Back to resultsA Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Ulcerative Colitis (U-Accomplish)
Primary Purpose
Ulcerative Colitis (UC)
Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Placebo
Upadacitinib
Sponsored by
About this trial
This is an interventional treatment trial for Ulcerative Colitis (UC) focused on measuring Upadacitinib, ABT-494, Ulcerative Colitis
Eligibility Criteria
Inclusion Criteria:
- Male or female participants ≥ 16 and ≤ 75 years of age at Baseline Note: Adolescent participants at the age of 16 or 17 years old will be eligible to participate if approved by the country or regulatory/health authorities.
Note: Adolescent participants at the age of 16 or 17 years old must weigh ≥ 40 kilograms and meet the definition of Tanner Stage 5 at the Screening Visit.
- Diagnosis of Ulcerative Colitis (UC) for 90 days or greater prior to Baseline, confirmed by colonoscopy during the Screening Period, with exclusion of current infection, colonic dysplasia and/or malignancy. Appropriate documentation of biopsy results consistent with the diagnosis of UC, in the assessment of the Investigator, must be available.
- Active UC with an Adapted Mayo score of 5 to 9 points and endoscopic subscore of 2 to 3.
- Demonstrated an inadequate response, loss of response, or intolerance to at lease one of the following treatments including, oral aminosalicylates, corticosteroids, immunosuppressants, and/or biologic therapies.
Note: Participants who have had inadequate response, loss of response to conventional therapy but have not failed biologic therapy (Non-bio-IR) and have received a prior biologic for up to 1 year may be enrolled, however they must have discontinued the biologic for reasons other than inadequate response or intolerance (e.g., change of insurance, well controlled disease), and must meet criteria for inadequate response, loss of response, or intolerance as defined above.
- Female Participants of childbearing potential must have a negative serum pregnancy test at the Screening Visit and a negative urine pregnancy test at the Baseline Visit.
- If female, participant must meet the contraception recommendation criteria.
Exclusion Criteria:
- Participant with current diagnosis of Crohn's disease (CD) or diagnosis of indeterminate colitis (IC).
- Current diagnosis of fulminant colitis and/or toxic megacolon.
- Participant with disease limited to the rectum (ulcerative proctitis) during the Screening endoscopy.
- Received cyclosporine, tacrolimus, mycophenolate mofetil, or thalidomide within 30 days prior to Baseline.
- Participant who received azathioprine or 6-mercaptopurine (6-MP) within 10 days of Baseline.
- Received intravenous corticosteroids within 14 days prior to Screening or during the Screening Period.
- Participant with previous exposure to Janus Activated Kinase (JAK) inhibitor (e.g., tofacitinib, baricitinib, filgotinib, upadacitinib).
- Screening laboratory and other analyses show any prespecified abnormal hematologic results.
Sites / Locations
- East View Medical Research, LLC /ID# 216933
- CB Flock Research Corporation /ID# 206094
- Arizona Arthritis & Rheumatology Research, PLLC /ID# 211030
- Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211887
- University of Arizona /ID# 208856
- Citrus Valley Gastroenterology /ID# 205627
- Care Access Research /ID# 217003
- Moore UC San Diego Cancer Center /ID# 204919
- United Medical Doctors /ID# 207867
- TLC Clinical Research Inc /ID# 216831
- Gastrointestinal Biosciences Clinical Trials, LLC /ID# 205314
- Facey Medical Foundation /ID# 205301
- United Medical Doctors - Murrieta /ID# 205313
- InSite Digestive Health Care - Oxnard /ID# 205628
- Inland Empire Clinical Trials, LLC /ID# 216164
- San Diego Clinical Trials /ID# 212122
- Medical Assoc Research Grp /ID# 205626
- Delta Waves, Inc. /ID# 206170
- Western States Clinical Res /ID# 206091
- Western Connecticut Medical Group /ID# 208290
- Gastroenterology Center of CT /ID# 208291
- Gastro Florida /ID# 206174
- Universal Axon Clinical Research /ID# 213462
- Palmetto Research, LLC /ID# 208293
- Nature Coast Clinical Research - Inverness /ID# 206087
- Encore Borland-Groover Clinical Research /Id# 208128
- Cfagi Llc /Id# 207995
- University of Miami /ID# 215445
- Coral Research Clinic /ID# 208292
- Advanced Research Institute, Inc /ID# 206077
- Endoscopic Research, Inc. /ID# 207360
- Omega Research Consultants /ID# 206066
- Clinical Research Trials of Florida, Inc. /ID# 206068
- University of South Florida /ID# 214495
- AdventHealth Tampa /ID# 207363
- Gastroenterology Associates of Central Georgia, LLC /ID# 216940
- Infinite Clinical Trials /ID# 215343
- Atlanta Gastroenterology Spec /ID# 206173
- Next Innovative Clinical Research - Chicago /ID# 217324
- The University of Chicago Medical Center /ID# 206172
- Carle Foundation Hospital /ID# 207397
- MediSphere Medical Research Center /ID# 206073
- Indianapolis Gastroenterology /ID# 206381
- University of Iowa Hospitals and Clinics /ID# 206167
- Cotton-O'Neil Clinical Res Ctr /ID# 206175
- Tri-State Gastroenterology /ID# 206124
- Houma Digestive Health Special /ID# 206176
- Louisana Research Center, LLC /ID# 206064
- Gastro Center of Maryland /ID# 206883
- University of Michigan Health Systems /ID# 206918
- Huron Gastroenterology Assoc /ID# 205109
- Clin Res Inst of Michigan, LLC /ID# 207078
- Revival Research Institute, LLC /ID# 207282
- Center for Digestive Health /ID# 207080
- Mayo Clinic /ID# 205645
- University of Mississippi Medical Center /ID# 213116
- Southern Therapy and Advanced Research (STAR) LLC /ID# 206069
- Las Vegas Medical Research /ID# 206814
- AGA Clinical Research Associates, LLC /ID# 206880
- Atlantic Digestive Health Inst /ID# 208748
- Rutgers Robert Wood Johnson /ID# 207382
- University of New Mexico Department of Internal Medicine /ID# 214397
- Advantage Clinical Trials /ID# 206082
- NY Scientific /ID# 206080
- NYU Langone Long Island Clinical Research Associates /ID# 206079
- DiGiovanna Institute for Medical Education & Research /ID# 206885
- Premier Medical Group - GI Division /ID# 206097
- Gastro Group of Rochester /ID# 206881
- Richmond University Medical Center /ID# 213185
- Digestive Health Partners, P.A /ID# 206842
- Atrium Health Carolinas Medical Center /ID# 206085
- Charlotte Gastroenterology and Hepatology, PLLC /ID# 206138
- Wake Forest Baptist Medical Center /ID# 206067
- Duplicate_Plains Clinical Research Center, LLC /ID# 205111
- University of Cincinnati /ID# 205633
- The Ohio State University /ID# 205637
- Optimed Research, Ltd. /ID# 205638
- Hometown Urgent Care and Resea /ID# 205630
- Dayton Gastroenterology, Inc. /ID# 205639
- Great Lakes Gastroenterology Research LLC /ID# 205631
- Hightower Clinical /ID# 216336
- Digestive Disease Specialists /ID# 206076
- Options Health Research, LLC /ID# 206707
- Healthcare Research Consultant /ID# 206706
- Guthrie Medical Group, PC /ID# 206078
- Pharmacorp Clinical Trials /ID# 206074
- Gastroenterology Associates, P.A. of Greenville /ID# 206098
- Gastro One /ID# 206178
- East Tennessee Research Institute /ID# 206169
- Quality Medical Research /ID# 206088
- Vanderbilt University Medical Center /ID# 210405
- TX Clinical Research Institute /ID# 206718
- Inquest Clinical Research /ID# 206132
- Texas Digestive Disease Consultants /ID# 209805
- Texas Digestive Disease Consultants /ID# 209948
- Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 207484
- DHAT Research Institute /ID# 206716
- Vilo Research Group Inc /ID# 212625
- Baylor College of Medicine - Baylor Medical Center /ID# 206717
- Centex Studies, Inc. - Houston /ID# 206168
- GI Specialists of Houston /ID# 206090
- Caprock Gastro Research /ID# 215115
- Clinical Associates in Research Therapeutics of America, LLC /ID# 206710
- Southern Star Research Institute, LLC /ID# 205379
- Baylor Scott & White Center for Diagnostic Medicine /ID# 206096
- Duplicate_Tyler Research Institue /ID# 206075
- Gastro Health & Nutrition - Victoria /ID# 205378
- Advanced Research Institute /ID# 206133
- Ctr for Gastrointestinal Healt /ID# 208475
- Washington Gastroenterology Associates /ID# 206177
- Virginia Mason - Seattle Orthapedics /ID# 206070
- The Vancouver Clinic, INC. PS /ID# 204973
- Wisconsin Center for Advanced Research, a division of GI Associates, LLC /ID# 206917
- Froedtert Memorial Lutheran Hospital /ID# 206945
- Cardio Alem /ID# 211282
- Mautalen Salud e Investigacion /ID# 206033
- Hospital Britanico de Buenos Aires /ID# 209497
- Gedyt /ID# 210017
- Hospital Privado Univesitario /ID# 206030
- Macquarie University Hospital /ID# 211955
- Duplicate_Mater Misericordiae /ID# 212687
- Griffith University /ID# 211956
- St Vincent's Hospital Melbourne /ID# 205758
- Monash Medical Centre /ID# 206486
- Fiona Stanley Hospital /ID# 211642
- Klinik Landstrasse /ID# 205764
- Medical University of Vienna /ID# 205763
- LKH Salzburg and Paracelsus /ID# 208788
- Universitair Ziekenhuis Leuven /ID# 205988
- AZ Maria Middelares /ID# 210928
- University Clinical Centre of the Republic of Srpska /ID# 208053
- University Clinical Centre of the Republic of Srpska /ID# 208055
- University Clinical Center Tuzla /ID# 208057
- University Clinical Hospital Mostar /ID# 208054
- Clinical Center University of Sarajevo /ID# 208058
- Hospital Nossa Senhora das Graças /ID# 206981
- Hospital de Clinicas de Porto Alegre /ID# 206985
- Upeclin Fmb - Unesp /Id# 206986
- Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 206504
- Faculdade de Medicina do ABC /ID# 206984
- Kaiser Clinica e Hospital Dia /ID# 206982
- University of Calgary - Cumming School of Medicine - Adult Cystic Fibrosis Clini /ID# 205755
- Allen Whey Khye Lim Professional Corporation /ID# 211167
- Covenant Health /ID# 205500
- Percuro Clinical Research, Ltd /ID# 205501
- Duplicate_Toronto Digestive Disease Asso /ID# 205498
- Crchum /Id# 207387
- CIUSSS de l'Estrie - CHUS /ID# 205499
- Research Group /ID# 208037
- M y F Estudios Clínicos Ltda. /ID# 208035
- Hospital Guillermo Grant Benavente de Concepción /ID# 212426
- CTR Estudios Clinicos /ID# 208036
- Hospital Clinico Universidad De Los Andes /ID# 207426
- Sun Yat-sen Memorial Hospital of Sun Yat-sen University /ID# 205267
- The Sixth Affiliated Hosp Sun /ID# 205268
- Affiliated Taihe Hospital of Hubei University of Medicine /ID# 216406
- Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 205266
- The First Affiliated Hospital of Nanchang University /ID# 212186
- The First Hospital of Jilin University /ID# 210088
- Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 205333
- The second Affiliated hospital of Zhejiang University school of Medicine /ID# 205271
- West China Hospital, Sichuan University /ID# 205332
- Duplicate_Tianjin Med Univ General Hosp /ID# 205246
- Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 205265
- Instituto Medico de Alta Tecnologia Oncomédica S.A /ID# 208887
- Corporacion Hospitalaria Juan Cuidad Sede Denominada Hospital Universitario Mayo /ID# 208886
- Hospital Universitario San Vic /ID# 208888
- Klinicka bolnica Dubrava Zagreb /ID# 208460
- Poliklinika Solmed /ID# 211568
- Klinicki bolnicki centar Rijeka /ID# 208650
- Klinicki bolnicki centar Split /ID# 217027
