Back to resultsA Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer (HER2CLIMB-05)
Primary Purpose
HER2 Positive Breast Cancer
Status
Recruiting
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Tucatinib
Trastuzumab
Pertuzumab
Combination product: Trastuzumab + Pertuzumab
Placebo
Sponsored by
About this trial
This is an interventional treatment trial for HER2 Positive Breast Cancer focused on measuring HER2+ breast cancer, Breast Cancer, Metastatic breast cancer, Seattle Genetics
Eligibility Criteria
Inclusion Criteria:
- Centrally confirmed HER2+ breast carcinoma per 2018 American Society of Clinical Oncologists (ASCO) College of American Pathologists (CAP) guidelines.
Have unresectable locally advanced or metastatic disease.
- If recurrent (after [neo]adjuvant therapy), must be at least 6 month treatment free from any trastuzumab or pertuzumab received for advanced HER2+ disease.
- Have received 4-8 cycles (21 day cycles) of previous treatment with trastuzumab, pertuzumab, and taxane as first-line therapy for advanced HER2+ breast cancer with no evidence of disease progression
- Known hormone receptor status (per local guidelines; may be hormone receptor positive [HR+] or negative [HR-])
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
CNS Inclusion - Based on screening contrast brain magnetic resonance imaging (MRI), participants may have any of the following:
- No evidence of brain metastases
- Untreated brain metastases which are asymptomatic and, if identified on prior brain imaging, without evidence of progression since starting first-line induction therapy with trastuzumab, pertuzumab, and taxane
Previously treated brain metastases which are asymptomatic
- Brain metastases previously treated with local therapy must not have progressed since treatment
Exclusion Criteria:
- Prior treatment with any anti-HER2 and/or anti-epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor including pyrotinib, lapatinib, tucatinib, neratinib, and afatinib (except neratinib if given in extended adjuvant setting and ≥ 12 months have elapsed since last neratinib dose prior to start of study drug)
- Unable to undergo contrast MRI of the brain
CNS Exclusion - Based on screening brain MRI and clinical assessment
- Symptomatic brain metastasis
- Progression of brain metastases since starting first line trastuzumab, pertuzumab, and taxane
- Ongoing use of systemic corticosteroids at a total daily dose of >2 mg of dexamethasone (or equivalent)
- Any untreated brain lesion in an anatomic site which may pose risk to participant
- Known or suspected leptomeningeal disease (LMD)
- Poorly controlled (>1/week) seizures, or other persistent neurologic symptoms
Sites / Locations
- Mayo Clinic ArizonaRecruiting
- CARTI Cancer CenterRecruiting
- UC San Diego / Moores Cancer CenterRecruiting
- UCLA Department of Medicine - Hematology & OncologyRecruiting
- Mayo Clinic FloridaRecruiting
- AdventHealth Cancer InstituteRecruiting
- Orlando Health, Inc. TRIORecruiting
- Winship Cancer Institute / Emory University School of MedicineRecruiting
- Kaiser Permanente Moanalua Medical CenterRecruiting
- University of Illinois at ChicagoRecruiting
- Norton Cancer InstituteRecruiting
- Norton Cancer InstituteRecruiting
- Norton Cancer InstituteRecruiting
- Mercy Medical Center -Weinberg CenterRecruiting
- Mayo Clinic RochesterRecruiting
- Saint Luke's Cancer Institute LLCRecruiting
- Nebraska Cancer SpecialistsRecruiting
- Oncology Hematology West, P.C.Recruiting
- Rutgers Cancer Institute of New JerseyRecruiting
- Monmouth Medical Center Southern CampusRecruiting
- Saint Barnabas Medical Center Cancer CenterRecruiting
- Monmouth Medical CenterRecruiting
- Rutgers Cancer Institute of New JerseyRecruiting
- Newark Beth Israel Medical CenterRecruiting
- Robert Wood Johnson University Hospital SomersetRecruiting
- Community Medical CenterRecruiting
- Montefiore Medical CenterRecruiting
- Cleveland Clinic, TheRecruiting
- Zangmeister Cancer CenterRecruiting
- Thomas Jefferson University
- Thomas Jefferson University
- Thomas Jefferson University
- Charleston Oncology
- Tennessee Oncology-Nashville/Sarah Cannon Research InstituteRecruiting
- Fred Hutchinson Cancer Center / Seattle Cancer Care Alliance / University of WashingtonRecruiting
- Medical College of Wisconsin (Milwaukee)Recruiting
- Cancer Research South AustraliaRecruiting
- Flinders Medical CentreRecruiting
- Box Hill HospitalRecruiting
- Chris O'Brien LifehouseRecruiting
- Peninsula and South East OncologyRecruiting
- Austin HealthRecruiting
- Macquarie University HospitalRecruiting
- St John of God Subiaco HospitalRecruiting
- Westmead HospitalRecruiting
- LKH- Universitat Klinikum GrazRecruiting
- Ordensklinikum Linz GmbH Barmherzige SchwesternRecruiting
- Ordination Priv.-Doz. Dr. M. HubalekRecruiting
- Institut Jules BordetRecruiting
- UCL Saint-LucRecruiting
- Universitair Ziekenhuis BrusselRecruiting
- Clinique Saint PierreRecruiting
- GZA Hospital Sint-AugustinusRecruiting
- Hospital de Cancer de Barretos - Fundacao Pio XIIRecruiting
- Clinica de Pesquisas e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda.Recruiting
- INCAN - Instituto do Cancer - Hospital Pompeia
- Centro Regional Integrado de OncologiaRecruiting
- Hospital Araujo Jorge - Associacao de Combate ao Cancer em GoiasRecruiting
- Fundação Doutor Amaral CarvalhoRecruiting
- Hospital do Cancer de LondrinaRecruiting
- Liga Norte-Rio-Grandense Contra o CancerRecruiting
- Irmandade da Santa Casa de Misericordia de Porto AlegreRecruiting
- Hospital de Clinicas de Porto AlegreRecruiting
- Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e PesquisaRecruiting
- Hospital Nossa Senhora da ConceiçãoRecruiting
- CEPHO - Centro de Estudos e Pesquisas de Hematologia e OncologiaRecruiting
- Praxis Pesquisa MedicaRecruiting
- Fundação Faculdade Regional de Medicina de São José do Rio PretoRecruiting
- Sao Camilo OncologiaRecruiting
- ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de OliveiraRecruiting
- Fundação NAtonio Prudente (AC Camargo Cancer Center)Recruiting
- University of Alberta / Cross Cancer InstituteRecruiting
- BC Cancer KelownaRecruiting
- Ottawa Hospital Cancer CentreRecruiting
- Sunnybrook Health Sciences CentreRecruiting
- CIUSSS du Saguenay Lac Saint JeanRecruiting
- Centre Hospitalier de l'Universite de MontrealRecruiting
- Jewish General HospitalRecruiting
- Clinica Universidad Catolica del MauleRecruiting
- Sociedad de Investigaciones Medicas LimitadaRecruiting
- Oncocentro APYSRecruiting
- Affiliated Hospital of Hebei UniversityRecruiting
- Beijing HospitalRecruiting
- The First Bethune Hospital of Jilin UniversityRecruiting
- The Second Xiangya Hospital of Central South UniversityRecruiting
- Affiliated Hospital of Chengde Medical University
- The First People's Hospital of Foshan
- Fujian Provincial Cancer HospitalRecruiting
- 900TH Hospital of Joint Logistics Support Force
- Guangdong Provincial People's HospitalRecruiting
- The first Affiliated Hospital of Hainan Medical UniversityRecruiting
- Zhejiang Cancer HospitalRecruiting
- The Second Affiliated Hospital of Zhejiang University School of MedicineRecruiting
- Sir Run Run Shaw Hospital, Zhejiang University, School of MedicineRecruiting
- Harbin Medical University Cancer Hospital
- The Second Hospital of Anhui Medical UniversityRecruiting
- The Affiliated Hospital of Inner Mongolia Medical University
- Jinan Central HospitalRecruiting
- Linyi Cancer HospitalRecruiting
- Liuzhou People's HospitalRecruiting
- Meizhou People's Hospital - Guangdong ProvinceRecruiting
- The Second Affiliated Hospital of Nanchang UniversityRecruiting
- Nanjing Medical University (NMU) - Jiangsu Province HospitalRecruiting
- The First Affiliated Hospital of Guangxi Medical UniversityRecruiting
- Nantong Tumor HospitalRecruiting
- Ruijin Hospital of Shanghai Jiaotong University School of MedicineRecruiting
