
Torrance
State/Province
California
ZIP/Postal Code
90505
Country
United States
Individual Site Status
Recruiting
Facility Name
Georgetown University Medical Center
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20007
Country
United States
Individual Site Status
Recruiting
Facility Name
Medstar Georgetown University Hospital
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20007
Country
United States
Individual Site Status
Recruiting
Facility Name
Mount Sinai Comprehensive Cancer Center, Aventura
City
Aventura
State/Province
Florida
ZIP/Postal Code
33180
Country
United States
Individual Site Status
Recruiting
Facility Name
Sylvester Comprehensive Cancer Center- The Lennar Foundation Medical Center
City
Coral Gables
State/Province
Florida
ZIP/Postal Code
33146
Country
United States
Individual Site Status
Recruiting
Facility Name
Holy Cross Hospital - Michael and Dianne Bienes Comprehensive Cancer Center
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33308
Country
United States
Individual Site Status
Recruiting
Facility Name
Mayo Clinic Florida
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32224
Country
United States
Individual Site Status
Recruiting
Facility Name
Mount Sinai Comprehensive Cancer Center
City
Miami Beach
State/Province
Florida
ZIP/Postal Code
33140
Country
United States
Individual Site Status
Recruiting
Facility Name
Mount Sinai Medical Center
City
Miami Beach
State/Province
Florida
ZIP/Postal Code
33140
Country
United States
Individual Site Status
Recruiting
Facility Name
Sylvester Comprehensive Cancer Center
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Individual Site Status
Recruiting
Facility Name
Baptist Hospital of Miami
City
Miami
State/Province
Florida
ZIP/Postal Code
33176
Country
United States
Individual Site Status
Recruiting
Facility Name
Miami Cancer Institute
City
Miami
State/Province
Florida
ZIP/Postal Code
33176
Country
United States
Individual Site Status
Recruiting
Facility Name
Orlando Health Cancer Institute
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Individual Site Status
Recruiting
Facility Name
Orlando Health, Inc.
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Individual Site Status
Recruiting
Facility Name
Orlando Health, Inc
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Individual Site Status
Recruiting
Facility Name
BRCR Global
City
Plantation
State/Province
Florida
ZIP/Postal Code
33322
Country
United States
Individual Site Status
Recruiting
Facility Name
BRCR Medical Center Inc.
City
Plantation
State/Province
Florida
ZIP/Postal Code
33322
Country
United States
Individual Site Status
Recruiting
Facility Name
Lewis Cancer & Research Pavilion at St Joseph's/Candler Health System
City
Savannah
State/Province
Georgia
ZIP/Postal Code
31405
Country
United States
Individual Site Status
Recruiting
Facility Name
Lewis Cancer & Research Pavilion Pharmacy
City
Savannah
State/Province
Georgia
ZIP/Postal Code
31405
Country
United States
Individual Site Status
Recruiting
Facility Name
St. Joseph's/Candler Health System, Inc.
City
Savannah
State/Province
Georgia
ZIP/Postal Code
31405
Country
United States
Individual Site Status
Recruiting
Facility Name
Summit Cancer Care, P.C.
City
Savannah
State/Province
Georgia
ZIP/Postal Code
31405
Country
United States
Individual Site Status
Recruiting
Facility Name
Summit Cancer Care
City
Savannah
State/Province
Georgia
ZIP/Postal Code
31405
Country
United States
Individual Site Status
Recruiting
Facility Name
St. Joseph's/Candler Health System, Inc.
City
Savannah
State/Province
Georgia
ZIP/Postal Code
31419
Country
United States
Individual Site Status
Recruiting
Facility Name
UChicago Medicine - River East
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611
Country
United States
Individual Site Status
Recruiting
Facility Name
The University of Chicago Medical Center, CCD - Investigational Drug Service Pharmacy
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
Individual Site Status
Recruiting
Facility Name
University of Chicago Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
Individual Site Status
Recruiting
Facility Name
UChicago Medicine at Ingalls - Flossmoor
City
Flossmoor
State/Province
Illinois
ZIP/Postal Code
60422
Country
United States
Individual Site Status
Recruiting
Facility Name
UChicago Medicine Ingalls Memorial
City
Harvey
State/Province
Illinois
ZIP/Postal Code
60426
Country
United States
Individual Site Status
Recruiting
Facility Name
University of Chicago Comprehensive Cancer Center at Silver Cross Hospital
City
New Lenox
State/Province
Illinois
ZIP/Postal Code
60451
Country
United States
Individual Site Status
Recruiting
Facility Name
The University of Chicago Medicine Center for Advanced Care Orland Park
City
Orland Park
State/Province
Illinois
ZIP/Postal Code
60462
Country
United States
Individual Site Status
Recruiting
Facility Name
UChicago Medicine at Ingalls - Tinley Park
City
Tinley Park
State/Province
Illinois
ZIP/Postal Code
60477
Country
United States
Individual Site Status
Recruiting
Facility Name
Ochsner Clinic Foundation Research Pharmacy
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Individual Site Status
Recruiting
Facility Name
Ochsner Clinic Foundation
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Individual Site Status
Recruiting
Facility Name
University of Michigan Hospitals
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Individual Site Status
Recruiting
Facility Name
University of Michigan
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Individual Site Status
Recruiting
Facility Name
Mayo Clinic in Rochester, Minnesota
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Individual Site Status
Recruiting
Facility Name
Mayo Clinic Rochester
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Individual Site Status
Recruiting
Facility Name
Mayo Clinic
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Individual Site Status
Recruiting
Facility Name
Siteman Cancer Center - West County
City
Creve Coeur
State/Province
Missouri
ZIP/Postal Code
63141
Country
United States
Individual Site Status
Recruiting
Facility Name
Siteman Cancer Center - North County
City
Florissant
State/Province
Missouri
ZIP/Postal Code
63031
Country
United States
Individual Site Status
Recruiting
Facility Name
Barnes- Jewish Hospital
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Individual Site Status
Recruiting
Facility Name
Washington University School of Medicine
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Individual Site Status
Recruiting
Facility Name
Siteman Cancer Center - South County
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63129
Country
United States
Individual Site Status
Recruiting
Facility Name
Siteman Cancer Center - St Peters
City
Saint Peters
State/Province
Missouri
ZIP/Postal Code
63376
Country
United States
Individual Site Status
Recruiting
Facility Name
St Vincent Healthcare
City
Billings
State/Province
Montana
ZIP/Postal Code
59101
Country
United States
Individual Site Status
Recruiting
Facility Name
St. Vincent Frontier Cancer Center
City
Billings
State/Province
Montana
ZIP/Postal Code
59102
Country
United States
Individual Site Status
Recruiting
Facility Name
Oncology Hematology West PC dba Nebraska Cancer Specialists
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68114
Country
United States
Individual Site Status
Recruiting
Facility Name
Oncology Hematology West PC dba Nebraska Cancer Specialists
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68124
Country
United States
Individual Site Status
Recruiting
Facility Name
Oncology Hematology West PC dba Nebraska Cancer Specialists
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68130
Country
United States
