A Study of the Effectiveness of an HIV Vaccine (ALVAC vCP205) to Boost Immune Functions in HIV-Negative Volunteers Who Have Already Received an HIV Vaccine
HIV Infections, HIV Seronegativity
About this trial
This is an interventional prevention trial for HIV Infections focused on measuring Injections, Intramuscular, HIV-1, AIDS Vaccines, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, T-Lymphocytes, Cytotoxic, Gene Products, gag, HIV Seronegativity, Immunologic Memory, Antibodies, Viral, Genetic Vectors, Gene Products, env, Poxviridae, HIV Preventive Vaccine
Eligibility Criteria
Inclusion Criteria You may be eligible for this study if you: Are 18-60 years old. Are willing to use adequate birth control for 1 month before study entry and during the study. Have a CD4 count of at least 400 cells/mm3. Have a normal medical history and physical examination. Are available for 3 months of follow-up. Have participated in AVEG Protocol 014C or 022A and received all the scheduled vaccinations 24 or more months before this study, or have never participated in HIV-vaccine studies. Are HIV-negative within 8 weeks of study entry. Are negative for hepatitis B surface antigen. Exclusion Criteria You will not be eligible for this study if you: Are pregnant or breast-feeding. Have a history of an immune system problem, any long-term illness, or any autoimmune disease. Have a history of using medications which affect your immune system. Have a history of cancer, except if it has been removed with surgery and cure is most likely. Have a medical or mental condition which interferes with the study. Have a job or work which interferes with the study. Have ever attempted suicide, thought of attempting suicide, or have a severe mental condition. Have received vaccines within 60 days of study entry. Have used experimental drugs within 30 days prior to study entry. Have received any blood products, such as immunoglobulin, in the last 6 months. Have active syphilis. Have active tuberculosis. Have any history of severe allergic reactions, including reactions to vaccines. Have an allergy to egg products or neomycin.
Sites / Locations
- UAB AVEG
- JHU AVEG
- St. Louis Univ. School of Medicine AVEG
- Univ. of Rochester AVEG
- Vanderbilt Univ. Hosp. AVEG
- UW - Seattle AVEG