- Fudan University Shanghai Cancer CenterRecruiting
- The First Hospital of China Medical UniversityRecruiting
- Liaoning Cancer Hospital and InstituteRecruiting
- Tianjin Medical University - Cancer Institute & HospitalRecruiting
- Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyRecruiting
- Hubei Cancer HospitalRecruiting
- The First Affiliated Hospital of Xi'an Jiaotong UniversityRecruiting
- Shaanxi Provincial People's HospitalRecruiting
- The First Affiliated Hospital of Xinxiang Medical University
- The Affiliated Hospital of Xuzhou Medical College
- Xuzhou Central HospitalRecruiting
- Yantai Yuhuangding Hospital
- Henan Provincial People's Hospital
- Henan Cancer HospitalRecruiting
- Nanchang Third Hospital
- Guangxi Medical University Affiliated Tumor HospitalRecruiting
- Masaryk Memorial Cancer InstituteRecruiting
- Thomayer University Hospital (Fakultní Thomayerova nemocnice)Recruiting
- Fakultni nemocnice v MotoleRecruiting
- Nemocnice Horovice (NH Hospital) a.s.Recruiting
- Helsinki University HospitalRecruiting
- Kuopio University HospitalRecruiting
- Tampere University HospitalRecruiting
- Vaasa Central HospitalRecruiting
- Sainte Catherine Institut du Cancer Avignon ProvenceRecruiting
- Centre Hospitalier Regional et Universitaire de Besancon - Hopital Jean-MinjozRecruiting
- Centre Hospitalier Universitaire Hopital AvicenneRecruiting
- Institut BergonieRecruiting
- Centre de Lutte contre le Cancer - François BaclesseRecruiting
- Centre Jean PerrinRecruiting
- CARIO - Centre Armoricain De Radiothérapie, D'imagerie Médicale Et D'oncologieRecruiting
- Center Georges Francois LeclercRecruiting
- Centre de Lutte contre le Cancer (CLCC) - Centre Oscar LambretRecruiting
- Centre Hospitalier Universitaire (CHU) De Limoges - Hopital DupuytrenRecruiting
- Centre Leon Berard - Centre regional de lutte contre le cancer Rhone-AlpesRecruiting
- Centre de Cancerologie du Grand MontpellierRecruiting
- Institut Regional du Cancer de MontpellierRecruiting
- Centre de Lutte contre le Cancer (CLCC) - Centre Antoine LacassagneRecruiting
- Hopitaux Civils de LyonRecruiting
- Centre Eugene MarquisRecruiting
- Centre Henri Becquerel / Centre Regional de Lutte Contre le CancerRecruiting
- Institut de Cancerologie de lOuest - Site Rene GauducheauRecruiting
- Institut CurieRecruiting
- Institut de cancerologie Strasbourg EuropeRecruiting
- Institut Curie
- Charite Universitatsmedizin BerlinRecruiting
- Universitaetsklinikum DusseldorfRecruiting
- Universitaetsklinikum EssenRecruiting
- Klinikum Esslingen GmbHRecruiting
- Medizinische Hochschule HannoverRecruiting
- St. Elisabeth-Krankenhaus Koln-HohenlindRecruiting
- Medical Faculty Mannheim, Heidelberg UniversityRecruiting
- Klinikum Rechts der Isar der Technischen Universitaet MuenchenRecruiting
- Universitaetsklinikum MuensterRecruiting
- Universitatsklinik TuebingenRecruiting
- Alexandra General Hospital of AthensRecruiting
- University General Hospital of Heraklion (PAGNI)Recruiting
- University Hospital of PatrasRecruiting
- Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-MalpighiRecruiting
- Azienda Ospedaliera Universitaria San MartinoRecruiting
- Fondazione IRCCS San Gerardo dei TintoriRecruiting
- Azienda Ospedaliera Universitaria (AOU) Federico IIRecruiting
- Istituto Nazionale Tumori IRCCS Fondazione G. PascaleRecruiting
- Ospedale Sacro Cuore Don CalabriaRecruiting
- Azienda USL 4 Prato - Ospedale Misericordia e Dolce di PratoRecruiting
- Istituto Clinico Humanitas-Humanitas Cancer CenterRecruiting
- A.O.U. - Ospedali Riuniti di AnconaRecruiting
- National Cancer Center HospitalRecruiting
- St. Luke's International HospitalRecruiting
- National Hospital Organization Kyushu Cancer CenterRecruiting
- Fukushima Medical University HospitalRecruiting
- University of Tsukuba HospitalRecruiting
- Tesshokai Kameda General HospitalRecruiting
- Ishikawa Prefectural Central HospitalRecruiting
- National Cancer Center Hospital EastRecruiting
- NHO Shikoku Cancer CenterRecruiting
- Toranomon HospitalRecruiting
- Naha Nishi ClinicRecruiting
- Kindai University HospitalRecruiting
- National Hospital Organization Hokkaido Cancer CenterRecruiting
- Showa University HospitalRecruiting
- Kanagawa Cancer CenterRecruiting
- Dong-A University HospitalRecruiting
- Chungbuk National University HospitalRecruiting
- National Cancer CenterRecruiting
- Gachon University Gil Medical CenterRecruiting
- Seoul National University Bundang HospitalRecruiting
- Korea University Anam HospitalRecruiting
- Seoul National University HospitalRecruiting
- Severance Hospital, Yonsei University Health SystemRecruiting
- Seoul Saint Mary's HospitalRecruiting
- Ewha Womans University Mokdong HospitalRecruiting
- St. Vincent's Hospital, The Catholic University of KoreaRecruiting
- Ajou University HospitalRecruiting
- Severance Hospital, Yonsei University Health SystemRecruiting
- Asan Medical CenterRecruiting
- Gangnam Severance HospitalRecruiting
- Netherlands Cancer InstituteRecruiting
- Albert Schweitzer HospitalRecruiting
- Medisch Centrum Leeuwarden (MCL)Recruiting
- St. Antonius HospitalRecruiting
- VieCuri Medisch CentrumRecruiting
- Przychodnia Lekarska KOMED Roman KaraszewskiRecruiting
- Hospital de BragaRecruiting
- Hospital Santa MariaRecruiting
- Hospital Cuf DescobertasRecruiting
- Champalimaud Clinical CenterRecruiting
- Hospital General Universitario AlicanteRecruiting
- Hospital Del MarRecruiting
- Hospital Universitari Vall d'HebronRecruiting
- Hospital de la Santa Creu i Sant PauRecruiting
- Hospital Universitario de BasurtoRecruiting
- Complejo Hospitalario De Caceres - Hospital General San Pedro De AlcantaraRecruiting
- Institut Catala d'Oncologia Girona - ICO GironaRecruiting
- Hospital Universitario Virgen de las NievesRecruiting
- Hospital Universitari Arnau de VilanovaRecruiting
- Hospital General Universitario Gregorio MaranonRecruiting
- Hospital Universitario Ramon y CajalRecruiting
- Hospital Universitario Son EspasesRecruiting
- Hospital Clinico Universitario de SalamancaRecruiting
- Hospital Universitario de CanariasRecruiting
- Hospital Universitario Virgen del RocioRecruiting
- Valencian Institute of Oncology FoundationRecruiting
- Hospital Clinico Universitario de ValenciaRecruiting
- Kantonsspital Baden AGRecruiting
- Kantonsspital Winterthur (KSW)Recruiting
- Brust-Zentrum ZurichRecruiting
- Changhua Christian HospitalRecruiting
- Kaohsiung Medical University HospitalRecruiting
- Taipei Medical University HospitalRecruiting
- China Medical University HospitalRecruiting
- National Cheng-Kung University HospitalRecruiting
- Chi Mei Hospital LiouyingRecruiting
- Mackay Memorial HospitalRecruiting
- Taipei Veterans General HospitalRecruiting
- Sun Yat-sen University Cancer CenterRecruiting
- Central Hospital of the Ministry of National DefenseRecruiting
- Chang Gung Memorial Hospital - LinkouRecruiting
- National Taiwan University HospitalRecruiting
- The University of EdinburghRecruiting
- University College London Hospitals NHS Foundation TrustRecruiting
- Royal Free London NHS Foundation TrustRecruiting
- The Royal Marsden NHS Foundation Trust (RM)Recruiting
- Christie Hospital NHS Foundation TrustRecruiting
- The Royal Marsden NHS Foundation Trust (RM)Recruiting
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
Tucatinib + trastuzumab + pertuzumab
Placebo + trastuzumab + pertuzumab
Arm Description
Tucatinib + trastuzumab + pertuzumab
Placebo + trastuzumab + pertuzumab
Outcomes
Primary Outcome Measures
Progression-free survival (PFS) by investigator assessment per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
The time from the date of randomization to the investigator assessment of disease progression according to RECIST v1.1 or death from any cause
Secondary Outcome Measures
Overall survival (OS)
The time from randomization to death from any cause.
