Back to resultsA Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer
Primary Purpose
HER2-positive Breast Cancer
Status
Recruiting
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
tucatinib
placebo
T-DM1
Sponsored by
About this trial
This is an interventional treatment trial for HER2-positive Breast Cancer focused on measuring Seattle Genetics
Eligibility Criteria
Inclusion Criteria:
- Histologically confirmed HER2+ breast carcinoma as determined by a sponsor-designated central laboratory
- History of prior treatment with a taxane and trastuzumab in any setting, separately or in combination
- Have progression of unresectable locally advanced/metastatic breast cancer after last systemic therapy, or be intolerant of last systemic therapy
- Measurable or non-measurable disease assessable by RECIST v1.1
- ECOG performance status score of 0 or 1
CNS Inclusion - Based on screening contrast brain magnetic resonance imaging (MRI), subjects must have at least one of the following:
(a) No evidence of brain metastases
(b) Untreated brain metastases not needing immediate local therapy
(c) Previously treated brain metastases
- Brain metastases previously treated with local therapy may either be stable since treatment or may have progressed since prior local CNS therapy, provided that there is no clinical indication for immediate re-treatment with local therapy
Subjects treated with CNS local therapy for newly identified lesions or previously treated and progressing lesions may be eligible to enroll if all of the following criteria are met:
(i) Time since SRS is at least 7 days prior to first dose of study treatment, time since WBRT is at least 14 days prior to first dose, or time since surgical resection is at least 28 days.
(ii) Other sites of evaluable disease are present
- Relevant records of any CNS treatment must be available to allow for classification of target and non-target lesions
Exclusion Criteria:
- Prior treatment with tucatinib, afatinib, trastuzumab deruxtecan (DS-8201a), or any other investigational anti-HER2, anti-EGFR, or HER2 TKI agent. Prior treatment with lapatinib or neratinib within 12 months of starting study treatment (except in cases where they were given for ≤21 days and was discontinued for reasons other than disease progression or severe toxicity). Prior treatment with pyrotinib for recurrent of mBC (except in cases where pyrotinib was given for ≤21 days and was discontinued for reasons other than disease progression or severe toxicity).
CNS Exclusion - Based on screening contrast brain magnetic resonance imaging (MRI), subjects must not have any of the following:
- Any untreated brain lesions >2 cm in size
- Ongoing use of corticosteroids for control of symptoms of brain metastases at a total daily dose of >2 mg of dexamethasone (or equivalent).
- Any brain lesion thought to require immediate local therapy
- Known or concurrent leptomeningeal disease as documented by the investigator
- Poorly controlled generalized or complex partial seizures
Sites / Locations
- University of South Alabama - Mitchell Cancer Institute
- Ironwood Cancer & Research Centers - Chandler
- Banner MD Anderson Cancer Center
- Cancer Treatment Centers of America / Western Regional Medical Center
- Arizona Oncology Associates, PC - HAL
- Arizona Oncology Associates, PC - HOPE
- St. Bernards Medical Center
- City of Hope National Medical Center
- California Cancer Associates for Research and Excellence Inc (cCARE)
- St. Joseph Heritage Healthcare TRIO
- Chao Family Comprehensive Cancer Center University of California Irvine
- University of California Irvine - Newport
- University of California Davis
- San Francisco General Hospital
- University of California at San Francisco
- UCLA Department of Medicine - Hematology & Oncology
- Torrance Memorial Physician Network - TRIO
- Kaiser Permanente Medical Center Northern California
- Rocky Mountain Cancer Centers - Aurora
- University of Colorado Hospital / University of Colorado
- SCL Health Good Samaritan Medical Center Cancer Centers of Colorado
- University of Colorado Health Memorial Hospital
- Cancer Centers of Colorado - Denver
- Poudre Valley Health System (PVHS)
- Helen F. Graham Cancer Center / Christiana Care Health Systems
- Lombardi Cancer Center / Georgetown University Medical Center
- Florida Cancer Specialists - South Region
- Baptist MD Anderson Cancer Center
- University of Miami
- Miami Cancer Institute at Baptist Health, Inc.
- AdventHealth Cancer Institute
- Orlando Health, Inc. TRIO
- Florida Cancer Specialists - North Region
- H. Lee Moffitt Cancer Center and Research Institute
- Florida Cancer Specialists - East West Palm Beach, FL (SCRI)
- Winship Cancer Institute / Emory University School of Medicine
- Northside Hospital
- Augusta University
- Kaiser Permanente Moanalua Medical Center
- Kapi'olani Medical Center for Women and Children
- Illinois Cancer Specialists - Arlington Heights
- Rush University Medical Center
- University of Chicago Medical Center
- Illinois Cancer Care
- Ft Wayne Medical Oncology and Hematology, Inc TRIO
- University of Kansas Medical Center
- CHI Saint Joseph Medical Group Cancer Care Center
- Ochsner Medical Center
- University of Maryland
- Mercy Medical Center -Weinberg Center
- American Oncology Networks LLC
- Maryland Oncology Hematology, P.A.
- Beth Israel Deaconess Medical Center
- Dana Farber Cancer Institute
- University of Michigan Comprehensive Cancer Center
- Henry Ford Health System
- Minnesota Oncology Hematology P.A.
- North Mississippi Medical Center Hematology Oncology - Tupelo
- Saint Luke's Cancer Institute LLC
- HCA Midwest Health Kansas City
- Washington University in St Louis
- St. Vincent Frontier Cancer Center
- Nebraska Cancer Specialists
- Comprehensive Cancer Centers of Nevada
- Summit Medical Group
- Saint Barnabas Medical Center Cancer Center
- Rutgers Cancer Institute of New Jersey
- New York Oncology Hematology, P.C.
- Stony Brook University Cancer Center
- UNC Lineberger Comprehensive Cancer Center / University of North Carolina
- Levine Cancer Institute
- Duke University Medical Center
- Providence Portland Medical Center
- Oregon Health and Science University
- Northwest Cancer Specialists, P.C.
