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A Study to Assess All-Cause Mortality and Cardiovascular Morbidity in Participants With Chronic Kidney Disease (CKD) on Dialysis and Those Not on Renal Replacement Therapy Receiving Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) or Reference Erythropoietin Stimulating Agents (ESAs)

Primary Purpose

Chronic Renal Anemia

Status
Completed
Phase
Phase 4
Locations
International
Study Type
Interventional
Intervention
Darbepoetin Alfa
Epoetin Alfa
Epoetin Beta
methoxy polyethylene glycol-epoetin beta
Sponsored by
Hoffmann-La Roche
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Chronic Renal Anemia

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Male or female participants with symptomatic anemia associated with CKD
  • Participants with renal anemia who are not treated with an ESA:
  • Anemia was defined as hemoglobin (Hb) concentration less than (<) 11.0 grams per deciliter (g/dL) (mean of 2 screening values with at least one day and a maximum of 2 weeks between measurements) with clinical indication for ESA treatment
  • Participants with renal anemia who are on maintenance ESA therapy:
  • If on dialysis: regular long-term hemodialysis or peritoneal dialysis therapy with the same mode of dialysis for at least 3 months before screening
  • Hb concentration between 10 and 12 g/dL (mean of 2 screening values with at least one day and a maximum of 2 weeks between measurements)
  • Participants with adequate iron status defined as: serum ferritin above or equal to 100 micrograms per liter or transferrin saturation above or equal to 20 percent

Exclusion Criteria:

  • Contraindications to ESA treatment: uncontrolled hypertension, hypersensitivity to the active substance or any of the excipients, any other contraindication to ESA therapy
  • Conditions known to cause inadequate response to ESA treatment or anemia other than symptomatic anemia associated with CKD:
  • History of hemoglobinopathy
  • Anemia due to hemolysis
  • Pure red cell aplasia
  • High likelihood of early withdrawal (for example, within 1 year) or interruption of the study
  • Pregnancy or breast-feeding
  • Women of childbearing potential without effective contraception
  • Administration of another investigational drug within 1 month before screening or planned during the study period