- Hepato-Gastroenterologie HK, s.r.o. /ID# 205672
- CTCenter MaVe s.r.o. /ID# 205671
- Artroscan s.r.o. /ID# 205668
- Nemocnice Pardubickeho kraje, a.s. /ID# 213540
- Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 216223
- Axon Clinical, s.r.o. /ID# 205670
- ISCARE a.s. /ID# 209240
- East Tallinn Central Hospital /ID# 207564
- West Tallinn Central Hospital /ID# 207356
- North Estonia Medical Centre /ID# 207357
- Tartu University Hospital /ID# 212282
- Tampere University Hospital /ID# 206161
- Keski-Suomen Sairaala Nova /ID# 206159
- Laakarikeskus Ikioma /ID# 205814
- Tyks /Id# 205813
- Chu de Nice-Hopital L'Archet Ii /Id# 209118
- Centre Hospitalier Lyon Sud /ID# 209121
- Universitatsklinikum Mannheim /ID# 206811
- Duplicate_Universitaetsklinikum Tuebingen /ID# 206737
- Gastroenterologische Gemeinschaftspraxis Herne /ID# 214576
- Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 215813
- Duplicate_Praxis am Bayrischen Platz /ID# 206733
- Agaplesion Markus Krankenhaus /ID# 206731
- Duplicate_Univ Hosp Schleswig-Holstein /ID# 206791
- Medizinisches Versorgungszentrum Portal 10 /ID# 207137
- General Hospital of Athens Laiko /ID# 208671
- University General Hospital of Heraklion PA.G.N.I /ID# 207061
- General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 206332
- Duplicate_General Hospital of Thessaloniki Hippokrateio /ID# 208822
- Bekes Megyei Kozponti Korhaz /ID# 205885
- Semmelweis Egyetem /ID# 205883
- Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet /ID# 207992
- Mentahaz Maganorvosi Kozpont /ID# 205882
- Beaumont Hospital /ID# 206509
- University Hospital Galway /ID# 218035
- Rambam Health Care Campus /ID# 206362
- Shaare Zedek Medical Center /ID# 206365
- A.O.U. Policlinico S.Orsola-Malpighi /ID# 206351
- ASST Rhodense/Presidio Ospedaliero di Rho /ID# 216611
- Istituto Clinico Humanitas /ID# 206346
- Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 206347
- IRCCS Ospedale Sacro Cuore Don Calabria /ID# 206354
- Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 206349
- A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 206350
- Nagoya City University Hospital /ID# 206058
- Nagoya University Hospital /ID# 206355
- Toyohashi Municipal Hospital /ID# 207625
- Ieda Hospital /ID# 207479
- Hirosaki National Hospital /ID# 206387
- Tokatsu Tsujinaka Hospital /ID# 214963
- Tsujinaka Hospital Kashiwanoha /ID# 209573
- Toho University Medical Center Sakura Hospital /ID# 207705
- Juntendo University Urayasu Hospital /ID# 208784
- Fukui Prefectural Hospital /ID# 210449
- Fukuoka University Chikushi Hospital /ID# 214405
- Saiseikai Fukuoka Genaral Hospital /ID# 209482
- Kurume University Hospital /ID# 206385
- Ogaki Municipal Hospital /ID# 208227
- NHO Fukuyama Medical Center /ID# 206295
- Hiroshima University Hospital /ID# 206464
- Asahikawa Medical University Hospital /ID# 206404
- Obihiro kosei Hospital /ID# 210424
- Sapporo Tokushukai Hospital /ID# 209448
- Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 206059
- Sapporo Medical University Hospital /ID# 206314
- Sapporo Higashi Tokushukai Hospital /ID# 208494
- Aoyama Clinic /ID# 206452
- Hyogo College of Medicine Hospital /ID# 206455
- Kanazawa University Hospital /ID# 206316
- Iwate Medical University Uchimaru Medical Center /ID# 207051
- Idzuro Imamura Hospital /ID# 207639
- Sameshima Hospital /ID# 207935
- St. Marianna University School of Medicine Hospital /ID# 209451
- Showa University Fujigaoka Hospital /ID# 208224
- Kyoto University Hospital /ID# 211809
- Mie University Hospital /ID# 206803
- Yokkaichi Hazu Medical Center /ID# 214348
- National Hospital Organization Sendai Medical Center /ID# 209528
- NHO Nagasaki Medical Center /ID# 210822
- Kenseikai Dongo Hospital /ID# 208101
- Saiseikai Niigata Hospital /ID# 209921
- Niigata University Medical & Dental Hospital /ID# 218049
- Ishida Clinic of IBD and Gastroenterology /ID# 210119
- Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 206646
- Okayama University Hospital /ID# 217925
- Kinshukai Infusion Clinic /ID# 207865
- Kitano Hospital /ID# 210397
- Japanese Red Cross Osaka Hospital /ID# 209478
- Osaka City University Hospital /ID# 206457
- Toyonaka Municipal Hospital /ID# 217082
- Saga University Hospital /ID# 209270
- Saitama Medical Center /ID# 206393
- Tokitokai Tokito clinic /ID# 206313
- National Hospital Organization Higashi-Ohmi General Medical Center /ID# 210710
- Shimane University School of Medicine /ID# 208905
- Hamamatsu University Hospital /ID# 206459
- NHO Shizuoka Medical Center /ID# 208785
- Tokyo Medical And Dental University, Medical Hospital /ID# 206453
- St.Luke's International Hospital /ID# 208076
- Tokai University Hachioji Hospital /ID# 208903
- Teikyo University Hospital /ID# 209866
- Center Hospital of the National Center for Global Health and Medicine /ID# 209532
- Tokyo Women's Medical University Hospital /ID# 206460
- Yamagata University Hospital /ID# 206465
- Tokuyama Central Hospital /ID# 216994
- Shoyukai Fujita Gastroenterological Hospital /ID# 216493
- Kangbuk Samsung Hospital /ID# 206960
- Dong-A University Hospital /ID# 206955
- Pusan National University Hospital /ID# 206956
- Yeungnam University Medical Center /ID# 206959
- Duplicate_CHA Bundang Medical Center /ID# 207432
- Yonsei University Health System, Severance hospital /ID# 206958
- Riga East Clinical Univ Hosp /ID# 206828
- P. Stradins Clinical Univ Hosp /ID# 206827
- Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 209052
- Klaipeda Seamens Hospital /ID# 208791
- Klaipeda University Hospital /ID# 208790
- Vilnius University Hospital /ID# 209051
- Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 207662
- Duplicate_Uni Malaya MC /ID# 208936
- Morales Vargas Centro de Investigacion S.C. /ID# 211326
- Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 208068
- Centro Regiomontano de Estudios Clínicos ROMA S.C /ID# 208067
- Erasmus Medisch Centrum /ID# 205280
- Akershus Universitetssykehus_MAIN /ID# 205293
- Universitetssykehuset Nord-Norge /ID# 205691
- Gastromed /Id# 216108
- Centrum Medyczne Reuma Park w Warszawie /ID# 212913
- Centrum Zdrowia MDM /ID# 205874
- NZOZ Vivamed /ID# 216697
- Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 215070
- Endoskopia Sp. z o.o. /ID# 212964
- Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 205554
- Centro Hospitalar de Entre Douro e Vouga /ID# 205563
- Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 205556
- Hospital Garcia de Orta, EPE /ID# 206143
- CCA Braga - Hospital de Braga /ID# 206144
- Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 206117
- Hospital Santo Antonio dos Cap /ID# 206145
- Centro Hospitalar Universitario de Sao Joao, EPE /ID# 206142
- School of Medicine University of Puerto Rico-Medical Science Campus /ID# 209626
- Immanuel Kant Baltic Federal University /ID# 208264
- NW State Medical Univ na Mechn /ID# 208258
- Perm Clinical Center of the Federal Medical and Biological Agency /ID# 211653
- Medical Company Hepatolog /ID# 208261
- Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 211652
- Kazan State Medical University /ID# 208256
- Olla-Med Clinic /ID# 215335
- Republican hospital named after V.A. Baranov /ID# 206507
- Euromedservice /ID# 208265
- LLC Novaya Clinica /ID# 208260
- Clinical Hosp Center Zvezdara /ID# 205258
- Military Medical Academy /ID# 205257
- University Clinical Center Serbia /ID# 205256
- Clin Hosp Ctr Bezanijska Kosa /ID# 206413
- University Clinical Center of Nis /ID# 206411
- University Clinical Center Kragujevac /ID# 206410
- Clinical Center Vojvodina /ID# 205259
- General Hospital Leskovac /ID# 217881
- National University Hospital /ID# 209099
- Gleneagles Medical Centre /ID# 206954
- Tan Tock Seng Hospital /ID# 207663
- Medak s.r.o. /ID# 205191
- Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 205147
- B+B MED, s.r.o. /ID# 205213
- Fakultna nemocnica s poliklini /ID# 211372
- GASTRO I., s.r.o. /ID# 205148
- MD Search /ID# 208084
- Clinresco Centers /ID# 208083
- Lenasia Clinical Trial Centre /ID# 214359
- Wits Clinical Research , Wits Health Consortium (PTY) Ltd /ID# 208082
- Wits Clinical Research Site /ID# 208949
- Mediclinic Milnerton /ID# 207979
- Kingsbury Hospital /ID# 205281
- Private Practice Dr MN Rajabally /ID# 205273
- Hospital Clínico Universitario de Santiago-CHUS /ID# 204411
- Hospital Unversitario Marques de Valdecilla /ID# 216622
- Hospital Universitario Dr. Negrin /ID# 206905
- Hospital Universitario A Coruna - CHUAC /ID# 206907
- Hospital Clinic de Barcelona /ID# 206906
- Hospital Universitario Reina Sofia /ID# 204412
- Hospital Universitario Ramon y Cajal /ID# 204410
- Hospital Universitario La Paz /ID# 214540
- Hospital Clinico Universitario de Salamanca /ID# 205013
- Hospital Universitario y Politecnico La Fe /ID# 206904
- Kantonsspital St. Gallen /ID# 211310
- Universitaetsspital Basel /ID# 211381
- Inselspital, Universitaetsklinik /ID# 211312
- Universitaetsspital Zuerich /ID# 211308
- China Medical University Hosp /ID# 207845
- National Taiwan University Hospital /ID# 207847
- Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 207848
- Taipei Veterans General Hosp /ID# 207849
- Erciyes University Medical Fac /ID# 207506
- Gazi University Med. Faculty /ID# 208040
- Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 207507
- Umraniye Training and Res Hosp /ID# 208206
- Mersin University Medical /ID# 208039
- Communal Non-Commercial Enterprize of Kharkiv Regional Council Regional Clinical /ID# 206939
- Kyiv Regional Hospital /ID# 217373
- PE PMC Acinus, Medical and Diagnostic Center /ID# 217218
- Medical centre of CONSILIUM MEDICAL LLC /ID# 217447
- Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 216300
- Basingstoke & North Hampshire /ID# 207985
- Queen Elizabeth University Hos /ID# 205154
- Huddersfield Royal Infirmary /ID# 217660
- St. George's Healthcare NHS /ID# 208375
- Barts and the London NHS Trust /ID# 205153
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Placebo Comparator
Arm Label
Upadacitinib 45 mg
Placebo
Arm Description
Participants received 45 mg upadacitinib once daily (QD) for 8 weeks. Participants who did not achieve clinical response per Adapted Mayo score at Week 8 received upadacitinib 45 mg once daily for 8 additional weeks in the open-label extension period.
Participants received placebo matching to upadacitinib once daily for 8 weeks. Participants who did not achieve clinical response per Adapted Mayo score at Week 8 received upadacitinib 45 mg once daily for 8 weeks in the open-label extension period.
Outcomes
Primary Outcome Measures
Percentage of Participants Who Achieved Clinical Remission Per Adapted Mayo Score at Week 8
The Adapted Mayo Score is a composite score of UC disease activity based on the following 3 subscores:
Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal).
Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed).
Endoscopic subscore, scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration).
The overall Adapted Mayo score ranges from 0 to 9 where higher scores represent more severe disease.
Clinical remission is defined as an Adapted Mayo score ≤ 2, with SFS ≤ 1 and not higher than Baseline, RBS of 0, and endoscopic subscore ≤ 1.
