Back to resultsA Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation (CheckMate 9DX)
Primary Purpose
Hepatocellular Carcinoma, Liver Cancer
Status
Active
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Nivolumab
Placebo
Sponsored by
About this trial
This is an interventional treatment trial for Hepatocellular Carcinoma
Eligibility Criteria
Inclusion Criteria:
- Participants with a first diagnosis of HCC who have undergone a curative resection or ablation
- Participants are eligible to enroll if they have non-viral related-HCC, or if they have HBV-HCC, or HCV-HCC
- Child-Pugh Score 5 or 6
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1
Exclusion Criteria:
- Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC
- Any evidence of tumor metastasis or co-existing malignant disease
- Participants previously receiving any prior therapy for HCC, including loco-regional therapies
- Participants who have undergone a liver transplant or those who are in the waiting list for liver transplantation
- Participants who have received a live/attenuated vaccine within 30 days of randomization (eg, varicella, zoster, yellow fever, rotavirus, oral polio and measles, mumps, rubella [MMR]).
Other protocol defined inclusion/exclusion criteria apply
Sites / Locations
- Local Institution - 0081
- Mayo Clinic in Arizona - Phoenix
- Arizona Oncology Associates, PC - HOPE
- Local Institution - 0135
- Local Institution - 0088
- Local Institution - 0085
- Local Institution - 0235
- Miami VA Healthcare System
- Sylvester Comprehensive Cancer Center/ UMHC
- Local Institution - 0163
- Local Institution - 0009
- Local Institution - 0025
- Local Institution - 0086
- University of Michigan
- Minnesota Oncology Hematology, P.A.
- Local Institution - 0209
- Laura and Issac Perlmutter Cancer Center at NYU Langone - Belleview Hospital
- Local Institution - 0208
- Memorial Sloan Kettering Cancer Center
- Local Institution - 0219
- Local Institution - 0206
- Local Institution - 0272
- Texas Oncology Sammons Cancer Center
- Local Institution - 0156
- Local Institution - 0273
- McGuire VA Medical Center
- Local Institution - 0154
- Local Institution - 0243
- Local Institution - 0254
- Local Institution - 0244
- Local Institution - 0239
- Local Institution - 0166
- Local Institution - 0141
- Local Institution - 0220
- Local Institution - 0164
- Local Institution - 0224
- Local Institution - 0124
- Local Institution - 0012
- Local Institution - 0001
- Local Institution - 0003
- Local Institution - 0033
- Local Institution - 0064
- Local Institution - 0068
- Local Institution - 0071
- Local Institution - 0108
- Local Institution - 0090
- Local Institution - 0275
- Local Institution - 0237
- Local Institution
- Local Institution
- Local Institution - 0023
- Local Institution - 0236
- Local Institution
- Local Institution - 0116
- Local Institution - 0248
- Local Institution - 0246
- Local Institution - 0245
- Local Institution - 0247
- Local Institution - 0256
- Local Institution - 0057
- Local Institution - 0052
- CHU Estaing
- Local Institution - 0046
- Local Institution - 0061
- Local Institution - 0013
- Local Institution - 0222
- Local Institution - 0051
- Local Institution - 0043
- Local Institution - 0037
- Local Institution
- Local Institution - 0098
- Local Institution - 0212
- Local Institution - 0044
- Local Institution - 0011
- Local Institution - 0054
- Local Institution - 0024
- Local Institution - 0258
- Local Institution - 0020
- Local Institution - 0026
- Local Institution - 0093
- Local Institution - 0040
- Local Institution - 0019
- Local Institution - 0050
- Local Institution
- Local Institution - 0036
- Local Institution - 0048
- Universitatsmedizin Mannheim
- Local Institution - 0096
- Local Institution - 0008
- Local Institution
- Local Institution - 0120
- Local Institution - 0076
- Local Institution - 0136
- Local Institution - 0102
- Local Institution - 0077
- Local Institution - 0104
- Local Institution - 0091
- Local Institution
- Local Institution - 0134
- Azienda Ospedaliera Specialistica dei Colli Monaldi-Cotugno-CTO
- Local Institution - 0119
- Local Institution - 0103
- Fondazione Policlinico Gemelli - Universita Cattolica del Sacro Cuore
- Local Institution - 0187
- Local Institution - 0183
- Local Institution - 0201
- Local Institution - 0184
- Local Institution - 0200
- Local Institution - 0216
- Local Institution - 0180
- Local Institution - 0257
- Local Institution - 0202
- Local Institution
- Local Institution - 0203
- Local Institution - 0198
- Local Institution - 0214
- Local Institution - 0185
- Local Institution - 0215
- Local Institution - 0196
- Local Institution - 0182
- Local Institution - 0210
- Local Institution - 0186