Sites / Locations

  • Fresenius Medical Care Martinez
  • Fresenius Medical Care Morón
  • Fresenius Medical Care San Martin
  • Fresenuis Medical Care Mansilla
  • Gosford Hospital; Renal
  • Renal Research Dr Simon Roger
  • Cairns Hospital; Renal Services
  • Gold Coast Hospital Department of Pharmacology & Therapeutics
  • ROYAL ADELAIDE HOSPITAL; Renal Clinical Trials, CNARTS
  • Launceston General Hospital; Diabetes and Renal Research Unit
  • Monash Medical Centre; Renal Transplant Unit
  • Royal Perth Hospital; Nephrology
  • UZ Brussel
  • UZ Gent
  • Jessa Zkh (Campus Virga Jesse)
  • UZ Leuven Gasthuisberg
  • AZ Delta (Campus Wilgenstraat)
  • Centro Mineiro de Pesquisa - CMIP
  • PUCPR
  • Hospital Univ. Pedro Ernesto - Hupe; Nefrologia
  • Santa Casa de Misericordia de Porto Alegre
  • Hospital Sao Lucas - PUCRS
  • Beneficencia Portuguesa de Sao Paulo
  • Universidade Federal de Sao Paulo - UNIFESP
  • Clinica de Medicina Interna e Nefrologia (CMIN)
  • Hospital das Clinicas - FMUSP; Nefrologia
  • Instituto de Hemodialise Sorocaba
  • General Hospital Karlovac; Dept of Haemodialysis
  • Clinical Hospital Osijek; Dept of Haemodialysis
  • Clinical Hospital Center Rijeka; Dialysis
  • General Hospital Josip Bencevic; Department of Haemodialysis
  • Clinical Hospital Split; Dialysis
  • General Hospital Zadar; Dialysis
  • Klinicki Bolnicki Centar Zagreb; Dialysis
  • Fakultni Nemocnice Kralovske Vinohrady (FNKV); Interni Hematologicka Klinika
  • Faculty Hospital; Dialysis Unit
  • Nemocnice Strahov; Interni Oddeleni-Strahov
  • Institut Klinicke A Experimentalni Mediciny Klinika Nefrologie
  • Centre Hospitalier; Hemodialyse
  • Hopital Pellegrin; Departement Nephrologie
  • Centre Hospitalier Du Dr Duchenes; Service De Nephrologie & Hemodialyse
  • Hopital La Cavale Blanche; Nephrologie
  • Hopital Louis Pasteur; Nephrologie - Hemodialyse
  • Clinique Lambert; Service de Néphrologie dialyse
  • Chu Dupuytren; Nephrologie-Hemodialyse
  • Aural
  • Hopital Edouard-Herriot; Nephrologie - Hemodialyse
  • Centre Hospitalier Les Chanaux; Service de Néphrologie Unité 12
  • Service de Nephrologie & D'Immunologie; Clinique
  • Centre Hospitalier Uni Ire Gaston Doumergue; Service D'Hemodialyse
  • Aura - Centre Henri Kunt Ziger
  • Hopital Laennec; Echo
  • Hopital Sud ; Nephrologie Hemodialyse
  • Hopital Civil; Nephrologie Clinique Medicale B
  • Hopital Rangueil; Nephrologie Hemodialyse
  • Ch De Valenciennes; Nephrologie
  • Gemeinschaftspraxis Dr. Stefan Zinn und Steffen Hengst
  • KFH Nierenzentrum Bad Hersfeld; Nephrologie
  • Universitätsklinikum Bonn; Medizinische Klinik und Poliklinik I; Allgemeine Innere Medizin
  • Dialysepraxis Dr. med. Uwe Kraatz
  • DaVita Clinical Research Deutschland GmbH
  • Universitätsklinikum Duesseldorf; Klinik fuer Nephrologie
  • Universitätsklinikum Erlangen; Medizinische Klinik 4; Nephrologie und Hypertensiologie
  • Georg-Haas-Dialysezentrum der PHV
  • Nephrologische Schwerpunktpraxis; Hamburg Barmbek
  • Klinikum Hann. Münden, Nephrologisches Zentrum Niedersachsen
  • Uniklinikum Heidelberg
  • Universitaetsklinikum des Saarlandes; Klinik f. Innere Medizin IV
  • UNI-Klinikum Campus Kiel Klinik f.Innere Medizin IV
  • KfH Kuratorium für Dialyse und Nierentransplantation e.V.; KfH-Nierenzentrum
  • KFH Nierenzentrum Oberschleissheim
  • Dres. Roland Erwin Winkler Ann Michelsen Dietmar Sehland u.w.
  • Praxis Dr.med. Joachim Leicht
  • Robert-Bosch-Krankenhaus; Allgemeine Innere Medizin und Nephrologie
  • Uni Hospital of Alexandroupoli; Nephrology Dept.
  • Laiko General Hospital; Nephrology Div.
  • Uni Hospital of Ioannina; Nephrology Dept.
  • Univeristy Hospital of Larissa; Nephrology
  • Hippokratio Hospital; Nefrology
  • Rabin MC- Belinson campus
  • Rabin MC- Hasharon campus
  • Sheba MC; Nephrology
  • Sourasky MC; Dept. of Nephrology
  • Assaf-Harofeh MC; Nephrology
  • Ospedale Bernardo Ramazzi; U.O. Di Nefrologia E Dialisi
  • Ospedale Civile; Servizio Di Nefrologia E Dialisi
  • A.O. Universitaria Policlinico Di Modena; Nefrologia E Dialisi
  • Ospedale Maggiore; U.O.Complessa di Nefrologia e Dialisi
  • Ospedale Civile; Divisione de Nefrologia E Dialisi
  • Ospedale Provinciale S. Maria delle Croci; Divisione Nefrologia e Dialsi
  • A.O. Santa Maria Nuova Di Reggio Emilia; Unita Operativa Di Nefrologia E Dialisi
  • Universita' Di Tor Vergata; Clinica Nefrologia Dialisi
  • A.O. Universitaria S. Martino Di Genova; Nefrologia
  • Ospedale Caduti Bollatesi; U.O. Nefrologia E Dialisi
  • ASST DI LECCO; Nefrologia e Dialisi
  • Presidio Ospedaliero Maggiore Policlinico Fondazione IRCCS; Pad Croff Div Nefrologia Dialisi
  • ASST SANTI PAOLO E CARLO; U.O.S. Nefrologia e Dialisi
  • ASST GRANDE OSPEDALE METROPOLITANO NIGUARDA; Dipartimento di Nefrologia e Dialisi
  • Fondazione Salvatore Maugeri; Divisione Di Nefrologia E Dialisi
  • ASST LARIANA; Divisione di Nefrologia e Dialisi
  • Azienda Ospedaliera San Salvatore; Divisione Nefrologia E Dialisi
  • Ospedale S. Marta S. Venera Nuovo; U.O. Nefrologia Dialisi
  • Azienda Ospedaliera Cannizzaro Unità Operativa Nefrologia
  • A.O.U. Policlinico G.Martino; U.O.C. Nefrologia e Dialisi
  • Presidio Ospedaliero Di Lodi; U.O. Nefrologia E Dialisi
  • Nuovo Ospedale Di Prato
  • Ospedale S. Giacomo; U.O. Di Nefrologia e Dialisi
  • Azienda Ospedaliera Sant'Anna Unità Operativa Complessa di Nefrologia Dialisi
  • P.O. Di Conegliano; U.O. Di Nefrologia E Dialisi
  • Az. Osp. Di Padova; U.O. Nefrologia 2 E Dialisi
  • Azienda Ospedaliera Santa Maria Misericordia; Divisione Nefrologia Dialisi
  • A.O. Cà Foncello; U.O.Nefrologia, Dialisi e Centro Trapianti
  • Seoul National Uni Hospital; Internal Medicine
  • Samsung Medical Center; Nephrology Department
  • Hospital of Lithuanian University of Health. Sciences Kaunas Clinics
  • Vilnius University Hospital Santariskiu Clinic, Nephrology Center
  • University Malaya Medical Centre; Division of Nephrology, Department of Medicine
  • Hospital Kuala Lumpur; Department of Medicine
  • Selayang Hospital; Dept of Medicine
  • Investigación Nefrológica S.C.
  • Centro Especializado San Fernando; Nefrología, Diálisis y Trasplante Renal
  • Cebu Doctors University Hospital
  • National Kidney and Transplant Institute
  • Akademia Medyczna; Klinika Nefrologii I Chorob Wewnetrznych
  • Specjalistyczny Szpital Wojewodzki w Ciechanowie; Oddzial Nefrologiczny
  • Fresenius Nephrocare Polska Sp zo.o.Centrum Dializ Fresenius Osrodek Dializ Nr 45 w Dabrowie Tarn
  • NZOZ Stacja Dializ Hand-Prod w Gorlicach
  • Fresenius Nephrocare Polska Sp zo.o. Centrum Dializ Fresenius Osrodek Dializ Nr 42 w Jasle
  • NZOZ Stacja Dializ Hand-Prod w Limanowej
  • Fresenius Nephrocare Polska Sp. z o.o., Centrum Dializ Fresenius, Osrodek Dializ nr 53 w Pabianicach
  • Fresenius Nephrocare Polska Sp. z o.o., Centrum Dializ Fresenius, Osrodek Dializ numer 71 w Poznaniu
  • Stacja Dializ NZOZ Centrum Medyczne MEDYK
  • Fresenius Nephrocare Polska Sp.zo.o.Centrum Dializ FreseniusOśrodek Dializ Nr 62 w Sandomierzu
  • Wojewodzki Szpital Zespolony, Stacja Dializ, Skierniewice
  • Powiatowy Szpital Specjalistyczny w Stalowej Woli; Oddział Nefrologii i Dializoterapii
  • Specjalistyczny Szpital im A.Sokołowskiego w Wałbrzychu; Oddzial Nefrologiczny
  • S.P. Szpital Wojewodzki im. Papieza Jana Pawla II
  • SBEI HPE "The First St.Petersburg State Medical University n.a. acad. I.P.Pavlova"of MoH of RF
  • SBEI of HPE "Northwestern State Medical University n.a. I.I.Mechnikov" of MoH of RF
  • St.Petersburg State Budget Institution of Healthcare "City Mariinskaya Hospital"
  • St.Petersburg State Budget Institution of Healthcare "City Hospital Saint Hosiomartyr Elisabeth".
  • Clinical Center of Serbia; Clinic of Urology
  • Clinical Hospital Center Zvezdara
  • Zemun Hospital; Nephrology
  • Clinical Center Nis; Clinic for Nephrology and Hemodialysis
  • Clinical Center Voivodina; Clinic for Immunology and Nephrology
  • National University Hospital; Dept of Medicine
  • Singapore General Hospital; Renal Medicine
  • Tan Tock Seng Hospital; Department of Renal Medicine
  • Hospital Txagorritxu; Servicio de Nefrologia
  • Complejo Hospitalario Torrecardenas; Servicio de Nefrologia
  • Hospital Severo Ochoa; Servicio de Nefrologia
  • Hospital Infanta Sofia; Servico de Nefrologia
  • Hospital de Navarra; Servicio de Nefrologia
  • Hospital de Cruces; Servicio de Nefrologia
  • Hospital de Basurto; Servicio de Nefrologia
  • Hospital de Galdakano; Servicio de Nefrologia
  • Hospital del Mar; Servicio de Nefrologia
  • Hospital Universitario San Cecilio
  • Complejo Hospitalario de Jaen- Hospital Universitario Medico Quirurgico
  • Hospital Ramon y Cajal; Servicio de Nefrologia
  • Hospital Clinico San Carlos; Servicio de Nefrologia
  • Danderyds Sjukhus; Dept. of Nephrology
  • Maelar Hospital; Department of Medicine
  • Uppsala University Hospital; Department of Internal Medicine, Nephrology Section
  • Chang Gung Medical Fundation Kaohsiung Branch; Nephrology
  • National Taiwan Uni Hospital; Nephrology Dept
  • King Chulalongkorn Memorial Hospital; Renal Unit, Department of Medicine
  • Maharaj Nakorn Chiang Mai Hospital; Dept. of Medicine, Renal Division
  • Buddhachinaraj Hospital Renal Division; Dept of Medicine
  • Cukurova University School of Medicine; Nefrology Department
  • Baskent University Hospital; Transplantation
  • Inonu Uni School of Medicine
  • Ulster Hospital; Nephrology
  • Belfast City Hospital; Nephrology Unit
  • St Luke'S Hospital; Renal Unit
  • University Hospital of Wales; Institute of Nephrology
  • St Helier Hospital; Renal Unit
  • University Hospital Coventry And Warwickshire Nhs Trust; Department Of Nephrology
  • Dorset County Hospital; Renal Unit
  • Royal Devon & Exeter Hospital; Dept of Nephrology
  • Hull Royal Infirmary; Renal Medicine
  • The Ipswich Hospital Nhs Trust; The Renal Unit
  • St James Uni Hospital; Renal Unit
  • Leicester General Hospital; Dept of Nephrology
  • Royal Free & University College Medical School; Centre for Nephrology
  • James Cook Hospital; Nephrology
  • Freeman Hospital; Nephrology
  • The Churchill; Oxford Kidney Unit
  • Derriford Hospital; Department Of Renal Medicine
  • Royal Preston Hospital; Department of Renal Medicine
  • Salford Royal Foundation Trust; Department Of Nephrology
  • Royal Shrewsbury Hospital
  • Morriston Hospital; Renal Medicine
  • Royal Cornwall Hospital; Renal Unit
  • Worthing Hospital; Renal Unit

