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A Study of Sodium Oligomannate (GV-971) in Participants With Mild to Moderate Alzheimer's Disease (GREEN MEMORY)

Primary Purpose

Alzheimer Disease

Status
Suspended
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
GV-971
Placebo
Sponsored by
Green Valley (Shanghai) Pharmaceuticals Co., Ltd.
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Alzheimer Disease

Eligibility Criteria

50 Years - 85 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Mild to moderate AD per NIA-AA.
  • History of cognitive and functional decline over at least 1 year.
  • MMSE scores between 11 and 24 (inclusive) at baseline.
  • Brain MRI scan show the highest possibility of AD.
  • Have a study partner/caregiver.

Exclusion Criteria:

  • Diagnosis of a dementia-related central nervous system disease other than AD.
  • Major structural brain disease as judged by MRI.
  • A resting heart rate of < 50 beats per minute (bpm) after 5 minutes of rest in sitting or supine position.
  • Major medical illness or unstable medical condition within 6 months of screening.
  • Concomitant use of AChEIs and/or memantine within 30 days before first MMSE score, and during the study.
  • Inadequate hepatic function.
  • Inadequate organ and marrow function.
  • ECG clinically significant abnormalities.

Sites / Locations

  • Cognitive Clinical Trials, LLC
  • Banner Alzheimer's Institute
  • St. Joseph's Hospital and Medical Center
  • Banner Sun Health Research Institute
  • Banner Alzheimer's Institute
  • Irvine Clinical Research
  • Sunwise Clinical Research
  • Pharmacology Research Institute
  • Pacific Research Network, Inc
  • Pacific Research Network
  • Syrentis Clinical Research
  • Schuster Med Research Institute
  • JEM Research LLC
  • Brain Matters Research
  • Finlay Medical Research Corp
  • Velocity Clinical Research
  • Jacksonville Center for Clinical Research
  • Charter Research, LLC
  • Innovative Clinical Research, Inc.
  • ClinCloud, LLC
  • Merritt Island Medical Research, LLC
  • Collier Neurologic Specialists
  • Suncoast Clinical Research Inc.
  • Clinical Neuroscience Solutions, Inc.
  • Synexus Clinical Research
  • Neurology Associates of Ormond Beach
  • Quantum Lab CNS Clinical Research
  • Progressive Medical Research
  • Intercoastal Medical Group
  • Stedman Clinical Trials, LLC
  • Meridien Research
  • Synexus The Villages
  • NeuroStudies.net, LLC
  • Great Lakes Clinical Trials
  • Indiana University
  • Alliance Multispecialty Research
  • Activmed Practices&Research
  • Quest Research Institute
  • Barnes-Jewish Hospital IDS
  • University of Nebraska Medical Center-Hematology/Oncology Section
  • Cognitive Clinical Trials, LLC
  • Altea Research Institute, Las Vegas
  • Global Medical Institutes, LLC
  • The Cognitive Research Center of New Jersey
  • Advanced Memory Research Institute of NJ, PC
  • Integrative Clinical Trials LLC
  • UBMD Neurology
  • Clarity Clinical Research
  • Richmond Behavioral Associates
  • Behavioral Health Research Center
  • AMC Research, LLC
  • Guilford Neurologic Associate
  • Insight Clinical Trials LLC
  • New Horizons Clinical Research
  • Cleveland Clinic Foundation
  • Columbus Neuroscience, LLC
  • Summit Research Network(Oregon)Inc.
  • Oregon Health&Science Universty
  • Oregon Neurology Associates
  • Abington Neurological Associates, LTD
  • SCarolina Institute Brain Health
  • Kerwin Research Center
  • Huston Methodist Hospital
  • Clinical Trials of Texas; Inc
  • Advanced Clinical Research
  • Cognition Health
  • University Washington MedCentre
  • Hornsby Ku-ring-gai Hospital
  • KaRa MINDS
  • Austin Health - Heidelberg Repatriation Hospital