- Local Institution - 0179
- Local Institution - 0197
- Local Institution - 0191
- Local Institution - 0127
- Local Institution - 0177
- Local Institution - 0190
- Local Institution - 0188
- Local Institution - 0178
- Local Institution - 0169
- Local Institution - 0128
- Local Institution - 0168
- Local Institution - 0167
- Local Institution - 0195
- Local Institution - 0189
- Local Institution - 0148
- Local Institution - 0264
- Local Institution - 0121
- Local Institution - 0226
- Local Institution - 0263
- Local Institution - 0260
- Local Institution - 0240
- Local Institution - 0231
- Local Institution
- Local Institution - 0078
- Local Institution - 0232
- Local Institution - 0242
- Local Institution - 0074
- Local Institution - 0070
- Local Institution - 0032
- Arkhangelsk Clinical Oncological Dispensary
- Local Institution
- Local Institution - 0230
- Local Institution - 0042
- Local Institution - 0067
- Local Institution - 0039
- Local Institution - 0069
- Local Institution - 0031
- Local Institution - 0016
- Local Institution - 0072
- Local Institution - 0199
- Local Institution - 0109
- Local Institution - 0100
- Local Institution - 0010
- Local Institution - 0028
- Local Institution - 0082
- Local Institution - 0097
- Local Institution - 0131
- Local Institution - 0204
- Local Institution - 0130
- Local Institution - 0140
- Local Institution - 0174
- Local Institution - 0207
- Local Institution - 0173
- Local Institution - 0129
- Local Institution - 0175
- Local Institution - 0176
- Local Institution - 0111
- Local Institution - 0092
- Local Institution - 0153
- Local Institution - 0114
- Local Institution - 0142
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Placebo Comparator
Arm Label
Arm A
Arm B
Arm Description
Outcomes
Primary Outcome Measures
Recurrence-free Survival (RFS)
Secondary Outcome Measures
Overall Survival (OS)
Time to recurrence (TTR)
Full Information
NCT ID
NCT03383458
First Posted
December 21, 2017
Last Updated
October 12, 2023
Sponsor
Bristol-Myers Squibb
Collaborators
Ono Pharmaceutical Co. Ltd
1. Study Identification
Unique Protocol Identification Number
NCT03383458
Brief Title
A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation
Acronym
CheckMate 9DX
Official Title
A Phase 3, Randomized, Double-blind Study of Adjuvant Nivolumab Versus Placebo for Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation
Study Type
Interventional
2. Study Status
Record Verification Date
October 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
April 18, 2018 (Actual)
Primary Completion Date
April 28, 2025 (Anticipated)
Study Completion Date
December 16, 2025 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Bristol-Myers Squibb
Collaborators
Ono Pharmaceutical Co. Ltd
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
This study will investigate if nivolumab will improve recurrence-free survival (RFS) compared to placebo in participants with HCC who have undergone complete resection or have achieved a complete response after local ablation, and who are at high risk of recurrence
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Hepatocellular Carcinoma, Liver Cancer
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
545 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Arm A
Arm Type
Experimental
Arm Title
Arm B
Arm Type
Placebo Comparator
Intervention Type
Biological
Intervention Name(s)
Nivolumab
Other Intervention Name(s)
Opdivo, BMS-936558
Intervention Description
Specified dose on specified days
Intervention Type
Other
Intervention Name(s)
Placebo
Intervention Description
specified dose on specified days
Primary Outcome Measure Information:
Title
Recurrence-free Survival (RFS)
Time Frame
Up to 49 months
Secondary Outcome Measure Information:
Title
Overall Survival (OS)
Time Frame
Up to 7 years
Title
Time to recurrence (TTR)
Time Frame
Up to 49 months
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Participants with a first diagnosis of HCC who have undergone a curative resection or ablation
Participants are eligible to enroll if they have non-viral related-HCC, or if they have HBV-HCC, or HCV-HCC
Child-Pugh Score 5 or 6
Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1
Exclusion Criteria:
Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC
Any evidence of tumor metastasis or co-existing malignant disease
Participants previously receiving any prior therapy for HCC, including loco-regional therapies
Participants who have undergone a liver transplant or those who are in the waiting list for liver transplantation
Participants who have received a live/attenuated vaccine within 30 days of randomization (eg, varicella, zoster, yellow fever, rotavirus, oral polio and measles, mumps, rubella [MMR]).
