A Study of Zidovudine Plus Interleukin-2 in HIV-Infected Patients Who Have No Symptoms of Infection But Who Have Tender Lymph Nodes
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Recombinant Proteins, HIV Seropositivity, Interleukin-2, Drug Evaluation, Drug Therapy, Combination, Acquired Immunodeficiency Syndrome, AIDS-Related Complex, Zidovudine
Eligibility Criteria
Inclusion Criteria Concurrent Medication: Allowed: Necessary topical agents, including nystatin or clotrimazole, as well as acyclovir. Patients on medications without which the patient would be placed at significant risk (seizures, diabetic control, respiratory embarrassment) may continue only at the discretion of the study pharmacologist. Patients must have: Asymptomatic HIV infection associated with lymphadenopathy. Walter Reed Stage II disease, with positive antibody to HIV confirmed by Western blot test. Exclusion Criteria Co-existing Condition: Patients will be excluded from the study for the following: Development of a disease requiring a drug which might potentiate toxicity of the study drugs or a drug likely to have antiretroviral effect. Active opportunistic infection. Major organ allograft. Significant cardiac or pulmonary disease or central nervous system (CNS) lesions. Concurrent Medication: Excluded: Ongoing therapy for an opportunistic infection. Beta-blockers. Antihypertensive medication other than diuretics. All nonessential medication including pain medications. Patients without interleukin 2 (IL-2) augmentable anti-HIV antibody-dependent cellular cytotoxicity (ADCC) or or cell-mediated cytotoxicity (CMC) in vitro are excluded. Prior Medication: Excluded within 12 weeks of study entry: Other antiretroviral agents (patients with CD4 counts of 400 - 500 per mm3 who are receiving AZT may continue to receive it until study treatment is initiated). Immunomodulators. Corticosteroids. Other experimental therapy. Antineoplastic chemotherapy. Active drug or alcohol abuse.
Sites / Locations
- Duke Univ. Med. Ctr. Adult CRS