  • Alzheimer's Research Foundation
  • Heritage Medical Research Clinic
  • The Medical Arts Health Research Group
  • Okanagan Clinical Trials
  • MedicalArtsHealth Research Grp
  • MedicalArtsHealth Research Grp
  • Vancouver Island Health Authority
  • Medical Arts Health Research Grp
  • True North Clinical Research Inc
  • True North Clinical Research
  • Recherches Neuro-Hippocampe Inc., d/b/a Ottawa Memory Clinic
  • Toronto Memory Program
  • Toronto Western Hospital
  • Clinique Memoire Outaouais
  • Q & T Research Sherbrooke Inc
  • Diex Recherche Sherbrooke
  • Douglas Hospital Research Centre
  • ALPHA Recherche Clinique
  • 1st Hospital of Anhui MU
  • Peking Union Hospital
  • Peking University 1st Hospital
  • Xuanwu Hospital
  • Beijing Tiantan Hospital
  • Beijing Anding Hospital
  • Beijing Hospital
  • Beijing Tong Ren Hospital
  • 1st Hospital of Chongqing MU
  • Fujian Union Hospital
  • 1st Hospital of Fujian MU
  • Zhongshan Hospital Xiamen U
  • 1st Hospital of Guangzhou MU
  • Guangzhou 1st People's Hospital
  • 2nd Hospital of Guangzhou MU
  • 2nd Hospital Zhongshan University
  • Kangning Hospital of Shenzhen
  • 1st Hospital of Hebei MU
  • Tangshan Gongren Hospital
  • Xiangya Hospital
  • Yueyang 1st People's Hospital
  • Nanjing Drum Tower Hospital
  • Zhong Da Hospital
  • 2nd Hospital Soochow University
  • Jiangxi Provincial Hospital
  • 1st Hospital Jilin University
  • General Hospital of Ningxia MU
  • Tang Du Hospital
  • Xi'an Mental Health Cente
  • Qilu Hospital
  • Shandong Provincial Hospital
  • Qingdao Municipal Hospital
  • Ruijin Hospital
  • Shanghai Mental Health Center
  • Huashan Hospital; Fudan U
  • Shanghai General Hospital
  • 1st Hospital of Shanxi MU
  • West China Hospital
  • Tianjin MU General Hospital
  • Tianjin Huanhu Hospital
  • 1st Hospital of Kunming MU
  • Zhejiang Provincial Hospital
  • 1st Hospital Zhejiang University
  • 1st Hospital of Wenzhou MU
  • NeuropsychiatrieHK s.r.o.
  • BRAIN-SOULTHERAPY s.r.o.
  • Neuroterapie KH s.r.o.
  • Clintrial s.r.o.
  • FORBELI s.r.o.
  • Neuropsychiatrie s.r.o.
  • Centred Investigation Clinique
  • CHUTimone Adultes Service
  • HOPITAL Gui de CHAULIAC
  • Centre Memoire Ressources
  • Groupe Hospitalier Pellegrin
  • Hopitaux Civils de Colmar
  • Recherche Clinique Gerontopole
  • Pharmacie CHU de Rennes
  • CHU Tours-Hopital Bretonneau
  • CHU Nantes-Hopital Nord Laennec
  • CHU Reims-Hopital Maison Blanche
  • Neurologique Pierre Wertheimer
  • Hopital des Charpennes
  • CMRR Paris Nord
  • Prince of Wales Hospital
  • VUmc Goederenontvangst
  • Amphia Hospital Breda
  • Pharmacy Jeroen Bosch Ziekenhuis
  • Klinische Farmacie
  • Podlaskie Centrum Psychogeriatri
  • NZOZ Vitamed
  • Wielospec. Poradnia Lekarska
  • Nzoz Novo Med
  • Specjalistyczne Gabinety Sp.zo.o
  • NZOZ Neuromed MiMNastajSpp
  • Medicome Sp z o o
  • Solumed Centrum Medyczne
  • Neuro Protect
  • Wrclawskie Cntrm Alzheimerowskie
  • Wielospecjalistyczne Centrm Med
  • National Taiwan UniversityHosp
  • Tri Service General Hospital
  • Chang GungMemorial Hosp Linkou

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

GV-971

Placebo

Arm Description

Outcomes

Primary Outcome Measures

Change from baseline in the ADAS-cog/11 score
Change from baseline in Alzheimer's Disease Assessments Scale - cognitive (ADAS-cog/11) scale total score. The total score of ADAS-cog/11 is 0-70, with higher scores mean a worse outcome.
Change from baseline in the ADCS-CGIC score
Change from baseline on Alzheimer's Disease Cooperative Study - Clinical Global Impression of Change (ADCS-CGIC) scale total score. The total score of ADCS-CGIC is 1-7, with higher scores mean a worse outcome.