- University of Pennsylvania / Perelman Center for Advanced Medicine
- Cancer Treatment Centers of America / Eastern Regional Medical Center
- Brig Center for Cancer Care and Survivorship
- Tennessee Oncology-Nashville/Sarah Cannon Research Institute
- Texas Oncology - Amarillo
- Texas Oncology - Austin Central
- Texas Oncology - DFWW
- Texas Oncology - Methodist Dallas Cancer Center
- Texas Oncology - Medical City Dallas
- Texas Oncology - Baylor Sammons Cancer Center
- University of Texas Southwestern Medical Center
- The Center for Cancer and Blood Disorders: Fortworth
- Texas Oncology - Houston Memorial City
- MD Anderson Cancer Center / University of Texas
- Baylor Clinic
- Oncology Consultants, PA
- Texas Oncology - San Antonio Medical Center
- Huntsman Cancer Institute/University of Utah
- Virginia Cancer Specialists, PC
- Saint Francis Hospital / Bon Secours - Virginia
- Peninsula Cancer Institute
- Oncology and Hematology Assoc of SW VA DBA Blue Ridge Cancer Care
- Swedish Cancer Institute - Edmonds
- Swedish Cancer Institute - Issaquah
- Swedish Cancer Institute
- Peter MacCallum Cancer Centre
- Austin Health
- Breast Cancer Research Centre
- Mater Hospital
- Westmead Hospital
- LKH- Universitat Klinikum Graz
- Medizinische Universitat Innsbruck
- LKH Salzburg, Universitatsklinikum der PMU
- Medizinische Universitat Wien
- Klinik Ottakring
- Institut Jules Bordet
- Cliniques Universitaires Saint Luc
- Grand Hôpital de Charleroi - Saint-Joseph
- Universitair Ziekenhuis Antwerpen
- Academisch Ziekenhuis Groeninge
- CHU de Liege
- Universitair Ziekenhuis Leuven
- CHU UCL Namur-Site de Saint Elisabeth
- University of Alberta / Cross Cancer Institute
- Queen Elizabeth II Health Sciences Centre
- Cancer Centre of Southeastern Ontario At Kingston General Hospital
- London Health Sciences Centre - Victoria Hospital
- University of Ottawa / Ottawa General Hospital
- University Health Network, Princess Margaret Hospital
- Centre Hospitalier de l'Universite de Montreal
- Jewish General Hospital
- Saskatoon Cancer Centre
- Hopital du Saint-Sacrement, CHU de Quebec-Universite Laval
- Cancer Hospital Chinese Academy of Medical SciencesRecruiting
- Jilin Province Cancer HospitalRecruiting
- Hunan Cancer HospitalRecruiting
- Sun Yat-sen University Cancer CenterRecruiting
- Zhejiang Cancer HospitalRecruiting
- First Affiliated Hospital of Zhejiang UniversityRecruiting
- The Second Affiliated Hospital of Zhejiang University School of MedicineRecruiting
- Gulou Hospital Affiliated to Nanjing University Medical CollegeRecruiting
- Shengjing Hospital of China Medical UniversityRecruiting
- Tianjin Medical University - Cancer Institute & HospitalRecruiting
- Hubei Cancer HospitalRecruiting
- Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyRecruiting
- Wuhan UniversityRecruiting
- The First Affiliated Hospital of Xi'an Jiaotong UniversityRecruiting
- Xi'An International Medical Center HospitalRecruiting
- Xuzhou Central HospitalRecruiting
- The Affiliated Hospital of Guangdong Medical UniversityRecruiting
- Henan Cancer HospitalRecruiting
- Bejing HospitalRecruiting
- Center of Women and Children Hospital of Guangdong ProvinceRecruiting
- Nanchang Third HospitalRecruiting
- Guangxi Medical University Affiliated Tumor HospitalRecruiting
- Aalborg Universitetshospital
- Aarhus University Hospital
- Rigs Hospiltalet
- Herlev Hospital
- Odense University Hospital
- Sygehus Lillebaelt - Vejle Sygehus
- University Hospital of Besancon
- Hospital Center Regional University Morvan De Brest
- Centre de Lutte contre le Cancer - François Baclesse
- Hopital Europeen Georges Pompidou
- Center Georges Francois Leclerc
- Clinique Victor Hugo Le Mans
- Centre Leon Berard - Centre regional de lutte contre le cancer Rhone-Alpes
- Institut Paoli Calmettes
- Hopital Saint-Louis / Service d'Hematologie
- Institute Curie - Centre de Lutte Contre Le Cancer CLCC de Paris
- Centre Henri Becquerel / Centre Regional de Lutte Contre le Cancer
- Hopitaux Universitaires de Strasbourg
- Institut Claudius Regaud IUCT-O
- CHU Tours - Hopital Bretonneau
- Helios Klinikum Berlin-Buch
- Stadtisches Klinikum Dessau
- Kliniken Essen-Mitte - Evang. Huyssens-Stiftung
- CHOP GmbH
- Universitaetsklinikum Hamburg-Eppendorf (UKE)
- Universitatsklinikum Heidelberg
- Universitatsklinikum Schleswig-Holstein
- InVO- Institut fUr Versorgungsforschung in der onkologie GbR
- Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
- Klinikum Rechts der Isar der Technischen Universitaet Muenchen
- Klinikum der Universitat Munchen
- Sana Klinikum Offenbach GmbH
- University of Rostock
- Shaare Zedek Medical Center
- Meir Medical Center
- Rabin Medical Center
- Kaplan Medical Center
- Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi
- Fondazione del Piemonte per l'Oncologia - Istituto di Candiolo FPO - IRCCS
- Irccs Irst
- Istituto Europeo di Oncologia
- Seconda Università degli Studi di Napoli, AOU
- Nuovo Ospedale di Prato - Santo Stefano
- Ospedale degli Infermi
- Policlinico Universitario Agostino Gemelli
- Azienda Ospedaliera S. Maria di Terni
- A.O.U. - Ospedali Riuniti di Ancona
- Chiba Cancer Center
- National Cancer Center Hospital
- National Hospital Organization Kyushu Cancer Center
- Hiroshima City Hiroshima Citizens Hospital
- University of Tsukuba Hospital
- Hakuaikai Sagara Hospital/Breast Surgery
- Kameda General Hospital
- National Cancer Center Hospital East
- Saitama Cancer Center
- Kumamoto Shinto General Hospital
- NHO Shikoku Cancer Center
- Aichi Cancer Center
- Hyogo College of Medicine Hospital
- National Hospital Organization Osaka
- Osaka International Cancer Institute
- National Hospital Organization Hokkaido Cancer Center
- Shizuoka Cancer Center
- The Cancer Institute Hospital of JFCR
- Kanagawa Cancer Center
- National Cancer Center
- Seoul National University Bundang Hospital
- Korea University Anam Hospital
- Seoul National University Hospital
- Severance Hospital, Yonsei University Health System
- Asan Medical Center - Oncology
- Samsung Medical Center
- Isala Ziekenhuis Zwolle
- Netherlands Cancer Institute
- Amphia Ziekenhuis
- Reinier de Graaf Hospital
- University Medical Center Groningen
- Martini Ziekenhuis
- Maastricht University Medical Center
- Erasmus Medisch Centrum Daniel Den Hoed
- National University Cancer Institute, Singapore
- National Cancer Centre Singapore
- Hospital del Mar
- Hospital Universitari Vall d'Hebron
- Hospital Universitario Reina Sofia
- Hospital General Universitario Gregorio Marañon
- Hospital Ruber Internacional
- Hospital Clinico San Carlos
- Hospital Universitario HM Sanchinarro
- Hospital Universitario Virgen de la Victoria
- Hospital Universitario Son Espases
- L'Institut Catala d'Oncologia
- Hospital Universitario de Canarias
- Hospital Universitario Virgen del Rocio
- Hospital Clinico Universitario de Valencia
- Hospital Universitario Miguel Servet
- Goteborgs Universitet - Sahlgrenska Akademin - Institutionen For Kliniska Vetenskaper (Institute Of Clinical Sciences)
- Ryhov Hospital
- Skanes University Hospital - Universitetssjukhus
- Orebro University Hospital
- Onkologklinike Sodersjukhuset
- University Hospital Basel - Brustzentrum
- Institute of Oncology of Southern Switzerland
- University Hospital Lausanne CHUV
- Kantonsspital Winterthur (KSW)
- National Cheng-Kung University Hospital
- National Taiwan University Hospital
- University Hospitals Birmingham NHS Foundation Trust
- Addenbrooke's Hospital
- The University of Edinburgh
- Oxford University Hospitals
- The Royal Marsden NHS Foundation Trust (RM)
- Sarah Cannon Research Institute UK
- Maidstone and Tunbridge Wells NHS Trust
- The Christie NHS Foundation Trust
- The Newcastle upon Tyne Hospitals NHS Foundation Trust
- Mount Vernon Hospital, UK
- The Royal Marsden Hospital (Surrey)
- Royal Cornwall Hospitals NHS Trust
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
Tucatinib + T-DM1
Placebo + T-DM1
Arm Description
Tucatinib + T-DM1
Placebo + T-DM1
Outcomes
Primary Outcome Measures
Progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 by investigator assessment
PFS per investigator is defined as the time from the date of randomization to the investigator assessment of disease progression according to RECIST v1.1 or death from any cause, whichever occurs first.
Secondary Outcome Measures
Overall Survival
OS is defined as the time from randomization to death due to any cause.
PFS per RECIST v1.1 by blinded independent committee review (BICR)
PFS per BICR is defined as the time from the date of randomization to the centrally-reviewed documented disease progression according to RECIST v1.1 or death from any cause, whichever occurs first.
PFS per RECIST v1.1 by investigator assessment in participants with brain metastases at baseline
PFS per RECIST v1.1 by BICR in patients with brain metastases at baseline
Objective response rate (ORR) per RECIST v1.1 by investigator assessment
ORR is defined as the proportion of subjects with complete response (CR) or partial response (PR) according to RECIST v1.1.