Secondary Outcome Measures
Percentage of Participants With Endoscopic Improvement at Week 8
Endoscopic improvement is defined as an endoscopic subscore of 0 or 1. Endoscopies were assessed by a blinded central reader and scored according to the following scale: 0 = Normal or inactive disease; 1 = Mild disease (erythema, decreased vascular pattern); 2 = Moderate disease (marked erythema, lack of vascular pattern, any friability, erosions); 3 = Severe disease (spontaneous bleeding, ulceration).
Percentage of Participants With Endoscopic Remission at Week 8
Endoscopic remission is defined as an endoscopic subscore of 0. Endoscopies were assessed by a blinded central reader and scored according to the following scale: 0 = Normal or inactive disease; 1 = Mild disease (erythema, decreased vascular pattern); 2 = Moderate disease (marked erythema, lack of vascular pattern, any friability, erosions); 3 = Severe disease (spontaneous bleeding, ulceration).
Percentage of Participants Who Achieved Clinical Response Per Adapted Mayo Score at Week 8
The Adapted Mayo Score is a composite score of UC disease activity based on the following 3 subscores:
Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal).
Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed).
Endoscopic subscore, scored from 0 (normal or inactive disease) to 3 (severe disease with spontaneous bleeding, ulceration).
The overall Adapted Mayo score ranges from 0 to 9 with higher scores representing more severe disease.
Clinical response per the Adapted Mayo Score is defined as a decrease in Adapted Mayo score ≥ 2 points and ≥ 30% from Baseline, plus a decrease in RBS ≥ 1 or an absolute RBS ≤ 1.
Percentage of Participants Who Achieved Clinical Response Per Partial Adapted Mayo Score at Week 2
The Partial Adapted Mayo Score is a composite score of UC disease activity based on the following 2 subscores:
Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal).
Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed).
The overall Partial Adapted Mayo score ranges from 0 to 6 with higher scores representing more severe disease.
Clinical response per Partial Adapted Mayo Score is defined as a decrease in Partial Adapted Mayo score ≥ 1 point and ≥ 30% from Baseline, plus a decrease in RBS ≥ 1 or an absolute RBS ≤ 1.
Percentage Of Participants Who Achieved Histologic-Endoscopic Mucosal Improvement at Week 8
Histologic endoscopic mucosal improvement is defined as an endoscopic subscore of 0 or 1 and a Geboes score ≤ 3.1.
The endoscopic subscore ranges from 0 (normal or inactive disease) to 3 (severe disease with spontaneous bleeding, ulceration).
The Geboes histologic index includes seven histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers). The Geboes score has 6 grades, each with 3-5 subgrades: Grade 0, structural change only; Grade 1, chronic inflammation; Grade 2, lamina propria neutrophils and eosinophils; Grade 3, neutrophils in epithelium; Grade 4, crypt destruction; and Grade 5, erosions or ulceration.
Percentage of Participants Who Reported No Bowel Urgency at Week 8
Bowel urgency was assessed by participants in a subject diary completed once a day.
Percentage of Participants Who Reported No Abdominal Pain at Week 8
Abdominal pain was assessed by participants in a subject diary completed once a day.
Percentage of Participants Who Achieved Histologic Improvement at Week 8
Histologic improvement is defined as a decrease from Baseline in Geboes score. The Geboes histologic index includes seven histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers). The Geboes score has 6 grades, each with 3-5 subgrades: Grade 0, structural change only; Grade 1, chronic inflammation; Grade 2, lamina propria neutrophils and eosinophils; Grade 3, neutrophils in epithelium; Grade 4, crypt destruction; and Grade 5, erosions or ulceration.
Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score at Week 8
The Inflammatory Bowel Disease Questionnaire (IBDQ) is used to assess health-related quality of life (HRQoL) in patients with ulcerative colitis. It consists of 32 questions evaluating bowel and systemic symptoms, as well as emotional and social functions. Each question is answered on a scale from 1 (worst) to 7 (best). The total score ranges from 32 to 224 with higher scores indicating better health-related quality of life. A positive change from Baseline indicates improvement.
Percentage of Participants Who Achieved Mucosal Healing at Week 8
Mucosal healing is defined as an endoscopic score of 0 and Geboes score < 2.0. The endoscopic subscore ranges from 0 (normal or inactive disease) to 3 (severe disease with spontaneous bleeding, ulceration).
The Geboes histologic index includes seven histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers). The Geboes score has 6 grades, each with 3-5 subgrades: Grade 0, structural change only; Grade 1, chronic inflammation; Grade 2, lamina propria neutrophils and eosinophils; Grade 3, neutrophils in epithelium; Grade 4, crypt destruction; and Grade 5, erosions or ulceration.
Change From Baseline in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Score at Week 8
The FACIT fatigue questionnaire was developed to assess fatigue associated with anemia. It consists of 13 fatigue-related questions. Each question is answered on a 5-point Likert scale: 0 (not at all); 1 (a little bit); 2 (somewhat); 3 (quite a bit); and 4 (very much). The total score ranges from 0 to 52, where higher scores represent less fatigue, and a positive change from Baseline indicates improvement.
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT03653026
Brief Title
A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Ulcerative Colitis
Acronym
U-Accomplish
Official Title
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study to Evaluate the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Moderately to Severely Active Ulcerative Colitis
Study Type
Interventional
2. Study Status
Record Verification Date
February 2022
Overall Recruitment Status
Completed
Study Start Date
December 6, 2018 (Actual)
Primary Completion Date
January 14, 2021 (Actual)
Study Completion Date
January 14, 2021 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
AbbVie
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Product Manufactured in and Exported from the U.S.
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo in inducing clinical remission (per Adapted Mayo score) in participants with moderately to severely active ulcerative colitis (UC).
Detailed Description
Study M14-675 consists of 2 parts, Part 1 and Part 2. Part 1 is a randomized, double-blind, placebo-controlled 8-week induction period. Part 2 is an open-label, 8-week extended treatment period for participants who did not achieve clinical response at Week 8 in Part 1.
Eligible participants are randomized in a 2:1 ratio to one of the two treatment groups (upadacitinib 45 mg or matching placebo) for 8 weeks. The randomization is stratified by biologic inadequate responder (bio-IR) status (bio-IR vs non-bio-IR), corticosteroid use (yes or no), and Adapted Mayo score (≤ 7 or > 7) at Baseline. Within bio-IR, the randomization is further stratified by number of prior biologic treatments (≤ 1 or > 1). Within non-bio-IR, the randomization is further stratified by previous biologic use (yes or no).
Participants who achieve clinical response defined by Adapted Mayo Score at Week 8 or Week 16 and do not meet any study discontinuation criteria are eligible to enroll into Study M14-234 Substudy 3 (NCT02819635; 52-week maintenance study) or Study M14-533 Cohort 1 (NCT03006068; long-term follow-up study).
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Ulcerative Colitis (UC)
Keywords
Upadacitinib, ABT-494, Ulcerative Colitis
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
522 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Upadacitinib 45 mg
Arm Type
Experimental
Arm Description
Participants received 45 mg upadacitinib once daily (QD) for 8 weeks. Participants who did not achieve clinical response per Adapted Mayo score at Week 8 received upadacitinib 45 mg once daily for 8 additional weeks in the open-label extension period.
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Participants received placebo matching to upadacitinib once daily for 8 weeks. Participants who did not achieve clinical response per Adapted Mayo score at Week 8 received upadacitinib 45 mg once daily for 8 weeks in the open-label extension period.
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Tablet for oral administration
Intervention Type
Drug
Intervention Name(s)
Upadacitinib
Other Intervention Name(s)
ABT-494, RINVOQ®
Intervention Description
Tablet for oral administration
Primary Outcome Measure Information:
Title
Percentage of Participants Who Achieved Clinical Remission Per Adapted Mayo Score at Week 8
Description
The Adapted Mayo Score is a composite score of UC disease activity based on the following 3 subscores:
Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal).
Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed).
Endoscopic subscore, scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration).
The overall Adapted Mayo score ranges from 0 to 9 where higher scores represent more severe disease.
Clinical remission is defined as an Adapted Mayo score ≤ 2, with SFS ≤ 1 and not higher than Baseline, RBS of 0, and endoscopic subscore ≤ 1.
Time Frame
Week 8
Secondary Outcome Measure Information:
Title
Percentage of Participants With Endoscopic Improvement at Week 8
Description
Endoscopic improvement is defined as an endoscopic subscore of 0 or 1. Endoscopies were assessed by a blinded central reader and scored according to the following scale: 0 = Normal or inactive disease; 1 = Mild disease (erythema, decreased vascular pattern); 2 = Moderate disease (marked erythema, lack of vascular pattern, any friability, erosions); 3 = Severe disease (spontaneous bleeding, ulceration).
Time Frame
Week 8
Title
Percentage of Participants With Endoscopic Remission at Week 8
Description
Endoscopic remission is defined as an endoscopic subscore of 0. Endoscopies were assessed by a blinded central reader and scored according to the following scale: 0 = Normal or inactive disease; 1 = Mild disease (erythema, decreased vascular pattern); 2 = Moderate disease (marked erythema, lack of vascular pattern, any friability, erosions); 3 = Severe disease (spontaneous bleeding, ulceration).
Time Frame
Week 8
Title
Percentage of Participants Who Achieved Clinical Response Per Adapted Mayo Score at Week 8
Description
The Adapted Mayo Score is a composite score of UC disease activity based on the following 3 subscores:
Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal).
Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed).
Endoscopic subscore, scored from 0 (normal or inactive disease) to 3 (severe disease with spontaneous bleeding, ulceration).
The overall Adapted Mayo score ranges from 0 to 9 with higher scores representing more severe disease.
Clinical response per the Adapted Mayo Score is defined as a decrease in Adapted Mayo score ≥ 2 points and ≥ 30% from Baseline, plus a decrease in RBS ≥ 1 or an absolute RBS ≤ 1.
Time Frame
Week 8
Title
Percentage of Participants Who Achieved Clinical Response Per Partial Adapted Mayo Score at Week 2
Description
The Partial Adapted Mayo Score is a composite score of UC disease activity based on the following 2 subscores:
Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal).
Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed).
The overall Partial Adapted Mayo score ranges from 0 to 6 with higher scores representing more severe disease.
Clinical response per Partial Adapted Mayo Score is defined as a decrease in Partial Adapted Mayo score ≥ 1 point and ≥ 30% from Baseline, plus a decrease in RBS ≥ 1 or an absolute RBS ≤ 1.
Time Frame
Week 2
Title
Percentage Of Participants Who Achieved Histologic-Endoscopic Mucosal Improvement at Week 8
Description
Histologic endoscopic mucosal improvement is defined as an endoscopic subscore of 0 or 1 and a Geboes score ≤ 3.1.
The endoscopic subscore ranges from 0 (normal or inactive disease) to 3 (severe disease with spontaneous bleeding, ulceration).
The Geboes histologic index includes seven histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers). The Geboes score has 6 grades, each with 3-5 subgrades: Grade 0, structural change only; Grade 1, chronic inflammation; Grade 2, lamina propria neutrophils and eosinophils; Grade 3, neutrophils in epithelium; Grade 4, crypt destruction; and Grade 5, erosions or ulceration.
Time Frame
Week 8
Title
Percentage of Participants Who Reported No Bowel Urgency at Week 8
Description
Bowel urgency was assessed by participants in a subject diary completed once a day.
Time Frame
Week 8
Title
Percentage of Participants Who Reported No Abdominal Pain at Week 8
Description
Abdominal pain was assessed by participants in a subject diary completed once a day.
Time Frame
Week 8
Title
Percentage of Participants Who Achieved Histologic Improvement at Week 8
Description
Histologic improvement is defined as a decrease from Baseline in Geboes score. The Geboes histologic index includes seven histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers). The Geboes score has 6 grades, each with 3-5 subgrades: Grade 0, structural change only; Grade 1, chronic inflammation; Grade 2, lamina propria neutrophils and eosinophils; Grade 3, neutrophils in epithelium; Grade 4, crypt destruction; and Grade 5, erosions or ulceration.
Time Frame
Week 8
Title
Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score at Week 8
Description
The Inflammatory Bowel Disease Questionnaire (IBDQ) is used to assess health-related quality of life (HRQoL) in patients with ulcerative colitis. It consists of 32 questions evaluating bowel and systemic symptoms, as well as emotional and social functions. Each question is answered on a scale from 1 (worst) to 7 (best). The total score ranges from 32 to 224 with higher scores indicating better health-related quality of life. A positive change from Baseline indicates improvement.