Secondary Outcome Measures

Change from baseline in NPI score
Change from baseline in Neuropsychiatric Inventory (NPI) score. The total score of NPI is 0-144, with higher scores mean a worse outcome.
Change from baseline in MMSE score
Change from baseline in Mini Mental State Examination (MMSE) score. The total score of MMSE is 0-30, with higher scores mean a better outcome.
Change from baseline in ADCS-ADL23 score
Change from baseline in Alzheimer's Disease Cooperative Study - Activities of Daily Living; 23-item Scale (ADCS-ADL23) score. The total score of ADCS-ADL23 is 0-78, with higher scores mean a better outcome.
Change from baseline in NPI caregiver items
Change from baseline in Neuropsychiatric Inventory (NPI) caregiver items . The total score of NPI caregiver items is 0-60, with higher scores mean a worse outcome.
Change from baseline in ZBI score
Change from baseline in Zarit Burden Interview (ZBI) score. The total score of ZBI is 0-88, with higher scores mean a worse outcome.
Assess the efficacy of GV-971 throughout the OLE period
Change from baseline in Alzheimer's Disease Assessments Scale - cognitive (ADAS-cog/11) scale total score. The total score of ADAS-cog/11 is 0-70, with higher scores mean a worse outcome.
Assess the efficacy of GV-971 throughout the OLE period
Change from baseline on Alzheimer's Disease Cooperative Study - Clinical Global Impression of Change (ADCS-CGIC) scale total score. The total score of ADCS-CGIC is 1-7, with higher scores mean a worse outcome.

Full Information

First Posted
August 11, 2020
Last Updated
November 18, 2022
Sponsor
Green Valley (Shanghai) Pharmaceuticals Co., Ltd.
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1. Study Identification

Unique Protocol Identification Number
NCT04520412
Brief Title
A Study of Sodium Oligomannate (GV-971) in Participants With Mild to Moderate Alzheimer's Disease
Acronym
GREEN MEMORY
Official Title
A Phase 3, Multi-center, Randomized, Double-blind, Parallel-group, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Sodium Oligomannate (GV-971) in Treatment of Mild to Moderate Alzheimer's Disease (GREEN MEMORY: GREen Valley 971 EvaluatioN Memory)
Study Type
Interventional

2. Study Status

Record Verification Date
November 2022
Overall Recruitment Status
Suspended
Why Stopped
The quality of study was seriously affected by the COVID-19, so it was decided to suspend the trial and restart it at the right time.
Study Start Date
October 27, 2020 (Actual)
Primary Completion Date
December 2025 (Anticipated)
Study Completion Date
October 2026 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Green Valley (Shanghai) Pharmaceuticals Co., Ltd.

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No

5. Study Description

Brief Summary
The purpose of this study is to evaluate the safety, tolerability and efficacy of GV-971 in mild to moderate Alzheimer's disease.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Alzheimer Disease