ORR per RECIST v1.1 by BICR
Duration of response (DOR) per RECIST v1.1 by investigator assessment
DOR is defined as the time from first documentation of objective response to the first documentation of disease progression or death from any cause, whichever occurs earlier.
DOR per RECIST v1.1 by BICR
Clinical benefit rate (CBR) per RECIST v1.1 by investigator assessment
CBR is defined as the proportion of subjects with stable disease (SD) or non-CR or non-PD for ≥6 months or best response of CR or PR according to RECIST v1.1.
CBR per RECIST v1.1 by BICR
Number of participants with adverse events (AEs)
An AE is any untoward medical occurrence in a subject or clinical investigational subject administered a medicinal product and which does not necessarily have a causal relationship with this treatment.
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT03975647
Brief Title
A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer
Official Title
Randomized, Double-blind, Phase 3 Study of Tucatinib or Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Subjects With Unresectable Locally-advanced or Metastatic HER2+ Breast Cancer (HER2CLIMB-02)
Study Type
Interventional
2. Study Status
Record Verification Date
October 2023
Overall Recruitment Status
Recruiting
Study Start Date
October 2, 2019 (Actual)
Primary Completion Date
June 29, 2023 (Actual)
Study Completion Date
April 30, 2024 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Seagen Inc.
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
This study is being done to see if tucatinib with ado-trastuzumab emtansine (T-DM1) works better than T-DM1 alone to help patients who have a specific type of breast cancer called HER2 positive breast carcinoma. The breast cancer in this study is either metastatic (spread into other parts of the body) or cannot be removed completely with surgery.
Patients in this study will be randomly assigned to get either tucatinib or placebo (a pill with no medicine). This is a blinded study, so neither patients nor their doctors will know whether a patient gets tucatinib or placebo. All patients in the study will get T-DM1, a drug that is often used to treat this cancer.
Each treatment cycle lasts 21 days. Patients will swallow tucatinib pills or placebo pills two times every day. Patients will get T-DM1 injections from the study site staff on the first day of every cycle.
Detailed Description
This study is designed to evaluate the efficacy and safety of tucatinib in combination with T-DM1 in subjects with unresectable locally-advanced or metastatic HER2+ breast cancer who have had prior treatment with a taxane and trastuzumab in any setting. Prior pertuzumab treatment is permitted, but not required. Subjects will be randomized in a 1:1 manner to receive 21-day cycles of either tucatinib or placebo in combination with T-DM1.
While on study treatment, subjects will be assessed for progression every 6 weeks for the first 24 weeks, and every 9 weeks thereafter, irrespective of dose holds or interruptions. Study treatment will continue until unacceptable toxicity, disease progression, withdrawal of consent, or study closure. After completion of study treatment and after occurrence of disease progression, subjects in both arms of the study will continue to be followed for survival until study closure or withdrawal of consent.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
HER2-positive Breast Cancer
Keywords
Seattle Genetics
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
565 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Tucatinib + T-DM1
Arm Type
Experimental
Arm Description
Tucatinib + T-DM1
Arm Title
Placebo + T-DM1
Arm Type
Active Comparator
Arm Description
Placebo + T-DM1
Intervention Type
Drug
Intervention Name(s)
tucatinib
Other Intervention Name(s)
ONT-380
Intervention Description
300mg given twice per day by mouth (orally)
Intervention Type
Drug
Intervention Name(s)
placebo
Intervention Description
Given twice per day orally
Intervention Type
Drug
Intervention Name(s)
T-DM1
Other Intervention Name(s)
Kadcyla
Intervention Description
3.6 mg/kg given into the vein (IV; intravenously) every 21 days
Primary Outcome Measure Information:
Title
Progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 by investigator assessment
Description
PFS per investigator is defined as the time from the date of randomization to the investigator assessment of disease progression according to RECIST v1.1 or death from any cause, whichever occurs first.
Time Frame
Up to approximately 5 years
Secondary Outcome Measure Information:
Title
Overall Survival
Description
OS is defined as the time from randomization to death due to any cause.
Time Frame
Up to approximately 5 years
Title
PFS per RECIST v1.1 by blinded independent committee review (BICR)
Description
PFS per BICR is defined as the time from the date of randomization to the centrally-reviewed documented disease progression according to RECIST v1.1 or death from any cause, whichever occurs first.
Time Frame
Up to approximately 5 years
Title
PFS per RECIST v1.1 by investigator assessment in participants with brain metastases at baseline
Time Frame
Up to approximately 5 years
Title
PFS per RECIST v1.1 by BICR in patients with brain metastases at baseline
Time Frame
Up to approximately 5 years
Title
Objective response rate (ORR) per RECIST v1.1 by investigator assessment
Description
ORR is defined as the proportion of subjects with complete response (CR) or partial response (PR) according to RECIST v1.1.
Time Frame
Up to approximately 3 years
Title
ORR per RECIST v1.1 by BICR
Time Frame
Up to approximately 3 years
Title
Duration of response (DOR) per RECIST v1.1 by investigator assessment
Description
DOR is defined as the time from first documentation of objective response to the first documentation of disease progression or death from any cause, whichever occurs earlier.
Time Frame
Up to approximately 5 years
Title
DOR per RECIST v1.1 by BICR
Time Frame
Up to approximately 5 years
Title
Clinical benefit rate (CBR) per RECIST v1.1 by investigator assessment
Description
CBR is defined as the proportion of subjects with stable disease (SD) or non-CR or non-PD for ≥6 months or best response of CR or PR according to RECIST v1.1.
Time Frame
Up to approximately 3 years
Title
CBR per RECIST v1.1 by BICR
Time Frame
Up to approximately 3 years
Title
Number of participants with adverse events (AEs)
Description
An AE is any untoward medical occurrence in a subject or clinical investigational subject administered a medicinal product and which does not necessarily have a causal relationship with this treatment.
Time Frame
Through 1 month following last dose; up to approximately 9 months overall per participant
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Histologically confirmed HER2+ breast carcinoma as determined by a sponsor-designated central laboratory
History of prior treatment with a taxane and trastuzumab in any setting, separately or in combination
Have progression of unresectable locally advanced/metastatic breast cancer after last systemic therapy, or be intolerant of last systemic therapy
Measurable or non-measurable disease assessable by RECIST v1.1
ECOG performance status score of 0 or 1
CNS Inclusion - Based on screening contrast brain magnetic resonance imaging (MRI), subjects must have at least one of the following:
(a) No evidence of brain metastases
(b) Untreated brain metastases not needing immediate local therapy
(c) Previously treated brain metastases
Brain metastases previously treated with local therapy may either be stable since treatment or may have progressed since prior local CNS therapy, provided that there is no clinical indication for immediate re-treatment with local therapy
Subjects treated with CNS local therapy for newly identified lesions or previously treated and progressing lesions may be eligible to enroll if all of the following criteria are met:
(i) Time since SRS is at least 7 days prior to first dose of study treatment, time since WBRT is at least 14 days prior to first dose, or time since surgical resection is at least 28 days.
(ii) Other sites of evaluable disease are present
Relevant records of any CNS treatment must be available to allow for classification of target and non-target lesions
Exclusion Criteria:
Prior treatment with tucatinib, afatinib, trastuzumab deruxtecan (DS-8201a), or any other investigational anti-HER2, anti-EGFR, or HER2 TKI agent. Prior treatment with lapatinib or neratinib within 12 months of starting study treatment (except in cases where they were given for ≤21 days and was discontinued for reasons other than disease progression or severe toxicity). Prior treatment with pyrotinib for recurrent of mBC (except in cases where pyrotinib was given for ≤21 days and was discontinued for reasons other than disease progression or severe toxicity).