Individual Site Status
Recruiting
Facility Name
Oncology Hematology West, PC dba Nebraska Cancer Specialists - IP Storage
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68130
Country
United States
Individual Site Status
Recruiting
Facility Name
Oncology Hematology West PC dba Nebraska Cancer Specialists
City
Papillion
State/Province
Nebraska
ZIP/Postal Code
68046
Country
United States
Individual Site Status
Recruiting
Facility Name
Memorial Sloan Kettering Cancer Center - Basking Ridge
City
Basking Ridge
State/Province
New Jersey
ZIP/Postal Code
07920
Country
United States
Individual Site Status
Recruiting
Facility Name
Summit Medical Group
City
Berkeley Heights
State/Province
New Jersey
ZIP/Postal Code
07922
Country
United States
Individual Site Status
Recruiting
Facility Name
Summit Medical Group
City
Florham Park
State/Province
New Jersey
ZIP/Postal Code
07932
Country
United States
Individual Site Status
Recruiting
Facility Name
Memorial Sloan Kettering Cancer Center- Monmouth
City
Middletown
State/Province
New Jersey
ZIP/Postal Code
07748
Country
United States
Individual Site Status
Recruiting
Facility Name
Memorial Sloan Kettering Cancer Center- Bergen
City
Montvale
State/Province
New Jersey
ZIP/Postal Code
07645
Country
United States
Individual Site Status
Recruiting
Facility Name
North Shore Hematology Oncology Assoc. P.C. DBA NY Cancer and Blood Specialists
City
Babylon
State/Province
New York
ZIP/Postal Code
11702
Country
United States
Individual Site Status
Recruiting
Facility Name
North Shore Hematology Oncology Assoc. P.C. DBA NY Cancer and Blood Specialists
City
Bronx
State/Province
New York
ZIP/Postal Code
10469
Country
United States
Individual Site Status
Recruiting
Facility Name
Memorial Sloan Kettering Cancer Center Commack
City
Commack
State/Province
New York
ZIP/Postal Code
11725
Country
United States
Individual Site Status
Recruiting
Facility Name
Memorial Sloan Kettering Cancer Center - Westchester
City
Harrison
State/Province
New York
ZIP/Postal Code
10604
Country
United States
Individual Site Status
Recruiting
Facility Name
Memorial Sloan Kettering Cancer Center
City
New York
State/Province
New York
ZIP/Postal Code
10022
Country
United States
Individual Site Status
Recruiting
Facility Name
North Shore Hematology Oncology Assoc. P.C. DBA NY Cancer and Blood Specialists
City
New York
State/Province
New York
ZIP/Postal Code
10028
Country
United States
Individual Site Status
Recruiting
Facility Name
Memorial Sloan Kettering Cancer Center - Main Campus
City
New York
State/Province
New York
ZIP/Postal Code
10065
Country
United States
Individual Site Status
Recruiting
Facility Name
North Shore Hematology Oncology Assoc. P.C. DBA NY Cancer and Blood Specialists
City
Patchogue
State/Province
New York
ZIP/Postal Code
11772
Country
United States
Individual Site Status
Recruiting
Facility Name
North Shore Hematology Oncology Assoc. P.C. DBA NY Cancer and Blood Specialists
City
Port Jefferson Station
State/Province
New York
ZIP/Postal Code
11776
Country
United States
Individual Site Status
Recruiting
Facility Name
North Shore Hematology Oncology Assoc. P.C. DBA NY Cancer and Blood Specialists
City
Riverhead
State/Province
New York
ZIP/Postal Code
11901
Country
United States
Individual Site Status
Recruiting
Facility Name
Memorial Sloan Kettering Cancer Center- Nassau
City
Uniondale
State/Province
New York
ZIP/Postal Code
11553
Country
United States
Individual Site Status
Recruiting
Facility Name
Carolinas Medical Center
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28203
Country
United States
Individual Site Status
Recruiting
Facility Name
Carolinas Medical Center Investigational Drug Services
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Individual Site Status
Recruiting
Facility Name
Levine Cancer Institute
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Individual Site Status
Recruiting
Facility Name
Atrium Health Mercy
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28207
Country
United States
Individual Site Status
Recruiting
Facility Name
Atrium Health Pineville
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28210
Country
United States
Individual Site Status
Recruiting
Facility Name
Levine Cancer Institute - Southpark
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28211
Country
United States
Individual Site Status
Recruiting
Facility Name
Atrium Health University City
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28262
Country
United States
Individual Site Status
Recruiting
Facility Name
Levine Cancer Institute University City
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28262
Country
United States
Individual Site Status
Recruiting
Facility Name
Atrium Health Cabarrus
City
Concord
State/Province
North Carolina
ZIP/Postal Code
28025
Country
United States
Individual Site Status
Recruiting
Facility Name
Levine Cancer Institute - Concord
City
Concord
State/Province
North Carolina
ZIP/Postal Code
28025
Country
United States
Individual Site Status
Recruiting
Facility Name
Atrium Health Union
City
Monroe
State/Province
North Carolina
ZIP/Postal Code
28112
Country
United States
Individual Site Status
Recruiting
Facility Name
Cleveland Clinic Taussig Cancer Center Investigational Pharmacy
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Individual Site Status
Recruiting
Facility Name
Cleveland Clinic
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Individual Site Status
Recruiting
Facility Name
Investigational Drug Service, The Ohio State University Wexner Medical Center
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Individual Site Status
Recruiting
Facility Name
The Ohio State University James Cancer Hospital and Solove Research Institute
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Individual Site Status
Recruiting
Facility Name
Stefanie Spielman Comprehensive Breast Cancer
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43212
Country
United States
Individual Site Status
Recruiting
Facility Name
Martha Morehouse Medical Plaza
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43221
Country
United States
Individual Site Status
Recruiting
Facility Name
The James Outpatient Care West Campus
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43221
Country
United States
Individual Site Status
Recruiting
Facility Name
University of Oklahoma Health Sciences Center, OU Health Stephenson Cancer Center
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73104
Country
United States
Individual Site Status
Recruiting
Facility Name
Providence Cancer Institute Franz Clinic
City
Portland
State/Province
Oregon
ZIP/Postal Code
97213
Country
United States
Individual Site Status
Recruiting
Facility Name
Providence Portland Medical Center
City
Portland
State/Province
Oregon
ZIP/Postal Code
97213
Country
United States
Individual Site Status
Recruiting
Facility Name
Providence Onc and Heme Care Clinic - Westside
City
Portland
State/Province
Oregon
ZIP/Postal Code
97225
Country
United States
Individual Site Status
Recruiting
Facility Name
Providence Oncology and Hematology Care Clinic - Westside
City
Portland
State/Province
Oregon
ZIP/Postal Code
97225
Country
United States
Individual Site Status
Recruiting
Facility Name
Providence St Vincent Medical Center
City
Portland
State/Province
Oregon
ZIP/Postal Code
97225
Country
United States
Individual Site Status
Recruiting
Facility Name
Providence St. Vincent Medical Center
City
Portland
State/Province
Oregon
ZIP/Postal Code
97225
Country
United States
Individual Site Status
Recruiting
Facility Name
AHN Cancer Institute at Jefferson Hospital
City
Jefferson Hills
State/Province
Pennsylvania
ZIP/Postal Code
15025
Country
United States
Individual Site Status