Other protocol defined inclusion/exclusion criteria apply
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Bristol-Myers Squibb
Organizational Affiliation
Bristol-Myers Squibb
Official's Role
Study Director
Facility Information:
Facility Name
Local Institution - 0081
City
Anniston
State/Province
Alabama
ZIP/Postal Code
36207
Country
United States
Facility Name
Mayo Clinic in Arizona - Phoenix
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85054
Country
United States
Facility Name
Arizona Oncology Associates, PC - HOPE
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85711
Country
United States
Facility Name
Local Institution - 0135
City
Los Angeles
State/Province
California
ZIP/Postal Code
90095
Country
United States
Facility Name
Local Institution - 0088
City
Palo Alto
State/Province
California
ZIP/Postal Code
94304
Country
United States
Facility Name
Local Institution - 0085
City
San Francisco
State/Province
California
ZIP/Postal Code
94115
Country
United States
Facility Name
Local Institution - 0235
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
Miami VA Healthcare System
City
Miami
State/Province
Florida
ZIP/Postal Code
33125
Country
United States
Facility Name
Sylvester Comprehensive Cancer Center/ UMHC
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Facility Name
Local Institution - 0163
City
Tampa
State/Province
Florida
ZIP/Postal Code
33612
Country
United States
Facility Name
Local Institution - 0009
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30322
Country
United States
Facility Name
Local Institution - 0025
City
Westwood
State/Province
Kansas
ZIP/Postal Code
66205
Country
United States
Facility Name
Local Institution - 0086
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
University of Michigan
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Facility Name
Minnesota Oncology Hematology, P.A.
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55404
Country
United States
Facility Name
Local Institution - 0209
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Laura and Issac Perlmutter Cancer Center at NYU Langone - Belleview Hospital
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States
Facility Name
Local Institution - 0208
City
New York
State/Province
New York
ZIP/Postal Code
10029
Country
United States
Facility Name
Memorial Sloan Kettering Cancer Center
City
New York
State/Province
New York
ZIP/Postal Code
10065
Country
United States
Facility Name
Local Institution - 0219
City
White Plains
State/Province
New York
ZIP/Postal Code
10601
Country
United States
Facility Name
Local Institution - 0206
City
Portland
State/Province
Oregon
ZIP/Postal Code
97225
Country
United States
Facility Name
Local Institution - 0272
City
Austin
State/Province
Texas
ZIP/Postal Code
78705
Country
United States
Facility Name
Texas Oncology Sammons Cancer Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
Local Institution - 0156
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390
Country
United States
Facility Name
Local Institution - 0273
City
Tyler
State/Province
Texas
ZIP/Postal Code
75702
Country
United States
Facility Name
McGuire VA Medical Center
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23249
Country
United States
Facility Name
Local Institution - 0154
City
Seattle
State/Province
Washington
ZIP/Postal Code
98109
Country
United States
Facility Name
Local Institution - 0243
City
Gorriti
State/Province
Buenos Aires
ZIP/Postal Code
5737
Country
Argentina
Facility Name
Local Institution - 0254
City
Pilar
State/Province
Buenos Aires
ZIP/Postal Code
1629
Country
Argentina
Facility Name
Local Institution - 0244
City
Rosario
State/Province
Santa FE
ZIP/Postal Code
2000
Country
Argentina
Facility Name
Local Institution - 0239
City
Blacktown
State/Province
New South Wales
ZIP/Postal Code
2148
Country
Australia
Facility Name
Local Institution - 0166
City
Camperdown
State/Province