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
2046 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
GV-971
Arm Type
Experimental
Arm Title
Placebo
Arm Type
Placebo Comparator
Intervention Type
Drug
Intervention Name(s)
GV-971
Intervention Description
Administered PO
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Administered PO
Primary Outcome Measure Information:
Title
Change from baseline in the ADAS-cog/11 score
Description
Change from baseline in Alzheimer's Disease Assessments Scale - cognitive (ADAS-cog/11) scale total score. The total score of ADAS-cog/11 is 0-70, with higher scores mean a worse outcome.
Time Frame
Baseline, 48 weeks and 52 weeks
Title
Change from baseline in the ADCS-CGIC score
Description
Change from baseline on Alzheimer's Disease Cooperative Study - Clinical Global Impression of Change (ADCS-CGIC) scale total score. The total score of ADCS-CGIC is 1-7, with higher scores mean a worse outcome.
Time Frame
Baseline, 48 weeks and 52 weeks
Secondary Outcome Measure Information:
Title
Change from baseline in NPI score
Description
Change from baseline in Neuropsychiatric Inventory (NPI) score. The total score of NPI is 0-144, with higher scores mean a worse outcome.
Time Frame
Baseline, 36 Weeks, 52 Weeks
Title
Change from baseline in MMSE score
Description
Change from baseline in Mini Mental State Examination (MMSE) score. The total score of MMSE is 0-30, with higher scores mean a better outcome.
Time Frame
Baseline, 52 Weeks
Title
Change from baseline in ADCS-ADL23 score
Description
Change from baseline in Alzheimer's Disease Cooperative Study - Activities of Daily Living; 23-item Scale (ADCS-ADL23) score. The total score of ADCS-ADL23 is 0-78, with higher scores mean a better outcome.
Time Frame
Baseline, 36 Weeks, 52 Weeks
Title
Change from baseline in NPI caregiver items
Description
Change from baseline in Neuropsychiatric Inventory (NPI) caregiver items . The total score of NPI caregiver items is 0-60, with higher scores mean a worse outcome.
Time Frame
Baseline, 52 Weeks
Title
Change from baseline in ZBI score
Description
Change from baseline in Zarit Burden Interview (ZBI) score. The total score of ZBI is 0-88, with higher scores mean a worse outcome.
Time Frame
Baseline, 52 Weeks
Title
Assess the efficacy of GV-971 throughout the OLE period
Description
Change from baseline in Alzheimer's Disease Assessments Scale - cognitive (ADAS-cog/11) scale total score. The total score of ADAS-cog/11 is 0-70, with higher scores mean a worse outcome.
Time Frame
Baseline, 52 Weeks, 78 Weeks
Title
Assess the efficacy of GV-971 throughout the OLE period
Description
Change from baseline on Alzheimer's Disease Cooperative Study - Clinical Global Impression of Change (ADCS-CGIC) scale total score. The total score of ADCS-CGIC is 1-7, with higher scores mean a worse outcome.
Time Frame
Baseline, 52 Weeks, 78 Weeks
Other Pre-specified Outcome Measures:
Title
Evaluate the population PK
Description
Determine serum levels of GV-971 in population PK
Time Frame
Baseline, 12 Weeks, 24 Weeks, 52 Weeks
Title
Evaluate the effect of GV-971 on brain structure neurodegeneration
Description
Changes from baseline in volumetric magnetic resonance imaging (MRI)
Time Frame
Baseline, 52 Weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
50 Years
Maximum Age & Unit of Time
85 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Mild to moderate AD per NIA-AA. History of cognitive and functional decline over at least 1 year. MMSE scores between 11 and 24 (inclusive) at baseline. Brain MRI scan show the highest possibility of AD. Have a study partner/caregiver. Exclusion Criteria: Diagnosis of a dementia-related central nervous system disease other than AD. Major structural brain disease as judged by MRI. A resting heart rate of < 50 beats per minute (bpm) after 5 minutes of rest in sitting or supine position. Major medical illness or unstable medical condition within 6 months of screening. Concomitant use of AChEIs and/or memantine within 30 days before first MMSE score, and during the study. Inadequate hepatic function. Inadequate organ and marrow function. ECG clinically significant abnormalities.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Study Director, Ph D
Organizational Affiliation
Green Valley (Shanghai) Pharmaceuticals Co., Ltd.
Official's Role
Study Director
Facility Information:
Facility Name
Cognitive Clinical Trials, LLC
City
Gilbert
State/Province
Arizona
ZIP/Postal Code
85297
Country
United States
Facility Name
Banner Alzheimer's Institute
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85006
Country
United States
Facility Name
St. Joseph's Hospital and Medical Center
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85013
Country
United States
Facility Name
Banner Sun Health Research Institute