Recruiting
Facility Name
AHN Cancer Institute Forbes Hospital
City
Monroeville
State/Province
Pennsylvania
ZIP/Postal Code
15146
Country
United States
Individual Site Status
Recruiting
Facility Name
AHN Cancer Institute - Allegheny General Hospital
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15212
Country
United States
Individual Site Status
Recruiting
Facility Name
AHN Cancer Institute Pharmacy
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15212
Country
United States
Individual Site Status
Recruiting
Facility Name
AHN Cancer Institute West Penn Hospital
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15224
Country
United States
Individual Site Status
Recruiting
Facility Name
UPMC Hillman Cancer Center Investigational Drug Service
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15232
Country
United States
Individual Site Status
Recruiting
Facility Name
UPMC Hillman Cancer Center
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15232
Country
United States
Individual Site Status
Recruiting
Facility Name
Wexford Health and Wellness Pavilion
City
Wexford
State/Province
Pennsylvania
ZIP/Postal Code
15090
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens Clarksville
City
Clarksville
State/Province
Tennessee
ZIP/Postal Code
37043
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens Cool Springs
City
Franklin
State/Province
Tennessee
ZIP/Postal Code
37067
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens Gallatin
City
Gallatin
State/Province
Tennessee
ZIP/Postal Code
37066
Country
United States
Individual Site Status
Recruiting
Facility Name
The West Clinic. PLLC. dba West Cancer Center
City
Germantown
State/Province
Tennessee
ZIP/Postal Code
38138
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens Hendersonville
City
Hendersonville
State/Province
Tennessee
ZIP/Postal Code
37075
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens Hermitage
City
Hermitage
State/Province
Tennessee
ZIP/Postal Code
37076
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens La Vergne
City
La Vergne
State/Province
Tennessee
ZIP/Postal Code
37086
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens Lebanon
City
Lebanon
State/Province
Tennessee
ZIP/Postal Code
37087
Country
United States
Individual Site Status
Recruiting
Facility Name
The West Clinic PLLC dba West Cancer Center
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38104
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens Murfreesboro
City
Murfreesboro
State/Province
Tennessee
ZIP/Postal Code
37128
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens Belle Meade
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37205
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens Nippers Corner
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37211
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens Donelson
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37214
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens Hart Lane
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37216
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens Bellevue
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37221
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt-Ingram Cancer Center
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232-6307
Country
United States
Individual Site Status
Recruiting
Facility Name
Henry-Joyce Cancer Center
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Oncology IDS Pharmacy
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232
Country
United States
Individual Site Status
Recruiting
Facility Name
Vanderbilt Health Clinic at Walgreens Smyrna
City
Smyrna
State/Province
Tennessee
ZIP/Postal Code
37167
Country
United States
Individual Site Status
Recruiting
Facility Name
The University of Texas MD Anderson Cancer Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77030-4009
Country
United States
Individual Site Status
Recruiting
Facility Name
The University of Texas MD Anderson Cancer Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Individual Site Status
Recruiting
Facility Name
VCU Health System, Investigational Drug Service Pharmacy
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23298
Country
United States
Individual Site Status
Recruiting
Facility Name
Virginia Commonwealth University Massey Cancer Center
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23298
Country
United States
Individual Site Status
Recruiting
Facility Name
Seattle Cancer Care Alliance
City
Seattle
State/Province
Washington
ZIP/Postal Code
98109
Country
United States
Individual Site Status
Recruiting
Facility Name
University of Washington Medical Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98195
Country
United States
Individual Site Status
Recruiting
Facility Name
University of Wisconsin Clinical Science Center
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53792
Country
United States
Individual Site Status
Recruiting
Facility Name
Froedtert Hospital and the Medical College of Wisconsin
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226
Country
United States
Individual Site Status
Recruiting
Facility Name
Centro Medico San Roque
City
San Miguel De Tucumán
State/Province
Tucumán
ZIP/Postal Code
4000
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Centro Medico San Roque
City
Tucuman
State/Province
Tucumán
ZIP/Postal Code
4000
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Instituto Médico Especializado Alexander Fleming
City
Ciudad Autónoma de Buenos Aires
ZIP/Postal Code
1426
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Clinica Universitaria Reina Fabiola
City
Cordoba
ZIP/Postal Code
X5004FHP
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Hospital Privado Centro Médico de Córdoba
City
Cordoba
ZIP/Postal Code
X5016KEH
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Hospital Privado Centro Médico de Córdoba
City
Córdoba
ZIP/Postal Code
X5016KEH
Country
Argentina
Individual Site Status
Recruiting
Facility Name
Chris O'Brien Lifehouse
City
Camperdown
State/Province
New South Wales
ZIP/Postal Code
2050
Country
Australia
Individual Site Status
Recruiting
Facility Name
Liverpool Hospital
City
Liverpool
State/Province
New South Wales
ZIP/Postal Code
2170
Country
Australia
Individual Site Status
Recruiting
Facility Name
Slade Pharmacy
City
Mount Kuring-Gai
State/Province
New South Wales
ZIP/Postal Code
2080
Country
Australia
Individual Site Status
Recruiting
Facility Name
GenesisCare - North Shore
City
St Leonards
State/Province
New South Wales
ZIP/Postal Code
2065
Country
Australia
Individual Site Status
Recruiting
Facility Name
GenesisCare North Shore
City
St Leonards
State/Province
New South Wales
ZIP/Postal Code
2065
Country
Australia
Individual Site Status
Recruiting
Facility Name
Royal Brisbane & Women's Hospital
City
Herston
State/Province
Queensland
ZIP/Postal Code
4029
Country
Australia
Individual Site Status
Recruiting
Facility Name
Princess Alexandra Hospital
City
Woolloongabba
State/Province
Queensland
ZIP/Postal Code
4102
Country
Australia
Individual Site Status
Recruiting
Facility Name
The Queen Elizabeth Hospital
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5011
Country
Australia
Individual Site Status
Recruiting
Facility Name
Monash Health
City
Clayton
State/Province
Victoria
ZIP/Postal Code
3168
Country
Australia
Individual Site Status
Recruiting
Facility Name
Austin Health
City
Heidelberg
State/Province
Victoria
ZIP/Postal Code
3084
Country
Australia
Individual Site Status
Recruiting
Facility Name
Peter MacCallum Cancer Centre
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3000
Country
Australia
Individual Site Status
Recruiting
Facility Name
Alfred Health