PFS by blinded independent central review (BICR) per RECIST v1.1
The time from the date of randomization to the documented disease progression assessed by BICR according to RECIST v1.1 or death from any cause
Time to deterioration of health-related quality of life (HRQoL)
Will be measured based on patient reported outcomes (PROs) according to the European Organization for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ C30).
Central nervous system (CNS) PFS
The time from randomization to investigator assessed disease progression in brain (RECIST v1.1), or death from any cause
Incidence of adverse events (AEs)
Any untoward medical occurrence in a clinical investigational participant administered a medicinal product and which does not necessarily have a causal relationship with this treatment.
Incidence of laboratory abnormalities
To be summarized using descriptive statistics.
Incidence of tucatinib dose alterations
To be summarized using descriptive statistics.
Incidence of trastuzumab dose alterations
To be summarized using descriptive statistics.
Incidence of pertuzumab dose alterations
To be summarized using descriptive statistics.
Maximum concentration (Cmax)
To be summarized using descriptive statistics.
Trough concentration (Ctrough)
To be summarized using descriptive statistics.
Full Information
NCT ID
NCT05132582
First Posted
November 12, 2021
Last Updated
October 23, 2023
Sponsor
Seagen Inc.
Collaborators
Merck Sharp & Dohme LLC
1. Study Identification
Unique Protocol Identification Number
NCT05132582
Brief Title
A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer
Acronym
HER2CLIMB-05
Official Title
A Randomized, Double-blind, Phase 3 Study of Tucatinib or Placebo in Combination With Trastuzumab and Pertuzumab as Maintenance Therapy for Metastatic HER2+ Breast Cancer (HER2CLIMB-05)
Study Type
Interventional
2. Study Status
Record Verification Date
October 2023
Overall Recruitment Status
Recruiting
Study Start Date
March 7, 2022 (Actual)
Primary Completion Date
October 31, 2024 (Anticipated)
Study Completion Date
June 30, 2027 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Seagen Inc.
Collaborators
Merck Sharp & Dohme LLC
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
This study is being done to see if tucatinib works better than placebo when given with other drugs to treat participants with HER2-positive breast cancer. A placebo is a pill that looks the same as tucatinib but has no medicine in it. This study will also test what side effects happen when participants take this combination of drugs. A side effect is anything a drug does to the body besides treating your disease.
Participants will have cancer that has spread in the body near where it started (locally advanced) and cannot be removed (unresectable) or has spread through the body (metastatic).
In this study, all participants will get either tucatinib or placebo. Participants will be assigned randomly to a group. This is a blinded study, so patients and their doctors will not know which group a participant is in.
All participants will also get trastuzumab and pertuzumab. These are 2 drugs used to treat this type of cancer.
Detailed Description
Control arm: Placebo given orally twice daily plus trastuzumab and pertuzumab every 21 days
Experimental arm: Tucatinib 300 mg given orally twice daily plus trastuzumab and pertuzumab every 21 days
Trastuzumab and pertuzumab will be administered as follows:
• Trastuzumab will be given intravenously (IV) at a dose of 6 mg/kg or subcutaneously (SC) at a fixed dose of 600 mg, once every 21 days.
AND
Pertuzumab will be given IV at 420 mg every 21 days. OR
Fixed dose combination of 600 mg pertuzumab, 600 mg trastuzumab, and 20,000 units hyaluronidase will be given SC, once every 21 days, in lieu of trastuzumab and pertuzumab individually.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
HER2 Positive Breast Cancer
Keywords
HER2+ breast cancer, Breast Cancer, Metastatic breast cancer, Seattle Genetics
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
650 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Tucatinib + trastuzumab + pertuzumab
Arm Type
Experimental
Arm Description
Tucatinib + trastuzumab + pertuzumab
Arm Title
Placebo + trastuzumab + pertuzumab
Arm Type
Active Comparator
Arm Description
Placebo + trastuzumab + pertuzumab
Intervention Type
Drug
Intervention Name(s)
Tucatinib
Other Intervention Name(s)
TUKYSA, ONT-380, ARRY-380
Intervention Description
300mg given by mouth (orally) twice daily
Intervention Type
Drug
Intervention Name(s)
Trastuzumab
Other Intervention Name(s)
Herceptin, Herceptin Hylecta
Intervention Description
6mg/kg given into the vein (IV; intravenously) or 600mg injected under the skin (SC; subcutaneous) every 21 days
Intervention Type
Drug
Intervention Name(s)
Pertuzumab
Other Intervention Name(s)
Perjeta
Intervention Description
420mg given by IV every 21 days
Intervention Type
Drug
Intervention Name(s)
Combination product: Trastuzumab + Pertuzumab
Other Intervention Name(s)
Phesgo
Intervention Description
600 mg pertuzumab, 600 mg trastuzumab, and 20,000 units hyaluronidase will be given by subcutaneous injection every 21 days. May be given in place of trastuzumab and pertuzumab individually.
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Given orally twice daily
Primary Outcome Measure Information:
Title
Progression-free survival (PFS) by investigator assessment per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
Description
The time from the date of randomization to the investigator assessment of disease progression according to RECIST v1.1 or death from any cause
Time Frame
Up to approximately 3 years
Secondary Outcome Measure Information:
Title
Overall survival (OS)
Description
The time from randomization to death from any cause.
Time Frame
Up to approximately 5 years
Title
PFS by blinded independent central review (BICR) per RECIST v1.1
Description
The time from the date of randomization to the documented disease progression assessed by BICR according to RECIST v1.1 or death from any cause
Time Frame
Up to approximately 3 years
Title
Time to deterioration of health-related quality of life (HRQoL)
Description
Will be measured based on patient reported outcomes (PROs) according to the European Organization for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ C30).
Time Frame
Up to approximately 3 years
Title
Central nervous system (CNS) PFS
Description
The time from randomization to investigator assessed disease progression in brain (RECIST v1.1), or death from any cause
Time Frame
Up to approximately 3 years
Title
Incidence of adverse events (AEs)
Description
Any untoward medical occurrence in a clinical investigational participant administered a medicinal product and which does not necessarily have a causal relationship with this treatment.
Time Frame
Through 30 days after last study treatment, approximately 18 months
Title
Incidence of laboratory abnormalities
Description
To be summarized using descriptive statistics.
Time Frame
Through 30 days after last study treatment, approximately 18 months
Title
Incidence of tucatinib dose alterations
Description
To be summarized using descriptive statistics.
Time Frame
Through 30 days after last study treatment, approximately 18 months
Title
Incidence of trastuzumab dose alterations
Description
To be summarized using descriptive statistics.
Time Frame
Through 30 days after last study treatment, approximately 18 months
Title
Incidence of pertuzumab dose alterations
Description
To be summarized using descriptive statistics.
Time Frame
Through 30 days after last study treatment, approximately 18 months
Title
Maximum concentration (Cmax)
Description
To be summarized using descriptive statistics.
Time Frame
Through 30 days after last study treatment, approximately 18 months
Title
Trough concentration (Ctrough)
Description
To be summarized using descriptive statistics.
Time Frame
Through 30 days after last study treatment, approximately 18 months
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Centrally confirmed HER2+ breast carcinoma according to the 2018 American Society of Clinical Oncologists (ASCO) College of American Pathologists (CAP) guidelines prior to randomization (defined as a 3+ score on immunohistochemistry (IHC) and/or 2+ IHC and concurrent positive by ISH).
Have unresectable locally advanced or metastatic disease.
If recurrent (after [neo]adjuvant therapy), must be at least 6 month treatment free from any trastuzumab and pertuzumab received in the early breast cancer setting for advanced HER2+ disease.
Have received 4-8 cycles of pre-study induction therapy including only trastuzumab, pertuzumab, and taxane as first-line of therapy for the treatment of advanced breast cancer prior to study enrollment. Participants are eligible provided they are without evidence of disease progression following completion of induction therapy.