CNS Exclusion - Based on screening contrast brain magnetic resonance imaging (MRI), subjects must not have any of the following:
Any untreated brain lesions >2 cm in size
Ongoing use of corticosteroids for control of symptoms of brain metastases at a total daily dose of >2 mg of dexamethasone (or equivalent).
Any brain lesion thought to require immediate local therapy
Known or concurrent leptomeningeal disease as documented by the investigator
Poorly controlled generalized or complex partial seizures
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Seagen Trial Information Support
Phone
866-333-7436
Email
clinicaltrials@seagen.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Mike Schmitt, MD
Organizational Affiliation
Seagen Inc.
Official's Role
Study Director
Facility Information:
Facility Name
University of South Alabama - Mitchell Cancer Institute
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36604
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Ironwood Cancer & Research Centers - Chandler
City
Chandler
State/Province
Arizona
ZIP/Postal Code
85224
Country
United States
Individual Site Status
Completed
Facility Name
Banner MD Anderson Cancer Center
City
Gilbert
State/Province
Arizona
ZIP/Postal Code
85234
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Cancer Treatment Centers of America / Western Regional Medical Center
City
Goodyear
State/Province
Arizona
ZIP/Postal Code
85338
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Arizona Oncology Associates, PC - HAL
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85016
Country
United States
Individual Site Status
Completed
Facility Name
Arizona Oncology Associates, PC - HOPE
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85710
Country
United States
Individual Site Status
Completed
Facility Name
St. Bernards Medical Center
City
Jonesboro
State/Province
Arkansas
ZIP/Postal Code
72401
Country
United States
Individual Site Status
Completed
Facility Name
City of Hope National Medical Center
City
Duarte
State/Province
California
ZIP/Postal Code
91010-3000
Country
United States
Individual Site Status
Completed
Facility Name
California Cancer Associates for Research and Excellence Inc (cCARE)
City
Encinitas
State/Province
California
ZIP/Postal Code
92024
Country
United States
Individual Site Status
Completed
Facility Name
St. Joseph Heritage Healthcare TRIO
City
Fullerton
State/Province
California
ZIP/Postal Code
92835
Country
United States
Individual Site Status
Completed
Facility Name
Chao Family Comprehensive Cancer Center University of California Irvine
City
Orange
State/Province
California
ZIP/Postal Code
92868
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
University of California Irvine - Newport
City
Orange
State/Province
California
ZIP/Postal Code
92868
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
University of California Davis
City
Sacramento
State/Province
California
ZIP/Postal Code
95817
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
San Francisco General Hospital
City
San Francisco
State/Province
California
ZIP/Postal Code
94110
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
University of California at San Francisco
City
San Francisco
State/Province
California
ZIP/Postal Code
94134
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
UCLA Department of Medicine - Hematology & Oncology
City
Santa Monica
State/Province
California
ZIP/Postal Code
90404
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Torrance Memorial Physician Network - TRIO
City
Torrance
State/Province
California
ZIP/Postal Code
90505
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Kaiser Permanente Medical Center Northern California
City
Vallejo
State/Province
California
ZIP/Postal Code
94589
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Rocky Mountain Cancer Centers - Aurora
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80012
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
University of Colorado Hospital / University of Colorado
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045-0510
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
SCL Health Good Samaritan Medical Center Cancer Centers of Colorado
City
Broomfield
State/Province
Colorado
ZIP/Postal Code
80021
Country
United States
Individual Site Status
Completed
Facility Name
University of Colorado Health Memorial Hospital
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80909
Country
United States
Individual Site Status
Completed
Facility Name
Cancer Centers of Colorado - Denver
City
Denver
State/Province
Colorado
ZIP/Postal Code
80218
Country
United States
Individual Site Status
Completed
Facility Name
Poudre Valley Health System (PVHS)
City
Fort Collins
State/Province
Colorado
ZIP/Postal Code
80524
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Helen F. Graham Cancer Center / Christiana Care Health Systems
City
Newark
State/Province
Delaware
ZIP/Postal Code
19713
Country
United States
Individual Site Status
Completed
Facility Name
Lombardi Cancer Center / Georgetown University Medical Center
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20007
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Florida Cancer Specialists - South Region
City
Fort Myers
State/Province
Florida
ZIP/Postal Code
33901
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Baptist MD Anderson Cancer Center
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32207
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
University of Miami
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Miami Cancer Institute at Baptist Health, Inc.
City
Miami
State/Province
Florida
ZIP/Postal Code
33176
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
AdventHealth Cancer Institute
City
Orlando
State/Province
Florida
ZIP/Postal Code
32804
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Orlando Health, Inc. TRIO
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Florida Cancer Specialists - North Region
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33705
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
H. Lee Moffitt Cancer Center and Research Institute
City
Tampa
State/Province
Florida
ZIP/Postal Code
33612
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Florida Cancer Specialists - East West Palm Beach, FL (SCRI)
City
West Palm Beach
State/Province
Florida
ZIP/Postal Code
33401
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Winship Cancer Institute / Emory University School of Medicine
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30322
Country
United States
Individual Site Status
Completed
Facility Name
Northside Hospital
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30342
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Augusta University
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Kaiser Permanente Moanalua Medical Center
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96819
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Kapi'olani Medical Center for Women and Children
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96826
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Illinois Cancer Specialists - Arlington Heights
City
Arlington Heights
State/Province
Illinois
ZIP/Postal Code
60005
Country
United States
Individual Site Status
Completed
Facility Name
Rush University Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Individual Site Status
Completed
Facility Name
University of Chicago Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637-1470
Country
United States
Individual Site Status
Completed
Facility Name
Illinois Cancer Care
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61615
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Ft Wayne Medical Oncology and Hematology, Inc TRIO
City
Fort Wayne
State/Province
Indiana
ZIP/Postal Code
46804
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
University of Kansas Medical Center
City
Kansas City
State/Province
Kansas
ZIP/Postal Code
66160
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
CHI Saint Joseph Medical Group Cancer Care Center
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40509
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Ochsner Medical Center
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Individual Site Status
Completed
Facility Name
University of Maryland
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21201
Country
United States
Individual Site Status
Completed
Facility Name
Mercy Medical Center -Weinberg Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21202
Country
United States
Individual Site Status
Completed
Facility Name
American Oncology Networks LLC
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20817
Country
United States
Individual Site Status
Completed
Facility Name
Maryland Oncology Hematology, P.A.
City
Rockville
State/Province
Maryland
ZIP/Postal Code
20850
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Beth Israel Deaconess Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Individual Site Status
Completed
Facility Name
Dana Farber Cancer Institute
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
University of Michigan Comprehensive Cancer Center
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Henry Ford Health System
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Minnesota Oncology Hematology P.A.
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55404
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
North Mississippi Medical Center Hematology Oncology - Tupelo
City
Tupelo
State/Province
Mississippi
ZIP/Postal Code
38801
Country
United States
Individual Site Status
Completed
Facility Name
Saint Luke's Cancer Institute LLC
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64113
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
HCA Midwest Health Kansas City
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64132
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Washington University in St Louis
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
St. Vincent Frontier Cancer Center
City
Billings
State/Province
Montana
ZIP/Postal Code
59102
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Nebraska Cancer Specialists
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68130
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Comprehensive Cancer Centers of Nevada
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89169
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Summit Medical Group
City
Florham Park
State/Province
New Jersey
ZIP/Postal Code
07932
Country
United States
Individual Site Status
Completed
Facility Name
Saint Barnabas Medical Center Cancer Center
City
Livingston
State/Province
New Jersey
ZIP/Postal Code
07039
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Rutgers Cancer Institute of New Jersey
City
New Brunswick
State/Province
New Jersey
ZIP/Postal Code
08903-2681
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
New York Oncology Hematology, P.C.