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3004
Country
Australia
Individual Site Status
Recruiting
Facility Name
Université Libre de Bruxelles - Hôpital Erasme
City
Brussels
State/Province
Bruxelles-capitale, Région DE
ZIP/Postal Code
1070
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Cliniques universitaires Saint-Luc
City
Brussels
State/Province
Bruxelles-capitale, Région DE
ZIP/Postal Code
1200
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Grand Hôpital de Charleroi
City
Charleroi
State/Province
Hainaut
ZIP/Postal Code
6000
Country
Belgium
Individual Site Status
Recruiting
Facility Name
CHR Verviers East Belgium
City
Verviers
State/Province
Liège
ZIP/Postal Code
4800
Country
Belgium
Individual Site Status
Recruiting
Facility Name
AZ Groeninge Campus Kennedylaan
City
Kortrijk
State/Province
West-vlaanderen
ZIP/Postal Code
8500
Country
Belgium
Individual Site Status
Recruiting
Facility Name
ZNA Middelheim
City
Antwerpen
ZIP/Postal Code
2020
Country
Belgium
Individual Site Status
Recruiting
Facility Name
UZ Leuven
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
City
Liège
ZIP/Postal Code
4000
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Hospital Bruno Born
City
Lajeado
State/Province
RIO Grande DO SUL
ZIP/Postal Code
95900-000
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital Bruno Born
City
Lajeado
State/Province
RIO Grande DO SUL
ZIP/Postal Code
95900-010
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital Bruno Born
City
Lajeado
State/Province
RIO Grande DO SUL
ZIP/Postal Code
95900-022
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital de Clinicas de Porto Alegre
City
Porto Alegre
State/Province
RIO Grande DO SUL
ZIP/Postal Code
90035-903
Country
Brazil
Individual Site Status
Recruiting
Facility Name
INCA
City
Rio de Janeiro
State/Province
RJ
ZIP/Postal Code
20230-130
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA
City
Rio de Janeiro
State/Province
RJ
ZIP/Postal Code
20230-130
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Reichow - Centro de Ensino e Pesquisa
City
Blumenau
State/Province
Santa Catarina
ZIP/Postal Code
89010-340
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Clínica de Neoplasias Litoral
City
Itajaí
State/Province
Santa Catarina
ZIP/Postal Code
88301-220
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital do Cancer de Barretos - Fundacao Pio XII
City
Barretos
State/Province
SP
ZIP/Postal Code
14784-400
Country
Brazil
Individual Site Status
Recruiting
Facility Name
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - Faculdade de Medicina do ABC
City
Santo Andre
State/Province
SP
ZIP/Postal Code
09060-650
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Fundacao do ABC-Faculdade de Medicina do ABC
City
Santo Andre
State/Province
SP
ZIP/Postal Code
09060-870
Country
Brazil
Individual Site Status
Recruiting
Facility Name
FUNDAÇÃO DO ABC - Faculdade de Medicina do ABC - Centro de Estudos e Pesquisas de Hematologia e On
City
Santo Andre
State/Province
SP
ZIP/Postal Code
09060-870
Country
Brazil
Individual Site Status
Recruiting
Facility Name
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - Faculdade de Medicina do ABC
City
Santo André
State/Province
SP
ZIP/Postal Code
09060-650
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Instituto do Cancer do Estado de Sao Paulo, ICESP
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
01246-000
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Fundação Pio XII - Hospital de Câncer de Barretos
City
Barretos
State/Province
SÃO Paulo
ZIP/Postal Code
14784400
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Medical School Famerp-HB-FUNFARME_Do not use - Duplicate facility
City
Sao jose do Rio Preto
State/Province
SÃO Paulo
ZIP/Postal Code
15090-000
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Fundação Faculdade Regional de Medicina de São José do Rio Preto
City
São José do Rio Preto
State/Province
SÃO Paulo
ZIP/Postal Code
15090000
Country
Brazil
Individual Site Status
Recruiting
Facility Name
MHAT Uni Hospital OOD
City
Panagyurishte
State/Province
Pazardzhik
ZIP/Postal Code
4500
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
MHAT "Dr. Tota Venkova" AD
City
Gabrovo
ZIP/Postal Code
5300
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Complex Oncology Center - Plovdiv EOOD
City
Plovdiv
ZIP/Postal Code
4000
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
MHAT Central Onco Hospital OOD
City
Plovdiv
ZIP/Postal Code
4000
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Complex Oncology Center - Plovdiv EOOD
City
Plovdiv
ZIP/Postal Code
4004
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Medical Center Nadezhda Clinical EOOD
City
Sofia
ZIP/Postal Code
1303
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Acibadem City Clinic MHAT Tokuda
City
Sofia
ZIP/Postal Code
1407
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
University Multiprofile Hospital for Active Treatment Sofiamed
City
Sofia
ZIP/Postal Code
1750
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Tom Baker Cancer Centre
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4N2
Country
Canada
Individual Site Status
Recruiting
Facility Name
Cross Cancer Institute
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 1Z2
Country
Canada
Individual Site Status
Recruiting
Facility Name
Kingston Health Sciences Centre-Kingston General Hospital Site
City
Kingston
State/Province
Ontario
ZIP/Postal Code
K7L 2V7
Country
Canada
Individual Site Status
Recruiting
Facility Name
London Regional Cancer Program, London Health Sciences Centre
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5W9
Country
Canada
Individual Site Status
Recruiting
Facility Name
Sunnybrook Health Sciences Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N 3M5
Country
Canada
Individual Site Status
Recruiting
Facility Name
Centre Intégré de Santé et de Services Sociaux (CISSS) de Laval / Hôpital de la Cité-de-la-Sant
City
Laval
State/Province
Quebec
ZIP/Postal Code
H7M 3L9
Country
Canada
Individual Site Status
Recruiting
Facility Name
Jewish General Hospital
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3T 1E2
Country
Canada
Individual Site Status
Recruiting
Facility Name
Anhui Provincial Cancer Hospital
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230031
Country
China
Individual Site Status
Not yet recruiting
Facility Name
The First Affiliated Hospital of Anhui Medical University
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230088
Country
China
Individual Site Status
Recruiting
Facility Name
Cancer Hospital Chinese Academy of Medical Science
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100021
Country
China
Individual Site Status
Recruiting
Facility Name
Beijing Cancer hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100142
Country
China
Individual Site Status
Recruiting
Facility Name
Beijing Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100730
Country
China
Individual Site Status
Recruiting
Facility Name
Chongqing University Cancer Hospital
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400030
Country
China
Individual Site Status
Recruiting
Facility Name
Fujian Medical University Union Hospital-1 Bingfanglou
City
Fuzhou
State/Province
Fujian
ZIP/Postal Code
350001
Country
China
Individual Site Status
Recruiting
Facility Name
Guangdong Provincial People's Hospital
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510080
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Guangdong Provincial People's Hospital
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510080
Country
China
Individual Site Status
Recruiting
Facility Name
The Sixth Affiliated Hospital of Sun Yat-sen University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510655