Known hormone receptor status (per local guidelines; may be hormone receptor positive [HR+] or negative [HR-])
Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
CNS Inclusion - Based on screening contrast-enhanced brain magnetic resonance imaging (MRI), participants may have any of the following:
No evidence of brain metastases
Untreated brain metastases which are asymptomatic not needing immediate local treatment and, if identified on prior brain imaging, without evidence of progression since starting first-line induction therapy with trastuzumab, pertuzumab, and taxane
Previously treated brain metastases which are asymptomatic
Brain metastases previously treated with local therapy must not have progressed since treatment
Exclusion Criteria:
Prior treatment with any tyrosine kinase inhibitor targeting HER2 and/or epidermal growth factor receptor (EGFR) including pyrotinib, lapatinib, tucatinib, neratinib, and afatinib (except neratinib if given in extended adjuvant setting and ≥ 12 months have elapsed since last neratinib dose prior to start of study drug)
Unable to undergo contrast-enhanced MRI of the brain
CNS Exclusion - Based on screening brain MRI and clinical assessment
Symptomatic brain metastasis after CNS-directed local therapy
Progression of brain metastases since starting first line trastuzumab, pertuzumab, and taxane
Ongoing use of systemic corticosteroids at a total daily dose of >2 mg of dexamethasone (or equivalent)
Any untreated brain lesion in an anatomic site which may pose risk to participant
Known or suspected leptomeningeal disease (LMD)
Poorly controlled (>1/week) seizures, or other persistent neurologic symptoms
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Seagen Trial Information Support
Phone
866-333-7436
Email
clinicaltrials@seagen.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Libero Santarpia, MD, PhD
Organizational Affiliation
Seagen Inc.
Official's Role
Study Director
Facility Information:
Facility Name
Mayo Clinic Arizona
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85054
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mayo Clinic Arizona Clinical Trials Referral Office Inbox
Phone
855-776-0015
First Name & Middle Initial & Last Name & Degree
Lida Mina
Facility Name
CARTI Cancer Center
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Issam Makhoul
Facility Name
UC San Diego / Moores Cancer Center
City
La Jolla
State/Province
California
ZIP/Postal Code
92093
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Molly Klipfel
Phone
858-822-4343
First Name & Middle Initial & Last Name & Degree
Kay Yeung
Facility Name
UCLA Department of Medicine - Hematology & Oncology
City
Santa Monica
State/Province
California
ZIP/Postal Code
90404
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nicholas P McAndrew
Phone
310-980-6537
Email
nmcandrew@mednet.ucla.edu
First Name & Middle Initial & Last Name & Degree
Nicholas P McAndrew
Facility Name
Mayo Clinic Florida
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32224
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pooja Advani
Phone
904-953-0707
Email
Advani.pooja@mayo.edu
First Name & Middle Initial & Last Name & Degree
Pooja Advani
Facility Name
AdventHealth Cancer Institute
City
Orlando
State/Province
Florida
ZIP/Postal Code
32804
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carlos Alemany
Phone
407-303-2024
Email
Carlos.alemany.md@adventhealth.com
First Name & Middle Initial & Last Name & Degree
Carlos Alemany
Facility Name
Orlando Health, Inc. TRIO
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ana Fernandez
Phone
321-841-8557
Email
Ana.cuestafernandez@orlandohealth.com
First Name & Middle Initial & Last Name & Degree
Ana Fernandez
Facility Name
Winship Cancer Institute / Emory University School of Medicine
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30322
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jane L Meisel
Phone
404-778-1900
Email
jane.l.meisel@emory.edu
First Name & Middle Initial & Last Name & Degree
Jane L Meisel
Facility Name
Kaiser Permanente Moanalua Medical Center
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96819
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jennifer Carney
Phone
202-432-0000
Email
Jennifer.F.Carney@kp.org
First Name & Middle Initial & Last Name & Degree
Jennifer Carney
Facility Name
University of Illinois at Chicago
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Oana Danciu
Phone
312-996-1581
Email
ocdanciu@uic.edu
First Name & Middle Initial & Last Name & Degree
Oana Danciu
Facility Name
Norton Cancer Institute
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Laila Agrawal
Facility Name
Norton Cancer Institute
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40207
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Laila Agrawal
Facility Name
Norton Cancer Institute
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40241
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Laila Agrawal
Phone
502-394-6350
Email
Laila.agrawal@nortonhealthcare.org
First Name & Middle Initial & Last Name & Degree
Laila Agrawal
Facility Name
Mercy Medical Center -Weinberg Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21202
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alexandra Cline
Phone
410-951-7956
Email
acline@mdmercy.com
First Name & Middle Initial & Last Name & Degree
David Riseberg
Facility Name
Mayo Clinic Rochester
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pyone Lei Lei Mon
Phone
(507) 266-7491
Email
mon.pyoneleilei@mayo.edu
First Name & Middle Initial & Last Name & Degree
Ciara O'Sullivan
Facility Name
Saint Luke's Cancer Institute LLC
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64113
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Timothy J Pluard
Phone
816-932-6005
Email
tpluard@saintlukeskc.org
First Name & Middle Initial & Last Name & Degree
Timothy J Pluard
Facility Name
Nebraska Cancer Specialists
City
Grand Island
State/Province
Nebraska
ZIP/Postal Code
68803
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Margaret Block
Facility Name
Oncology Hematology West, P.C.
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68130
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Margaret Block
Phone
402-334-4773
Email
mblock@nebraskacancer.com
First Name & Middle Initial & Last Name & Degree
Margaret Block
Facility Name
Rutgers Cancer Institute of New Jersey
City
Jersey City
State/Province
New Jersey
ZIP/Postal Code
07302
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mridula George
Facility Name
Monmouth Medical Center Southern Campus
City
Lakewood
State/Province
New Jersey
ZIP/Postal Code
08701
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mridula George
Facility Name
Saint Barnabas Medical Center Cancer Center
City
Livingston
State/Province
New Jersey
ZIP/Postal Code
07039
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mridula George
Facility Name
Monmouth Medical Center
City
Long Branch
State/Province
New Jersey
ZIP/Postal Code
07740
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mridula George
Facility Name
Rutgers Cancer Institute of New Jersey
City
New Brunswick
State/Province
New Jersey
ZIP/Postal Code
08903-2681
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mridula George
Phone
732-235-2465
Email
mridula@rwjms.rutgers.edu
First Name & Middle Initial & Last Name & Degree
Mridula George
Facility Name
Newark Beth Israel Medical Center
City
Newark
State/Province
New Jersey
ZIP/Postal Code
07112
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mridula George
Facility Name
Robert Wood Johnson University Hospital Somerset
City
Somerville
State/Province
New Jersey
ZIP/Postal Code
08876
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mridula George
Facility Name
Community Medical Center
City
Toms River
State/Province
New Jersey
ZIP/Postal Code
08755
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mridula George
Facility Name
Montefiore Medical Center
City
Bronx
State/Province
New York
ZIP/Postal Code
10461
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sun Young Oh
Phone
718-405-8404
Email
suyoung@montefiore.org
First Name & Middle Initial & Last Name & Degree
Sun Young Oh
Facility Name
Cleveland Clinic, The
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Halle C Moore, MD
Phone
216-445-4624
Email
MOOREH1@ccf.org
First Name & Middle Initial & Last Name & Degree
Halle C Moore, MD
Facility Name
Zangmeister Cancer Center
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43219
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jeanna L Knoble
Phone
614-383-6000
First Name & Middle Initial & Last Name & Degree
Jeanna L Knoble
Facility Name
Thomas Jefferson University
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Individual Site Status
Completed
Facility Name
Thomas Jefferson University
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19114
Country
United States
Individual Site Status
Completed
Facility Name
Thomas Jefferson University
City
Willow Grove
State/Province
Pennsylvania
ZIP/Postal Code
19090
Country
United States
Individual Site Status
Completed
Facility Name
Charleston Oncology
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29414
Country
United States
Individual Site Status
Completed
Facility Name
Tennessee Oncology-Nashville/Sarah Cannon Research Institute
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Erika P Hamilton
Phone
615-329-7274
Email
erika.hamilton@sarahcannon.com
First Name & Middle Initial & Last Name & Degree
Erika P Hamilton
Facility Name
Fred Hutchinson Cancer Center / Seattle Cancer Care Alliance / University of Washington
City
Seattle
State/Province
Washington
ZIP/Postal Code
98109
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Natasha Hunter
Phone
206-288-7222
Email
nhunter@uw.edu
First Name & Middle Initial & Last Name & Degree
Natasha Hunter
Facility Name
Medical College of Wisconsin (Milwaukee)
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sailaja Kamaraju
Phone
414-975-6889
Email
skamaraju@mcw.edu
First Name & Middle Initial & Last Name & Degree
Sailaja Kamaraju
First Name & Middle Initial & Last Name & Degree
Yee Chung Cheng
Facility Name
Cancer Research South Australia
City
Adelaide
State/Province
Other
ZIP/Postal Code
5000
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Meena Okera
Facility Name
Flinders Medical Centre
City
Bedford Park
State/Province
Other
ZIP/Postal Code
5042
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sina Vatandoust
Facility Name
Box Hill Hospital
City
Box Hill
State/Province
Other
ZIP/Postal Code
3128
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Susan Chua
Facility Name
Chris O'Brien Lifehouse
City
Camperdown
State/Province
Other
ZIP/Postal Code
2050
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jane Beith
Facility Name
Peninsula and South East Oncology
City
Frankston
State/Province
Other
ZIP/Postal Code
3199
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vinod Ganju
Facility Name
Austin Health
City
Heidelberg
State/Province
Other
ZIP/Postal Code
3084
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shane White
Facility Name
Macquarie University Hospital
City
Macquarie University
State/Province
Other
ZIP/Postal Code
2109
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dhanusha Sabanathan
Facility Name
St John of God Subiaco Hospital
City
Subiaco
State/Province
Other
ZIP/Postal Code
6008
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Daphne Tsoi
Facility Name
Westmead Hospital
City
Sydney
State/Province
Other
ZIP/Postal Code
2145
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nicholas Wilcken
Facility Name
LKH- Universitat Klinikum Graz
City
Graz
State/Province
Other
ZIP/Postal Code
8036
Country
Austria
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Edgar Petru
Facility Name
Ordensklinikum Linz GmbH Barmherzige Schwestern
City
Linz
State/Province
Other
ZIP/Postal Code
A-4010
Country
Austria
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andreas Petzer
Facility Name
Ordination Priv.-Doz. Dr. M. Hubalek
City
Schwaz
State/Province
Other
ZIP/Postal Code
6130
Country
Austria
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Hubalek
Facility Name
Institut Jules Bordet
City
Anderlecht
State/Province
Other
ZIP/Postal Code
B-1070
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michail Ignatiadis
Facility Name
UCL Saint-Luc
City
Brussels
State/Province
Other
ZIP/Postal Code
1200
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Francois Pierre Duhoux
Facility Name
Universitair Ziekenhuis Brussel
City
Bruxelles-Capitale
State/Province
Other
ZIP/Postal Code
1090
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christel Fontaine
Facility Name
Clinique Saint Pierre
City
Ottignies
State/Province
Other
ZIP/Postal Code
1340
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Renaud Poncin
Facility Name
GZA Hospital Sint-Augustinus
City
Wilrijk
State/Province
Other
ZIP/Postal Code
2610
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Luc Dirix
Facility Name
Hospital de Cancer de Barretos - Fundacao Pio XII
City
Barretos
State/Province
Other
ZIP/Postal Code
14784-400
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carlos Eduardo Paiva, MD
Facility Name
Clinica de Pesquisas e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda.