City
Albany
State/Province
New York
ZIP/Postal Code
12206
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Stony Brook University Cancer Center
City
Stony Brook
State/Province
New York
ZIP/Postal Code
11794-7263
Country
United States
Individual Site Status
Completed
Facility Name
UNC Lineberger Comprehensive Cancer Center / University of North Carolina
City
Chapel Hill
State/Province
North Carolina
ZIP/Postal Code
27599
Country
United States
Individual Site Status
Completed
Facility Name
Levine Cancer Institute
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Duke University Medical Center
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27710
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Providence Portland Medical Center
City
Portland
State/Province
Oregon
ZIP/Postal Code
97213
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Oregon Health and Science University
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239-3098
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Northwest Cancer Specialists, P.C.
City
Tigard
State/Province
Oregon
ZIP/Postal Code
97223
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
University of Pennsylvania / Perelman Center for Advanced Medicine
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Cancer Treatment Centers of America / Eastern Regional Medical Center
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19124
Country
United States
Individual Site Status
Completed
Facility Name
Brig Center for Cancer Care and Survivorship
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37909
Country
United States
Individual Site Status
Completed
Facility Name
Tennessee Oncology-Nashville/Sarah Cannon Research Institute
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Texas Oncology - Amarillo
City
Amarillo
State/Province
Texas
ZIP/Postal Code
79124
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Texas Oncology - Austin Central
City
Austin
State/Province
Texas
ZIP/Postal Code
78731
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Texas Oncology - DFWW
City
Bedford
State/Province
Texas
ZIP/Postal Code
76022
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Texas Oncology - Methodist Dallas Cancer Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75203
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Texas Oncology - Medical City Dallas
City
Dallas
State/Province
Texas
ZIP/Postal Code
75230
Country
United States
Individual Site Status
Completed
Facility Name
Texas Oncology - Baylor Sammons Cancer Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
University of Texas Southwestern Medical Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390
Country
United States
Individual Site Status
Completed
Facility Name
The Center for Cancer and Blood Disorders: Fortworth
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Texas Oncology - Houston Memorial City
City
Houston
State/Province
Texas
ZIP/Postal Code
77024
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
MD Anderson Cancer Center / University of Texas
City
Houston
State/Province
Texas
ZIP/Postal Code
77030-4095
Country
United States
Individual Site Status
Completed
Facility Name
Baylor Clinic
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Oncology Consultants, PA
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Individual Site Status
Completed
Facility Name
Texas Oncology - San Antonio Medical Center
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78240
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Huntsman Cancer Institute/University of Utah
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84112
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Virginia Cancer Specialists, PC
City
Fairfax
State/Province
Virginia
ZIP/Postal Code
22031
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Saint Francis Hospital / Bon Secours - Virginia
City
Midlothian
State/Province
Virginia
ZIP/Postal Code
23114
Country
United States
Individual Site Status
Completed
Facility Name
Peninsula Cancer Institute
City
Newport News
State/Province
Virginia
ZIP/Postal Code
23601
Country
United States
Individual Site Status
Completed
Facility Name
Oncology and Hematology Assoc of SW VA DBA Blue Ridge Cancer Care
City
Salem
State/Province
Virginia
ZIP/Postal Code
24153
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Swedish Cancer Institute - Edmonds
City
Edmonds
State/Province
Washington
ZIP/Postal Code
98026
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Swedish Cancer Institute - Issaquah
City
Issaquah
State/Province
Washington
ZIP/Postal Code
98029
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Swedish Cancer Institute
City
Seattle
State/Province
Washington
ZIP/Postal Code
98104
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Peter MacCallum Cancer Centre
City
Melbourne
State/Province
Other
ZIP/Postal Code
3000
Country
Australia
Individual Site Status
Active, not recruiting
Facility Name
Austin Health
City
Melbourne
State/Province
Other
ZIP/Postal Code
3084
Country
Australia
Individual Site Status
Active, not recruiting
Facility Name
Breast Cancer Research Centre
City
Nedlands
State/Province
Other
ZIP/Postal Code
6009
Country
Australia
Individual Site Status
Active, not recruiting
Facility Name
Mater Hospital
City
Sydney
State/Province
Other
ZIP/Postal Code
2060
Country
Australia
Individual Site Status
Active, not recruiting
Facility Name
Westmead Hospital
City
Westmead
State/Province
Other
ZIP/Postal Code
2145
Country
Australia
Individual Site Status
Active, not recruiting
Facility Name
LKH- Universitat Klinikum Graz
City
Graz
State/Province
Other
ZIP/Postal Code
8036
Country
Austria
Individual Site Status
Completed
Facility Name
Medizinische Universitat Innsbruck
City
Innsbruck
State/Province
Other
ZIP/Postal Code
6020
Country
Austria
Individual Site Status
Completed
Facility Name
LKH Salzburg, Universitatsklinikum der PMU
City
Salzburg
State/Province
Other
ZIP/Postal Code
5020
Country
Austria
Individual Site Status
Completed
Facility Name
Medizinische Universitat Wien
City
Vienna
State/Province
Other
ZIP/Postal Code
1090
Country
Austria
Individual Site Status
Completed
Facility Name
Klinik Ottakring
City
Vienna
State/Province
Other
ZIP/Postal Code
1160
Country
Austria
Individual Site Status
Completed
Facility Name
Institut Jules Bordet
City
Anderlecht
State/Province
Other
ZIP/Postal Code
B-1070
Country
Belgium
Individual Site Status
Active, not recruiting
Facility Name
Cliniques Universitaires Saint Luc
City
Brussels
State/Province
Other
ZIP/Postal Code
1200
Country
Belgium
Individual Site Status
Completed
Facility Name
Grand Hôpital de Charleroi - Saint-Joseph
City
Charleroi
State/Province
Other
ZIP/Postal Code
6000
Country
Belgium
Individual Site Status
Completed
Facility Name
Universitair Ziekenhuis Antwerpen
City
Edegem
State/Province
Other
ZIP/Postal Code
2650
Country
Belgium
Individual Site Status
Active, not recruiting
Facility Name
Academisch Ziekenhuis Groeninge
City
Kortrijk
State/Province
Other
ZIP/Postal Code
8500
Country
Belgium
Individual Site Status
Active, not recruiting
Facility Name
CHU de Liege
City
Liege
State/Province
Other
ZIP/Postal Code
4000
Country
Belgium
Individual Site Status
Active, not recruiting
Facility Name
Universitair Ziekenhuis Leuven
City
Lueven
State/Province
Other
ZIP/Postal Code
3000
Country
Belgium
Individual Site Status
Active, not recruiting
Facility Name
CHU UCL Namur-Site de Saint Elisabeth
City
Namur
State/Province
Other
ZIP/Postal Code
5000
Country
Belgium
Individual Site Status
Active, not recruiting
Facility Name
University of Alberta / Cross Cancer Institute
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 1Z2
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
Queen Elizabeth II Health Sciences Centre
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 2Y9
Country
Canada
Individual Site Status
Completed
Facility Name
Cancer Centre of Southeastern Ontario At Kingston General Hospital
City
Kingston
State/Province
Ontario
ZIP/Postal Code
K7L 5P9
Country
Canada
Individual Site Status
Completed