Country
China
Individual Site Status
Not yet recruiting
Facility Name
Affiliated Tumor Hospital of Guangxi Medical University
City
Nanning
State/Province
Guangxi
ZIP/Postal Code
530021
Country
China
Individual Site Status
Recruiting
Facility Name
Henan provincial people's hospital
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450003
Country
China
Individual Site Status
Recruiting
Facility Name
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430030
Country
China
Individual Site Status
Recruiting
Facility Name
The Second Xiangya Hospital of Central South University
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410011
Country
China
Individual Site Status
Recruiting
Facility Name
The Third Xiangya Hospital of Central South University
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410013
Country
China
Individual Site Status
Recruiting
Facility Name
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210008
Country
China
Individual Site Status
Recruiting
Facility Name
Shengjing Hospital Of China Medical University
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110022
Country
China
Individual Site Status
Recruiting
Facility Name
Jinan Central Hospital
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250013
Country
China
Individual Site Status
Recruiting
Facility Name
Shandong province cancer hospital
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250117
Country
China
Individual Site Status
Recruiting
Facility Name
The Affiliated Hospital of Qingdao University
City
Qingdao
State/Province
Shandong
ZIP/Postal Code
266031
Country
China
Individual Site Status
Recruiting
Facility Name
Shanghai Jiaotong University School of Medicine Ruijin Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200025
Country
China
Individual Site Status
Recruiting
Facility Name
Shanghai General Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200080
Country
China
Individual Site Status
Recruiting
Facility Name
Sichuan Province Cancer Hospital
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610041
Country
China
Individual Site Status
Recruiting
Facility Name
Yunnan Cancer Hospital(The Third Affiliated Hospital of Kunming Medical University)
City
Kunming
State/Province
Yunnan
ZIP/Postal Code
650118
Country
China
Individual Site Status
Recruiting
Facility Name
The second Affiliated Hospital of College of Medicine, Zhejiang University
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Individual Site Status
Recruiting
Facility Name
Peking University First Hospital
City
Beijing
ZIP/Postal Code
100034
Country
China
Individual Site Status
Recruiting
Facility Name
Fudan University Shanghai Cancer Center
City
Shanghai
ZIP/Postal Code
201321
Country
China
Individual Site Status
Recruiting
Facility Name
Tianjin Union Medical Center
City
Tianjin
ZIP/Postal Code
300000
Country
China
Individual Site Status
Recruiting
Facility Name
Fakultní nemocnice Brno Bohunice
City
Brno
State/Province
Brno-město
ZIP/Postal Code
625 00
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni nemocnice Hradec Kralove
City
Hradec Kralove
State/Province
Hradec Králové
ZIP/Postal Code
500 05
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni Thomayerova nemocnice
City
Prague
State/Province
Praha 4
ZIP/Postal Code
14059
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni nemocnice Olomouc
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni nemocnice v Motole
City
Praha 5
ZIP/Postal Code
150 06
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni nemocnice Bulovka
City
Praha 8
ZIP/Postal Code
180 81
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Aalborg Universitetshospital, Syd
City
Aalborg
State/Province
Nordjylland
ZIP/Postal Code
9000
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Vejle Hospital-Sygehus Lillebaelt
City
Vejle
State/Province
Syddanmark
ZIP/Postal Code
7100
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Vejle Sygehus
City
Vejle
State/Province
Syddanmark
ZIP/Postal Code
7100
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Aalborg Universitetshospital
City
Aalborg
ZIP/Postal Code
9000
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Rigshospitalet
City
Copenhagen
ZIP/Postal Code
2100
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Herlev and Gentofte Hospital
City
Herlev
ZIP/Postal Code
2730
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Odense University Hospital
City
Odense C
ZIP/Postal Code
5000
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Docrates Syöpäsairaala
City
Helsinki
State/Province
Nyland
ZIP/Postal Code
00180
Country
Finland
Individual Site Status
Recruiting
Facility Name
Tampereen yliopistollinen sairaala
City
Tampere
State/Province
Pirkanmaa
ZIP/Postal Code
33520
Country
Finland
Individual Site Status
Recruiting
Facility Name
Helsinki University Central Hospital
City
Helsinki
ZIP/Postal Code
00029
Country
Finland
Individual Site Status
Recruiting
Facility Name
Oulu University Hospital
City
Oulu
ZIP/Postal Code
90220
Country
Finland
Individual Site Status
Recruiting
Facility Name
Satakunnan Keskussairaala
City
Pori
ZIP/Postal Code
28500
Country
Finland
Individual Site Status
Recruiting
Facility Name
Tampereen yliopistollinen sairaala
City
Tampere
ZIP/Postal Code
33520
Country
Finland
Individual Site Status
Recruiting
Facility Name
Turku University Hospital
City
Turku
ZIP/Postal Code
20520
Country
Finland
Individual Site Status
Recruiting
Facility Name
Muenchen Klinik Neuperlach, Klinik fuer Haematologie und Onkologie
City
Muenchen
State/Province
Bayern
ZIP/Postal Code
81737
Country
Germany
Individual Site Status
Recruiting
Facility Name
Institut für Klinisch Onkologische Forschung
City
Frankfurt
State/Province
Hessen
ZIP/Postal Code
60488
Country
Germany
Individual Site Status
Recruiting
Facility Name
Medizinische Hochschule Hannover
City
Hannover
State/Province
Lower Saxony
ZIP/Postal Code
30625
Country
Germany
Individual Site Status
Recruiting
Facility Name
Medizinische Hochschule Hannover
City
Hannover
State/Province
Niedersachsen
ZIP/Postal Code
30625
Country
Germany
Individual Site Status
Recruiting
Facility Name
Universitätsklinikum Leipzig
City
Leipzig
State/Province
Sachsen
ZIP/Postal Code
04103
Country
Germany
Individual Site Status
Recruiting
Facility Name
Radiologie Berlin
City
Berlin - Charlottenburg
ZIP/Postal Code
10719
Country
Germany
Individual Site Status
Recruiting
Facility Name
Onkologische Schwerpunktpraxis Kurfuerstendamm
City
Berlin
ZIP/Postal Code
10707
Country
Germany
Individual Site Status
Recruiting
Facility Name
Waage Apotheke
City
Berlin
ZIP/Postal Code
10709
Country
Germany
Individual Site Status
Recruiting
Facility Name
HELIOS Klinikum Berlin Buch GmbH
City
Berlin
ZIP/Postal Code
13125
Country
Germany
Individual Site Status
Recruiting
Facility Name
Helios Klinikum Berlin-Buch
City
Berlin
ZIP/Postal Code
13125
Country
Germany
Individual Site Status
Recruiting
Facility Name
Technische Universität Dresden, Medizinische Fakultät Carl Gustav Carus
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Individual Site Status
Recruiting
Facility Name
Universitätsklinikum Carl Gustav Carus Dresden
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Individual Site Status
Recruiting
Facility Name
Facharztzentrum Eppendorf
City
Hamburg
ZIP/Postal Code
20249
Country
Germany
Individual Site Status
Recruiting
Facility Name
ZytoService Deutschland GmbH, Standort-Hamburg-Jenfeld
City
Hamburg
ZIP/Postal Code
22045
Country
Germany
Individual Site Status
Recruiting
Facility Name
Radiologie im Israelitischen Krankenhaus
City
Hamburg
ZIP/Postal Code
22297
Country
Germany
Individual Site Status
Recruiting
Facility Name
Klinikum Oldenburg AöR
City
Oldenburg
ZIP/Postal Code
26133
Country