New South Wales
ZIP/Postal Code
2050
Country
Australia
Facility Name
Local Institution - 0141
City
Concord
State/Province
New South Wales
ZIP/Postal Code
2139
Country
Australia
Facility Name
Local Institution - 0220
City
Herston
State/Province
Queensland
ZIP/Postal Code
4029
Country
Australia
Facility Name
Local Institution - 0164
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Local Institution - 0224
City
Heidelberg
State/Province
Victoria
ZIP/Postal Code
3084
Country
Australia
Facility Name
Local Institution - 0124
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
Facility Name
Local Institution - 0012
City
Graz
ZIP/Postal Code
8036
Country
Austria
Facility Name
Local Institution - 0001
City
Vienna
ZIP/Postal Code
1100
Country
Austria
Facility Name
Local Institution - 0003
City
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
Local Institution - 0033
City
Brussels
ZIP/Postal Code
1070
Country
Belgium
Facility Name
Local Institution - 0064
City
Bruxelles
ZIP/Postal Code
1200
Country
Belgium
Facility Name
Local Institution - 0068
City
Edegem
ZIP/Postal Code
2650
Country
Belgium
Facility Name
Local Institution - 0071
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
Local Institution - 0108
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
Local Institution - 0090
City
Belo Horizonte
State/Province
Minas Gerais
ZIP/Postal Code
30130-090
Country
Brazil
Facility Name
Local Institution - 0275
City
Barretos
State/Province
Sao Paulo
ZIP/Postal Code
14780-070
Country
Brazil
Facility Name
Local Institution - 0237
City
Cerqueira Cesar
State/Province
SAO Paulo
ZIP/Postal Code
01246-000
Country
Brazil
Facility Name
Local Institution
City
Sao Jose Do Rio Preto
State/Province
Sao Paulo
ZIP/Postal Code
15090-000
Country
Brazil
Facility Name
Local Institution
City
São Paulo
State/Province
SAO Paulo
ZIP/Postal Code
08270-120
Country
Brazil
Facility Name
Local Institution - 0023
City
Sao Paulo
ZIP/Postal Code
01308-050
Country
Brazil
Facility Name
Local Institution - 0236
City
Sao Paulo
ZIP/Postal Code
01509-010
Country
Brazil
Facility Name
Local Institution
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4Z6
Country
Canada
Facility Name
Local Institution - 0116
City
Edmonton
ZIP/Postal Code
T6G 1Z2
Country
Canada
Facility Name
Local Institution - 0248
City
Santiago de Chile
State/Province
Metropolitana
ZIP/Postal Code
0
Country
Chile
Facility Name
Local Institution - 0246
City
Santiago
State/Province
Metropolitana
ZIP/Postal Code
7710007
Country
Chile
Facility Name
Local Institution - 0245
City
Santiago
State/Province
Región Metropolitana De Santiago
ZIP/Postal Code
8380420
Country
Chile
Facility Name
Local Institution - 0247
City
Vina del Mar
State/Province
Valparaiso
ZIP/Postal Code
2520598
Country
Chile
Facility Name
Local Institution - 0256
City
Bogota
ZIP/Postal Code
0
Country
Colombia
Facility Name
Local Institution - 0057
City
Bobigny
ZIP/Postal Code
93000
Country
France
Facility Name
Local Institution - 0052
City
Brest
ZIP/Postal Code
29200
Country
France
Facility Name
CHU Estaing
City
Clermont Ferrand
ZIP/Postal Code
63003
Country
France
Facility Name
Local Institution - 0046
City
Clichy
ZIP/Postal Code
92110
Country
France
Facility Name
Local Institution - 0061
City
Creteil Cedex
ZIP/Postal Code
94010
Country
France
Facility Name
Local Institution - 0013
City
Grenoble Cedex 09
ZIP/Postal Code
38043
Country
France
Facility Name
Local Institution - 0222
City
Lille
ZIP/Postal Code
59037
Country
France
Facility Name
Local Institution - 0051
City
Lyon Cedex 04
ZIP/Postal Code
69317
Country
France
Facility Name
Local Institution - 0043
City
Montpellier Cedex
ZIP/Postal Code
34295
Country
France
Facility Name
Local Institution - 0037
City
Nice
ZIP/Postal Code
06202
Country
France
Facility Name
Local Institution
City
Poitiers
ZIP/Postal Code
86021
Country
France
Facility Name
Local Institution - 0098
City