Facility Name
London Health Sciences Centre - Victoria Hospital
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5W9
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
University of Ottawa / Ottawa General Hospital
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 8L6
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
University Health Network, Princess Margaret Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 2M9
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
Centre Hospitalier de l'Universite de Montreal
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2X 3E4
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
Jewish General Hospital
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3T 1E2
Country
Canada
Individual Site Status
Completed
Facility Name
Saskatoon Cancer Centre
City
Saskatoon
State/Province
Saskatchewan
ZIP/Postal Code
S7N 4H4
Country
Canada
Individual Site Status
Completed
Facility Name
Hopital du Saint-Sacrement, CHU de Quebec-Universite Laval
City
Quebec
ZIP/Postal Code
G1S 4L8
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
Cancer Hospital Chinese Academy of Medical Sciences
City
Beijing City
State/Province
Other
ZIP/Postal Code
100021
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Binghe Xu
Facility Name
Jilin Province Cancer Hospital
City
Changghun
State/Province
Other
ZIP/Postal Code
130012
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ying Cheng
Facility Name
Hunan Cancer Hospital
City
Changsha
State/Province
Other
ZIP/Postal Code
410013
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Quchang Ouyang
Facility Name
Sun Yat-sen University Cancer Center
City
Guangzhou City
State/Province
Other
ZIP/Postal Code
510060
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shusen Wang
Facility Name
Zhejiang Cancer Hospital
City
Hangzhou City
State/Province
Other
ZIP/Postal Code
310022
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiaojia Wang
Facility Name
First Affiliated Hospital of Zhejiang University
City
Hangzhou City
State/Province
Other
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Peng Shen
Facility Name
The Second Affiliated Hospital of Zhejiang University School of Medicine
City
Hangzhou
State/Province
Other
ZIP/Postal Code
0571
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yiding Chen
Facility Name
Gulou Hospital Affiliated to Nanjing University Medical College
City
Nanjing
State/Province
Other
ZIP/Postal Code
210008
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Li Xie
Facility Name
Shengjing Hospital of China Medical University
City
Shenyang City
State/Province
Other
ZIP/Postal Code
110022
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Caigang Liu
Facility Name
Tianjin Medical University - Cancer Institute & Hospital
City
Tianjin
State/Province
Other
ZIP/Postal Code
453000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhongsheng Tong
Facility Name
Hubei Cancer Hospital
City
Wuhan
State/Province
Other
ZIP/Postal Code
430000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xinhong Wu
Facility Name
Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology
City
Wuhan
State/Province
Other
ZIP/Postal Code
430000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jing Cheng
Facility Name
Wuhan University
City
Wuhan
State/Province
Other
ZIP/Postal Code
430060
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Weiping Tao
Facility Name
The First Affiliated Hospital of Xi'an Jiaotong University
City
Xi'an
State/Province
Other
ZIP/Postal Code
710061
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jin Yang
Facility Name
Xi'An International Medical Center Hospital
City
Xi'An
State/Province
Other
ZIP/Postal Code
710100
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xue Yan
Facility Name
Xuzhou Central Hospital
City
Xuzhou
State/Province
Other
ZIP/Postal Code
21009
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Li Sun
Facility Name
The Affiliated Hospital of Guangdong Medical University
City
Zhan Jiang City
State/Province
Other
ZIP/Postal Code
524000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ying Zhang
Facility Name
Henan Cancer Hospital
City
Zhengzhou
State/Province
Other
ZIP/Postal Code
45003
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Min Yan
Facility Name
Bejing Hospital
City
Bejing
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yong Qiang Zhang
Facility Name
Center of Women and Children Hospital of Guangdong Province
City
Guangzhou
ZIP/Postal Code
511400
Country
China
Individual Site Status
Recruiting
Facility Name
Nanchang Third Hospital
City
Nanchang City
ZIP/Postal Code
330009
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hong Wang
Facility Name
Guangxi Medical University Affiliated Tumor Hospital
City
Nanning
ZIP/Postal Code
530021
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Weimin Xie
Facility Name
Aalborg Universitetshospital
City
Aalborg
State/Province
Other
ZIP/Postal Code
9100
Country
Denmark
Individual Site Status
Completed
Facility Name
Aarhus University Hospital
City
Aarhus N
State/Province
Other
ZIP/Postal Code
8200
Country
Denmark
Individual Site Status
Completed
Facility Name
Rigs Hospiltalet
City
Copenhagen
State/Province
Other
ZIP/Postal Code
2100
Country
Denmark
Individual Site Status
Completed
Facility Name
Herlev Hospital
City
Herlev
State/Province
Other
ZIP/Postal Code
2730
Country
Denmark
Individual Site Status
Active, not recruiting
Facility Name
Odense University Hospital
City
Odense C
State/Province
Other
ZIP/Postal Code
5000
Country
Denmark
Individual Site Status
Active, not recruiting
Facility Name
Sygehus Lillebaelt - Vejle Sygehus
City
Vejle
State/Province
Other
ZIP/Postal Code
7100
Country
Denmark
Individual Site Status
Active, not recruiting
Facility Name
University Hospital of Besancon
City
Besancon cedex
State/Province
Other
ZIP/Postal Code
25030
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Hospital Center Regional University Morvan De Brest
City
Brest
State/Province
Other
ZIP/Postal Code
29200
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Centre de Lutte contre le Cancer - François Baclesse
City
Caen Cedex 5
State/Province
Other
ZIP/Postal Code
14076
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Hopital Europeen Georges Pompidou
City
Cedex 15
State/Province
Other
ZIP/Postal Code
75908
Country
France
Individual Site Status
Completed
Facility Name
Center Georges Francois Leclerc
City
Dijon
State/Province
Other
ZIP/Postal Code
21000
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Clinique Victor Hugo Le Mans
City
Le Mans
State/Province
Other
ZIP/Postal Code
72000
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Centre Leon Berard - Centre regional de lutte contre le cancer Rhone-Alpes
City
Lyon cedex 08
State/Province
Other
ZIP/Postal Code
69008
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Institut Paoli Calmettes
City
Marseille
State/Province
Other
ZIP/Postal Code
13273
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Hopital Saint-Louis / Service d'Hematologie
City
Paris Cedex 10
State/Province
Other
ZIP/Postal Code
75475
Country
France
Individual Site Status
Completed
Facility Name
Institute Curie - Centre de Lutte Contre Le Cancer CLCC de Paris
City
Paris
State/Province
Other
ZIP/Postal Code
75298 CEDEX 05
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Centre Henri Becquerel / Centre Regional de Lutte Contre le Cancer
City
Rouen
State/Province
Other
ZIP/Postal Code
76038
Country
France
Individual Site Status
Completed
Facility Name
Hopitaux Universitaires de Strasbourg
City
Strasbourg
State/Province
Other
ZIP/Postal Code
67200
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Institut Claudius Regaud IUCT-O
City
Toulouse Cedex 9
State/Province
Other
ZIP/Postal Code
31059
Country
France
Individual Site Status
Active, not recruiting
Facility Name
CHU Tours - Hopital Bretonneau
City
TOURS Cedex 09
State/Province
Other
ZIP/Postal Code
37044
Country
France
Individual Site Status
Active, not recruiting
Facility Name
Helios Klinikum Berlin-Buch
City
Berlin
State/Province
Other