Germany
Individual Site Status
Recruiting
Facility Name
Klinikum Oldenburg AöR
City
Oldenburg
ZIP/Postal Code
26135
Country
Germany
Individual Site Status
Recruiting
Facility Name
Rajiv Gandhi Cancer Institute And Research Centre
City
New Delhi
State/Province
Delhi
ZIP/Postal Code
110 085
Country
India
Individual Site Status
Recruiting
Facility Name
Rajiv Gandhi Cancer Institute And Research Centre
City
New Delhi
State/Province
Delhi
ZIP/Postal Code
110085
Country
India
Individual Site Status
Recruiting
Facility Name
Tata Memorial Hospital
City
Mumbai
State/Province
Maharashtra
ZIP/Postal Code
400012
Country
India
Individual Site Status
Recruiting
Facility Name
Deenanath Mangeshkar Hospital & Research Centre
City
Pune
State/Province
Maharashtra
ZIP/Postal Code
411 004
Country
India
Individual Site Status
Recruiting
Facility Name
Sahyadri Speciality Hospital
City
Pune
State/Province
Maharashtra
ZIP/Postal Code
411 004
Country
India
Individual Site Status
Recruiting
Facility Name
Bhakti Vedanta Hospital and Research Institute
City
Thane
State/Province
Maharashtra
ZIP/Postal Code
401107
Country
India
Individual Site Status
Recruiting
Facility Name
R K Birla Cancer Center, SMS Hospital
City
Jaipur
State/Province
Rajasthan
ZIP/Postal Code
302004
Country
India
Individual Site Status
Recruiting
Facility Name
Sawai Man Singh Medical College Hospital (SMS Hospital)
City
Jaipur
State/Province
Rajasthan
ZIP/Postal Code
302004
Country
India
Individual Site Status
Recruiting
Facility Name
Azienda Ospedaliera Universitaria di Cagliari - Presidio Policlinico Universitario "D.Casula"
City
Monserrato (CA)
State/Province
Cagliari
ZIP/Postal Code
09042
Country
Italy
Individual Site Status
Recruiting
Facility Name
IRCCS Casa Sollievo della Sofferenza
City
San Giovanni Rotondo
State/Province
Foggia
ZIP/Postal Code
71013
Country
Italy
Individual Site Status
Recruiting
Facility Name
ASST Grande Ospedale Metropolitano Niguarda
City
Milan
State/Province
Milano
ZIP/Postal Code
20162
Country
Italy
Individual Site Status
Recruiting
Facility Name
Fondazione del Piemonte per l'Oncologia - Istituto di Candiolo IRCCS
City
Candiolo
State/Province
Torino
ZIP/Postal Code
10060
Country
Italy
Individual Site Status
Recruiting
Facility Name
Azienda Ospedaliero Universitaria San Luigi Gonzaga
City
Orbassano
State/Province
Torino
ZIP/Postal Code
10043
Country
Italy
Individual Site Status
Recruiting
Facility Name
Fondazione Poliambulanza Istituto Ospedaliero
City
Brescia
ZIP/Postal Code
25124
Country
Italy
Individual Site Status
Recruiting
Facility Name
Istituto Europeo di Oncologia IRCCS
City
Milano
ZIP/Postal Code
20141
Country
Italy
Individual Site Status
Recruiting
Facility Name
Azienda Ospedaliera Universitaria dell'Università "Luigi Vanvitelli" di Napoli
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Individual Site Status
Recruiting
Facility Name
IRCCS Istituto Oncologico Veneto (IOV)
City
Padova
ZIP/Postal Code
35128
Country
Italy
Individual Site Status
Recruiting
Facility Name
Azienda USL - IRCCS di Reggio Emilia - Arcispedale Santa Maria Nuova
City
Reggio Emilia
ZIP/Postal Code
42123
Country
Italy
Individual Site Status
Recruiting
Facility Name
Chiba cancer center
City
Chiba-shi
State/Province
Chiba
ZIP/Postal Code
260-8717
Country
Japan
Individual Site Status
Recruiting
Facility Name
National Cancer Center Hospital East
City
Kashiwa
State/Province
Chiba
ZIP/Postal Code
277-8577
Country
Japan
Individual Site Status
Recruiting
Facility Name
National Hospital Organization Shikoku Cancer Center
City
Matsuyama
State/Province
Ehime
ZIP/Postal Code
791-0280
Country
Japan
Individual Site Status
Recruiting
Facility Name
Hokkaido University Hospital
City
Sapporo
State/Province
Hokkaido
ZIP/Postal Code
060-8648
Country
Japan
Individual Site Status
Recruiting
Facility Name
Kanazawa University Hospital
City
Kanazawa
State/Province
Ishikawa
ZIP/Postal Code
920-8641
Country
Japan
Individual Site Status
Recruiting
Facility Name
St. Marianna University Hospital
City
Kawasaki
State/Province
Kanagawa
ZIP/Postal Code
216-8511
Country
Japan
Individual Site Status
Recruiting
Facility Name
Kanagawa cancer center
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
2418515
Country
Japan
Individual Site Status
Recruiting
Facility Name
Aichi Cancer Center Hospital
City
Nagoya
State/Province
Nagoya, Aichi
ZIP/Postal Code
464-8681
Country
Japan
Individual Site Status
Recruiting
Facility Name
Osaka Prefectural Hospital Organization Osaka International Cancer Institute
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
5418567
Country
Japan
Individual Site Status
Recruiting
Facility Name
Kindai University Hospital
City
Osakasayama
State/Province
Osaka
ZIP/Postal Code
589-8511
Country
Japan
Individual Site Status
Recruiting
Facility Name
Osaka University Hospital
City
Suita
State/Province
Osaka
ZIP/Postal Code
565-0871
Country
Japan
Individual Site Status
Recruiting
Facility Name
Osaka Medical and Pharmaceutical University Hospital
City
Takatsuki
State/Province
Osaka
ZIP/Postal Code
569-8686
Country
Japan
Individual Site Status
Recruiting
Facility Name
Saitama Medical University International Medical Center
City
Hidaka-city
State/Province
Saitama
ZIP/Postal Code
350-1298
Country
Japan
Individual Site Status
Recruiting
Facility Name
Saitama Prefectural Cancer Center
City
Ina-machi
State/Province
Saitama
ZIP/Postal Code
362-0806
Country
Japan
Individual Site Status
Recruiting
Facility Name
Shizuoka Cancer Center
City
Nagaizumi
State/Province
Shizuoka
ZIP/Postal Code
411-8777
Country
Japan
Individual Site Status
Recruiting
Facility Name
National Cancer Center Hospital
City
Chuo-ku
State/Province
Tokyo
ZIP/Postal Code
104-0045
Country
Japan
Individual Site Status
Recruiting
Facility Name
Japanese Foundation for Cancer Research
City
Koto-ku
State/Province
Tokyo
ZIP/Postal Code
135-8550
Country
Japan
Individual Site Status
Recruiting
Facility Name
National Hospital Organization Kyushu Cancer Center
City
Fukuoka
ZIP/Postal Code
811-1395
Country
Japan
Individual Site Status
Recruiting
Facility Name
National Hospital Organization - Osaka National Hospital - Institute For Clinical Research
City
Osaka
ZIP/Postal Code
540-0006
Country
Japan
Individual Site Status
Recruiting
Facility Name
Keio University Hospital
City
Tokyo
ZIP/Postal Code
1600035
Country
Japan
Individual Site Status
Recruiting
Facility Name
National Cancer Center
City
Goyang-si
State/Province
Gyeonggi-do
ZIP/Postal Code
10408
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Kyungpook National University Hospital
City
Daegu
State/Province
Taegu-kwangyǒkshi
ZIP/Postal Code
41404
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Dong-A University Hospital
City
Busan
ZIP/Postal Code
49201
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Kyungpook National University Chilgok Hospital
City
Daegu
ZIP/Postal Code
41404
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Gachon University Gil Medical Center
City
Incheon
ZIP/Postal Code
21565
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Chonnam National University Hwasun Hospital Pharmacy
City
Jeonnam
ZIP/Postal Code
58128
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Chonnam National University Hwasun Hospital
City
Jeonnam
ZIP/Postal Code
58128
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Korea University Anam Hospital
City
Seoul
ZIP/Postal Code
02841
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Seoul National University Hospital
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Severance Hospital, Yonsei University Health System
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Samsung Medical Center
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Accelerium, S. de R.L. de C.V.