Time Frame
Baseline (Week 0) to Week 8
Title
Percentage of Participants Who Achieved Mucosal Healing at Week 8
Description
Mucosal healing is defined as an endoscopic score of 0 and Geboes score < 2.0. The endoscopic subscore ranges from 0 (normal or inactive disease) to 3 (severe disease with spontaneous bleeding, ulceration).
The Geboes histologic index includes seven histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers). The Geboes score has 6 grades, each with 3-5 subgrades: Grade 0, structural change only; Grade 1, chronic inflammation; Grade 2, lamina propria neutrophils and eosinophils; Grade 3, neutrophils in epithelium; Grade 4, crypt destruction; and Grade 5, erosions or ulceration.
Time Frame
Week 8
Title
Change From Baseline in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Score at Week 8
Description
The FACIT fatigue questionnaire was developed to assess fatigue associated with anemia. It consists of 13 fatigue-related questions. Each question is answered on a 5-point Likert scale: 0 (not at all); 1 (a little bit); 2 (somewhat); 3 (quite a bit); and 4 (very much). The total score ranges from 0 to 52, where higher scores represent less fatigue, and a positive change from Baseline indicates improvement.
Time Frame
Baseline (Week 0) to Week 8
10. Eligibility
Sex
All
Minimum Age & Unit of Time
16 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
- Male or female participants ≥ 16 and ≤ 75 years of age at Baseline Note: Adolescent participants at the age of 16 or 17 years old will be eligible to participate if approved by the country or regulatory/health authorities.
Note: Adolescent participants at the age of 16 or 17 years old must weigh ≥ 40 kilograms and meet the definition of Tanner Stage 5 at the Screening Visit.
Diagnosis of Ulcerative Colitis (UC) for 90 days or greater prior to Baseline, confirmed by colonoscopy during the Screening Period, with exclusion of current infection, colonic dysplasia and/or malignancy. Appropriate documentation of biopsy results consistent with the diagnosis of UC, in the assessment of the Investigator, must be available.
Active UC with an Adapted Mayo score of 5 to 9 points and endoscopic subscore of 2 to 3.
Demonstrated an inadequate response, loss of response, or intolerance to at lease one of the following treatments including, oral aminosalicylates, corticosteroids, immunosuppressants, and/or biologic therapies.
Note: Participants who have had inadequate response, loss of response to conventional therapy but have not failed biologic therapy (Non-bio-IR) and have received a prior biologic for up to 1 year may be enrolled, however they must have discontinued the biologic for reasons other than inadequate response or intolerance (e.g., change of insurance, well controlled disease), and must meet criteria for inadequate response, loss of response, or intolerance as defined above.
Female Participants of childbearing potential must have a negative serum pregnancy test at the Screening Visit and a negative urine pregnancy test at the Baseline Visit.
If female, participant must meet the contraception recommendation criteria.
Exclusion Criteria:
Participant with current diagnosis of Crohn's disease (CD) or diagnosis of indeterminate colitis (IC).
Current diagnosis of fulminant colitis and/or toxic megacolon.
Participant with disease limited to the rectum (ulcerative proctitis) during the Screening endoscopy.
Received cyclosporine, tacrolimus, mycophenolate mofetil, or thalidomide within 30 days prior to Baseline.
Participant who received azathioprine or 6-mercaptopurine (6-MP) within 10 days of Baseline.
Received intravenous corticosteroids within 14 days prior to Screening or during the Screening Period.
Participant with previous exposure to Janus Activated Kinase (JAK) inhibitor (e.g., tofacitinib, baricitinib, filgotinib, upadacitinib).
Screening laboratory and other analyses show any prespecified abnormal hematologic results.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
ABBVIE INC.
Organizational Affiliation
AbbVie
Official's Role
Study Director
Facility Information:
Facility Name
East View Medical Research, LLC /ID# 216933
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36606
Country
United States
Facility Name
CB Flock Research Corporation /ID# 206094
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
Facility Name
Arizona Arthritis & Rheumatology Research, PLLC /ID# 211030
City
Sun City
State/Province
Arizona
ZIP/Postal Code
85306
Country
United States
Facility Name
Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211887
City
Tempe
State/Province
Arizona
ZIP/Postal Code
85284-2604
Country
United States
Facility Name
University of Arizona /ID# 208856
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85724
Country
United States
Facility Name
Citrus Valley Gastroenterology /ID# 205627
City
Covina
State/Province
California
ZIP/Postal Code
91722-3797
Country
United States
Facility Name
Care Access Research /ID# 217003
City
Huntington Beach
State/Province
California
ZIP/Postal Code
92648-5994
Country
United States
Facility Name
Moore UC San Diego Cancer Center /ID# 204919
City
La Jolla
State/Province
California
ZIP/Postal Code
92093
Country
United States
Facility Name
United Medical Doctors /ID# 207867
City
Los Alamitos
State/Province
California
ZIP/Postal Code
90720-3309
Country
United States
Facility Name
TLC Clinical Research Inc /ID# 216831
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
Gastrointestinal Biosciences Clinical Trials, LLC /ID# 205314
City
Los Angeles
State/Province
California
ZIP/Postal Code
90067-2001
Country
United States
Facility Name
Facey Medical Foundation /ID# 205301
City
Mission Hills
State/Province
California
ZIP/Postal Code
91345
Country
United States
Facility Name
United Medical Doctors - Murrieta /ID# 205313
City
Murrieta
State/Province
California
ZIP/Postal Code
92563
Country
United States
Facility Name
InSite Digestive Health Care - Oxnard /ID# 205628
City
Oxnard
State/Province
California
ZIP/Postal Code
93030
Country
United States
Facility Name
Inland Empire Clinical Trials, LLC /ID# 216164
City
Rialto
State/Province
California
ZIP/Postal Code
92377
Country
United States
Facility Name
San Diego Clinical Trials /ID# 212122
City
San Diego
State/Province
California
ZIP/Postal Code
92120
Country
United States
Facility Name
Medical Assoc Research Grp /ID# 205626
City
San Diego
State/Province
California
ZIP/Postal Code
92123
Country
United States
Facility Name
Delta Waves, Inc. /ID# 206170
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80918
Country
United States
Facility Name
Western States Clinical Res /ID# 206091
City
Wheat Ridge
State/Province
Colorado
ZIP/Postal Code
80033-2896
Country
United States
Facility Name
Western Connecticut Medical Group /ID# 208290
City
Danbury
State/Province
Connecticut
ZIP/Postal Code
06810-6000
Country
United States
Facility Name
Gastroenterology Center of CT /ID# 208291
City
Hamden
State/Province
Connecticut
ZIP/Postal Code
06518
Country
United States
Facility Name
Gastro Florida /ID# 206174
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
Universal Axon Clinical Research /ID# 213462
City
Doral
State/Province
Florida
ZIP/Postal Code
33166
Country
United States
Facility Name
Palmetto Research, LLC /ID# 208293
City
Hialeah
State/Province
Florida
ZIP/Postal Code
33016
Country
United States
Facility Name
Nature Coast Clinical Research - Inverness /ID# 206087
City
Inverness
State/Province
Florida
ZIP/Postal Code
34452-4717
Country
United States
Facility Name
Encore Borland-Groover Clinical Research /Id# 208128
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32256
Country
United States
Facility Name
Cfagi Llc /Id# 207995
City
Maitland
State/Province
Florida
ZIP/Postal Code
32751-6108
Country
United States
Facility Name
University of Miami /ID# 215445
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Facility Name
Coral Research Clinic /ID# 208292
City
Miami
State/Province
Florida
ZIP/Postal Code
33186-4643
Country
United States
Facility Name
Advanced Research Institute, Inc /ID# 206077
City
New Port Richey
State/Province
Florida
ZIP/Postal Code
34653
Country
United States
Facility Name
Endoscopic Research, Inc. /ID# 207360
City
Orlando
State/Province
Florida
ZIP/Postal Code
32803
Country
United States
Facility Name
Omega Research Consultants /ID# 206066
City
Orlando
State/Province
Florida
ZIP/Postal Code
32810
Country
United States
Facility Name
Clinical Research Trials of Florida, Inc. /ID# 206068
City
Tampa
State/Province
Florida
ZIP/Postal Code
33607
Country
United States
Facility Name
University of South Florida /ID# 214495
City
Tampa
State/Province
Florida
ZIP/Postal Code
33612
Country
United States
Facility Name
AdventHealth Tampa /ID# 207363
City
Tampa
State/Province
Florida
ZIP/Postal Code
33613-4680
Country
United States
Facility Name
Gastroenterology Associates of Central Georgia, LLC /ID# 216940
City
Macon
State/Province
Georgia
ZIP/Postal Code
31201
Country
United States
Facility Name
Infinite Clinical Trials /ID# 215343
City
Riverdale
State/Province
Georgia
ZIP/Postal Code
30274
Country
United States
Facility Name
Atlanta Gastroenterology Spec /ID# 206173
City
Suwanee
State/Province
Georgia
ZIP/Postal Code
30024
Country
United States
Facility Name
Next Innovative Clinical Research - Chicago /ID# 217324
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60605-2168
Country
United States
Facility Name
The University of Chicago Medical Center /ID# 206172
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637-1443
Country
United States
Facility Name
Carle Foundation Hospital /ID# 207397
City
Effingham
State/Province
Illinois
ZIP/Postal Code
62401
Country
United States
Facility Name
MediSphere Medical Research Center /ID# 206073
City
Evansville
State/Province
Indiana
ZIP/Postal Code
47714-8011
Country
United States
Facility Name
Indianapolis Gastroenterology /ID# 206381
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46237
Country
United States
Facility Name
University of Iowa Hospitals and Clinics /ID# 206167
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
Cotton-O'Neil Clinical Res Ctr /ID# 206175
City
Topeka
State/Province
Kansas
ZIP/Postal Code
66606
Country
United States
Facility Name
Tri-State Gastroenterology /ID# 206124
City
Crestview Hills
State/Province
Kentucky
ZIP/Postal Code
41017
Country
United States
Facility Name
Houma Digestive Health Special /ID# 206176
City
Houma
State/Province
Louisiana
ZIP/Postal Code
70360
Country
United States
Facility Name
Louisana Research Center, LLC /ID# 206064
City
Shreveport
State/Province
Louisiana
ZIP/Postal Code
71105-6800
Country
United States
Facility Name
Gastro Center of Maryland /ID# 206883
City
Columbia
State/Province
Maryland
ZIP/Postal Code
21045
Country
United States
Facility Name
University of Michigan Health Systems /ID# 206918
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Facility Name
Huron Gastroenterology Assoc /ID# 205109
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48197
Country
United States
Facility Name
Clin Res Inst of Michigan, LLC /ID# 207078
City
Chesterfield
State/Province
Michigan
ZIP/Postal Code
48047
Country
United States
Facility Name
Revival Research Institute, LLC /ID# 207282
City
Southfield