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Experimental

Arm Label

Erythropoiesis Stimulating Agents

Methoxy Polyethylene Glycol-Epoetin Beta

Arm Description

Participants will receive reference ESA according to approved label. The approved reference ESA compounds in the study will be darbepoetin alfa, epoetin alfa and epoetin beta.

Participants not currently being treated with an ESA will receive methoxy polyethylene glycol-epoetin beta iv or sc once every 2 weeks for correction of renal anemia (target Hb 10-12 g/dL). Once corrected and in participants currently being treated with an ESA, methoxy polyethylene glycol-epoetin beta will be administered once monthly.

Outcomes

Primary Outcome Measures

Time to Composite of All-Cause Mortality and Non-Fatal Cardiovascular Events (Myocardial Infarction, Stroke) Defined as Time Between First Dose of Study Medication and Date of Death or Non-Fatal Cardiovascular Events, Whichever Occurred First

Secondary Outcome Measures

Time to All-Cause Mortality
Time to Non-Fatal and Fatal Myocardial Infarction
Time to Non-Fatal and Fatal Stroke
Time to Non-Fatal Cardiovascular Events (Myocardial Infarction or Stroke, Whichever Occurred First)
Percentage of Participants With Anti-Erythropoietin Antibody-Mediated Pure Red Cell Aplasia (PRCA)
Percentage of Participants With Gastrointestinal Bleeding
Percentage of Participants With Thromboembolic Events

Full Information

First Posted
October 15, 2008
Last Updated
August 16, 2019
Sponsor
Hoffmann-La Roche
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1. Study Identification

Unique Protocol Identification Number
NCT00773513
Brief Title
A Study to Assess All-Cause Mortality and Cardiovascular Morbidity in Participants With Chronic Kidney Disease (CKD) on Dialysis and Those Not on Renal Replacement Therapy Receiving Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) or Reference Erythropoietin Stimulating Agents (ESAs)
Official Title
A Randomized, Controlled, Open-Label, Multi-Centre, Parallel-Group Study To Assess All-Cause Mortality And Cardiovascular Morbidity In Patients With Chronic Kidney Disease On Dialysis And Those Not On Renal Replacement Therapy Under Treatment With MIRCERA® Or Reference ESAs.
Study Type
Interventional

2. Study Status

Record Verification Date
August 2019
Overall Recruitment Status
Completed
Study Start Date
December 12, 2008 (Actual)
Primary Completion Date
July 27, 2017 (Actual)
Study Completion Date
July 27, 2017 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Hoffmann-La Roche

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No

5. Study Description

Brief Summary
This 2 arm safety study will compare the outcome with respect to a composite endpoint of all-cause mortality and non-fatal cardiovascular events (myocardial infarction, stroke) in CKD participants either on dialysis or not receiving renal replacement therapy under treatment with methoxy polyethylene glycol-epoetin beta or reference ESAs. Participants will be randomized to receive intravenous (iv) or subcutaneous (sc) methoxy polyethylene glycol-epoetin beta at the following doses: for participants not already receiving ESA treatment, methoxy polyethylene glycol-epoetin beta will be administered at a starting dose of 0.6 micrograms per kilograms every 2 weeks (mcg/kg/2wks) iv or sc; for participants receiving maintenance ESA treatment, iv or sc methoxy polyethylene glycol-epoetin beta will be administered at an initial monthly dose of 120, 200 or 360 micrograms (mcg) depending on the weekly dose of ESA received prior to first methoxy polyethylene glycol-epoetin beta administration. Participants randomized to reference ESA treatment will receive iv or sc ESAs in accordance with their prescribed dosing information.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Chronic Renal Anemia