Reims
ZIP/Postal Code
51100
Country
France
Facility Name
Local Institution - 0212
City
Rennes Cedex 9
ZIP/Postal Code
35033
Country
France
Facility Name
Local Institution - 0044
City
Saint-Priest-en-Jarez
ZIP/Postal Code
42270
Country
France
Facility Name
Local Institution - 0011
City
Vandoeuvre Les Nancy Cedex
ZIP/Postal Code
54511
Country
France
Facility Name
Local Institution - 0054
City
Villejuif
ZIP/Postal Code
94800
Country
France
Facility Name
Local Institution - 0024
City
Aachen
ZIP/Postal Code
52057
Country
Germany
Facility Name
Local Institution - 0258
City
Berlin
ZIP/Postal Code
13353
Country
Germany
Facility Name
Local Institution - 0020
City
Bonn
ZIP/Postal Code
53127
Country
Germany
Facility Name
Local Institution - 0026
City
Essen
ZIP/Postal Code
45147
Country
Germany
Facility Name
Local Institution - 0093
City
Frankfurt am Main
ZIP/Postal Code
60590
Country
Germany
Facility Name
Local Institution - 0040
City
Hannover
ZIP/Postal Code
30625
Country
Germany
Facility Name
Local Institution - 0019
City
Homburg
ZIP/Postal Code
66421
Country
Germany
Facility Name
Local Institution - 0050
City
Koln
ZIP/Postal Code
50937
Country
Germany
Facility Name
Local Institution
City
Leipzig
ZIP/Postal Code
04103
Country
Germany
Facility Name
Local Institution - 0036
City
Magdeburg
ZIP/Postal Code
39104 Magdeburg
Country
Germany
Facility Name
Local Institution - 0048
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Universitatsmedizin Mannheim
City
Mannheim
ZIP/Postal Code
68167
Country
Germany
Facility Name
Local Institution - 0096
City
Muenchen
ZIP/Postal Code
81377
Country
Germany
Facility Name
Local Institution - 0008
City
Tuebingen
ZIP/Postal Code
72076
Country
Germany
Facility Name
Local Institution
City
Wuerzburg
ZIP/Postal Code
97078
Country
Germany
Facility Name
Local Institution - 0120
City
Hong Kong
ZIP/Postal Code
999077
Country
Hong Kong
Facility Name
Local Institution - 0076
City
Hong Kong
Country
Hong Kong
Facility Name
Local Institution - 0136
City
Messina
State/Province
ME
ZIP/Postal Code
98125
Country
Italy
Facility Name
Local Institution - 0102
City
Bologna
ZIP/Postal Code
40138
Country
Italy
Facility Name
Local Institution - 0077
City
Firenze
ZIP/Postal Code
50134
Country
Italy
Facility Name
Local Institution - 0104
City
Meldola
ZIP/Postal Code
47014
Country
Italy
Facility Name
Local Institution - 0091
City
Milano
ZIP/Postal Code
20133
Country
Italy
Facility Name
Local Institution
City
Modena
ZIP/Postal Code
41124
Country
Italy
Facility Name
Local Institution - 0134
City
Monserrato
ZIP/Postal Code
09042
Country
Italy
Facility Name
Azienda Ospedaliera Specialistica dei Colli Monaldi-Cotugno-CTO
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Facility Name
Local Institution - 0119
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Facility Name
Local Institution - 0103
City
Padova
ZIP/Postal Code
35128
Country
Italy
Facility Name
Fondazione Policlinico Gemelli - Universita Cattolica del Sacro Cuore
City
Rome
ZIP/Postal Code
00168
Country
Italy
Facility Name
Local Institution - 0187
City
Chiba-shi
State/Province
Chiba
ZIP/Postal Code
2608677
Country
Japan
Facility Name
Local Institution - 0183
City
Kashiwa-shi
State/Province
Chiba
ZIP/Postal Code
2778577
Country
Japan
Facility Name
Local Institution - 0201
City
Kurume-shi
State/Province
Fukuoka
ZIP/Postal Code
8300011
Country
Japan
Facility Name
Local Institution - 0184
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
0600033
Country
Japan
Facility Name
Local Institution - 0200
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
0608648
Country
Japan
Facility Name
Local Institution - 0216
City
Nishinomiya-shi
State/Province
Hyogo
ZIP/Postal Code
6638501
Country
Japan
Facility Name
Local Institution - 0180
City
Kanazawa-shi
State/Province
Ishikawa
ZIP/Postal Code
9208641
Country
Japan
Facility Name
Local Institution - 0257
City
Morioka-shi
State/Province