State/Province
Michigan
ZIP/Postal Code
48034-1659
Country
United States
Facility Name
Center for Digestive Health /ID# 207080
City
Troy
State/Province
Michigan
ZIP/Postal Code
48098-6363
Country
United States
Facility Name
Mayo Clinic /ID# 205645
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905-0001
Country
United States
Facility Name
University of Mississippi Medical Center /ID# 213116
City
Jackson
State/Province
Mississippi
ZIP/Postal Code
39216-4500
Country
United States
Facility Name
Southern Therapy and Advanced Research (STAR) LLC /ID# 206069
City
Jackson
State/Province
Mississippi
ZIP/Postal Code
39216
Country
United States
Facility Name
Las Vegas Medical Research /ID# 206814
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89113
Country
United States
Facility Name
AGA Clinical Research Associates, LLC /ID# 206880
City
Egg Harbor Township
State/Province
New Jersey
ZIP/Postal Code
08234
Country
United States
Facility Name
Atlantic Digestive Health Inst /ID# 208748
City
Morristown
State/Province
New Jersey
ZIP/Postal Code
07960
Country
United States
Facility Name
Rutgers Robert Wood Johnson /ID# 207382
City
New Brunswick
State/Province
New Jersey
ZIP/Postal Code
08901
Country
United States
Facility Name
University of New Mexico Department of Internal Medicine /ID# 214397
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87131-0001
Country
United States
Facility Name
Advantage Clinical Trials /ID# 206082
City
Bronx
State/Province
New York
ZIP/Postal Code
10468
Country
United States
Facility Name
NY Scientific /ID# 206080
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11235
Country
United States
Facility Name
NYU Langone Long Island Clinical Research Associates /ID# 206079
City
Lake Success
State/Province
New York
ZIP/Postal Code
11042
Country
United States
Facility Name
DiGiovanna Institute for Medical Education & Research /ID# 206885
City
North Massapequa
State/Province
New York
ZIP/Postal Code
11758
Country
United States
Facility Name
Premier Medical Group - GI Division /ID# 206097
City
Poughkeepsie
State/Province
New York
ZIP/Postal Code
12601
Country
United States
Facility Name
Gastro Group of Rochester /ID# 206881
City
Rochester
State/Province
New York
ZIP/Postal Code
14618-5703
Country
United States
Facility Name
Richmond University Medical Center /ID# 213185
City
Staten Island
State/Province
New York
ZIP/Postal Code
10310-1664
Country
United States
Facility Name
Digestive Health Partners, P.A /ID# 206842
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28801
Country
United States
Facility Name
Atrium Health Carolinas Medical Center /ID# 206085
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28203
Country
United States
Facility Name
Charlotte Gastroenterology and Hepatology, PLLC /ID# 206138
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28207
Country
United States
Facility Name
Wake Forest Baptist Medical Center /ID# 206067
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157-0001
Country
United States
Facility Name
Duplicate_Plains Clinical Research Center, LLC /ID# 205111
City
Fargo
State/Province
North Dakota
ZIP/Postal Code
58104
Country
United States
Facility Name
University of Cincinnati /ID# 205633
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45267-0585
Country
United States
Facility Name
The Ohio State University /ID# 205637
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
Optimed Research, Ltd. /ID# 205638
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43235
Country
United States
Facility Name
Hometown Urgent Care and Resea /ID# 205630
City
Dayton
State/Province
Ohio
ZIP/Postal Code
45424
Country
United States
Facility Name
Dayton Gastroenterology, Inc. /ID# 205639
City
Englewood
State/Province
Ohio
ZIP/Postal Code
45415
Country
United States
Facility Name
Great Lakes Gastroenterology Research LLC /ID# 205631
City
Mentor
State/Province
Ohio
ZIP/Postal Code
44060-6211
Country
United States
Facility Name
Hightower Clinical /ID# 216336
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73102
Country
United States
Facility Name
Digestive Disease Specialists /ID# 206076
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Options Health Research, LLC /ID# 206707
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74104
Country
United States
Facility Name
Healthcare Research Consultant /ID# 206706
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74135
Country
United States
Facility Name
Guthrie Medical Group, PC /ID# 206078
City
Sayre
State/Province
Pennsylvania
ZIP/Postal Code
18840
Country
United States
Facility Name
Pharmacorp Clinical Trials /ID# 206074
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29412
Country
United States
Facility Name
Gastroenterology Associates, P.A. of Greenville /ID# 206098
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29615-3593
Country
United States
Facility Name
Gastro One /ID# 206178
City
Germantown
State/Province
Tennessee
ZIP/Postal Code
38138
Country
United States
Facility Name
East Tennessee Research Institute /ID# 206169
City
Johnson City
State/Province
Tennessee
ZIP/Postal Code
37604
Country
United States
Facility Name
Quality Medical Research /ID# 206088
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37211
Country
United States
Facility Name
Vanderbilt University Medical Center /ID# 210405
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232-0011
Country
United States
Facility Name
TX Clinical Research Institute /ID# 206718
City
Arlington
State/Province
Texas
ZIP/Postal Code
76012
Country
United States
Facility Name
Inquest Clinical Research /ID# 206132
City
Baytown
State/Province
Texas
ZIP/Postal Code
77521
Country
United States
Facility Name
Texas Digestive Disease Consultants /ID# 209805
City
Cedar Park
State/Province
Texas
ZIP/Postal Code
78613-5028
Country
United States
Facility Name
Texas Digestive Disease Consultants /ID# 209948
City
Cedar Park
State/Province
Texas
ZIP/Postal Code
78613-5028
Country
United States
Facility Name
Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 207484
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
DHAT Research Institute /ID# 206716
City
Garland
State/Province
Texas
ZIP/Postal Code
75044-2208
Country
United States
Facility Name
Vilo Research Group Inc /ID# 212625
City
Houston
State/Province
Texas
ZIP/Postal Code
77017-2337
Country
United States
Facility Name
Baylor College of Medicine - Baylor Medical Center /ID# 206717
City
Houston
State/Province
Texas
ZIP/Postal Code
77030-3411
Country
United States
Facility Name
Centex Studies, Inc. - Houston /ID# 206168
City
Houston
State/Province
Texas
ZIP/Postal Code
77058
Country
United States
Facility Name
GI Specialists of Houston /ID# 206090
City
Houston
State/Province
Texas
ZIP/Postal Code
77070-4347
Country
United States
Facility Name
Caprock Gastro Research /ID# 215115
City
Lubbock
State/Province
Texas
ZIP/Postal Code
79424-3017
Country
United States
Facility Name
Clinical Associates in Research Therapeutics of America, LLC /ID# 206710
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78212
Country
United States
Facility Name
Southern Star Research Institute, LLC /ID# 205379
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229-5390
Country
United States
Facility Name
Baylor Scott & White Center for Diagnostic Medicine /ID# 206096
City
Temple
State/Province
Texas
ZIP/Postal Code
76508
Country
United States
Facility Name
Duplicate_Tyler Research Institue /ID# 206075
City
Tyler
State/Province
Texas
ZIP/Postal Code
75701
Country
United States
Facility Name
Gastro Health & Nutrition - Victoria /ID# 205378
City
Victoria
State/Province
Texas
ZIP/Postal Code
77904
Country
United States
Facility Name
Advanced Research Institute /ID# 206133
City
Ogden
State/Province
Utah
ZIP/Postal Code
84403
Country
United States
Facility Name
Ctr for Gastrointestinal Healt /ID# 208475
City
Franklin
State/Province
Virginia
ZIP/Postal Code
23851
Country
United States
Facility Name
Washington Gastroenterology Associates /ID# 206177
City
Bellevue
State/Province
Washington
ZIP/Postal Code
98004
Country
United States
Facility Name
Virginia Mason - Seattle Orthapedics /ID# 206070
City
Seattle
State/Province
Washington
ZIP/Postal Code
98101
Country
United States
Facility Name
The Vancouver Clinic, INC. PS /ID# 204973
City
Vancouver
State/Province
Washington
ZIP/Postal Code
98664
Country
United States
Facility Name
Wisconsin Center for Advanced Research, a division of GI Associates, LLC /ID# 206917
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53215
Country
United States
Facility Name
Froedtert Memorial Lutheran Hospital /ID# 206945
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226-3522
Country
United States
Facility Name
Cardio Alem /ID# 211282
City
San Isidro
State/Province
Buenos Aires
ZIP/Postal Code
1642
Country
Argentina
Facility Name
Mautalen Salud e Investigacion /ID# 206033
City
Ciudad Autonoma de Buenos Aire
State/Province
Ciuadad Autonoma De Buenos Aires
ZIP/Postal Code
1128
Country
Argentina
Facility Name
Hospital Britanico de Buenos Aires /ID# 209497
City
Ciudad Autonoma de Buenos Aire
State/Province
Ciuadad Autonoma De Buenos Aires
ZIP/Postal Code
1280
Country
Argentina
Facility Name
Gedyt /ID# 210017
City
Ciudad Autonoma de Buenos Aire
State/Province
Ciuadad Autonoma De Buenos Aires
ZIP/Postal Code
1426
Country
Argentina
Facility Name
Hospital Privado Univesitario /ID# 206030
City
Cordoba
ZIP/Postal Code
5016
Country
Argentina
Facility Name
Macquarie University Hospital /ID# 211955
City
Macquarie University
State/Province
New South Wales
ZIP/Postal Code
2109
Country
Australia
Facility Name
Duplicate_Mater Misericordiae /ID# 212687
City
South Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Facility Name
Griffith University /ID# 211956
City
Southport
State/Province
Queensland
ZIP/Postal Code
4222
Country
Australia
Facility Name
St Vincent's Hospital Melbourne /ID# 205758
City
Fitzroy
State/Province
Victoria
ZIP/Postal Code
3065
Country
Australia
Facility Name
Monash Medical Centre /ID# 206486
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3168
Country
Australia
Facility Name
Fiona Stanley Hospital /ID# 211642
City
Murdoch
State/Province
Western Australia
ZIP/Postal Code
6150
Country
Australia
Facility Name
Klinik Landstrasse /ID# 205764
City
Vienna
State/Province
Wien
ZIP/Postal Code
1030
Country
Austria
Facility Name
Medical University of Vienna /ID# 205763
City
Vienna
State/Province
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
LKH Salzburg and Paracelsus /ID# 208788
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
Facility Name
Universitair Ziekenhuis Leuven /ID# 205988
City
Leuven
State/Province
Vlaams-Brabant
ZIP/Postal Code
3000
Country
Belgium
Facility Name
AZ Maria Middelares /ID# 210928
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
University Clinical Centre of the Republic of Srpska /ID# 208053
City
Banja Luka
State/Province
Republika Srpska
ZIP/Postal Code
78000
Country
Bosnia and Herzegovina
Facility Name
University Clinical Centre of the Republic of Srpska /ID# 208055
City
Banja Luka
State/Province
Republika Srpska
ZIP/Postal Code
78000
Country
Bosnia and Herzegovina
Facility Name
University Clinical Center Tuzla /ID# 208057
City
Tuzla
State/Province
Tuzlanski
ZIP/Postal Code
75000
Country