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 4
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
2825 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Erythropoiesis Stimulating Agents
Arm Type
Active Comparator
Arm Description
Participants will receive reference ESA according to approved label. The approved reference ESA compounds in the study will be darbepoetin alfa, epoetin alfa and epoetin beta.
Arm Title
Methoxy Polyethylene Glycol-Epoetin Beta
Arm Type
Experimental
Arm Description
Participants not currently being treated with an ESA will receive methoxy polyethylene glycol-epoetin beta iv or sc once every 2 weeks for correction of renal anemia (target Hb 10-12 g/dL). Once corrected and in participants currently being treated with an ESA, methoxy polyethylene glycol-epoetin beta will be administered once monthly.
Intervention Type
Drug
Intervention Name(s)
Darbepoetin Alfa
Other Intervention Name(s)
Aranesp®, Nespo®, Aranest®
Intervention Description
Darbepoetin alfa will be administered as per approved label.
Intervention Type
Drug
Intervention Name(s)
Epoetin Alfa
Other Intervention Name(s)
Eprex®, Epogen®, Epopen®, Erypo®
Intervention Description
Epoetin alfa will be administered as per approved label.
Intervention Type
Drug
Intervention Name(s)
Epoetin Beta
Other Intervention Name(s)
Neorecormon®, Recormon®
Intervention Description
Epoetin beta will be administered as per approved label.
Intervention Type
Drug
Intervention Name(s)
methoxy polyethylene glycol-epoetin beta
Other Intervention Name(s)
Mircera®
Intervention Description
Participants who are currently not being treated with an ESA will receive methoxy polyethylene glycol-epoetin beta administered at a starting dose of 0.6 mcg/kg body weight once every 2 weeks. Participants who are currently being treated with an ESA will receive methoxy polyethylene glycol-epoetin beta at a dose of 120, 200 or 360 mcg once monthly (based on ESA dose administered in Week -1)
Primary Outcome Measure Information:
Title
Time to Composite of All-Cause Mortality and Non-Fatal Cardiovascular Events (Myocardial Infarction, Stroke) Defined as Time Between First Dose of Study Medication and Date of Death or Non-Fatal Cardiovascular Events, Whichever Occurred First
Time Frame
Baseline up to approximately 8.5 years
Secondary Outcome Measure Information:
Title
Time to All-Cause Mortality
Time Frame
Baseline up to approximately 8.5 years
Title
Time to Non-Fatal and Fatal Myocardial Infarction
Time Frame
Baseline up to approximately 8.5 years
Title
Time to Non-Fatal and Fatal Stroke
Time Frame
Baseline up to approximately 8.5 years
Title
Time to Non-Fatal Cardiovascular Events (Myocardial Infarction or Stroke, Whichever Occurred First)
Time Frame
Baseline up to approximately 8.5 years
Title
Percentage of Participants With Anti-Erythropoietin Antibody-Mediated Pure Red Cell Aplasia (PRCA)
Time Frame
Baseline up to approximately 8.5 years
Title
Percentage of Participants With Gastrointestinal Bleeding
Time Frame
Baseline up to approximately 8.5 years
Title
Percentage of Participants With Thromboembolic Events
Time Frame
Baseline up to approximately 8.5 years