Iwate
ZIP/Postal Code
0208505
Country
Japan
Facility Name
Local Institution - 0202
City
Kumamoto-shi
State/Province
Kumamoto
ZIP/Postal Code
8608556
Country
Japan
Facility Name
Local Institution
City
Osaka-sayama
State/Province
Osaka
ZIP/Postal Code
5898511
Country
Japan
Facility Name
Local Institution - 0203
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
5438555
Country
Japan
Facility Name
Local Institution - 0198
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
5458586
Country
Japan
Facility Name
Local Institution - 0214
City
Suita-shi
State/Province
Osaka
ZIP/Postal Code
565-0871
Country
Japan
Facility Name
Local Institution - 0185
City
Tokushima-shi
State/Province
Tokushima
ZIP/Postal Code
770-8503
Country
Japan
Facility Name
Local Institution - 0215
City
Bunkyo-ku
State/Province
Tokyo
ZIP/Postal Code
1138655
Country
Japan
Facility Name
Local Institution - 0196
City
Chuo-ku
State/Province
Tokyo
ZIP/Postal Code
1040045
Country
Japan
Facility Name
Local Institution - 0182
City
Mitaka-shi
State/Province
Tokyo
ZIP/Postal Code
181-8611
Country
Japan
Facility Name
Local Institution - 0210
City
Musashino-shi
State/Province
Tokyo
ZIP/Postal Code
1808610
Country
Japan
Facility Name
Local Institution - 0186
City
Shinjuku-ku
State/Province
Tokyo
ZIP/Postal Code
162-8655
Country
Japan
Facility Name
Local Institution - 0179
City
Hiroshima
ZIP/Postal Code
734-8551
Country
Japan
Facility Name
Local Institution - 0197
City
Kanagawa
ZIP/Postal Code
213-8587
Country
Japan
Facility Name
Local Institution - 0191
City
Suwon-si
State/Province
Gyeonggi-do
ZIP/Postal Code
16499
Country
Korea, Republic of
Facility Name
Local Institution - 0127
City
Seoul
State/Province
Seoul-teukbyeolsi [Seoul]
ZIP/Postal Code
06351
Country
Korea, Republic of
Facility Name
Local Institution - 0177
City
Daegu
ZIP/Postal Code
41944
Country
Korea, Republic of
Facility Name
Local Institution - 0190
City
Goyang-si
ZIP/Postal Code
10408
Country
Korea, Republic of
Facility Name
Local Institution - 0188
City
Gyeongsangnam-do
ZIP/Postal Code
50612
Country
Korea, Republic of
Facility Name
Local Institution - 0178
City
Jeollanam-do
ZIP/Postal Code
58128
Country
Korea, Republic of
Facility Name
Local Institution - 0169
City
Seongnam-si
ZIP/Postal Code
13620
Country
Korea, Republic of
Facility Name
Local Institution - 0128
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Facility Name
Local Institution - 0168
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Facility Name
Local Institution - 0167
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Facility Name
Local Institution - 0195
City
Seoul
ZIP/Postal Code
06591
Country
Korea, Republic of
Facility Name
Local Institution - 0189
City
Seoul
ZIP/Postal Code
08308
Country
Korea, Republic of
Facility Name
Local Institution - 0148
City
Cuauhtemoc
State/Province
Durango
ZIP/Postal Code
06700
Country
Mexico
Facility Name
Local Institution - 0264
City
Monterrey
State/Province
Nuevo Leon
ZIP/Postal Code
64460
Country
Mexico
Facility Name
Local Institution - 0121
City
Monterrey
State/Province
Nuevo León
ZIP/Postal Code
64000
Country
Mexico
Facility Name
Local Institution - 0226
City
San Luis Potosi
ZIP/Postal Code
78250
Country
Mexico
Facility Name
Local Institution - 0263
City
Maastricht
ZIP/Postal Code
6229 HX
Country
Netherlands
Facility Name
Local Institution - 0260
City
Utrecht
ZIP/Postal Code
3584CX
Country
Netherlands
Facility Name
Local Institution - 0240
City
Auckland
ZIP/Postal Code
1023
Country
New Zealand
Facility Name
Local Institution - 0231
City
San Juan
ZIP/Postal Code
00927
Country
Puerto Rico
Facility Name
Local Institution
City
Brasov
ZIP/Postal Code
500091
Country
Romania
Facility Name
Local Institution - 0078
City
Bucharest
ZIP/Postal Code
022328
Country
Romania
Facility Name
Local Institution - 0232
City
Cluj-Napoca
ZIP/Postal Code
400015
Country
Romania
Facility Name
Local Institution - 0242