City
Monterrey
State/Province
Nuevo LEON
ZIP/Postal Code
64000
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Centro de Investigacion Clinica de Oaxaca
City
Oaxaca
ZIP/Postal Code
68020
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Maastricht UMC+
City
Maastricht
State/Province
Limburg
ZIP/Postal Code
6229 HX
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Catharina Ziekenhuis
City
Eindhoven
State/Province
Noord-brabant
ZIP/Postal Code
5623 EJ
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL)
City
Amsterdam
State/Province
Noord-holland
ZIP/Postal Code
1066 CX
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Haaglanden Medisch Centrum
City
Leidschendam
State/Province
Zuid-holland
ZIP/Postal Code
2262 BA
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Amsterdam UMC, location VUMc
City
Amsterdam
ZIP/Postal Code
1081 HV
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Maastricht University Medical Center
City
Maastricht
ZIP/Postal Code
6229 HX
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Universitair Medisch Centrum Utrecht
City
Utrecht
ZIP/Postal Code
3584 CX
Country
Netherlands
Individual Site Status
Recruiting
Facility Name
Tauranga Hospital
City
Tauranga
State/Province
BAY OF Plenty
ZIP/Postal Code
3112
Country
New Zealand
Individual Site Status
Recruiting
Facility Name
Auckland City Hospital
City
Auckland
ZIP/Postal Code
1023
Country
New Zealand
Individual Site Status
Recruiting
Facility Name
Auckland District Health Board Charitable Trust
City
Auckland
ZIP/Postal Code
1023
Country
New Zealand
Individual Site Status
Recruiting
Facility Name
Haukeland University Hospital
City
Bergen
State/Province
Hordaland
ZIP/Postal Code
5021
Country
Norway
Individual Site Status
Recruiting
Facility Name
Stavanger Universitetssykehus
City
Stavanger
State/Province
Rogaland
ZIP/Postal Code
4011
Country
Norway
Individual Site Status
Recruiting
Facility Name
St. Olavs hospital
City
Trondheim
State/Province
Sør-trøndelag
ZIP/Postal Code
7030
Country
Norway
Individual Site Status
Recruiting
Facility Name
Sørlandet Sykehus Kristiansand
City
Kristiansand
State/Province
Vest-agder
ZIP/Postal Code
N-4615
Country
Norway
Individual Site Status
Recruiting
Facility Name
Oslo universitetssykehus, Radiumhospitalet
City
Oslo
ZIP/Postal Code
0379
Country
Norway
Individual Site Status
Recruiting
Facility Name
Oslo Universitetssykehus Ullevål
City
Oslo
ZIP/Postal Code
0450
Country
Norway
Individual Site Status
Recruiting
Facility Name
Przychodnia Lekarska KOMED
City
Konin
State/Province
Wielkopolskie
ZIP/Postal Code
62-500
Country
Poland
Individual Site Status
Recruiting
Facility Name
Szpital Specjalistyczny W Brzozowie, Podkarpacki Osrodek Onkologiczny Im.Ks.B.Markiewicza
City
Brzozow
ZIP/Postal Code
36-200
Country
Poland
Individual Site Status
Recruiting
Facility Name
Wojewodzki Szpital Specjalistyczny Nr 4 w Bytomiu Oddzial Onkologii
City
Bytom
ZIP/Postal Code
41-902
Country
Poland
Individual Site Status
Recruiting
Facility Name
COPERNICUS PL sp. z. o. o. Wojewodzkie Centrum Onkologii w Gdansku Ambulatoryjna
City
Gdansk
ZIP/Postal Code
80-219
Country
Poland
Individual Site Status
Recruiting
Facility Name
COPERNICUS Podmiot Leczniczy Sp. z o.o. Wojewodzkie Centrum Onkologii
City
Gdansk
ZIP/Postal Code
80-219
Country
Poland
Individual Site Status
Recruiting
Facility Name
Przychodnia Lekarska KOMED
City
Konin
ZIP/Postal Code
62-500
Country
Poland
Individual Site Status
Recruiting
Facility Name
Private Medical Institution "Euromedservice"
City
Pushkin
State/Province
Saint-petersburg
ZIP/Postal Code
196603
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
Private Medical Institution "Euromedservice"
City
Pushkin
State/Province
Sankt-peterburg
ZIP/Postal Code
196603
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
GBUZ
City
Chelyabinsk
ZIP/Postal Code
454087
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
Kaluga Regional Clinical Oncology Center
City
Kaluga
ZIP/Postal Code
248007
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
FSAEI HE I.M Sechenov First MSMU MoH Russia (Sechenovskiy University),
City
Moscow
ZIP/Postal Code
119991
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
BHI of Omsk Region "Clinical Oncology Dispensary"
City
Omsk
ZIP/Postal Code
644013
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
BHI of Omsk Region "Clinical Oncology Dispensary"
City
Omsk
ZIP/Postal Code
644046
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
LLC "EuroCityClinic"
City
Saint Petersburg
ZIP/Postal Code
197022
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
LLC "Medicina Severnoy Stolitsy"
City
Saint-Petersburg
ZIP/Postal Code
191025
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
LLC "Severo-Zapadny Medical Center"
City
Saint-Petersburg
ZIP/Postal Code
192007
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
Private Healthcare Institution "Clinical Hospital "RZD-Medicine" of St. Petersburg
City
Saint-Petersburg
ZIP/Postal Code
195271
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
FSBI "Russian Scientific Center For Radiology and Surgical Technologies n.a. Academician A.M. Granov
City
St. Petersburg
ZIP/Postal Code
197758
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
SHI YR Regional Clinical Oncology Hospital
City
Yaroslavl
ZIP/Postal Code
150040
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
SHI YR Regional Clinical Oncology Hospital
City
Yaroslavl
ZIP/Postal Code
150054
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
SHI YR Regional Clinical Oncology Hospital
City
Yaroslav
ZIP/Postal Code
150054
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica
City
Banska Bystrica
ZIP/Postal Code
974 01
Country
Slovakia
Individual Site Status
Recruiting
Facility Name
Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica
City
Banska Bystrica
ZIP/Postal Code
975 17
Country
Slovakia
Individual Site Status
Recruiting
Facility Name
Onkologicky ustav sv. Alzbety s.r.o.
City
Bratislava
ZIP/Postal Code
812 50
Country
Slovakia
Individual Site Status
Recruiting
Facility Name
Narodny Onkologicky Ustav
City
Bratislava
ZIP/Postal Code
833 10
Country
Slovakia
Individual Site Status
Recruiting
Facility Name
Vychodoslovensky onkologicky ustav, a.s.
City
Kosice
ZIP/Postal Code
04191
Country
Slovakia
Individual Site Status
Recruiting
Facility Name
POKO Poprad s.r.o.