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Male or female participants with symptomatic anemia associated with CKD Participants with renal anemia who are not treated with an ESA: Anemia was defined as hemoglobin (Hb) concentration less than (<) 11.0 grams per deciliter (g/dL) (mean of 2 screening values with at least one day and a maximum of 2 weeks between measurements) with clinical indication for ESA treatment Participants with renal anemia who are on maintenance ESA therapy: If on dialysis: regular long-term hemodialysis or peritoneal dialysis therapy with the same mode of dialysis for at least 3 months before screening Hb concentration between 10 and 12 g/dL (mean of 2 screening values with at least one day and a maximum of 2 weeks between measurements) Participants with adequate iron status defined as: serum ferritin above or equal to 100 micrograms per liter or transferrin saturation above or equal to 20 percent Exclusion Criteria: Contraindications to ESA treatment: uncontrolled hypertension, hypersensitivity to the active substance or any of the excipients, any other contraindication to ESA therapy Conditions known to cause inadequate response to ESA treatment or anemia other than symptomatic anemia associated with CKD: History of hemoglobinopathy Anemia due to hemolysis Pure red cell aplasia High likelihood of early withdrawal (for example, within 1 year) or interruption of the study Pregnancy or breast-feeding Women of childbearing potential without effective contraception Administration of another investigational drug within 1 month before screening or planned during the study period
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Clinical Trials
Organizational Affiliation
Hoffmann-La Roche
Official's Role
Study Director
Facility Information:
Facility Name
Fresenius Medical Care Martinez
City
Buenos Aires
ZIP/Postal Code
1640
Country
Argentina
Facility Name
Fresenius Medical Care Morón
City
Buenos Aires
ZIP/Postal Code
1708
Country
Argentina
Facility Name
Fresenius Medical Care San Martin
City
Buenos Aires
ZIP/Postal Code
B1650IHM
Country
Argentina
Facility Name
Fresenuis Medical Care Mansilla
City
Caba
ZIP/Postal Code
1425
Country
Argentina
Facility Name
Gosford Hospital; Renal
City
Gosford
State/Province
New South Wales
ZIP/Postal Code
2250
Country
Australia
Facility Name
Renal Research Dr Simon Roger
City
Gosford
State/Province
New South Wales
ZIP/Postal Code
2250
Country
Australia
Facility Name
Cairns Hospital; Renal Services
City
Cairns
State/Province
Queensland
ZIP/Postal Code
4870
Country
Australia
Facility Name
Gold Coast Hospital Department of Pharmacology & Therapeutics
City
Southport
State/Province
Queensland
ZIP/Postal Code
4215
Country
Australia
Facility Name
ROYAL ADELAIDE HOSPITAL; Renal Clinical Trials, CNARTS
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Launceston General Hospital; Diabetes and Renal Research Unit
City
Launceston
State/Province
Tasmania
ZIP/Postal Code
7250
Country
Australia
Facility Name
Monash Medical Centre; Renal Transplant Unit
City
Clayton
State/Province
Victoria
ZIP/Postal Code
3186
Country
Australia
Facility Name
Royal Perth Hospital; Nephrology
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6847
Country
Australia
Facility Name
UZ Brussel
City
Brussel
ZIP/Postal Code
1090
Country
Belgium
Facility Name
UZ Gent
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
Jessa Zkh (Campus Virga Jesse)
City
Hasselt
ZIP/Postal Code
3500
Country
Belgium
Facility Name
UZ Leuven Gasthuisberg
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
AZ Delta (Campus Wilgenstraat)
City
Roeselare
ZIP/Postal Code
8800
Country
Belgium
Facility Name
Centro Mineiro de Pesquisa - CMIP
City
Juiz de Fora
State/Province
MG
ZIP/Postal Code
36036-330
Country
Brazil
Facility Name
PUCPR
City
Curitiba
State/Province
PR
ZIP/Postal Code
80050-350
Country
Brazil
Facility Name
Hospital Univ. Pedro Ernesto - Hupe; Nefrologia
City
Rio de Janeiro
State/Province
RJ
ZIP/Postal Code
20551-030
Country
Brazil
Facility Name
Santa Casa de Misericordia de Porto Alegre
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90020-090
Country
Brazil
Facility Name
Hospital Sao Lucas - PUCRS
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90610-000
Country
Brazil
Facility Name
Beneficencia Portuguesa de Sao Paulo
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
01323-900
Country
Brazil
Facility Name
Universidade Federal de Sao Paulo - UNIFESP
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
04038-002
Country
Brazil
Facility Name
Clinica de Medicina Interna e Nefrologia (CMIN)
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
05001-000
Country
Brazil
Facility Name
Hospital das Clinicas - FMUSP; Nefrologia
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
05403-000
Country
Brazil
Facility Name
Instituto de Hemodialise Sorocaba
City
Sorocaba
State/Province
SP
ZIP/Postal Code
18040-335
Country
Brazil
Facility Name
General Hospital Karlovac; Dept of Haemodialysis
City
Karlovac
ZIP/Postal Code
47000
Country
Croatia
Facility Name
Clinical Hospital Osijek; Dept of Haemodialysis
City
Osijek
ZIP/Postal Code
31000
Country
Croatia
Facility Name
Clinical Hospital Center Rijeka; Dialysis
City
Rijeka
ZIP/Postal Code
51000
Country
Croatia
Facility Name
General Hospital Josip Bencevic; Department of Haemodialysis
City
Slavonski Brod
ZIP/Postal Code
35000
Country
Croatia
Facility Name
Clinical Hospital Split; Dialysis
City
Split
ZIP/Postal Code
21000
Country
Croatia
Facility Name
General Hospital Zadar; Dialysis
City
Zadar
ZIP/Postal Code
23000
Country
Croatia
Facility Name
Klinicki Bolnicki Centar Zagreb; Dialysis
City
Zagreb
ZIP/Postal Code
10000
Country
Croatia
Facility Name