Bosnia and Herzegovina
Facility Name
University Clinical Hospital Mostar /ID# 208054
City
Mostar
ZIP/Postal Code
88000
Country
Bosnia and Herzegovina
Facility Name
Clinical Center University of Sarajevo /ID# 208058
City
Sarajevo
ZIP/Postal Code
71000
Country
Bosnia and Herzegovina
Facility Name
Hospital Nossa Senhora das Graças /ID# 206981
City
Curitiba
State/Province
Parana
ZIP/Postal Code
80810-040
Country
Brazil
Facility Name
Hospital de Clinicas de Porto Alegre /ID# 206985
City
Porto Alegre
State/Province
Rio Grande Do Sul
ZIP/Postal Code
90035-903
Country
Brazil
Facility Name
Upeclin Fmb - Unesp /Id# 206986
City
Botucatu
State/Province
Sao Paulo
ZIP/Postal Code
18618-686
Country
Brazil
Facility Name
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 206504
City
Ribeirão Preto
State/Province
Sao Paulo
ZIP/Postal Code
14051-140
Country
Brazil
Facility Name
Faculdade de Medicina do ABC /ID# 206984
City
Santo André
State/Province
Sao Paulo
ZIP/Postal Code
09060-870
Country
Brazil
Facility Name
Kaiser Clinica e Hospital Dia /ID# 206982
City
Sao Jose Do Rio Preto
State/Province
Sao Paulo
ZIP/Postal Code
15015-110
Country
Brazil
Facility Name
University of Calgary - Cumming School of Medicine - Adult Cystic Fibrosis Clini /ID# 205755
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4Z6
Country
Canada
Facility Name
Allen Whey Khye Lim Professional Corporation /ID# 211167
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T5R 1W2
Country
Canada
Facility Name
Covenant Health /ID# 205500
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6K 4B2
Country
Canada
Facility Name
Percuro Clinical Research, Ltd /ID# 205501
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8V 3M9
Country
Canada
Facility Name
Duplicate_Toronto Digestive Disease Asso /ID# 205498
City
Vaughan
State/Province
Ontario
ZIP/Postal Code
L4L 4Y7
Country
Canada
Facility Name
Crchum /Id# 207387
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2X 0A9
Country
Canada
Facility Name
CIUSSS de l'Estrie - CHUS /ID# 205499
City
Sherbrooke
State/Province
Quebec
ZIP/Postal Code
J1G 2E8
Country
Canada
Facility Name
Research Group /ID# 208037
City
Santiago
State/Province
Region Metropolitana De Santiago
ZIP/Postal Code
2540364
Country
Chile
Facility Name
M y F Estudios Clínicos Ltda. /ID# 208035
City
Santiago
State/Province
Region Metropolitana De Santiago
ZIP/Postal Code
7750495
Country
Chile
Facility Name
Hospital Guillermo Grant Benavente de Concepción /ID# 212426
City
Concepción
ZIP/Postal Code
4070038
Country
Chile
Facility Name
CTR Estudios Clinicos /ID# 208036
City
Providencia
ZIP/Postal Code
7500571
Country
Chile
Facility Name
Hospital Clinico Universidad De Los Andes /ID# 207426
City
Santiago
ZIP/Postal Code
7501504
Country
Chile
Facility Name
Sun Yat-sen Memorial Hospital of Sun Yat-sen University /ID# 205267
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510120
Country
China
Facility Name
The Sixth Affiliated Hosp Sun /ID# 205268
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510655
Country
China
Facility Name
Affiliated Taihe Hospital of Hubei University of Medicine /ID# 216406
City
Shiyan
State/Province
Hubei
ZIP/Postal Code
442700
Country
China
Facility Name
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 205266
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430022
Country
China
Facility Name
The First Affiliated Hospital of Nanchang University /ID# 212186
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330006
Country
China
Facility Name
The First Hospital of Jilin University /ID# 210088
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130021
Country
China
Facility Name
Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 205333
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200025
Country
China
Facility Name
The second Affiliated hospital of Zhejiang University school of Medicine /ID# 205271
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310009
Country
China
Facility Name
West China Hospital, Sichuan University /ID# 205332
City
Chengdu
ZIP/Postal Code
610041
Country
China
Facility Name
Duplicate_Tianjin Med Univ General Hosp /ID# 205246
City
Tianjin
ZIP/Postal Code
300052
Country
China
Facility Name
Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 205265
City
Wuhan
ZIP/Postal Code
430030
Country
China
Facility Name
Instituto Medico de Alta Tecnologia Oncomédica S.A /ID# 208887
City
Monteria
State/Province
Cordoba
ZIP/Postal Code
230002
Country
Colombia
Facility Name
Corporacion Hospitalaria Juan Cuidad Sede Denominada Hospital Universitario Mayo /ID# 208886
City
Bogota DC
State/Province
Cundinamarca
ZIP/Postal Code
111221
Country
Colombia
Facility Name
Hospital Universitario San Vic /ID# 208888
City
Medellin
ZIP/Postal Code
50010
Country
Colombia
Facility Name
Klinicka bolnica Dubrava Zagreb /ID# 208460
City
Zagreb
State/Province
Grad Zagreb
ZIP/Postal Code
10000
Country
Croatia
Facility Name
Poliklinika Solmed /ID# 211568
City
Zagreb
State/Province
Grad Zagreb
ZIP/Postal Code
10000
Country
Croatia
Facility Name
Klinicki bolnicki centar Rijeka /ID# 208650
City
Rijeka
State/Province
Primorsko-goranska Zupanija
ZIP/Postal Code
51000
Country
Croatia
Facility Name
Klinicki bolnicki centar Split /ID# 217027
City
Split
ZIP/Postal Code
21000
Country
Croatia
Facility Name
Hepato-Gastroenterologie HK, s.r.o. /ID# 205672
City
Hradec Kralove
ZIP/Postal Code
500 12
Country
Czechia
Facility Name
CTCenter MaVe s.r.o. /ID# 205671
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Facility Name
Artroscan s.r.o. /ID# 205668
City
Ostrava
ZIP/Postal Code
722 00
Country
Czechia
Facility Name
Nemocnice Pardubickeho kraje, a.s. /ID# 213540
City
Pardubice
ZIP/Postal Code
530 03
Country
Czechia
Facility Name
Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 216223
City
Praha
ZIP/Postal Code
118 33
Country
Czechia
Facility Name
Axon Clinical, s.r.o. /ID# 205670
City
Praha
ZIP/Postal Code
140 00
Country
Czechia
Facility Name
ISCARE a.s. /ID# 209240
City
Praha
ZIP/Postal Code
190 00
Country
Czechia
Facility Name
East Tallinn Central Hospital /ID# 207564
City
Tallinn
State/Province
Harjumaa
ZIP/Postal Code
10138
Country
Estonia
Facility Name
West Tallinn Central Hospital /ID# 207356
City
Tallinn
ZIP/Postal Code
10617
Country
Estonia
Facility Name
North Estonia Medical Centre /ID# 207357
City
Tallinn
ZIP/Postal Code
13419
Country
Estonia
Facility Name
Tartu University Hospital /ID# 212282
City
Tartu
ZIP/Postal Code
51014
Country
Estonia
Facility Name
Tampere University Hospital /ID# 206161
City
Tampere
State/Province
Pirkanmaa
ZIP/Postal Code
33520
Country
Finland
Facility Name
Keski-Suomen Sairaala Nova /ID# 206159
City
Jyvaskyla
ZIP/Postal Code
40620
Country
Finland
Facility Name
Laakarikeskus Ikioma /ID# 205814
City
Mikkeli
ZIP/Postal Code
50100
Country
Finland
Facility Name
Tyks /Id# 205813
City
Turku
ZIP/Postal Code
20521
Country
Finland
Facility Name
Chu de Nice-Hopital L'Archet Ii /Id# 209118
City
Nice CEDEX 3
State/Province
Alpes-Maritimes
ZIP/Postal Code
06202
Country
France
Facility Name
Centre Hospitalier Lyon Sud /ID# 209121
City
Pierre Benite CEDEX
State/Province
Rhone
ZIP/Postal Code
69495
Country
France
Facility Name
Universitatsklinikum Mannheim /ID# 206811
City
Mannheim
State/Province
Baden-Wuerttemberg
ZIP/Postal Code
68167
Country
Germany
Facility Name
Duplicate_Universitaetsklinikum Tuebingen /ID# 206737
City
Tübingen
State/Province
Baden-Wuerttemberg
ZIP/Postal Code
72076
Country
Germany
Facility Name
Gastroenterologische Gemeinschaftspraxis Herne /ID# 214576
City
Herne
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
44623
Country
Germany
Facility Name
Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 215813
City
Saarbrücken
State/Province
Saarland
ZIP/Postal Code
66111
Country
Germany
Facility Name
Duplicate_Praxis am Bayrischen Platz /ID# 206733
City
Berlin
ZIP/Postal Code
10825
Country
Germany
Facility Name
Agaplesion Markus Krankenhaus /ID# 206731
City
Frankfurt am Main
ZIP/Postal Code
60431
Country
Germany
Facility Name
Duplicate_Univ Hosp Schleswig-Holstein /ID# 206791
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Facility Name
Medizinisches Versorgungszentrum Portal 10 /ID# 207137
City
Muenster
ZIP/Postal Code
48155
Country
Germany
Facility Name
General Hospital of Athens Laiko /ID# 208671
City
Athens
State/Province
Attiki
ZIP/Postal Code
11527
Country
Greece
Facility Name
University General Hospital of Heraklion PA.G.N.I /ID# 207061
City
Heraklion
State/Province
Kriti
ZIP/Postal Code
711 10
Country
Greece
Facility Name
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 206332
City
Athens
ZIP/Postal Code
10676
Country
Greece
Facility Name
Duplicate_General Hospital of Thessaloniki Hippokrateio /ID# 208822
City
Thessaloniki
ZIP/Postal Code
54642
Country
Greece
Facility Name
Bekes Megyei Kozponti Korhaz /ID# 205885
City
Bekescsaba
ZIP/Postal Code
5600
Country
Hungary
Facility Name
Semmelweis Egyetem /ID# 205883
City
Budapest
ZIP/Postal Code
1085
Country
Hungary
Facility Name
Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet /ID# 207992
City
Sopron
ZIP/Postal Code
9400
Country
Hungary
Facility Name
Mentahaz Maganorvosi Kozpont /ID# 205882
City
Szekesfehervar
ZIP/Postal Code
8000
Country
Hungary
Facility Name
Beaumont Hospital /ID# 206509
City
Dublin
ZIP/Postal Code
D09 XR63
Country
Ireland
Facility Name
University Hospital Galway /ID# 218035
City
Galway
ZIP/Postal Code
H91 YR71
Country
Ireland
Facility Name
Rambam Health Care Campus /ID# 206362
City
Haifa
ZIP/Postal Code
3109601
Country
Israel
Facility Name
Shaare Zedek Medical Center /ID# 206365
City
Jerusalem
ZIP/Postal Code
91031
Country
Israel
Facility Name
A.O.U. Policlinico S.Orsola-Malpighi /ID# 206351
City
Bologna
State/Province
Emilia-Romagna
ZIP/Postal Code
40138
Country
Italy
Facility Name
ASST Rhodense/Presidio Ospedaliero di Rho /ID# 216611
City
Rho
State/Province
Milano
ZIP/Postal Code
20017
Country
Italy
Facility Name
Istituto Clinico Humanitas /ID# 206346
City
Rozzano
State/Province
Milano
ZIP/Postal Code
20089
Country
Italy
Facility Name
Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 206347
City
Rome
State/Province
Roma
ZIP/Postal Code
00168
Country
Italy
Facility Name
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 206354
City
Negrar
State/Province
Verona
ZIP/Postal Code
37024
Country
Italy
Facility Name
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 206349
City
Milan
ZIP/Postal Code
20122
Country
Italy
Facility Name
A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 206350
City
Palermo
ZIP/Postal Code
90146
Country
Italy
Facility Name
Nagoya City University Hospital /ID# 206058
City
Nagoya shi
State/Province
Aichi
ZIP/Postal Code
467-8602
Country
Japan
Facility Name
Nagoya University Hospital /ID# 206355
City
Nagoyashi
State/Province
Aichi
ZIP/Postal Code
4668560
Country
Japan
Facility Name
Toyohashi Municipal Hospital /ID# 207625
City
Toyohashi-shi
State/Province
Aichi
ZIP/Postal Code
441-8570
Country
Japan
Facility Name
Ieda Hospital /ID# 207479
City
Toyota-shi
State/Province
Aichi
ZIP/Postal Code
470-1219
Country
Japan
Facility Name
Hirosaki National Hospital /ID# 206387
City
Hirosaki-shi
State/Province
Aomori
ZIP/Postal Code
036-8545
Country
Japan
Facility Name
Tokatsu Tsujinaka Hospital /ID# 214963
City
Abiko-shi