City
Bela Vista
State/Province
Other
ZIP/Postal Code
01317-001
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Roberto Hegg
Facility Name
INCAN - Instituto do Cancer - Hospital Pompeia
City
Caxias do Sul
State/Province
Other
ZIP/Postal Code
95010-005
Country
Brazil
Individual Site Status
Completed
Facility Name
Centro Regional Integrado de Oncologia
City
Fortaleza
State/Province
Other
ZIP/Postal Code
60336-045
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eduardo Henrique Cronemberger Costa e Silva
Facility Name
Hospital Araujo Jorge - Associacao de Combate ao Cancer em Goias
City
Goiania
State/Province
Other
ZIP/Postal Code
74605-070
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ruffo de Freitas Junior
Facility Name
Fundação Doutor Amaral Carvalho
City
Jaú
State/Province
Other
ZIP/Postal Code
17210-120
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Patricia Medeiros Milhomem Beato
Facility Name
Hospital do Cancer de Londrina
City
Londrina
State/Province
Other
ZIP/Postal Code
86015-520
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vitor Liutti
Facility Name
Liga Norte-Rio-Grandense Contra o Cancer
City
Natal
State/Province
Other
ZIP/Postal Code
59151-600
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Luciana Carla Aquino Pimentel, MD
Facility Name
Irmandade da Santa Casa de Misericordia de Porto Alegre
City
Porto Alegre
State/Province
Other
ZIP/Postal Code
90020-090
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Katsuki Arima Tiscoski, MD
Facility Name
Hospital de Clinicas de Porto Alegre
City
Porto Alegre
State/Province
Other
ZIP/Postal Code
90035-903
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pedro Emanuel Rubini Liedke
Facility Name
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa
City
Porto Alegre
State/Province
Other
ZIP/Postal Code
90110-270
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christina Pimentel Oppermann
Facility Name
Hospital Nossa Senhora da Conceição
City
Porto Alegre
State/Province
Other
ZIP/Postal Code
91350-200
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jose Luiz Pedrini
Facility Name
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia
City
Santo Andre
State/Province
Other
ZIP/Postal Code
09060-870
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Patricia Santi
Facility Name
Praxis Pesquisa Medica
City
Santo Andre
State/Province
Other
ZIP/Postal Code
09090-790
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mariana Santo Rosario
Facility Name
Fundação Faculdade Regional de Medicina de São José do Rio Preto
City
Sao Jose Rio Preto
State/Province
Other
ZIP/Postal Code
15090-000
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joao Daniel Cardoso Guedes
Facility Name
Sao Camilo Oncologia
City
Sao Paulo
State/Province
Other
ZIP/Postal Code
04014-002
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Felipe Jose Silva Melo Cruz
Facility Name
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira
City
São Paulo
State/Province
Other
ZIP/Postal Code
01246-000
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vanessa Petry Helena
Facility Name
Fundação NAtonio Prudente (AC Camargo Cancer Center)
City
Sao Paulo
ZIP/Postal Code
01509-010
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marcelle Cesca
Facility Name
University of Alberta / Cross Cancer Institute
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 1Z2
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sanraj Basi
Facility Name
BC Cancer Kelowna
City
Kelowna
State/Province
British Columbia
ZIP/Postal Code
V1Y5L3
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Susan Ellard
Facility Name
Ottawa Hospital Cancer Centre
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 8L6
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marie-France Savard
Facility Name
Sunnybrook Health Sciences Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N 3M5
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Katarzyna Jerzak
Facility Name
CIUSSS du Saguenay Lac Saint Jean
City
Chicoutimi
State/Province
Quebec
ZIP/Postal Code
G7H 5H6
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jose Luiz Guimaraes, MD
Facility Name
Centre Hospitalier de l'Universite de Montreal
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2X 3E4
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jean-Pierre Ayoub
Facility Name
Jewish General Hospital
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3T 1E2
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Cristiano Ferrario
Facility Name
Clinica Universidad Catolica del Maule
City
Talca
State/Province
Other
ZIP/Postal Code
3460000
Country
Chile
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hernan Araya Moya
Facility Name
Sociedad de Investigaciones Medicas Limitada
City
Temuco
State/Province
Other
ZIP/Postal Code
4810469
Country
Chile
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eduardo Yañez Ruiz
Facility Name
Oncocentro APYS
City
Viña del Mar
State/Province
Other
ZIP/Postal Code
2520598
Country
Chile
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alejandro Acevedo Gaete
Facility Name
Affiliated Hospital of Hebei University
City
Baoding
State/Province
Other
ZIP/Postal Code
071000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zang Aimin
Facility Name
Beijing Hospital
City
Beijing
State/Province
Other
ZIP/Postal Code
100730
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yong Qiang Zhang
Facility Name
The First Bethune Hospital of Jilin University
City
Changchun
State/Province
Other
ZIP/Postal Code
130021
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wei Li
Facility Name
The Second Xiangya Hospital of Central South University
City
Changsha
State/Province
Other
ZIP/Postal Code
410011
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chunhong Hu
Facility Name
Affiliated Hospital of Chengde Medical University
City
Chengde
State/Province
Other
ZIP/Postal Code
067000
Country
China
Individual Site Status
Completed
Facility Name
The First People's Hospital of Foshan
City
Foshan
State/Province
Other
ZIP/Postal Code
528000
Country
China
Individual Site Status
Completed
Facility Name
Fujian Provincial Cancer Hospital
City
Fuzhou
State/Province
Other
ZIP/Postal Code
350015
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Liu Jian
Facility Name
900TH Hospital of Joint Logistics Support Force
City
Fuzhou
State/Province
Other
ZIP/Postal Code
350025
Country
China
Individual Site Status
Completed
Facility Name
Guangdong Provincial People's Hospital
City
Guangzhou
State/Province
Other
ZIP/Postal Code
510081
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Liao Ning
Facility Name
The first Affiliated Hospital of Hainan Medical University
City
Haikou
State/Province
Other
ZIP/Postal Code
570102
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wu Jinsheng
Facility Name
Zhejiang Cancer Hospital
City
Hangzhou City
State/Province
Other
ZIP/Postal Code
310022
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiaojia Wang
Facility Name
The Second Affiliated Hospital of Zhejiang University School of Medicine
City
Hangzhou
State/Province
Other
ZIP/Postal Code
310009
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jian Huang
Facility Name
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
City
Hangzhou
State/Province
Other
ZIP/Postal Code
310016
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wang Xian
Facility Name
Harbin Medical University Cancer Hospital
City
Harbin
State/Province
Other
ZIP/Postal Code
150081
Country
China
Individual Site Status
Completed
Facility Name
The Second Hospital of Anhui Medical University
City
Hefei
State/Province
Other
ZIP/Postal Code
230601
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fanfan Li
Facility Name
The Affiliated Hospital of Inner Mongolia Medical University
City
Hohhot
State/Province
Other
ZIP/Postal Code
010050
Country
China
Individual Site Status
Completed
Facility Name
Jinan Central Hospital
City
Jinan
State/Province
Other
ZIP/Postal Code
250013
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Meili Sun
Facility Name
Linyi Cancer Hospital
City
Linyi
State/Province
Other
ZIP/Postal Code
276000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wang Jingfen
Facility Name
Liuzhou People's Hospital
City
Liuzhou
State/Province
Other
ZIP/Postal Code
545006
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Minmin Zhang
Facility Name
Meizhou People's Hospital - Guangdong Province
City
Meizhou
State/Province
Other
ZIP/Postal Code
514031
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jingna Wu
Facility Name
The Second Affiliated Hospital of Nanchang University
City
Nanchang
State/Province
Other
ZIP/Postal Code
330006
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Luo Yonghui
Facility Name
Nanjing Medical University (NMU) - Jiangsu Province Hospital
City
Nanjing
State/Province
Other
ZIP/Postal Code
210029