Fakultni Nemocnice Kralovske Vinohrady (FNKV); Interni Hematologicka Klinika
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Facility Name
Faculty Hospital; Dialysis Unit
City
Ostrava
ZIP/Postal Code
708 52
Country
Czechia
Facility Name
Nemocnice Strahov; Interni Oddeleni-Strahov
City
Praha 6
ZIP/Postal Code
169 00
Country
Czechia
Facility Name
Institut Klinicke A Experimentalni Mediciny Klinika Nefrologie
City
Praha
ZIP/Postal Code
140 21
Country
Czechia
Facility Name
Centre Hospitalier; Hemodialyse
City
Annonay
ZIP/Postal Code
07103
Country
France
Facility Name
Hopital Pellegrin; Departement Nephrologie
City
Bordeaux
ZIP/Postal Code
33076
Country
France
Facility Name
Centre Hospitalier Du Dr Duchenes; Service De Nephrologie & Hemodialyse
City
Boulogne
ZIP/Postal Code
62321
Country
France
Facility Name
Hopital La Cavale Blanche; Nephrologie
City
Brest
ZIP/Postal Code
29609
Country
France
Facility Name
Hopital Louis Pasteur; Nephrologie - Hemodialyse
City
Colmar
ZIP/Postal Code
68024
Country
France
Facility Name
Clinique Lambert; Service de Néphrologie dialyse
City
La Garenne-Colombes
ZIP/Postal Code
92250
Country
France
Facility Name
Chu Dupuytren; Nephrologie-Hemodialyse
City
Limoges
ZIP/Postal Code
87042
Country
France
Facility Name
Aural
City
Lyon
ZIP/Postal Code
69008
Country
France
Facility Name
Hopital Edouard-Herriot; Nephrologie - Hemodialyse
City
Lyon
ZIP/Postal Code
69437
Country
France
Facility Name
Centre Hospitalier Les Chanaux; Service de Néphrologie Unité 12
City
Macon
ZIP/Postal Code
71018
Country
France
Facility Name
Service de Nephrologie & D'Immunologie; Clinique
City
Nantes
ZIP/Postal Code
44035
Country
France
Facility Name
Centre Hospitalier Uni Ire Gaston Doumergue; Service D'Hemodialyse
City
Nimes
ZIP/Postal Code
30059
Country
France
Facility Name
Aura - Centre Henri Kunt Ziger
City
Paris
ZIP/Postal Code
75014
Country
France
Facility Name
Hopital Laennec; Echo
City
Saint Herblain
ZIP/Postal Code
44805
Country
France
Facility Name
Hopital Sud ; Nephrologie Hemodialyse
City
Salouel
ZIP/Postal Code
80480
Country
France
Facility Name
Hopital Civil; Nephrologie Clinique Medicale B
City
Strasbourg
ZIP/Postal Code
67091
Country
France
Facility Name
Hopital Rangueil; Nephrologie Hemodialyse
City
Toulouse
ZIP/Postal Code
31059
Country
France
Facility Name
Ch De Valenciennes; Nephrologie
City
Valenciennes
ZIP/Postal Code
59322
Country
France
Facility Name
Gemeinschaftspraxis Dr. Stefan Zinn und Steffen Hengst
City
Alsfeld
ZIP/Postal Code
36304
Country
Germany
Facility Name
KFH Nierenzentrum Bad Hersfeld; Nephrologie
City
Bad Hersfeld
ZIP/Postal Code
36251
Country
Germany
Facility Name
Universitätsklinikum Bonn; Medizinische Klinik und Poliklinik I; Allgemeine Innere Medizin
City
Bonn
ZIP/Postal Code
53127
Country
Germany
Facility Name
Dialysepraxis Dr. med. Uwe Kraatz
City
Demmin
ZIP/Postal Code
17109
Country
Germany
Facility Name
DaVita Clinical Research Deutschland GmbH
City
Düsseldorf
ZIP/Postal Code
40210
Country
Germany
Facility Name
Universitätsklinikum Duesseldorf; Klinik fuer Nephrologie
City
Düsseldorf
ZIP/Postal Code
40225
Country
Germany
Facility Name
Universitätsklinikum Erlangen; Medizinische Klinik 4; Nephrologie und Hypertensiologie
City
Erlangen
ZIP/Postal Code
91054
Country
Germany
Facility Name
Georg-Haas-Dialysezentrum der PHV
City
Gießen
ZIP/Postal Code
35392
Country
Germany
Facility Name
Nephrologische Schwerpunktpraxis; Hamburg Barmbek
City
Hamburg
ZIP/Postal Code
22297
Country
Germany
Facility Name
Klinikum Hann. Münden, Nephrologisches Zentrum Niedersachsen
City
Hann. Münden
ZIP/Postal Code
34346
Country
Germany
Facility Name
Uniklinikum Heidelberg
City
Heidelberg
ZIP/Postal Code
69120
Country
Germany
Facility Name
Universitaetsklinikum des Saarlandes; Klinik f. Innere Medizin IV
City
Homburg/Saar
ZIP/Postal Code
66424
Country
Germany
Facility Name
UNI-Klinikum Campus Kiel Klinik f.Innere Medizin IV
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Facility Name
KfH Kuratorium für Dialyse und Nierentransplantation e.V.; KfH-Nierenzentrum
City
München
ZIP/Postal Code
80804
Country
Germany
Facility Name
KFH Nierenzentrum Oberschleissheim
City
Oberschleissheim
ZIP/Postal Code
85764
Country
Germany
Facility Name
Dres. Roland Erwin Winkler Ann Michelsen Dietmar Sehland u.w.
City
Rostock
ZIP/Postal Code
18107
Country
Germany
Facility Name
Praxis Dr.med. Joachim Leicht
City
Schwandorf
ZIP/Postal Code
92421
Country
Germany
Facility Name
Robert-Bosch-Krankenhaus; Allgemeine Innere Medizin und Nephrologie
City
Stuttgart
ZIP/Postal Code
70376
Country
Germany
Facility Name
Uni Hospital of Alexandroupoli; Nephrology Dept.
City
Alexandroupolis
ZIP/Postal Code
68100
Country
Greece
Facility Name
Laiko General Hospital; Nephrology Div.
City
Athens
ZIP/Postal Code
115 27
Country
Greece
Facility Name
Uni Hospital of Ioannina; Nephrology Dept.
City
Ioannina
ZIP/Postal Code
455 00
Country
Greece
Facility Name
Univeristy Hospital of Larissa; Nephrology
City
Larissa
ZIP/Postal Code
41 110
Country
Greece
Facility Name
Hippokratio Hospital; Nefrology
City
Thessaloniki
ZIP/Postal Code
546 42
Country
Greece
Facility Name
Rabin MC- Belinson campus
City
Petach Tikva
ZIP/Postal Code
49100
Country
Israel
Facility Name
Rabin MC- Hasharon campus
City
Petah Tikva
ZIP/Postal Code
4937211
Country
Israel
Facility Name
Sheba MC; Nephrology
City
Ramat-Gan
ZIP/Postal Code
52621
Country
Israel
Facility Name
Sourasky MC; Dept. of Nephrology
City
Tel Aviv
ZIP/Postal Code
6423906
Country
Israel
Facility Name
Assaf-Harofeh MC; Nephrology
City
Zrifin
ZIP/Postal Code
70300
Country
Israel
Facility Name
Ospedale Bernardo Ramazzi; U.O. Di Nefrologia E Dialisi
City
Carpi
State/Province
Emilia-Romagna
ZIP/Postal Code
41012