State/Province
Chiba
ZIP/Postal Code
270-1168
Country
Japan
Facility Name
Tsujinaka Hospital Kashiwanoha /ID# 209573
City
Kashiwa-shi
State/Province
Chiba
ZIP/Postal Code
277-0871
Country
Japan
Facility Name
Toho University Medical Center Sakura Hospital /ID# 207705
City
Sakura-shi
State/Province
Chiba
ZIP/Postal Code
285-8741
Country
Japan
Facility Name
Juntendo University Urayasu Hospital /ID# 208784
City
Urayasu-shi
State/Province
Chiba
ZIP/Postal Code
279-0021
Country
Japan
Facility Name
Fukui Prefectural Hospital /ID# 210449
City
Fukui-shi
State/Province
Fukui
ZIP/Postal Code
910-8526
Country
Japan
Facility Name
Fukuoka University Chikushi Hospital /ID# 214405
City
Chikushino-shi
State/Province
Fukuoka
ZIP/Postal Code
818-8502
Country
Japan
Facility Name
Saiseikai Fukuoka Genaral Hospital /ID# 209482
City
Fukuoka-shi
State/Province
Fukuoka
ZIP/Postal Code
810-0001
Country
Japan
Facility Name
Kurume University Hospital /ID# 206385
City
Kurume-shi
State/Province
Fukuoka
ZIP/Postal Code
830-0011
Country
Japan
Facility Name
Ogaki Municipal Hospital /ID# 208227
City
Ogaki-shi
State/Province
Gifu
ZIP/Postal Code
503-8502
Country
Japan
Facility Name
NHO Fukuyama Medical Center /ID# 206295
City
Fukuyama-shi
State/Province
Hiroshima
ZIP/Postal Code
720-8520
Country
Japan
Facility Name
Hiroshima University Hospital /ID# 206464
City
Hiroshima-shi
State/Province
Hiroshima
ZIP/Postal Code
734-8551
Country
Japan
Facility Name
Asahikawa Medical University Hospital /ID# 206404
City
Midorigaokahiga-shi
State/Province
Hokkaido
ZIP/Postal Code
078-8510
Country
Japan
Facility Name
Obihiro kosei Hospital /ID# 210424
City
Obihiro-shi
State/Province
Hokkaido
ZIP/Postal Code
080-0024
Country
Japan
Facility Name
Sapporo Tokushukai Hospital /ID# 209448
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
004-0041
Country
Japan
Facility Name
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 206059
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
060-0033
Country
Japan
Facility Name
Sapporo Medical University Hospital /ID# 206314
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
060-8543
Country
Japan
Facility Name
Sapporo Higashi Tokushukai Hospital /ID# 208494
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
065-0033
Country
Japan
Facility Name
Aoyama Clinic /ID# 206452
City
Kobe-shi
State/Province
Hyogo
ZIP/Postal Code
650-0015
Country
Japan
Facility Name
Hyogo College of Medicine Hospital /ID# 206455
City
Nishinomiya-shi
State/Province
Hyogo
ZIP/Postal Code
663-8501
Country
Japan
Facility Name
Kanazawa University Hospital /ID# 206316
City
Kanazawa-shi
State/Province
Ishikawa
ZIP/Postal Code
920-8641
Country
Japan
Facility Name
Iwate Medical University Uchimaru Medical Center /ID# 207051
City
Morioka-shi
State/Province
Iwate
ZIP/Postal Code
020-8505
Country
Japan
Facility Name
Idzuro Imamura Hospital /ID# 207639
City
Kagoshima-shi
State/Province
Kagoshima
ZIP/Postal Code
892-0824
Country
Japan
Facility Name
Sameshima Hospital /ID# 207935
City
Kagoshima-shi
State/Province
Kagoshima
ZIP/Postal Code
892-0846
Country
Japan
Facility Name
St. Marianna University School of Medicine Hospital /ID# 209451
City
Kawasaki-shi
State/Province
Kanagawa
ZIP/Postal Code
216-8511
Country
Japan
Facility Name
Showa University Fujigaoka Hospital /ID# 208224
City
Yokohama-shi
State/Province
Kanagawa
ZIP/Postal Code
227-8501
Country
Japan
Facility Name
Kyoto University Hospital /ID# 211809
City
Kyoto-shi
State/Province
Kyoto
ZIP/Postal Code
606-8507
Country
Japan
Facility Name
Mie University Hospital /ID# 206803
City
Tsu-shi
State/Province
Mie
ZIP/Postal Code
514-8507
Country
Japan
Facility Name
Yokkaichi Hazu Medical Center /ID# 214348
City
Yokkaichi-shi
State/Province
Mie
ZIP/Postal Code
510-0016
Country
Japan
Facility Name
National Hospital Organization Sendai Medical Center /ID# 209528
City
Sendai-shi
State/Province
Miyagi
ZIP/Postal Code
983-8520
Country
Japan
Facility Name
NHO Nagasaki Medical Center /ID# 210822
City
Omura-shi
State/Province
Nagasaki
ZIP/Postal Code
856-8562
Country
Japan
Facility Name
Kenseikai Dongo Hospital /ID# 208101
City
Yamatotakada-shi
State/Province
Nara
ZIP/Postal Code
635-0022
Country
Japan
Facility Name
Saiseikai Niigata Hospital /ID# 209921
City
Niigata-shi
State/Province
Niigata
ZIP/Postal Code
950-1104
Country
Japan
Facility Name
Niigata University Medical & Dental Hospital /ID# 218049
City
Niigata-shi
State/Province
Niigata
ZIP/Postal Code
951-8520
Country
Japan
Facility Name
Ishida Clinic of IBD and Gastroenterology /ID# 210119
City
Oita-shi
State/Province
Oita
ZIP/Postal Code
870-0823
Country
Japan
Facility Name
Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 206646
City
Kurashiki-shi
State/Province
Okayama
ZIP/Postal Code
710-0142
Country
Japan
Facility Name
Okayama University Hospital /ID# 217925
City
Okayama-shi
State/Province
Okayama
ZIP/Postal Code
700-8558
Country
Japan
Facility Name
Kinshukai Infusion Clinic /ID# 207865
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
530-0011
Country
Japan
Facility Name
Kitano Hospital /ID# 210397
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
530-8480
Country
Japan
Facility Name
Japanese Red Cross Osaka Hospital /ID# 209478
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
543-8555
Country
Japan
Facility Name
Osaka City University Hospital /ID# 206457
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
545-8586
Country
Japan
Facility Name
Toyonaka Municipal Hospital /ID# 217082
City
Toyonaka-shi
State/Province
Osaka
ZIP/Postal Code
560-0055
Country
Japan
Facility Name
Saga University Hospital /ID# 209270
City
Saga-shi
State/Province
Saga
ZIP/Postal Code
849-8501
Country
Japan
Facility Name
Saitama Medical Center /ID# 206393
City
Kawagoe-shi
State/Province
Saitama
ZIP/Postal Code
350-8550
Country
Japan
Facility Name
Tokitokai Tokito clinic /ID# 206313
City
Saitama-shi
State/Province
Saitama
ZIP/Postal Code
336-0963
Country
Japan
Facility Name
National Hospital Organization Higashi-Ohmi General Medical Center /ID# 210710
City
Higashi-ohmi-shi
State/Province
Shiga
ZIP/Postal Code
527-8505
Country
Japan
Facility Name
Shimane University School of Medicine /ID# 208905
City
Izumo-shi
State/Province
Shimane
ZIP/Postal Code
693-0021
Country
Japan
Facility Name
Hamamatsu University Hospital /ID# 206459
City
Hamamatsu-shi
State/Province
Shizuoka
ZIP/Postal Code
431-3192
Country
Japan
Facility Name
NHO Shizuoka Medical Center /ID# 208785
City
Sunto-gun
State/Province
Shizuoka
ZIP/Postal Code
411-8611
Country
Japan
Facility Name
Tokyo Medical And Dental University, Medical Hospital /ID# 206453
City
Bunkyo-ku
State/Province
Tokyo
ZIP/Postal Code
113-8519
Country
Japan
Facility Name
St.Luke's International Hospital /ID# 208076
City
Chuo-ku
State/Province
Tokyo
ZIP/Postal Code
104-8560
Country
Japan
Facility Name
Tokai University Hachioji Hospital /ID# 208903
City
Hachioji-shi
State/Province
Tokyo
ZIP/Postal Code
192-0032
Country
Japan
Facility Name
Teikyo University Hospital /ID# 209866
City
Itabashi-ku
State/Province
Tokyo
ZIP/Postal Code
173-8606
Country
Japan
Facility Name
Center Hospital of the National Center for Global Health and Medicine /ID# 209532
City
Shinjuku-ku
State/Province
Tokyo
ZIP/Postal Code
162-8655
Country
Japan
Facility Name
Tokyo Women's Medical University Hospital /ID# 206460
City
Shinjuku-ku
State/Province
Tokyo
ZIP/Postal Code
162-8666
Country
Japan
Facility Name
Yamagata University Hospital /ID# 206465
City
Yamagata-shi
State/Province
Yamagata
ZIP/Postal Code
990-9585
Country
Japan
Facility Name
Tokuyama Central Hospital /ID# 216994
City
Shunan-shi
State/Province
Yamaguchi
ZIP/Postal Code
745-8522
Country
Japan
Facility Name
Shoyukai Fujita Gastroenterological Hospital /ID# 216493
City
Takatsuki-shi
ZIP/Postal Code
569-0086
Country
Japan
Facility Name
Kangbuk Samsung Hospital /ID# 206960
City
Seoul
State/Province
Seoul Teugbyeolsi
ZIP/Postal Code
03181
Country
Korea, Republic of
Facility Name
Dong-A University Hospital /ID# 206955
City
Busan
ZIP/Postal Code
49201
Country
Korea, Republic of
Facility Name
Pusan National University Hospital /ID# 206956
City
Busan
ZIP/Postal Code
49241
Country
Korea, Republic of
Facility Name
Yeungnam University Medical Center /ID# 206959
City
Daegu
ZIP/Postal Code
42415
Country
Korea, Republic of
Facility Name
Duplicate_CHA Bundang Medical Center /ID# 207432
City
Seongnam-si, Gyeonggi-do
ZIP/Postal Code
13496
Country
Korea, Republic of
Facility Name
Yonsei University Health System, Severance hospital /ID# 206958
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Facility Name
Riga East Clinical Univ Hosp /ID# 206828
City
Riga
ZIP/Postal Code
1038
Country
Latvia
Facility Name
P. Stradins Clinical Univ Hosp /ID# 206827
City
Riga
ZIP/Postal Code
LV-1002
Country
Latvia
Facility Name
Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 209052
City
Kaunas
ZIP/Postal Code
50161
Country
Lithuania
Facility Name
Klaipeda Seamens Hospital /ID# 208791
City
Klaipeda
ZIP/Postal Code
92288
Country
Lithuania
Facility Name
Klaipeda University Hospital /ID# 208790
City
Klaipeda
ZIP/Postal Code
92288
Country
Lithuania
Facility Name
Vilnius University Hospital /ID# 209051
City
Vilnius
ZIP/Postal Code
LT-08661
Country
Lithuania
Facility Name
Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 207662
City
Kuala Lumpur
State/Province
Selangor
ZIP/Postal Code
56000
Country
Malaysia
Facility Name
Duplicate_Uni Malaya MC /ID# 208936
City
Kuala Lumpur
ZIP/Postal Code
59100
Country
Malaysia
Facility Name
Morales Vargas Centro de Investigacion S.C. /ID# 211326
City
Leon
State/Province
Guanajuato
ZIP/Postal Code
37000
Country
Mexico
Facility Name
Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 208068
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44650
Country
Mexico
Facility Name
Centro Regiomontano de Estudios Clínicos ROMA S.C /ID# 208067
City
Monterrey
State/Province
Nuevo Leon
ZIP/Postal Code
64610
Country
Mexico
Facility Name
Erasmus Medisch Centrum /ID# 205280
City
Rotterdam
ZIP/Postal Code
3015 GD
Country
Netherlands
Facility Name
Akershus Universitetssykehus_MAIN /ID# 205293
City
Lorenskog
State/Province
Akershus
ZIP/Postal Code
1478
Country
Norway
Facility Name
Universitetssykehuset Nord-Norge /ID# 205691
City
Tromsø
State/Province
Troms
ZIP/Postal Code
9019
Country
Norway
Facility Name
Gastromed /Id# 216108
City
Torun
State/Province
Kujawsko-pomorskie
ZIP/Postal Code
87-100
Country
Poland
Facility Name
Centrum Medyczne Reuma Park w Warszawie /ID# 212913
City
Warsaw
State/Province
Mazowieckie
ZIP/Postal Code
02-691
Country
Poland
Facility Name
Centrum Zdrowia MDM /ID# 205874
City
Warszawa
State/Province
Mazowieckie
ZIP/Postal Code
00-635
Country
Poland
Facility Name
NZOZ Vivamed /ID# 216697
City
Warszawa
State/Province
Mazowieckie
ZIP/Postal Code
03-580
Country
Poland
Facility Name
Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 215070
City
Warszawa
State/Province
Mazowieckie
ZIP/Postal Code
04-730
Country
Poland
Facility Name
Endoskopia Sp. z o.o. /ID# 212964
City
Sopot
State/Province
Pomorskie
ZIP/Postal Code
81-756
Country
Poland
Facility Name
Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 205554
City
Guimaraes
State/Province
Braga
ZIP/Postal Code
4835-044
Country
Portugal
Facility Name
Centro Hospitalar de Entre Douro e Vouga /ID# 205563