ZIP/Postal Code
13125
Country
Germany
Individual Site Status
Completed
Facility Name
Stadtisches Klinikum Dessau
City
Dessau-Rosslau
State/Province
Other
ZIP/Postal Code
06847
Country
Germany
Individual Site Status
Completed
Facility Name
Kliniken Essen-Mitte - Evang. Huyssens-Stiftung
City
Essen
State/Province
Other
ZIP/Postal Code
45136
Country
Germany
Individual Site Status
Completed
Facility Name
CHOP GmbH
City
Frankfurt
State/Province
Other
ZIP/Postal Code
60389
Country
Germany
Individual Site Status
Completed
Facility Name
Universitaetsklinikum Hamburg-Eppendorf (UKE)
City
Hamburg
State/Province
Other
ZIP/Postal Code
20246
Country
Germany
Individual Site Status
Completed
Facility Name
Universitatsklinikum Heidelberg
City
Heidelberg
State/Province
Other
ZIP/Postal Code
69120
Country
Germany
Individual Site Status
Completed
Facility Name
Universitatsklinikum Schleswig-Holstein
City
Kiel
State/Province
Other
ZIP/Postal Code
24105
Country
Germany
Individual Site Status
Active, not recruiting
Facility Name
InVO- Institut fUr Versorgungsforschung in der onkologie GbR
City
Koblenz
State/Province
Other
ZIP/Postal Code
56068
Country
Germany
Individual Site Status
Active, not recruiting
Facility Name
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
City
Mainz
State/Province
Other
ZIP/Postal Code
55101
Country
Germany
Individual Site Status
Active, not recruiting
Facility Name
Klinikum Rechts der Isar der Technischen Universitaet Muenchen
City
Muenchen
State/Province
Other
ZIP/Postal Code
81675
Country
Germany
Individual Site Status
Active, not recruiting
Facility Name
Klinikum der Universitat Munchen
City
Munchen
State/Province
Other
ZIP/Postal Code
80337
Country
Germany
Individual Site Status
Completed
Facility Name
Sana Klinikum Offenbach GmbH
City
Offenbach am Main
State/Province
Other
ZIP/Postal Code
63069
Country
Germany
Individual Site Status
Active, not recruiting
Facility Name
University of Rostock
City
Rostock
State/Province
Other
ZIP/Postal Code
18059
Country
Germany
Individual Site Status
Completed
Facility Name
Shaare Zedek Medical Center
City
Jerusalem
State/Province
Other
ZIP/Postal Code
9103102
Country
Israel
Individual Site Status
Completed
Facility Name
Meir Medical Center
City
Kfar Saba
State/Province
Other
ZIP/Postal Code
44281
Country
Israel
Individual Site Status
Completed
Facility Name
Rabin Medical Center
City
Petach Tikva
State/Province
Other
ZIP/Postal Code
49414
Country
Israel
Individual Site Status
Active, not recruiting
Facility Name
Kaplan Medical Center
City
Rehovot
State/Province
Other
ZIP/Postal Code
76100
Country
Israel
Individual Site Status
Active, not recruiting
Facility Name
Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi
City
Bologna
State/Province
Other
ZIP/Postal Code
40138
Country
Italy
Individual Site Status
Completed
Facility Name
Fondazione del Piemonte per l'Oncologia - Istituto di Candiolo FPO - IRCCS
City
Candiolo
State/Province
Other
ZIP/Postal Code
10060
Country
Italy
Individual Site Status
Completed
Facility Name
Irccs Irst
City
Meldola
State/Province
Other
ZIP/Postal Code
47014
Country
Italy
Individual Site Status
Completed
Facility Name
Istituto Europeo di Oncologia
City
Milano
State/Province
Other
ZIP/Postal Code
20132
Country
Italy
Individual Site Status
Active, not recruiting
Facility Name
Seconda Università degli Studi di Napoli, AOU
City
Napoli
State/Province
Other
ZIP/Postal Code
80131
Country
Italy
Individual Site Status
Completed
Facility Name
Nuovo Ospedale di Prato - Santo Stefano
City
Prato
State/Province
Other
ZIP/Postal Code
59100
Country
Italy
Individual Site Status
Completed
Facility Name
Ospedale degli Infermi
City
Rimini
State/Province
Other
ZIP/Postal Code
47923
Country
Italy
Individual Site Status
Completed
Facility Name
Policlinico Universitario Agostino Gemelli
City
Roma
State/Province
Other
ZIP/Postal Code
00168
Country
Italy
Individual Site Status
Active, not recruiting
Facility Name
Azienda Ospedaliera S. Maria di Terni
City
Terni
State/Province
Other
ZIP/Postal Code
05100
Country
Italy
Individual Site Status
Completed
Facility Name
A.O.U. - Ospedali Riuniti di Ancona
City
Torrette
State/Province
Other
ZIP/Postal Code
60126
Country
Italy
Individual Site Status
Completed
Facility Name
Chiba Cancer Center
City
Chiba
State/Province
Other
ZIP/Postal Code
260-8717
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
National Cancer Center Hospital
City
Chuo-ku
State/Province
Other
ZIP/Postal Code
104-0045
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
National Hospital Organization Kyushu Cancer Center
City
Fukuoka-shi
State/Province
Other
ZIP/Postal Code
811-1395
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
Hiroshima City Hiroshima Citizens Hospital
City
Hiroshima
State/Province
Other
ZIP/Postal Code
730-8518
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
University of Tsukuba Hospital
City
Ibaraki
State/Province
Other
ZIP/Postal Code
305-8576
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
Hakuaikai Sagara Hospital/Breast Surgery
City
Kagosima
State/Province
Other
ZIP/Postal Code
892-0833
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
Kameda General Hospital
City
Kamogawa
State/Province
Other
ZIP/Postal Code
296-8602
Country
Japan
Individual Site Status
Completed
Facility Name
National Cancer Center Hospital East
City
Kashiwa-shi
State/Province
Other
ZIP/Postal Code
277-8577
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
Saitama Cancer Center
City
Kitaadachi-gun
State/Province
Other
ZIP/Postal Code
362-0806
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
Kumamoto Shinto General Hospital
City
Kumamoto
State/Province
Other
ZIP/Postal Code
862-8655
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
NHO Shikoku Cancer Center
City
Matsuyama
State/Province
Other
ZIP/Postal Code
791-0280
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
Aichi Cancer Center
City
Nagoya-shi
State/Province
Other
ZIP/Postal Code
464-8681
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
Hyogo College of Medicine Hospital
City
Nishinomiya
State/Province
Other
ZIP/Postal Code
730-8518
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
National Hospital Organization Osaka
City
Osaka
State/Province
Other
ZIP/Postal Code
540-0006
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
Osaka International Cancer Institute
City
Osaka
State/Province
Other
ZIP/Postal Code
541-8567
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
National Hospital Organization Hokkaido Cancer Center
City
Sapporo
State/Province
Other
ZIP/Postal Code
003-0804
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
Shizuoka Cancer Center
City
Sunto-Gun
State/Province
Other
ZIP/Postal Code
411-8777
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
The Cancer Institute Hospital of JFCR
City
Tokyo
State/Province
Other
ZIP/Postal Code
135-8550
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
Kanagawa Cancer Center
City
Yokohama
State/Province
Other
ZIP/Postal Code
241-8515
Country
Japan
Individual Site Status
Active, not recruiting
Facility Name
National Cancer Center
City
Goyang-si
State/Province
Other
ZIP/Postal Code
10408
Country
Korea, Republic of
Individual Site Status
Active, not recruiting
Facility Name
Seoul National University Bundang Hospital
City
Seongnam-si
State/Province
Other
ZIP/Postal Code
13605
Country
Korea, Republic of
Individual Site Status
Active, not recruiting
Facility Name
Korea University Anam Hospital
City
Seoul
State/Province
Other
ZIP/Postal Code
02841
Country
Korea, Republic of
Individual Site Status
Active, not recruiting
Facility Name
Seoul National University Hospital
City
Seoul
State/Province
Other
ZIP/Postal Code
03080
Country
Korea, Republic of
Individual Site Status
Active, not recruiting
Facility Name
Severance Hospital, Yonsei University Health System
City
Seoul
State/Province
Other
ZIP/Postal Code
03722
Country
Korea, Republic of
Individual Site Status
Active, not recruiting
Facility Name
Asan Medical Center - Oncology
City
Seoul
State/Province
Other
ZIP/Postal Code
05505
Country
