A Study of Stress Echocardiography in Post-Menopausal Women at Risk for Coronary Disease
Coronary Artery Disease, Heart Disease
About this trial
This is an interventional diagnostic trial for Coronary Artery Disease
Eligibility Criteria
Inclusion Criteria: Peri or Post menopausal women either: without symptoms but with risk factors for heart disease OR experiencing atypical chest pain, OR experiencing exertional dyspnea AND 2 or more risk factors for CAD Must be able to perform an exercise stress test Peri-or post-menopausal (including surgical menopause) based on history. Post-menopausal is defined as females age 40-65 who self-report the absence of menstrual periods for at least 12 months. Peri-menopausal is defined as females age 40-65 who self-report the absence or irregularity of menstrual periods for 6-12 months. Surgical menopause is defined as females who have had a bilateral salpingo-oophorectomy with or without hysterectomy. Exclusion Criteria: Previous confirmed heart disease
Sites / Locations
- Local Institution
- Local Institution
- Local Institution
Arms of the Study
Arm 1
Experimental
Definity
All patients will undergo a gray scale baseline unenhanced imaging session (apical 2- or 4 chamber view), as well as a DEFINITY (Perflutren Lipid Microsphere Injectable Suspension)-enhanced rest and a DEFINITY enhanced exercise or dobutamine stress echocardiography imaging session. The unenhanced and DEFINITY-enhanced rest and stress echocardiography imaging sessions will be performed on the same day. For the DEFINITY-enhanced imaging sessions all patients will receive diluted DEFINITY intravenously (IV). Diluted DEFINITY will be prepared by mixing 1 mL of activated DEFINITY® with 9 mL of normal saline in a 10 mL syringe.