Country
Italy
Facility Name
Ospedale Civile; Servizio Di Nefrologia E Dialisi
City
Imola
State/Province
Emilia-Romagna
ZIP/Postal Code
40026
Country
Italy
Facility Name
A.O. Universitaria Policlinico Di Modena; Nefrologia E Dialisi
City
Modena
State/Province
Emilia-Romagna
ZIP/Postal Code
41100
Country
Italy
Facility Name
Ospedale Maggiore; U.O.Complessa di Nefrologia e Dialisi
City
Parma
State/Province
Emilia-Romagna
ZIP/Postal Code
43100
Country
Italy
Facility Name
Ospedale Civile; Divisione de Nefrologia E Dialisi
City
Piacenza
State/Province
Emilia-Romagna
ZIP/Postal Code
29100
Country
Italy
Facility Name
Ospedale Provinciale S. Maria delle Croci; Divisione Nefrologia e Dialsi
City
Ravenna
State/Province
Emilia-Romagna
ZIP/Postal Code
48100
Country
Italy
Facility Name
A.O. Santa Maria Nuova Di Reggio Emilia; Unita Operativa Di Nefrologia E Dialisi
City
Reggio Emilia
State/Province
Emilia-Romagna
ZIP/Postal Code
42100
Country
Italy
Facility Name
Universita' Di Tor Vergata; Clinica Nefrologia Dialisi
City
Roma
State/Province
Lazio
ZIP/Postal Code
00100
Country
Italy
Facility Name
A.O. Universitaria S. Martino Di Genova; Nefrologia
City
Genova
State/Province
Liguria
ZIP/Postal Code
16132
Country
Italy
Facility Name
Ospedale Caduti Bollatesi; U.O. Nefrologia E Dialisi
City
Bollate
State/Province
Lombardia
ZIP/Postal Code
20021
Country
Italy
Facility Name
ASST DI LECCO; Nefrologia e Dialisi
City
Lecco
State/Province
Lombardia
ZIP/Postal Code
23900
Country
Italy
Facility Name
Presidio Ospedaliero Maggiore Policlinico Fondazione IRCCS; Pad Croff Div Nefrologia Dialisi
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20122
Country
Italy
Facility Name
ASST SANTI PAOLO E CARLO; U.O.S. Nefrologia e Dialisi
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20153
Country
Italy
Facility Name
ASST GRANDE OSPEDALE METROPOLITANO NIGUARDA; Dipartimento di Nefrologia e Dialisi
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20162
Country
Italy
Facility Name
Fondazione Salvatore Maugeri; Divisione Di Nefrologia E Dialisi
City
Pavia
State/Province
Lombardia
ZIP/Postal Code
27100
Country
Italy
Facility Name
ASST LARIANA; Divisione di Nefrologia e Dialisi
City
S Fermo Della Battaglia
State/Province
Lombardia
ZIP/Postal Code
22020
Country
Italy
Facility Name
Azienda Ospedaliera San Salvatore; Divisione Nefrologia E Dialisi
City
Pesaro
State/Province
Marche
ZIP/Postal Code
61100
Country
Italy
Facility Name
Ospedale S. Marta S. Venera Nuovo; U.O. Nefrologia Dialisi
City
Acireale
State/Province
Sicilia
ZIP/Postal Code
95024
Country
Italy
Facility Name
Azienda Ospedaliera Cannizzaro Unità Operativa Nefrologia
City
Catania
State/Province
Sicilia
ZIP/Postal Code
95126
Country
Italy
Facility Name
A.O.U. Policlinico G.Martino; U.O.C. Nefrologia e Dialisi
City
Messina
State/Province
Sicilia
ZIP/Postal Code
98147
Country
Italy
Facility Name
Presidio Ospedaliero Di Lodi; U.O. Nefrologia E Dialisi
City
Lodi
State/Province
Toscana
ZIP/Postal Code
26900
Country
Italy
Facility Name
Nuovo Ospedale Di Prato
City
Prato
State/Province
Toscana
ZIP/Postal Code
50047
Country
Italy
Facility Name
Ospedale S. Giacomo; U.O. Di Nefrologia e Dialisi
City
Castelfranco
State/Province
Veneto
ZIP/Postal Code
31033
Country
Italy
Facility Name
Azienda Ospedaliera Sant'Anna Unità Operativa Complessa di Nefrologia Dialisi
City
Cona (FE)
State/Province
Veneto
ZIP/Postal Code
44124
Country
Italy
Facility Name
P.O. Di Conegliano; U.O. Di Nefrologia E Dialisi
City
Conegliano
State/Province
Veneto
ZIP/Postal Code
31015
Country
Italy
Facility Name
Az. Osp. Di Padova; U.O. Nefrologia 2 E Dialisi
City
Padova
State/Province
Veneto
ZIP/Postal Code
35128
Country
Italy
Facility Name
Azienda Ospedaliera Santa Maria Misericordia; Divisione Nefrologia Dialisi
City
Rovigo
State/Province
Veneto
ZIP/Postal Code
45100
Country
Italy
Facility Name
A.O. Cà Foncello; U.O.Nefrologia, Dialisi e Centro Trapianti
City
Treviso
State/Province
Veneto
ZIP/Postal Code
31100
Country
Italy
Facility Name
Seoul National Uni Hospital; Internal Medicine
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Facility Name
Samsung Medical Center; Nephrology Department
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Facility Name
Hospital of Lithuanian University of Health. Sciences Kaunas Clinics
City
Kaunas
ZIP/Postal Code
50009
Country
Lithuania
Facility Name
Vilnius University Hospital Santariskiu Clinic, Nephrology Center
City
Vilnius
ZIP/Postal Code
08661
Country
Lithuania
Facility Name
University Malaya Medical Centre; Division of Nephrology, Department of Medicine
City
Kuala Lumpur
State/Province
FED. Territory OF Kuala Lumpur
ZIP/Postal Code
50603
Country
Malaysia
Facility Name
Hospital Kuala Lumpur; Department of Medicine
City
Kuala Lumpur
ZIP/Postal Code
50586
Country
Malaysia
Facility Name
Selayang Hospital; Dept of Medicine
City
Selangor
ZIP/Postal Code
68100
Country
Malaysia
Facility Name
Investigación Nefrológica S.C.
City
Cuernavaca
State/Province
Morelos
ZIP/Postal Code
62448
Country
Mexico
Facility Name
Centro Especializado San Fernando; Nefrología, Diálisis y Trasplante Renal
City
Panama
ZIP/Postal Code
0834-02723
Country
Panama
Facility Name
Cebu Doctors University Hospital
City
CEBU City
ZIP/Postal Code
6000
Country
Philippines
Facility Name
National Kidney and Transplant Institute
City
Quezon City
ZIP/Postal Code
1100
Country
Philippines
Facility Name
Akademia Medyczna; Klinika Nefrologii I Chorob Wewnetrznych
City
Bydgoszcz
ZIP/Postal Code
85-094
Country
Poland
Facility Name
Specjalistyczny Szpital Wojewodzki w Ciechanowie; Oddzial Nefrologiczny
City
Ciechanow
ZIP/Postal Code
06-400
Country
Poland
Facility Name
Fresenius Nephrocare Polska Sp zo.o.Centrum Dializ Fresenius Osrodek Dializ Nr 45 w Dabrowie Tarn