City
Poprad
ZIP/Postal Code
058 01
Country
Slovakia
Individual Site Status
Recruiting
Facility Name
Cancercare Rondebosch Oncology
City
Rondebosch
State/Province
Cape Town
ZIP/Postal Code
7700
Country
South Africa
Individual Site Status
Recruiting
Facility Name
Cancercare Langenhoven Drive Oncology Centre
City
Port Elizabeth
State/Province
Eastern CAPE
ZIP/Postal Code
6045
Country
South Africa
Individual Site Status
Recruiting
Facility Name
Charlotte Maxeke Johannesburg Academic Hospital
City
Johannesburg
State/Province
Gauteng
ZIP/Postal Code
2193
Country
South Africa
Individual Site Status
Recruiting
Facility Name
Wits Clinical Research
City
Parktown, Johannesburg
State/Province
Gauteng
ZIP/Postal Code
2193
Country
South Africa
Individual Site Status
Recruiting
Facility Name
Cape Town Oncology Trials
City
Cape Town
State/Province
Western CAPE
ZIP/Postal Code
7570
Country
South Africa
Individual Site Status
Not yet recruiting
Facility Name
Mary Potter Oncology Centre
City
Pretoria
ZIP/Postal Code
0181
Country
South Africa
Individual Site Status
Recruiting
Facility Name
Complejo Hospitalario Universitario Santiago de Compostela
City
Santiago de Compostela
State/Province
A Coruña
ZIP/Postal Code
15706
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital General Universitario de Elche
City
Elche
State/Province
Alicante
ZIP/Postal Code
03203
Country
Spain
Individual Site Status
Recruiting
Facility Name
ICO L'Hospitalet (Hospital Duran i Reynals)
City
Hospitalet de Llobregat
State/Province
Barcelona
ZIP/Postal Code
08908
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Vall d'Hebron
City
Barcelona
ZIP/Postal Code
08035
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Clinic Barcelona
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital General Universitario Gregorio Marañon
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Ramon Y Cajal
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario 12 de octubre
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Virgen Del Rocio
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Clinico Universitario de Valencia
City
Valencia
ZIP/Postal Code
46010
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital General Universitario de Valencia
City
Valencia
ZIP/Postal Code
46014
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Miguel Servet
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Individual Site Status
Recruiting
Facility Name
Karolinska Universitetssjukhuset Solna
City
Solna
State/Province
Stockholms LÄN [se-01]
ZIP/Postal Code
171 64
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Akademiska sjukhuset
City
Uppsala
State/Province
Uppsala LÄN [se-03]
ZIP/Postal Code
751 85
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Norrlands universitetssjukhus
City
Umeå
State/Province
Västerbottens LÄN [se-24]
ZIP/Postal Code
90185
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Sahlgrenska Universitetssjukhuset
City
Göteborg
State/Province
Västra Götalands LÄN [se14]
ZIP/Postal Code
413 45
Country
Sweden
Individual Site Status
Recruiting
Facility Name
Kaohsiung Medical University Chung-Ho Memorial Hospital
City
Kaohsiung
ZIP/Postal Code
807
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
China Medical University Hospital
City
Taichung
ZIP/Postal Code
40447
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
China Medical University Hospital
City
Taichung
ZIP/Postal Code
404
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
National Cheng-Kung University Hospital
City
Tainan
ZIP/Postal Code
704
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Chi Mei Hospital, Liouying
City
Tainan
ZIP/Postal Code
73657
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
National Taiwan University Hospital
City
Taipei
ZIP/Postal Code
10002
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
National Taiwan University Hospital
City
Taipei
ZIP/Postal Code
100
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Taipei Medical University Hospital
City
Taipei
ZIP/Postal Code
11031
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Taipei Veterans General Hospital
City
Taipei
ZIP/Postal Code
11217
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Taipei Veterans General Hospital
City
Taipei
ZIP/Postal Code
112
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Chang Gung Medical Foundation-Linkou Branch
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Medical and diagnostic center of MediX-Ray International Group LLC Israeli Oncology Hospital "LISOD"
City
Pliuty Village
State/Province
KYIV Region, Obuhovskiy District
ZIP/Postal Code
08720
Country
Ukraine
Individual Site Status
Not yet recruiting
Facility Name
Municipal Non-profit Enterprise "City Clinical Hospital #4" of Dnipro City Council
City
Dnipro
ZIP/Postal Code
49102
Country
Ukraine
Individual Site Status
Active, not recruiting
Facility Name
PRECARPATHIAN NUCLEAR MEDICINE CENTER, Limited Liability Company
City
Ivano-Frankivsk
ZIP/Postal Code
76011
Country
Ukraine
Individual Site Status
Active, not recruiting
Facility Name
Ivano-Frankivsk National Medical University
City
Ivano-Frankivsk
ZIP/Postal Code
76018
Country
Ukraine
Individual Site Status
Active, not recruiting
Facility Name
MNPE "Prykarpatski Clinical Oncological Center" of Ivano-Frankivsk Regional Council"
City
Ivano-Frankivsk
ZIP/Postal Code
76018
Country
Ukraine
Individual Site Status
Active, not recruiting
Facility Name
Municipal non-profit enterprise "City clinical hospital #2 named after O.O.Shalimov"
City
Kharkiv
ZIP/Postal Code
61037
Country
Ukraine
Individual Site Status
Not yet recruiting
Facility Name
Communal Non-Profit Enterprise "Regional Center of Oncology"
City
Kharkiv
ZIP/Postal Code
61070
Country
Ukraine
Individual Site Status
Not yet recruiting
Facility Name
Communal enterprise "Kryvyi Rih Oncology Dispensary" of Dnipropetrovsk Regional Council
City
Kryvyi Rih
ZIP/Postal Code
50048
Country
Ukraine
Individual Site Status
Active, not recruiting
Facility Name
SI "Insitute of Neurosurgery n.a.acad. A.P.
City
Kyiv
ZIP/Postal Code
04050
Country
Ukraine
Individual Site Status
Active, not recruiting
Facility Name
SI "Insitute of Neurosurgery n.a.acad. A.P.
City
Kyiv
ZIP/Postal Code
04050
Country
Ukraine
Individual Site Status
Not yet recruiting
Facility Name
Municipal non-profit enterprise of Kyiv regional council "Kyiv regional clinical hospital"
City
Kyiv
ZIP/Postal Code
04107
Country
Ukraine
Individual Site Status
Not yet recruiting
Facility Name
Municipal non-profit enterprise "Zaporizhzhia Regional Antitumor Center" Zaporizhzhia Regional
City
Zaporizhzhia
ZIP/Postal Code
69040
Country
Ukraine
Individual Site Status
Recruiting
Facility Name
Freeman Hospital
City
Newcastle upon Tyne
State/Province
HIGH Heaton
ZIP/Postal Code
NE7 7DN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Royal Marsden NHS Foundation Trust
City
Sutton
State/Province
Surrey
ZIP/Postal Code
SM2 5PT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Heartlands Hospital
City
Birmingham
ZIP/Postal Code
B9 5SS
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Royal Marsden NHS Foundation Trust
City
London
ZIP/Postal Code
SW3 6JJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Hammersmith Hospital, Imperial College Healthcare NHS Trust
City
London
ZIP/Postal Code
W12 0HS
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Charing Cross Hospital, Imperial College Healthcare NHS Trust
City
London
ZIP/Postal Code
W6 8RF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Churchill Hospital - Oncology
City
Oxford
ZIP/Postal Code
OX3 7LE
Country
United Kingdom
Individual Site Status
Recruiting
12. IPD Sharing Statement
Plan to Share IPD
Yes
IPD Sharing Plan Description
Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.
IPD Sharing URL
https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests
Links:
URL
https://pmiform.com/clinical-trial-info-request?StudyID=C4221015
Description
To obtain contact information for a study center near you, click here.
URL
http://www.breakwatercrcstudy.com
Description
Breakwater Study on Pfizer Clinical Trials
Learn more about this trial
A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
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