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yin Yongmei
Facility Name
The First Affiliated Hospital of Guangxi Medical University
City
Nanning
State/Province
Other
ZIP/Postal Code
530021
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xie Yanyan
Facility Name
Nantong Tumor Hospital
City
Nantong
State/Province
Other
ZIP/Postal Code
226361
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Baochun Zhang
Facility Name
Ruijin Hospital of Shanghai Jiaotong University School of Medicine
City
Shanghai
State/Province
Other
ZIP/Postal Code
200025
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shen Kunwei
Facility Name
Fudan University Shanghai Cancer Center
City
Shanghai
State/Province
Other
ZIP/Postal Code
200030
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hu Xichun
Facility Name
The First Hospital of China Medical University
City
Shenyang
State/Province
Other
ZIP/Postal Code
110001
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Teng Yuee
Facility Name
Liaoning Cancer Hospital and Institute
City
Shenyang
State/Province
Other
ZIP/Postal Code
110042
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sun Tao
Facility Name
Tianjin Medical University - Cancer Institute & Hospital
City
Tianjin
State/Province
Other
ZIP/Postal Code
453000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhongsheng Tong
Facility Name
Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology
City
Wuhan City
State/Province
Other
ZIP/Postal Code
430030
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yu Shiying
Facility Name
Hubei Cancer Hospital
City
Wuhan
State/Province
Other
ZIP/Postal Code
430000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xinhong Wu
Facility Name
The First Affiliated Hospital of Xi'an Jiaotong University
City
Xi'an
State/Province
Other
ZIP/Postal Code
710061
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jin Yang
Facility Name
Shaanxi Provincial People's Hospital
City
Xi'an
State/Province
Other
ZIP/Postal Code
710068
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Song Zhangjun
Facility Name
The First Affiliated Hospital of Xinxiang Medical University
City
Xinxiang
State/Province
Other
ZIP/Postal Code
453700
Country
China
Individual Site Status
Completed
Facility Name
The Affiliated Hospital of Xuzhou Medical College
City
Xuzhou
State/Province
Other
ZIP/Postal Code
221006
Country
China
Individual Site Status
Completed
Facility Name
Xuzhou Central Hospital
City
Xuzhou
State/Province
Other
ZIP/Postal Code
221009
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sanyuan Sun
Facility Name
Yantai Yuhuangding Hospital
City
Yantai
State/Province
Other
ZIP/Postal Code
26400
Country
China
Individual Site Status
Completed
Facility Name
Henan Provincial People's Hospital
City
Zhengzhou
State/Province
Other
ZIP/Postal Code
450003
Country
China
Individual Site Status
Completed
Facility Name
Henan Cancer Hospital
City
Zhengzhou
State/Province
Other
ZIP/Postal Code
45003
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Min Yan
Facility Name
Nanchang Third Hospital
City
Nanchang City
ZIP/Postal Code
330009
Country
China
Individual Site Status
Completed
Facility Name
Guangxi Medical University Affiliated Tumor Hospital
City
Nanning
ZIP/Postal Code
530021
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Weimin Xie
Facility Name
Masaryk Memorial Cancer Institute
City
Brno
State/Province
Other
ZIP/Postal Code
62800
Country
Czechia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Milos Holanek
Facility Name
Thomayer University Hospital (Fakultní Thomayerova nemocnice)
City
Praha 4-Krc
State/Province
Other
ZIP/Postal Code
140 59
Country
Czechia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eugen Kubala
Facility Name
Fakultni nemocnice v Motole
City
Praha 5
State/Province
Other
ZIP/Postal Code
150 06
Country
Czechia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vlastimila Cmejlova
Facility Name
Nemocnice Horovice (NH Hospital) a.s.
City
Praha
State/Province
Other
ZIP/Postal Code
155 00
Country
Czechia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin Smakal
Facility Name
Helsinki University Hospital
City
Helsinki
State/Province
Other
ZIP/Postal Code
00290
Country
Finland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Johanna Mattson
Facility Name
Kuopio University Hospital
City
Kuopio
State/Province
Other
ZIP/Postal Code
70200
Country
Finland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paivi Auvinen
Facility Name
Tampere University Hospital
City
Tampere, Pirkanmaa
State/Province
Other
ZIP/Postal Code
33520
Country
Finland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Minna Tanner
Facility Name
Vaasa Central Hospital
City
Vaasa
State/Province
Other
ZIP/Postal Code
65130
Country
Finland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Antti Jekunen
Facility Name
Sainte Catherine Institut du Cancer Avignon Provence
City
Avignon
State/Province
Other
ZIP/Postal Code
84000
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Julien Grenier
Facility Name
Centre Hospitalier Regional et Universitaire de Besancon - Hopital Jean-Minjoz
City
Besancon Cedex
State/Province
Other
ZIP/Postal Code
25000
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Elsa Curtit
Facility Name
Centre Hospitalier Universitaire Hopital Avicenne
City
Bobigny
State/Province
Other
ZIP/Postal Code
93000
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Laurent Zelek
Facility Name
Institut Bergonie
City
Bordeaux
State/Province
Other
ZIP/Postal Code
33076
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nathalie Quenel-Tueux
Facility Name
Centre de Lutte contre le Cancer - François Baclesse
City
Caen Cedex 5
State/Province
Other
ZIP/Postal Code
14076
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christelle Levy
Facility Name
Centre Jean Perrin
City
Clermont-Ferrand
State/Province
Other
ZIP/Postal Code
63011
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marie-Ange Mouret-Reynier
Facility Name
CARIO - Centre Armoricain De Radiothérapie, D'imagerie Médicale Et D'oncologie
City
Cotes d'Armor
State/Province
Other
ZIP/Postal Code
22190
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anne-Claire Hardy-Bessard
Facility Name
Center Georges Francois Leclerc
City
Dijon
State/Province
Other
ZIP/Postal Code
21000
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Isabelle Desmoulins
Facility Name
Centre de Lutte contre le Cancer (CLCC) - Centre Oscar Lambret
City
Lille
State/Province
Other
ZIP/Postal Code
59000
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Emilie Kaczmarek
Facility Name
Centre Hospitalier Universitaire (CHU) De Limoges - Hopital Dupuytren
City
Limoges Cedex
State/Province
Other
ZIP/Postal Code
87042
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Elise Deluche
Facility Name
Centre Leon Berard - Centre regional de lutte contre le cancer Rhone-Alpes
City
Lyon cedex 08
State/Province
Other
ZIP/Postal Code
69008
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Thomas Bachelot
Facility Name
Centre de Cancerologie du Grand Montpellier
City
Montpellier
State/Province
Other
ZIP/Postal Code
34070
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Cristian Villanueva
Facility Name
Institut Regional du Cancer de Montpellier
City
Montpellier
State/Province
Other
ZIP/Postal Code
34298
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
William Jacot
Facility Name
Centre de Lutte contre le Cancer (CLCC) - Centre Antoine Lacassagne
City
Nice Cedex 2
State/Province
Other
ZIP/Postal Code
06189
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jean-Marc Ferrero
Facility Name
Hopitaux Civils de Lyon
City
Pierre Benite
State/Province
Other
ZIP/Postal Code
69310
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nathalie Bonnin
Facility Name
Centre Eugene Marquis
City
Rennes
State/Province
Other
ZIP/Postal Code
35042
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Veronique Dieras
Facility Name
Centre Henri Becquerel / Centre Regional de Lutte Contre le Cancer
City
Rouen
State/Province
Other
ZIP/Postal Code
76038
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Olivier Rigal
Facility Name
Institut de Cancerologie de lOuest - Site Rene Gauducheau
City
Saint Herblain cedex
State/Province
Other
ZIP/Postal Code
44800
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jean Sebastien Frenel
Facility Name
Institut Curie
City
Saint-Cloude
State/Province
Other
ZIP/Postal Code
92210
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Florence Lerebours
Facility Name
Institut de cancerologie Strasbourg Europe
City
Strasbourg
State/Province
Other
ZIP/Postal Code
67033
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Thierry Petit
Facility Name
Institut Curie
City
Paris
ZIP/Postal Code
75005
Country
France
Individual Site Status
Completed
Facility Name
Charite Universitatsmedizin Berlin
City
Berlin
State/Province
Other
ZIP/Postal Code
10117