City
Sun City
State/Province
Arizona
ZIP/Postal Code
85351
Country
United States
Facility Name
Banner Alzheimer's Institute
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85718
Country
United States
Facility Name
Irvine Clinical Research
City
Irvine
State/Province
California
ZIP/Postal Code
92614
Country
United States
Facility Name
Sunwise Clinical Research
City
Lafayette
State/Province
California
ZIP/Postal Code
94549
Country
United States
Facility Name
Pharmacology Research Institute
City
Los Alamitos
State/Province
California
ZIP/Postal Code
90720
Country
United States
Facility Name
Pacific Research Network, Inc
City
San Diego
State/Province
California
ZIP/Postal Code
92103
Country
United States
Facility Name
Pacific Research Network
City
San Diego
State/Province
California
ZIP/Postal Code
92103
Country
United States
Facility Name
Syrentis Clinical Research
City
Santa Ana
State/Province
California
ZIP/Postal Code
92705
Country
United States
Facility Name
Schuster Med Research Institute
City
Sherman Oaks
State/Province
California
ZIP/Postal Code
91403
Country
United States
Facility Name
JEM Research LLC
City
Atlantis
State/Province
Florida
ZIP/Postal Code
33462
Country
United States
Facility Name
Brain Matters Research
City
Delray Beach
State/Province
Florida
ZIP/Postal Code
33445
Country
United States
Facility Name
Finlay Medical Research Corp
City
Greenacres City
State/Province
Florida
ZIP/Postal Code
33467
Country
United States
Facility Name
Velocity Clinical Research
City
Hallandale Beach
State/Province
Florida
ZIP/Postal Code
33009
Country
United States
Facility Name
Jacksonville Center for Clinical Research
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Charter Research, LLC
City
Lady Lake
State/Province
Florida
ZIP/Postal Code
32159
Country
United States
Facility Name
Innovative Clinical Research, Inc.
City
Lauderhill
State/Province
Florida
ZIP/Postal Code
33319
Country
United States
Facility Name
ClinCloud, LLC
City
Maitland
State/Province
Florida
ZIP/Postal Code
32751
Country
United States
Facility Name
Merritt Island Medical Research, LLC
City
Merritt Island
State/Province
Florida
ZIP/Postal Code
32952
Country
United States
Facility Name
Collier Neurologic Specialists
City
Naples
State/Province
Florida
ZIP/Postal Code
34105
Country
United States
Facility Name
Suncoast Clinical Research Inc.
City
New Port Richey
State/Province
Florida
ZIP/Postal Code
34652
Country
United States
Facility Name
Clinical Neuroscience Solutions, Inc.
City
Orlando
State/Province
Florida
ZIP/Postal Code
32801
Country
United States
Facility Name
Synexus Clinical Research
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Facility Name
Neurology Associates of Ormond Beach
City
Ormond Beach
State/Province
Florida
ZIP/Postal Code
32174
Country
United States
Facility Name
Quantum Lab CNS Clinical Research
City
Pompano Beach
State/Province
Florida
ZIP/Postal Code
33064
Country
United States
Facility Name
Progressive Medical Research
City
Port Orange
State/Province
Florida
ZIP/Postal Code
32127
Country
United States
Facility Name
Intercoastal Medical Group
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
Stedman Clinical Trials, LLC
City
Tampa
State/Province
Florida
ZIP/Postal Code
33613
Country
United States
Facility Name
Meridien Research
City
Tampa
State/Province
Florida
ZIP/Postal Code
33634
Country
United States
Facility Name
Synexus The Villages
City
The Villages
State/Province
Florida
ZIP/Postal Code
32162
Country
United States
Facility Name
NeuroStudies.net, LLC
City
Decatur
State/Province
Georgia
ZIP/Postal Code
30033
Country
United States
Facility Name
Great Lakes Clinical Trials
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60640
Country
United States
Facility Name
Indiana University
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Facility Name
Alliance Multispecialty Research
City
Wichita
State/Province
Kansas
ZIP/Postal Code
67207
Country
United States
Facility Name
Activmed Practices&Research
City
Lawrence
State/Province
Massachusetts
ZIP/Postal Code
01843
Country
United States
Facility Name
Quest Research Institute
City
Farmington Hills
State/Province
Michigan
ZIP/Postal Code
48334
Country
United States
Facility Name
Barnes-Jewish Hospital IDS
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
University of Nebraska Medical Center-Hematology/Oncology Section
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68106
Country
United States
Facility Name
Cognitive Clinical Trials, LLC
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68130
Country
United States
Facility Name
Altea Research Institute, Las Vegas
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89102
Country
United States
Facility Name
Global Medical Institutes, LLC
City
Princeton
State/Province
New Jersey
ZIP/Postal Code
08540