Korea, Republic of
Individual Site Status
Active, not recruiting
Facility Name
Samsung Medical Center
City
Seoul
State/Province
Other
ZIP/Postal Code
06351
Country
Korea, Republic of
Individual Site Status
Active, not recruiting
Facility Name
Isala Ziekenhuis Zwolle
City
AB Zwolle
State/Province
Other
ZIP/Postal Code
8025
Country
Netherlands
Individual Site Status
Completed
Facility Name
Netherlands Cancer Institute
City
Amsterdam
State/Province
Other
ZIP/Postal Code
1066 WX
Country
Netherlands
Individual Site Status
Active, not recruiting
Facility Name
Amphia Ziekenhuis
City
Breda
State/Province
Other
ZIP/Postal Code
4818 CK
Country
Netherlands
Individual Site Status
Active, not recruiting
Facility Name
Reinier de Graaf Hospital
City
Delft
State/Province
Other
ZIP/Postal Code
2625
Country
Netherlands
Individual Site Status
Completed
Facility Name
University Medical Center Groningen
City
Groningen
State/Province
Other
ZIP/Postal Code
9713 GZ
Country
Netherlands
Individual Site Status
Completed
Facility Name
Martini Ziekenhuis
City
Groningen
State/Province
Other
ZIP/Postal Code
9728
Country
Netherlands
Individual Site Status
Completed
Facility Name
Maastricht University Medical Center
City
Maastricht
State/Province
Other
ZIP/Postal Code
6229 HX
Country
Netherlands
Individual Site Status
Completed
Facility Name
Erasmus Medisch Centrum Daniel Den Hoed
City
Rotterdam
State/Province
Other
ZIP/Postal Code
3015GD
Country
Netherlands
Individual Site Status
Active, not recruiting
Facility Name
National University Cancer Institute, Singapore
City
Singapore
State/Province
Other
ZIP/Postal Code
119228
Country
Singapore
Individual Site Status
Active, not recruiting
Facility Name
National Cancer Centre Singapore
City
Singapore
State/Province
Other
ZIP/Postal Code
169610
Country
Singapore
Individual Site Status
Active, not recruiting
Facility Name
Hospital del Mar
City
Barcelona
State/Province
Other
ZIP/Postal Code
08003
Country
Spain
Individual Site Status
Completed
Facility Name
Hospital Universitari Vall d'Hebron
City
Barcelona
State/Province
Other
ZIP/Postal Code
08035
Country
Spain
Individual Site Status
Active, not recruiting
Facility Name
Hospital Universitario Reina Sofia
City
Cordoba
State/Province
Other
ZIP/Postal Code
14004
Country
Spain
Individual Site Status
Completed
Facility Name
Hospital General Universitario Gregorio Marañon
City
Madrid
State/Province
Other
ZIP/Postal Code
28007
Country
Spain
Individual Site Status
Completed
Facility Name
Hospital Ruber Internacional
City
Madrid
State/Province
Other
ZIP/Postal Code
28034
Country
Spain
Individual Site Status
Completed
Facility Name
Hospital Clinico San Carlos
City
Madrid
State/Province
Other
ZIP/Postal Code
28040
Country
Spain
Individual Site Status
Active, not recruiting
Facility Name
Hospital Universitario HM Sanchinarro
City
Madrid
State/Province
Other
ZIP/Postal Code
28050
Country
Spain
Individual Site Status
Active, not recruiting
Facility Name
Hospital Universitario Virgen de la Victoria
City
Malaga
State/Province
Other
ZIP/Postal Code
29010
Country
Spain
Individual Site Status
Completed
Facility Name
Hospital Universitario Son Espases
City
Palma
State/Province
Other
ZIP/Postal Code
07120
Country
Spain
Individual Site Status
Active, not recruiting
Facility Name
L'Institut Catala d'Oncologia
City
Saint Joan Despi
State/Province
Other
ZIP/Postal Code
08970
Country
Spain
Individual Site Status
Active, not recruiting
Facility Name
Hospital Universitario de Canarias
City
San Cristóbal de la Laguna
State/Province
Other
ZIP/Postal Code
38320
Country
Spain
Individual Site Status
Active, not recruiting
Facility Name
Hospital Universitario Virgen del Rocio
City
Sevilla
State/Province
Other
ZIP/Postal Code
41013
Country
Spain
Individual Site Status
Active, not recruiting
Facility Name
Hospital Clinico Universitario de Valencia
City
Valencia
State/Province
Other
ZIP/Postal Code
46010
Country
Spain
Individual Site Status
Active, not recruiting
Facility Name
Hospital Universitario Miguel Servet
City
Zaragoza
State/Province
Other
ZIP/Postal Code
50009
Country
Spain
Individual Site Status
Active, not recruiting
Facility Name
Goteborgs Universitet - Sahlgrenska Akademin - Institutionen For Kliniska Vetenskaper (Institute Of Clinical Sciences)
City
Gothenburg
State/Province
Other
ZIP/Postal Code
SE-40530
Country
Sweden
Individual Site Status
Active, not recruiting
Facility Name
Ryhov Hospital
City
Jonkoping
State/Province
Other
ZIP/Postal Code
55185
Country
Sweden
Individual Site Status
Active, not recruiting
Facility Name
Skanes University Hospital - Universitetssjukhus
City
Lund
State/Province
Other
ZIP/Postal Code
22185
Country
Sweden
Individual Site Status
Completed
Facility Name
Orebro University Hospital
City
Orebro
State/Province
Other
ZIP/Postal Code
70185
Country
Sweden
Individual Site Status
Completed
Facility Name
Onkologklinike Sodersjukhuset
City
Stockholm
State/Province
Other
ZIP/Postal Code
S-11883
Country
Sweden
Individual Site Status
Completed
Facility Name
University Hospital Basel - Brustzentrum
City
Basel
State/Province
Other
ZIP/Postal Code
4031
Country
Switzerland
Individual Site Status
Completed
Facility Name
Institute of Oncology of Southern Switzerland
City
Bellinzona
State/Province
Other
ZIP/Postal Code
6500
Country
Switzerland
Individual Site Status
Completed
Facility Name
University Hospital Lausanne CHUV
City
Lausanne
State/Province
Other
ZIP/Postal Code
1011
Country
Switzerland
Individual Site Status
Active, not recruiting
Facility Name
Kantonsspital Winterthur (KSW)
City
Winterthur
State/Province
Other
ZIP/Postal Code
8400
Country
Switzerland
Individual Site Status
Active, not recruiting
Facility Name
National Cheng-Kung University Hospital
City
Tainan
State/Province
Other
ZIP/Postal Code
704
Country
Taiwan
Individual Site Status
Active, not recruiting
Facility Name
National Taiwan University Hospital
City
Tainan
State/Province
Other
ZIP/Postal Code
704
Country
Taiwan
Individual Site Status
Active, not recruiting
Facility Name
University Hospitals Birmingham NHS Foundation Trust
City
Birmingham
State/Province
Other
ZIP/Postal Code
B15 2TH
Country
United Kingdom
Individual Site Status
Completed
Facility Name
Addenbrooke's Hospital
City
Cambridge
State/Province
Other
ZIP/Postal Code
CB2 0QQ
Country
United Kingdom
Individual Site Status
Completed
Facility Name
The University of Edinburgh
City
Edinburgh
State/Province
Other
ZIP/Postal Code
EH4 2XU
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Oxford University Hospitals
City
Headington
State/Province
Other
ZIP/Postal Code
OX3 7LE
Country
United Kingdom
Individual Site Status
Completed
Facility Name
The Royal Marsden NHS Foundation Trust (RM)
City
London
State/Province
Other
ZIP/Postal Code
SW3 6JJ
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Sarah Cannon Research Institute UK
City
London
State/Province
Other
ZIP/Postal Code
W1G 6AD
Country
United Kingdom
Individual Site Status
Completed
Facility Name
Maidstone and Tunbridge Wells NHS Trust
City
Maidstone
State/Province
Other
ZIP/Postal Code
ME16 9QQ
Country
United Kingdom
Individual Site Status
Completed
Facility Name
The Christie NHS Foundation Trust
City
Manchester
State/Province
Other
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
The Newcastle upon Tyne Hospitals NHS Foundation Trust
City
Newcastle Upon Tyne
State/Province
Other
ZIP/Postal Code
NE7 7DN
Country
United Kingdom
Individual Site Status
Completed
Facility Name
Mount Vernon Hospital, UK
City
Northwood
State/Province
Other
ZIP/Postal Code
HA6 2RN
Country
United Kingdom
Individual Site Status
Completed
Facility Name
The Royal Marsden Hospital (Surrey)
City
Sutton
State/Province
Other
ZIP/Postal Code
SM2 5PT
Country
United Kingdom
Individual Site Status
Completed
Facility Name
Royal Cornwall Hospitals NHS Trust
City
Truro
State/Province
Other
ZIP/Postal Code
TR1 3LQ
Country
United Kingdom
Individual Site Status
Completed
12. IPD Sharing Statement
Learn more about this trial
A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer
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