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Verena Kiver, MD
Facility Name
Universitaetsklinikum Dusseldorf
City
Dusseldorf
State/Province
Other
ZIP/Postal Code
40225
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tanja Fehm
Facility Name
Universitaetsklinikum Essen
City
Essen
State/Province
Other
ZIP/Postal Code
45147
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Oliver Hoffmann
Facility Name
Klinikum Esslingen GmbH
City
Esslingen
State/Province
Other
ZIP/Postal Code
73730
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alexander Hein
Facility Name
Medizinische Hochschule Hannover
City
Hannover
State/Province
Other
ZIP/Postal Code
30625
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tjoung-Won Park-Simon
Facility Name
St. Elisabeth-Krankenhaus Koln-Hohenlind
City
Koln
State/Province
Other
ZIP/Postal Code
50935
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Johannes Holtschmidt
Facility Name
Medical Faculty Mannheim, Heidelberg University
City
Mannheim
State/Province
Other
ZIP/Postal Code
68167
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Frederik Marme
Facility Name
Klinikum Rechts der Isar der Technischen Universitaet Muenchen
City
München
State/Province
Other
ZIP/Postal Code
81675
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Franziska Kotzur
Facility Name
Universitaetsklinikum Muenster
City
Münster
State/Province
Other
ZIP/Postal Code
48149
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tio Joke
Facility Name
Universitatsklinik Tuebingen
City
Tubingen
State/Province
Other
ZIP/Postal Code
72076
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eva-Maria Grischke
Facility Name
Alexandra General Hospital of Athens
City
Athens
State/Province
Other
ZIP/Postal Code
11528
Country
Greece
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Flora Zagouri
Facility Name
University General Hospital of Heraklion (PAGNI)
City
Heraklion
State/Province
Other
ZIP/Postal Code
711 10
Country
Greece
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dimitrios Mavroudis
Facility Name
University Hospital of Patras
City
Patras
State/Province
Other
ZIP/Postal Code
26504
Country
Greece
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Angelos Koutras
Facility Name
Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi
City
Bologna
State/Province
Other
ZIP/Postal Code
40138
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Claudio Zamagni
Facility Name
Azienda Ospedaliera Universitaria San Martino
City
Genova
State/Province
Other
ZIP/Postal Code
16132
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lucia Del Mastro
Facility Name
Fondazione IRCCS San Gerardo dei Tintori
City
Monza
State/Province
Other
ZIP/Postal Code
20900
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marina Elena Cazzaniga
Facility Name
Azienda Ospedaliera Universitaria (AOU) Federico II
City
Napoli
State/Province
Other
ZIP/Postal Code
80131
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sabino de Placido
Facility Name
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
City
Napoli
State/Province
Other
ZIP/Postal Code
80131
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michelino De Laurentiis
Facility Name
Ospedale Sacro Cuore Don Calabria
City
Negrar Di Valpolicella
State/Province
Other
ZIP/Postal Code
37024
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stefania Gori
Facility Name
Azienda USL 4 Prato - Ospedale Misericordia e Dolce di Prato
City
Prato
State/Province
Other
ZIP/Postal Code
59100
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Laura Biganzoli
Facility Name
Istituto Clinico Humanitas-Humanitas Cancer Center
City
Rozzano (Milano)
State/Province
Other
ZIP/Postal Code
20089
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Armando Santoro
Facility Name
A.O.U. - Ospedali Riuniti di Ancona
City
Torrette (AN)
State/Province
Other
ZIP/Postal Code
60126
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rossana Berardi
Facility Name
National Cancer Center Hospital
City
Chuo-ku
State/Province
Other
ZIP/Postal Code
104-0045
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tatsunori Shimoi
Facility Name
St. Luke's International Hospital
City
Chuo-ku
State/Province
Other
ZIP/Postal Code
104-8560
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shin Ogita
Facility Name
National Hospital Organization Kyushu Cancer Center
City
Fukuoka-shi
State/Province
Other
ZIP/Postal Code
811-1395
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eriko Tokunaga
Facility Name
Fukushima Medical University Hospital
City
Fukushima-shi
State/Province
Other
ZIP/Postal Code
960-1295
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shigehira Saji
Facility Name
University of Tsukuba Hospital
City
Ibaraki
State/Province
Other
ZIP/Postal Code
305-8576
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hiroko Bando
Facility Name
Tesshokai Kameda General Hospital
City
Kamogawa-shi
State/Province
Other
ZIP/Postal Code
296-8602
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eisuke Fukuma
Facility Name
Ishikawa Prefectural Central Hospital
City
Kanazawa-shi
State/Province
Other
ZIP/Postal Code
920-8530
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hiroshi Yoshino
Facility Name
National Cancer Center Hospital East
City
Kashiwa-shi
State/Province
Other
ZIP/Postal Code
277-8577
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Toru Mukohara
Facility Name
NHO Shikoku Cancer Center
City
Matsuyama
State/Province
Other
ZIP/Postal Code
791-0280
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kenjiro Aogi
Facility Name
Toranomon Hospital
City
Minato-ku
State/Province
Other
ZIP/Postal Code
105-8470
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yuko Tanabe
Facility Name
Naha Nishi Clinic
City
Naha-shi
State/Province
Other
ZIP/Postal Code
901-0154
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kentaro Tamaki
Facility Name
Kindai University Hospital
City
Osakasayama-Shi
State/Province
Other
ZIP/Postal Code
589-8511
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tsutomu Iwasa
Facility Name
National Hospital Organization Hokkaido Cancer Center
City
Sapporo-shi
State/Province
Other
ZIP/Postal Code
003-0804
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hideki Maeda
Facility Name
Showa University Hospital
City
Shinagawa-ku
State/Province
Other
ZIP/Postal Code
142-8666
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Junji Tsurutani
Facility Name
Kanagawa Cancer Center
City
Yokohama
State/Province
Other
ZIP/Postal Code
241-8515
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Toshinari Yamashita
Facility Name
Dong-A University Hospital
City
Busan
State/Province
Other
ZIP/Postal Code
49201
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Suee Lee
Facility Name
Chungbuk National University Hospital
City
Cheongju-si
State/Province
Other
ZIP/Postal Code
28644
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yaewon Yang
Facility Name
National Cancer Center
City
Goyang-si
State/Province
Other
ZIP/Postal Code
10408
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Keun Seok Lee
Facility Name
Gachon University Gil Medical Center
City
Incheon
State/Province
Other
ZIP/Postal Code
21565
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hee Kyung Ahn
Facility Name
Seoul National University Bundang Hospital
City
Seongnam-si
State/Province
Other
ZIP/Postal Code
13620
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jee Hyun Kim
Facility Name
Korea University Anam Hospital
City
Seoul
State/Province
Other
ZIP/Postal Code
02841
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kyong Hwa Park
Facility Name
Seoul National University Hospital
City
Seoul
State/Province
Other
ZIP/Postal Code
03080
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kyung Hun Lee
Facility Name
Severance Hospital, Yonsei University Health System
City
Seoul
State/Province
Other
ZIP/Postal Code
03722
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joo Hyuk Sohn
Facility Name
Seoul Saint Mary's Hospital
City
Seoul
State/Province
Other
ZIP/Postal Code
06591
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ji Eun Lee
Facility Name
Ewha Womans University Mokdong Hospital
City
Seoul
State/Province
Other
ZIP/Postal Code
07985
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kyoung Eun Lee
Facility Name
St. Vincent's Hospital, The Catholic University of Korea
City
Suwon-si
State/Province
Other
ZIP/Postal Code
16247
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Byoung Yong Shim
Facility Name
Ajou University Hospital
City
Suwon-si
State/Province
Other
ZIP/Postal Code
16499
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Seok Yun Kang
Facility Name
Severance Hospital, Yonsei University Health System
City
Wonju-si
State/Province
Other
ZIP/Postal Code
26426
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Seungtaek Lim
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sung Bae Kim
