A Study of Jaktinib Hydrochloride Tablets in the Treatment of Severe Novel Coronavirus Pneumonia (COVID-19)

Inclusion Criteria: Aged ≥18 years old, regardless of gender; There is a history of novel coronavirus antigen- or nucleic acid-positive infection within 1-2 weeks; HRCT is consistent with the manifestation of viral pneumonia (judged by the investigator) Participants who voluntarily sign informed consent. Exclusion Criteria: Participants who cannot take orally, or are suspected to be allergic to Jaktinib hydrochloride, similar drugs, or their excipients, or have severe gastrointestinal dysfunction that affects drug absorption; Critical pneumonia Participants with other organ failure requiring ICU monitoring and treatment; Participants who have received the following treatments within the specified time window before randomization: Participants have received Janus kinase (JAK) inhibitor, interleukin 6 (IL-6) inhibitor, IL-1 inhibitor, tumor necrosis factor (TNF) inhibitor, T cell or B cell depletion agent, interferon and other immunosuppressive drugs within the first two weeks of randomization, except glucocorticoid; Systematically used CYP 3A4 potent inhibitor or potent inducer in the first five drug half-lives at random; Immune deficiency; Participants who have received the novel coronavirus vaccine within 1 week before randomization; Prior to randomization, there were the following active and uncontrolled infections: tuberculosis, HIV, syphilis, mycoplasma, chlamydia, parasites, and viral infections other than SARS CoV-2 that required systemic anti-infection treatment; Renal diseases requiring dialysis treatment; Pregnant and lactating women; Any other Participants that were considered unsuitable by the investigator.