City
Santa Maria Da Feira
State/Province
Porto
ZIP/Postal Code
4520-211
Country
Portugal
Facility Name
Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 205556
City
Ponte de Lima
State/Province
Viana Do Castelo
ZIP/Postal Code
4990-041
Country
Portugal
Facility Name
Hospital Garcia de Orta, EPE /ID# 206143
City
Almada
ZIP/Postal Code
2805-267
Country
Portugal
Facility Name
CCA Braga - Hospital de Braga /ID# 206144
City
Braga
ZIP/Postal Code
4710-243
Country
Portugal
Facility Name
Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 206117
City
Lisboa
ZIP/Postal Code
1649-035
Country
Portugal
Facility Name
Hospital Santo Antonio dos Cap /ID# 206145
City
Lisbon
ZIP/Postal Code
1150-069
Country
Portugal
Facility Name
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 206142
City
Porto
ZIP/Postal Code
4200-319
Country
Portugal
Facility Name
School of Medicine University of Puerto Rico-Medical Science Campus /ID# 209626
City
San Juan
ZIP/Postal Code
00935
Country
Puerto Rico
Facility Name
Immanuel Kant Baltic Federal University /ID# 208264
City
Kaliningrad
State/Province
Kaliningradskaya Oblast
ZIP/Postal Code
236016
Country
Russian Federation
Facility Name
NW State Medical Univ na Mechn /ID# 208258
City
St. Petersburg
State/Province
Leningradskaya Oblast
ZIP/Postal Code
191015
Country
Russian Federation
Facility Name
Perm Clinical Center of the Federal Medical and Biological Agency /ID# 211653
City
Perm
State/Province
Permskiy Kray
ZIP/Postal Code
614109
Country
Russian Federation
Facility Name
Medical Company Hepatolog /ID# 208261
City
Samara
State/Province
Samarskaya Oblast
ZIP/Postal Code
443063
Country
Russian Federation
Facility Name
Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 211652
City
Stavropol
State/Province
Stavropol Skiy Kray
ZIP/Postal Code
355012
Country
Russian Federation
Facility Name
Kazan State Medical University /ID# 208256
City
Kazan
State/Province
Tatarstan, Respublika
ZIP/Postal Code
420012
Country
Russian Federation
Facility Name
Olla-Med Clinic /ID# 215335
City
Moscow
ZIP/Postal Code
105554
Country
Russian Federation
Facility Name
Republican hospital named after V.A. Baranov /ID# 206507
City
Petrozavodsk
ZIP/Postal Code
185019
Country
Russian Federation
Facility Name
Euromedservice /ID# 208265
City
Pushkin
ZIP/Postal Code
196603
Country
Russian Federation
Facility Name
LLC Novaya Clinica /ID# 208260
City
Pyatigorsk
ZIP/Postal Code
357532
Country
Russian Federation
Facility Name
Clinical Hosp Center Zvezdara /ID# 205258
City
Belgrade
State/Province
Beograd
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Military Medical Academy /ID# 205257
City
Belgrade
State/Province
Beograd
ZIP/Postal Code
11000
Country
Serbia
Facility Name
University Clinical Center Serbia /ID# 205256
City
Belgrade
State/Province
Beograd
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Clin Hosp Ctr Bezanijska Kosa /ID# 206413
City
Belgrade
State/Province
Beograd
ZIP/Postal Code
11080
Country
Serbia
Facility Name
University Clinical Center of Nis /ID# 206411
City
NIS
State/Province
Nisavski Okrug
ZIP/Postal Code
18000
Country
Serbia
Facility Name
University Clinical Center Kragujevac /ID# 206410
City
Kragujevac
State/Province
Sumadijski Okrug
ZIP/Postal Code
34000
Country
Serbia
Facility Name
Clinical Center Vojvodina /ID# 205259
City
Novi Sad
State/Province
Vojvodina
ZIP/Postal Code
21000
Country
Serbia
Facility Name
General Hospital Leskovac /ID# 217881
City
Leskovac
ZIP/Postal Code
16000
Country
Serbia
Facility Name
National University Hospital /ID# 209099
City
Singapore
ZIP/Postal Code
119074
Country
Singapore
Facility Name
Gleneagles Medical Centre /ID# 206954
City
Singapore
ZIP/Postal Code
258499
Country
Singapore
Facility Name
Tan Tock Seng Hospital /ID# 207663
City
Singapore
ZIP/Postal Code
308433
Country
Singapore
Facility Name
Medak s.r.o. /ID# 205191
City
Bratislava
State/Province
Bratislavsky Kraj
ZIP/Postal Code
851 01
Country
Slovakia
Facility Name
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 205147
City
Banska Bystrica
ZIP/Postal Code
975 17
Country
Slovakia
Facility Name
B+B MED, s.r.o. /ID# 205213
City
Kosice
ZIP/Postal Code
040 01
Country
Slovakia
Facility Name
Fakultna nemocnica s poliklini /ID# 211372
City
Nove Zamky
ZIP/Postal Code
940 34
Country
Slovakia
Facility Name
GASTRO I., s.r.o. /ID# 205148
City
Presov
ZIP/Postal Code
080 01
Country
Slovakia
Facility Name
MD Search /ID# 208084
City
Boksburg North
State/Province
Gauteng
ZIP/Postal Code
1460
Country
South Africa
Facility Name
Clinresco Centers /ID# 208083
City
Johannesburg
State/Province
Gauteng
ZIP/Postal Code
1619
Country
South Africa
Facility Name
Lenasia Clinical Trial Centre /ID# 214359
City
Johannesburg
State/Province
Gauteng
ZIP/Postal Code
1820
Country
South Africa
Facility Name
Wits Clinical Research , Wits Health Consortium (PTY) Ltd /ID# 208082
City
Johannesburg
State/Province
Gauteng
ZIP/Postal Code
2193
Country
South Africa
Facility Name
Wits Clinical Research Site /ID# 208949
City
Johannesburg
State/Province
Gauteng
ZIP/Postal Code
2193
Country
South Africa
Facility Name
Mediclinic Milnerton /ID# 207979
City
CAPE TOWN Milnerton
State/Province
Western Cape
ZIP/Postal Code
7441
Country
South Africa
Facility Name
Kingsbury Hospital /ID# 205281
City
Cape Town
State/Province
Western Cape
ZIP/Postal Code
7708
Country
South Africa
Facility Name
Private Practice Dr MN Rajabally /ID# 205273
City
Cape Town
State/Province
Western Cape
ZIP/Postal Code
7800
Country
South Africa
Facility Name
Hospital Clínico Universitario de Santiago-CHUS /ID# 204411
City
Santiago de Compostela
State/Province
A Coruna
ZIP/Postal Code
15706
Country
Spain
Facility Name
Hospital Unversitario Marques de Valdecilla /ID# 216622
City
Santander
State/Province
Cantabria
ZIP/Postal Code
39008
Country
Spain
Facility Name
Hospital Universitario Dr. Negrin /ID# 206905
City
Las Palmas de Gran Canaria
State/Province
Las Palmas
ZIP/Postal Code
35010
Country
Spain
Facility Name
Hospital Universitario A Coruna - CHUAC /ID# 206907
City
A Coruna
ZIP/Postal Code
15006
Country
Spain
Facility Name
Hospital Clinic de Barcelona /ID# 206906
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Facility Name
Hospital Universitario Reina Sofia /ID# 204412
City
Cordoba
ZIP/Postal Code
14004
Country
Spain
Facility Name
Hospital Universitario Ramon y Cajal /ID# 204410
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Facility Name
Hospital Universitario La Paz /ID# 214540
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Facility Name
Hospital Clinico Universitario de Salamanca /ID# 205013
City
Salamanca
ZIP/Postal Code
37007
Country
Spain
Facility Name
Hospital Universitario y Politecnico La Fe /ID# 206904
City
Valencia
ZIP/Postal Code
46026
Country
Spain
Facility Name
Kantonsspital St. Gallen /ID# 211310
City
St. Gallen
State/Province
Sankt Gallen
ZIP/Postal Code
9007
Country
Switzerland
Facility Name
Universitaetsspital Basel /ID# 211381
City
Basel
ZIP/Postal Code
4031
Country
Switzerland
Facility Name
Inselspital, Universitaetsklinik /ID# 211312
City
Bern
ZIP/Postal Code
3010
Country
Switzerland
Facility Name
Universitaetsspital Zuerich /ID# 211308
City
Zurich
ZIP/Postal Code
8091
Country
Switzerland
Facility Name
China Medical University Hosp /ID# 207845
City
Taichung City
State/Province
Taichung
ZIP/Postal Code
40447
Country
Taiwan
Facility Name
National Taiwan University Hospital /ID# 207847
City
Taipei City
State/Province
Taipei
ZIP/Postal Code
100
Country
Taiwan
Facility Name
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 207848
City
Kaohsiung
ZIP/Postal Code
80708
Country
Taiwan
Facility Name
Taipei Veterans General Hosp /ID# 207849
City
Taipei City
ZIP/Postal Code
11217
Country
Taiwan
Facility Name
Erciyes University Medical Fac /ID# 207506
City
Melikgazi
State/Province
Kayseri
ZIP/Postal Code
38030
Country
Turkey
Facility Name
Gazi University Med. Faculty /ID# 208040
City
Ankara GAZI
ZIP/Postal Code
06500
Country
Turkey
Facility Name
Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 207507
City
Istanbul
ZIP/Postal Code
34098
Country
Turkey
Facility Name
Umraniye Training and Res Hosp /ID# 208206
City
Istanbul
ZIP/Postal Code
34764
Country
Turkey
Facility Name
Mersin University Medical /ID# 208039
City
Mersin
ZIP/Postal Code
33343
Country
Turkey
Facility Name
Communal Non-Commercial Enterprize of Kharkiv Regional Council Regional Clinical /ID# 206939
City
Kharkiv
State/Province
Kharkivska Oblast
ZIP/Postal Code
61204
Country
Ukraine
Facility Name
Kyiv Regional Hospital /ID# 217373
City
Kyiv
State/Province
Kyivska Oblast
ZIP/Postal Code
04073
Country
Ukraine
Facility Name
PE PMC Acinus, Medical and Diagnostic Center /ID# 217218
City
Kropyvnytskyi
ZIP/Postal Code
25006
Country
Ukraine
Facility Name
Medical centre of CONSILIUM MEDICAL LLC /ID# 217447
City
Kyiv
ZIP/Postal Code
04050
Country
Ukraine
Facility Name
Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 216300
City
Vinnytsia
ZIP/Postal Code
21018
Country
Ukraine
Facility Name
Basingstoke & North Hampshire /ID# 207985
City
Basingstoke
ZIP/Postal Code
RG24 9NA
Country
United Kingdom
Facility Name
Queen Elizabeth University Hos /ID# 205154
City
Glasgow
ZIP/Postal Code
G514TF
Country
United Kingdom
Facility Name
Huddersfield Royal Infirmary /ID# 217660
City
Huddersfield
ZIP/Postal Code
HD3 3EA
Country
United Kingdom
Facility Name
St. George's Healthcare NHS /ID# 208375
City
London
ZIP/Postal Code
SW17 0QT
Country
United Kingdom
Facility Name
Barts and the London NHS Trust /ID# 205153
City
Whitechapel
ZIP/Postal Code
E1 1 BB
Country
United Kingdom
12. IPD Sharing Statement
Plan to Share IPD
Yes
IPD Sharing Plan Description
AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols and clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.
IPD Sharing Time Frame
For details on when studies are available for sharing, please refer to the link below.
IPD Sharing Access Criteria
Access to this clinical trial data can be requested by any qualified researchers who engage in rigorous, independent scientific research, and will be provided following review and approval of a research proposal and Statistical Analysis Plan (SAP) and execution of a Data Use Agreement (DUA). For more information on the process, or to submit a request, visit the following link.
IPD Sharing URL
https://vivli.org/ourmember/abbvie/
Citations:
PubMed Identifier
35644166
Citation
Danese S, Vermeire S, Zhou W, Pangan AL, Siffledeen J, Greenbloom S, Hebuterne X, D'Haens G, Nakase H, Panes J, Higgins PDR, Juillerat P, Lindsay JO, Loftus EV Jr, Sandborn WJ, Reinisch W, Chen MH, Sanchez Gonzalez Y, Huang B, Xie W, Liu J, Weinreich MA, Panaccione R. Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: results from three phase 3, multicentre, double-blind, randomised trials. Lancet. 2022 Jun 4;399(10341):2113-2128. doi: 10.1016/S0140-6736(22)00581-5. Epub 2022 May 26. Erratum In: Lancet. 2022 Sep 24;400(10357):996.
Results Reference
derived
Links:
URL
https://www.rxabbvie.com
Description
This clinical study may be evaluating a usage that is not currently FDA approved. Please see US Prescribing Information for approved uses.
Learn more about this trial
A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Ulcerative Colitis
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