Country
United States
Facility Name
The Cognitive Research Center of New Jersey
City
Springfield
State/Province
New Jersey
ZIP/Postal Code
07081
Country
United States
Facility Name
Advanced Memory Research Institute of NJ, PC
City
Toms River
State/Province
New Jersey
ZIP/Postal Code
08755
Country
United States
Facility Name
Integrative Clinical Trials LLC
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11229
Country
United States
Facility Name
UBMD Neurology
City
Buffalo
State/Province
New York
ZIP/Postal Code
14203
Country
United States
Facility Name
Clarity Clinical Research
City
East Syracuse
State/Province
New York
ZIP/Postal Code
13057
Country
United States
Facility Name
Richmond Behavioral Associates
City
Staten Island
State/Province
New York
ZIP/Postal Code
10312
Country
United States
Facility Name
Behavioral Health Research Center
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28211
Country
United States
Facility Name
AMC Research, LLC
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28270
Country
United States
Facility Name
Guilford Neurologic Associate
City
Greensboro
State/Province
North Carolina
ZIP/Postal Code
27405
Country
United States
Facility Name
Insight Clinical Trials LLC
City
Beachwood
State/Province
Ohio
ZIP/Postal Code
44122
Country
United States
Facility Name
New Horizons Clinical Research
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45040
Country
United States
Facility Name
Cleveland Clinic Foundation
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
Columbus Neuroscience, LLC
City
Westerville
State/Province
Ohio
ZIP/Postal Code
43082
Country
United States
Facility Name
Summit Research Network(Oregon)Inc.
City
Portland
State/Province
Oregon
ZIP/Postal Code
97210
Country
United States
Facility Name
Oregon Health&Science Universty
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Oregon Neurology Associates
City
Springfield
State/Province
Oregon
ZIP/Postal Code
97477
Country
United States
Facility Name
Abington Neurological Associates, LTD
City
Abington
State/Province
Pennsylvania
ZIP/Postal Code
19001
Country
United States
Facility Name
SCarolina Institute Brain Health
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29401
Country
United States
Facility Name
Kerwin Research Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75231
Country
United States
Facility Name
Huston Methodist Hospital
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Clinical Trials of Texas; Inc
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Advanced Clinical Research
City
West Jordan
State/Province
Utah
ZIP/Postal Code
84088
Country
United States
Facility Name
Cognition Health
City
Fairfax
State/Province
Virginia
ZIP/Postal Code
22031
Country
United States
Facility Name
University Washington MedCentre
City
Seattle
State/Province
Washington
ZIP/Postal Code
98104-2499
Country
United States
Facility Name
Hornsby Ku-ring-gai Hospital
City
Hornsby
State/Province
New South Wales
ZIP/Postal Code
2077
Country
Australia
Facility Name
KaRa MINDS
City
Macquarie Park
State/Province
New South Wales
ZIP/Postal Code
2113
Country
Australia
Facility Name
Austin Health - Heidelberg Repatriation Hospital
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3081
Country
Australia
Facility Name
Alzheimer's Research Foundation
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
Facility Name
Heritage Medical Research Clinic
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4Z6
Country
Canada
Facility Name
The Medical Arts Health Research Group
City
Kamloops
State/Province
British Columbia
ZIP/Postal Code
V2C 5T1
Country
Canada
Facility Name
Okanagan Clinical Trials
City
Kelowna
State/Province
British Columbia
ZIP/Postal Code
V1Y 1Z9
Country
Canada
Facility Name
MedicalArtsHealth Research Grp
City
Kelowna
State/Province
British Columbia
ZIP/Postal Code
V1Y 4N7
Country
Canada
Facility Name
MedicalArtsHealth Research Grp
City
Penticton
State/Province
British Columbia
ZIP/Postal Code
V2A 5L5
Country
Canada
Facility Name
Vancouver Island Health Authority
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8R1J8
Country
Canada
Facility Name
Medical Arts Health Research Grp
City
West Vancouver
State/Province
British Columbia
ZIP/Postal Code
V7T 1C5
Country
Canada
Facility Name
True North Clinical Research Inc
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3M 1N2
Country
Canada
Facility Name
True North Clinical Research
City
New Minas
State/Province
Nova Scotia
ZIP/Postal Code
B4N 3R7
Country
Canada
Facility Name
Recherches Neuro-Hippocampe Inc., d/b/a Ottawa Memory Clinic
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1Z 1G3
Country
Canada
Facility Name
Toronto Memory Program
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M3B 2S7
Country
Canada
Facility Name