City
Constanta
ZIP/Postal Code
900591
Country
Romania
Facility Name
Local Institution - 0074
City
Craiova
ZIP/Postal Code
200542
Country
Romania
Facility Name
Local Institution - 0070
City
Timisoara
ZIP/Postal Code
300166
Country
Romania
Facility Name
Local Institution - 0032
City
St. Petersburg
State/Province
Sankt-Peterburg
ZIP/Postal Code
198255
Country
Russian Federation
Facility Name
Arkhangelsk Clinical Oncological Dispensary
City
Arkhangelsk
ZIP/Postal Code
163045
Country
Russian Federation
Facility Name
Local Institution
City
Leningrad Region
ZIP/Postal Code
188663
Country
Russian Federation
Facility Name
Local Institution - 0230
City
Moscow
ZIP/Postal Code
115478
Country
Russian Federation
Facility Name
Local Institution - 0042
City
Singapore
ZIP/Postal Code
119228
Country
Singapore
Facility Name
Local Institution - 0067
City
Singapore
ZIP/Postal Code
169610
Country
Singapore
Facility Name
Local Institution - 0039
City
Singapore
ZIP/Postal Code
308433
Country
Singapore
Facility Name
Local Institution - 0069
City
Barcelona
ZIP/Postal Code
08035
Country
Spain
Facility Name
Local Institution - 0031
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Facility Name
Local Institution - 0016
City
Córdoba
ZIP/Postal Code
14004
Country
Spain
Facility Name
Local Institution - 0072
City
Donostia-San Sebastian
ZIP/Postal Code
20014
Country
Spain
Facility Name
Local Institution - 0199
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Local Institution - 0109
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Facility Name
Local Institution - 0100
City
Pamplona
ZIP/Postal Code
31008
Country
Spain
Facility Name
Local Institution - 0010
City
Sabadell (Barcelona)
ZIP/Postal Code
08208
Country
Spain
Facility Name
Local Institution - 0028
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Facility Name
Local Institution - 0082
City
Valencia
ZIP/Postal Code
46026
Country
Spain
Facility Name
Local Institution - 0097
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Facility Name
Local Institution - 0131
City
Tainan
State/Province
TNN
ZIP/Postal Code
704
Country
Taiwan
Facility Name
Local Institution - 0204
City
Kaohsiung
ZIP/Postal Code
883
Country
Taiwan
Facility Name
Local Institution - 0130
City
Taichung
ZIP/Postal Code
40447
Country
Taiwan
Facility Name
Local Institution - 0140
City
Taichung
ZIP/Postal Code
40705
Country
Taiwan
Facility Name
Local Institution - 0174
City
Tainan
ZIP/Postal Code
736
Country
Taiwan
Facility Name
Local Institution - 0207
City
Taipei
ZIP/Postal Code
100
Country
Taiwan
Facility Name
Local Institution - 0173
City
Taipei
ZIP/Postal Code
105
Country
Taiwan
Facility Name
Local Institution - 0129
City
Taipei
ZIP/Postal Code
11217
Country
Taiwan
Facility Name
Local Institution - 0175
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan
Facility Name
Local Institution - 0176
City
Yunlin
ZIP/Postal Code
632
Country
Taiwan
Facility Name
Local Institution - 0111
City
London
ZIP/Postal Code
NW3 2QG
Country
United Kingdom
Facility Name
Local Institution - 0092
City
London
ZIP/Postal Code
SE5 9RS
Country
United Kingdom
Facility Name
Local Institution - 0153
City
London
ZIP/Postal Code
W12 0HS
Country
United Kingdom
Facility Name
Local Institution - 0114
City
Manchester
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Facility Name
Local Institution - 0142
City
Wirral
ZIP/Postal Code
CH63 4JY
Country
United Kingdom
12. IPD Sharing Statement
Links:
URL
https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html
Description
BMS Clinical Trial Information
URL
https://www.bmsstudyconnect.com/s/US/English/USenHome
Description
BMS Clinical Trial Patient Recruiting
URL
https://www.fda.gov/Safety/MedWatch/SafetyInformation/default.htm
Description
FDA Safety Alerts and Recalls
Learn more about this trial
A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation
We'll reach out to this number within 24 hrs