Facility Name
Gangnam Severance Hospital
City
Seoul
ZIP/Postal Code
06273
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joon Jeong
Facility Name
Netherlands Cancer Institute
City
Amsterdam
State/Province
Other
ZIP/Postal Code
1066 WX
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gabe S Sonke
Facility Name
Albert Schweitzer Hospital
City
Doedrecht
State/Province
Other
ZIP/Postal Code
3318AT
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Esther Bouman
Facility Name
Medisch Centrum Leeuwarden (MCL)
City
Leeuwarden
State/Province
Other
ZIP/Postal Code
8934 AD
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lisanne Hamming
Facility Name
St. Antonius Hospital
City
Nieuwegein
State/Province
Other
ZIP/Postal Code
3435 CM
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mariette Agterof
Facility Name
VieCuri Medisch Centrum
City
Venlo
State/Province
Other
ZIP/Postal Code
5912 BL
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Agnes Josephine van de Wouw
Facility Name
Przychodnia Lekarska KOMED Roman Karaszewski
City
Konin
State/Province
Other
ZIP/Postal Code
62-500
Country
Poland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Boguslawa Karaszewska
Facility Name
Hospital de Braga
City
Braga
State/Province
Other
ZIP/Postal Code
4710-243
Country
Portugal
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Catarina Portela
Facility Name
Hospital Santa Maria
City
Lisboa
State/Province
Other
ZIP/Postal Code
1649-028
Country
Portugal
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rita Teixeira de Sousa
Facility Name
Hospital Cuf Descobertas
City
Lisboa
State/Province
Other
ZIP/Postal Code
1998-018
Country
Portugal
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sofia Braga
Facility Name
Champalimaud Clinical Center
City
Lisbon
State/Province
Other
ZIP/Postal Code
1400-038
Country
Portugal
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fatima Cardoso
Facility Name
Hospital General Universitario Alicante
City
Alicante
State/Province
Other
ZIP/Postal Code
03010
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jose Ponce Lorenzo
Facility Name
Hospital Del Mar
City
Barcelona
State/Province
Other
ZIP/Postal Code
08003
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joan Albanell
Facility Name
Hospital Universitari Vall d'Hebron
City
Barcelona
State/Province
Other
ZIP/Postal Code
08035
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Santiago Escriva de Romani Munoz, MD
Facility Name
Hospital de la Santa Creu i Sant Pau
City
Barcelona
State/Province
Other
ZIP/Postal Code
08041
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Agusti Barnadas Molins
Facility Name
Hospital Universitario de Basurto
City
Bilbao
State/Province
Other
ZIP/Postal Code
48013
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Elena Galve
Facility Name
Complejo Hospitalario De Caceres - Hospital General San Pedro De Alcantara
City
Caceres
State/Province
Other
ZIP/Postal Code
10003
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Santiago Gonzalez Santiago
Facility Name
Institut Catala d'Oncologia Girona - ICO Girona
City
Girona
State/Province
Other
ZIP/Postal Code
17007
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sonia Del Barco
Facility Name
Hospital Universitario Virgen de las Nieves
City
Granada
State/Province
Other
ZIP/Postal Code
18014
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Encarnacion Gonzalez Flores
Facility Name
Hospital Universitari Arnau de Vilanova
City
Lleida
State/Province
Other
ZIP/Postal Code
25198
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Serafin Morales Murillo
Facility Name
Hospital General Universitario Gregorio Maranon
City
Madrid
State/Province
Other
ZIP/Postal Code
28007
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Miguel Martin Jimenez
Facility Name
Hospital Universitario Ramon y Cajal
City
Madrid
State/Province
Other
ZIP/Postal Code
28034
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Elena Lopez Miranda
Facility Name
Hospital Universitario Son Espases
City
Palma
State/Province
Other
ZIP/Postal Code
07120
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Neus Ferrer Tur
Facility Name
Hospital Clinico Universitario de Salamanca
City
Salamanca
State/Province
Other
ZIP/Postal Code
37007
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Cesar Rodriguez Sanchez
Facility Name
Hospital Universitario de Canarias
City
San Cristóbal de la Laguna
State/Province
Other
ZIP/Postal Code
38320
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Josefina Cruz Jurado
Facility Name
Hospital Universitario Virgen del Rocio
City
Sevilla
State/Province
Other
ZIP/Postal Code
41013
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Manuel Ruiz Borrego
Facility Name
Valencian Institute of Oncology Foundation
City
Valencia
State/Province
Other
ZIP/Postal Code
46009
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joaquin G Gavila Gregori
Facility Name
Hospital Clinico Universitario de Valencia
City
Valencia
State/Province
Other
ZIP/Postal Code
46010
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Begona Bermejo
Facility Name
Kantonsspital Baden AG
City
Baden
State/Province
Other
ZIP/Postal Code
5404
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tilly Nothhelfer
Facility Name
Kantonsspital Winterthur (KSW)
City
Winterthur
State/Province
Other
ZIP/Postal Code
8401
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ursina Zurrer
Facility Name
Brust-Zentrum Zurich
City
Zurich
State/Province
Other
ZIP/Postal Code
8008
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Urs Breitenstein
Facility Name
Changhua Christian Hospital
City
Changhua
State/Province
Other
ZIP/Postal Code
50006
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chen Shou-Tung
Facility Name
Kaohsiung Medical University Hospital
City
Kaohsiung
State/Province
Other
ZIP/Postal Code
807
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hou Ming-Feng
Facility Name
Taipei Medical University Hospital
City
New Taipei City
State/Province
Other
ZIP/Postal Code
23561
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chao Tsu-Yi
Facility Name
China Medical University Hospital
City
Taichung
State/Province
Other
ZIP/Postal Code
40447
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wang Hwei-Chung
Facility Name
National Cheng-Kung University Hospital
City
Tainan
State/Province
Other
ZIP/Postal Code
704
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wei-Pang Chung
Facility Name
Chi Mei Hospital Liouying
City
Tainan
State/Province
Other
ZIP/Postal Code
71004
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yu-Hsuan Kuo, MD
Facility Name
Mackay Memorial Hospital
City
Taipei City
State/Province
Other
ZIP/Postal Code
10449
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chang Yuan-Ching
Facility Name
Taipei Veterans General Hospital
City
Taipei
State/Province
Other
ZIP/Postal Code
11217
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ling-Ming Tseng
Facility Name
Sun Yat-sen University Cancer Center
City
Taipei
State/Province
Other
ZIP/Postal Code
112
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chung Chi-Feng
Facility Name
Central Hospital of the Ministry of National Defense
City
Taipei
State/Province
Other
ZIP/Postal Code
11490
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dai Ming-Shen
Facility Name
Chang Gung Memorial Hospital - Linkou
City
Taoyuan
State/Province
Other
ZIP/Postal Code
333
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shin-Cheh Chen
Facility Name
National Taiwan University Hospital
City
Taipei
ZIP/Postal Code
10002
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chiun-Sheng Huang
Facility Name
The University of Edinburgh
City
Edinburgh
State/Province
Other
ZIP/Postal Code
EH4 2XU
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Allan Cameron, MD
Facility Name
University College London Hospitals NHS Foundation Trust
City
London
State/Province
Other
ZIP/Postal Code
NW1 2PG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rebecca Roylance
Facility Name
Royal Free London NHS Foundation Trust
City
London
State/Province
Other
ZIP/Postal Code
NW3 2QG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Judith King
Facility Name
The Royal Marsden NHS Foundation Trust (RM)
City
London
State/Province
Other
ZIP/Postal Code
SW3 6JJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alicia Okines, MD
Facility Name
Christie Hospital NHS Foundation Trust
City
Manchester
State/Province
Other
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anne Armstrong, MD
Facility Name
The Royal Marsden NHS Foundation Trust (RM)
City
Sutton
State/Province
Other
ZIP/Postal Code
SM2 5PT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alicia Okines, MD
12. IPD Sharing Statement
Learn more about this trial
A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer
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