Toronto Western Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5T 2S8
Country
Canada
Facility Name
Clinique Memoire Outaouais
City
Gatineau
State/Province
Quebec
ZIP/Postal Code
J8T 8J1
Country
Canada
Facility Name
Q & T Research Sherbrooke Inc
City
Sherbrooke
State/Province
Quebec
ZIP/Postal Code
J1J 2G2
Country
Canada
Facility Name
Diex Recherche Sherbrooke
City
Sherbrooke
State/Province
Quebec
ZIP/Postal Code
J1L0H8
Country
Canada
Facility Name
Douglas Hospital Research Centre
City
Verdun
State/Province
Quebec
ZIP/Postal Code
H4H 1R3
Country
Canada
Facility Name
ALPHA Recherche Clinique
City
Quebec
ZIP/Postal Code
Qc G3K 2P8
Country
Canada
Facility Name
1st Hospital of Anhui MU
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230022
Country
China
Facility Name
Peking Union Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100032
Country
China
Facility Name
Peking University 1st Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100034
Country
China
Facility Name
Xuanwu Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100053
Country
China
Facility Name
Beijing Tiantan Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100070
Country
China
Facility Name
Beijing Anding Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100088
Country
China
Facility Name
Beijing Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100730
Country
China
Facility Name
Beijing Tong Ren Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100730
Country
China
Facility Name
1st Hospital of Chongqing MU
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400016
Country
China
Facility Name
Fujian Union Hospital
City
Fuzhou
State/Province
Fujian
ZIP/Postal Code
350001
Country
China
Facility Name
1st Hospital of Fujian MU
City
Fuzhou
State/Province
Fujian
ZIP/Postal Code
350005
Country
China
Facility Name
Zhongshan Hospital Xiamen U
City
Xiamen
State/Province
Fujian
ZIP/Postal Code
361004
Country
China
Facility Name
1st Hospital of Guangzhou MU
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510120
Country
China
Facility Name
Guangzhou 1st People's Hospital
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510180
Country
China
Facility Name
2nd Hospital of Guangzhou MU
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510260
Country
China
Facility Name
2nd Hospital Zhongshan University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510260
Country
China
Facility Name
Kangning Hospital of Shenzhen
City
Shenzhen
State/Province
Guangdong
ZIP/Postal Code
518118
Country
China
Facility Name
1st Hospital of Hebei MU
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
50030
Country
China
Facility Name
Tangshan Gongren Hospital
City
Tangshan
State/Province
Hebei
ZIP/Postal Code
63000
Country
China
Facility Name
Xiangya Hospital
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410008
Country
China
Facility Name
Yueyang 1st People's Hospital
City
Yueyang
State/Province
Hunan
ZIP/Postal Code
414000
Country
China
Facility Name
Nanjing Drum Tower Hospital
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210000
Country
China
Facility Name
Zhong Da Hospital
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210009
Country
China
Facility Name
2nd Hospital Soochow University
City
Suzhou
State/Province
Jiangsu
ZIP/Postal Code
215004
Country
China
Facility Name
Jiangxi Provincial Hospital
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Facility Name
1st Hospital Jilin University
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130021
Country
China
Facility Name
General Hospital of Ningxia MU
City
Yinchuan
State/Province
Ningxia Hui Autonomous Region
ZIP/Postal Code
750004
Country
China
Facility Name
Tang Du Hospital
City
Xi'an
State/Province
Shaanxi
ZIP/Postal Code
710038
Country
China
Facility Name
Xi'an Mental Health Cente
City
Xi'an
State/Province
Shaanxi
ZIP/Postal Code
710061
Country
China
Facility Name
Qilu Hospital
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250012
Country
China
Facility Name
Shandong Provincial Hospital
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250021
Country
China
Facility Name
Qingdao Municipal Hospital
City
Qingdao
State/Province
Shandong
ZIP/Postal Code
266071
Country
China
Facility Name
Ruijin Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200020
Country
China
Facility Name
Shanghai Mental Health Center
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200030
Country
China
Facility Name
Huashan Hospital; Fudan U
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200040
Country
China
Facility Name
Shanghai General Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200080
Country
China
Facility Name
1st Hospital of Shanxi MU
City
Taiyuan
State/Province
Shanxi
ZIP/Postal Code
30001
Country
China
Facility Name
West China Hospital
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610041
Country
China
Facility Name
Tianjin MU General Hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300052
Country
China
Facility Name
Tianjin Huanhu Hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300060
Country
China
Facility Name
1st Hospital of Kunming MU
City
Kunming
State/Province
Yunnan
ZIP/Postal Code
650032
Country
China
Facility Name
Zhejiang Provincial Hospital
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Facility Name
1st Hospital Zhejiang University
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310003
Country
China
Facility Name
1st Hospital of Wenzhou MU
City
Wenzhou
State/Province
Zhejiang
ZIP/Postal Code
325000
Country
China
Facility Name
NeuropsychiatrieHK s.r.o.
City
Hradec Králové
ZIP/Postal Code
50341
Country
Czechia
Facility Name
BRAIN-SOULTHERAPY s.r.o.
City
Kladno
ZIP/Postal Code
27204
Country
Czechia
Facility Name
Neuroterapie KH s.r.o.
City
Kutná Hora
ZIP/Postal Code
28401
Country
Czechia
Facility Name
Clintrial s.r.o.
City
Praha 10
ZIP/Postal Code
10100
Country
Czechia
Facility Name
FORBELI s.r.o.
City
Praha
ZIP/Postal Code
16000
Country
Czechia
Facility Name
Neuropsychiatrie s.r.o.
City
Praha
ZIP/Postal Code
16100
Country
Czechia
Facility Name
Centred Investigation Clinique
City
Strasbourg
State/Province
Bas Rhin
ZIP/Postal Code
67098
Country
France
Facility Name
CHUTimone Adultes Service
City
Marseille
State/Province
Bouches-du-Rhône
ZIP/Postal Code
13005
Country
France
Facility Name
HOPITAL Gui de CHAULIAC
City
Montpellier
State/Province
Cedex 5
ZIP/Postal Code
34295
Country
France
Facility Name
Centre Memoire Ressources
City
Dijon
State/Province
De Lattre De Tassigny
ZIP/Postal Code
21000
Country
France
Facility Name
Groupe Hospitalier Pellegrin
City
Bordeaux
State/Province
Gironde
ZIP/Postal Code
33076
Country
France
Facility Name
Hopitaux Civils de Colmar
City
Colmar
State/Province
Grand Est
ZIP/Postal Code
68024
Country
France
Facility Name
Recherche Clinique Gerontopole
City
Toulouse
State/Province
Haute Garonne
ZIP/Postal Code
31059
Country
France
Facility Name
Pharmacie CHU de Rennes
City
Rennes
State/Province
Ille Et Vilaine
ZIP/Postal Code
35033
Country
France
Facility Name
CHU Tours-Hopital Bretonneau
City
Tonnerre
State/Province
Indre Et Loire
ZIP/Postal Code
37044
Country
France
Facility Name
CHU Nantes-Hopital Nord Laennec
City
Nantes
State/Province
Loire Atlantique
ZIP/Postal Code
44093
Country
France
Facility Name
CHU Reims-Hopital Maison Blanche
City
Reims
State/Province
Marne
ZIP/Postal Code
51092
Country
France
Facility Name
Neurologique Pierre Wertheimer
City
Bron
State/Province
Rhone
ZIP/Postal Code
69677
Country
France
Facility Name
Hopital des Charpennes
City
Villeurbanne
State/Province
Rhone
ZIP/Postal Code
69100
Country
France
Facility Name
CMRR Paris Nord
City
Paris
ZIP/Postal Code
75010
Country
France
Facility Name
Prince of Wales Hospital
City
Shatin
Country
Hong Kong
Facility Name
VUmc Goederenontvangst
City
Amsterdam
State/Province
Van Der Boechorststraat 6
ZIP/Postal Code
1081 GN
Country
Netherlands
Facility Name
Amphia Hospital Breda
City
Breda
ZIP/Postal Code
4818 C.K
Country
Netherlands
Facility Name
Pharmacy Jeroen Bosch Ziekenhuis
City
Herzogenbusch
ZIP/Postal Code
5223 LA
Country
Netherlands
Facility Name
Klinische Farmacie
City
Zwolle
ZIP/Postal Code
8025 AB
Country
Netherlands
Facility Name
Podlaskie Centrum Psychogeriatri
City
Bialystok
ZIP/Postal Code
15-756
Country
Poland
Facility Name
NZOZ Vitamed
City
Bydgoszcz
ZIP/Postal Code
85-079
Country
Poland
Facility Name
Wielospec. Poradnia Lekarska
City
Katowice
ZIP/Postal Code
40-123
Country
Poland
Facility Name
Nzoz Novo Med
City
Katowice
ZIP/Postal Code
40-650
Country
Poland
Facility Name
Specjalistyczne Gabinety Sp.zo.o
City
Kraków
ZIP/Postal Code
30-539
Country
Poland
Facility Name
NZOZ Neuromed MiMNastajSpp
City
Lublin
ZIP/Postal Code
20-064
Country
Poland
Facility Name
Medicome Sp z o o
City
Oświęcim
ZIP/Postal Code
32-600
Country
Poland
Facility Name
Solumed Centrum Medyczne
City
Poznań
ZIP/Postal Code
60-529
Country
Poland
Facility Name
Neuro Protect
City
Warszawa
ZIP/Postal Code
01-684
Country
Poland
Facility Name
Wrclawskie Cntrm Alzheimerowskie
City
Wrocław
ZIP/Postal Code
53659
Country
Poland
Facility Name
Wielospecjalistyczne Centrm Med
City
Zabrze
ZIP/Postal Code
41-800
Country
Poland
Facility Name
National Taiwan UniversityHosp
City
Taipei
ZIP/Postal Code
10048
Country
Taiwan
Facility Name
Tri Service General Hospital
City
Taipei
ZIP/Postal Code
11490
Country
Taiwan
Facility Name
Chang GungMemorial Hosp Linkou
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan

12. IPD Sharing Statement

Plan to Share IPD
Undecided

Learn more about this trial

A Study of Sodium Oligomannate (GV-971) in Participants With Mild to Moderate Alzheimer's Disease

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