City
Dabrowa Tarnowska
ZIP/Postal Code
33-200
Country
Poland
Facility Name
NZOZ Stacja Dializ Hand-Prod w Gorlicach
City
Gorlice
ZIP/Postal Code
38-300
Country
Poland
Facility Name
Fresenius Nephrocare Polska Sp zo.o. Centrum Dializ Fresenius Osrodek Dializ Nr 42 w Jasle
City
Jaslo
ZIP/Postal Code
38-200
Country
Poland
Facility Name
NZOZ Stacja Dializ Hand-Prod w Limanowej
City
Limanowa
ZIP/Postal Code
34-600
Country
Poland
Facility Name
Fresenius Nephrocare Polska Sp. z o.o., Centrum Dializ Fresenius, Osrodek Dializ nr 53 w Pabianicach
City
Pabianice
ZIP/Postal Code
95-200
Country
Poland
Facility Name
Fresenius Nephrocare Polska Sp. z o.o., Centrum Dializ Fresenius, Osrodek Dializ numer 71 w Poznaniu
City
Poznan
ZIP/Postal Code
61-485
Country
Poland
Facility Name
Stacja Dializ NZOZ Centrum Medyczne MEDYK
City
Rzeszow
ZIP/Postal Code
35-055
Country
Poland
Facility Name
Fresenius Nephrocare Polska Sp.zo.o.Centrum Dializ FreseniusOśrodek Dializ Nr 62 w Sandomierzu
City
Sandomierz
ZIP/Postal Code
27-600
Country
Poland
Facility Name
Wojewodzki Szpital Zespolony, Stacja Dializ, Skierniewice
City
Skierniewice
ZIP/Postal Code
96-100
Country
Poland
Facility Name
Powiatowy Szpital Specjalistyczny w Stalowej Woli; Oddział Nefrologii i Dializoterapii
City
Stalowa Wola
ZIP/Postal Code
37-450
Country
Poland
Facility Name
Specjalistyczny Szpital im A.Sokołowskiego w Wałbrzychu; Oddzial Nefrologiczny
City
Walbrzych
ZIP/Postal Code
58-309
Country
Poland
Facility Name
S.P. Szpital Wojewodzki im. Papieza Jana Pawla II
City
Zamosc
ZIP/Postal Code
22-400
Country
Poland
Facility Name
SBEI HPE "The First St.Petersburg State Medical University n.a. acad. I.P.Pavlova"of MoH of RF
City
Sankt-peterburg
State/Province
Leningrad
ZIP/Postal Code
197022
Country
Russian Federation
Facility Name
SBEI of HPE "Northwestern State Medical University n.a. I.I.Mechnikov" of MoH of RF
City
Saint-Petersburg
ZIP/Postal Code
195067
Country
Russian Federation
Facility Name
St.Petersburg State Budget Institution of Healthcare "City Mariinskaya Hospital"
City
St.Petersburg
ZIP/Postal Code
191104
Country
Russian Federation
Facility Name
St.Petersburg State Budget Institution of Healthcare "City Hospital Saint Hosiomartyr Elisabeth".
City
St.Petersburg
ZIP/Postal Code
195257
Country
Russian Federation
Facility Name
Clinical Center of Serbia; Clinic of Urology
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Clinical Hospital Center Zvezdara
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Zemun Hospital; Nephrology
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Clinical Center Nis; Clinic for Nephrology and Hemodialysis
City
NIS
ZIP/Postal Code
18000
Country
Serbia
Facility Name
Clinical Center Voivodina; Clinic for Immunology and Nephrology
City
Novi Sad
ZIP/Postal Code
21000
Country
Serbia
Facility Name
National University Hospital; Dept of Medicine
City
Singapore
ZIP/Postal Code
117599
Country
Singapore
Facility Name
Singapore General Hospital; Renal Medicine
City
Singapore
ZIP/Postal Code
169608
Country
Singapore
Facility Name
Tan Tock Seng Hospital; Department of Renal Medicine
City
Singapore
ZIP/Postal Code
308433
Country
Singapore
Facility Name
Hospital Txagorritxu; Servicio de Nefrologia
City
Vitoria
State/Province
Alava
ZIP/Postal Code
01009
Country
Spain
Facility Name
Complejo Hospitalario Torrecardenas; Servicio de Nefrologia
City
Almería
State/Province
Almeria
ZIP/Postal Code
04009
Country
Spain
Facility Name
Hospital Severo Ochoa; Servicio de Nefrologia
City
Leganes
State/Province
Madrid
ZIP/Postal Code
28911
Country
Spain
Facility Name
Hospital Infanta Sofia; Servico de Nefrologia
City
San Sebastian de los Reyes
State/Province
Madrid
ZIP/Postal Code
28702
Country
Spain
Facility Name
Hospital de Navarra; Servicio de Nefrologia
City
Pamplona
State/Province
Navarra
ZIP/Postal Code
31008
Country
Spain
Facility Name
Hospital de Cruces; Servicio de Nefrologia
City
Barakaldo
State/Province
Vizcaya
ZIP/Postal Code
48903
Country
Spain
Facility Name
Hospital de Basurto; Servicio de Nefrologia
City
Bilbao
State/Province
Vizcaya
ZIP/Postal Code
48013
Country
Spain
Facility Name
Hospital de Galdakano; Servicio de Nefrologia
City
Galdakao
State/Province
Vizcaya
ZIP/Postal Code
48960
Country
Spain
Facility Name
Hospital del Mar; Servicio de Nefrologia
City
Barcelona
ZIP/Postal Code
08003
Country
Spain
Facility Name
Hospital Universitario San Cecilio
City
Granada
ZIP/Postal Code
18012
Country
Spain
Facility Name
Complejo Hospitalario de Jaen- Hospital Universitario Medico Quirurgico
City
Jaen
ZIP/Postal Code
23007
Country
Spain
Facility Name
Hospital Ramon y Cajal; Servicio de Nefrologia
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Facility Name
Hospital Clinico San Carlos; Servicio de Nefrologia
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Danderyds Sjukhus; Dept. of Nephrology
City
Danderyd
ZIP/Postal Code
18288
Country
Sweden
Facility Name
Maelar Hospital; Department of Medicine
City
Eskilstuna
ZIP/Postal Code
63188
Country
Sweden
Facility Name
Uppsala University Hospital; Department of Internal Medicine, Nephrology Section
City
Uppsala
ZIP/Postal Code
75185
Country
Sweden
Facility Name
Chang Gung Medical Fundation Kaohsiung Branch; Nephrology
City
Kaohsiung
ZIP/Postal Code
833
Country
Taiwan
Facility Name
National Taiwan Uni Hospital; Nephrology Dept
City
Taipei
ZIP/Postal Code
100
Country
Taiwan
Facility Name
King Chulalongkorn Memorial Hospital; Renal Unit, Department of Medicine
City
Bangkok
ZIP/Postal Code
10310
Country
Thailand
Facility Name
Maharaj Nakorn Chiang Mai Hospital; Dept. of Medicine, Renal Division
City
Chiang Mai
ZIP/Postal Code
50200
Country
Thailand
Facility Name
Buddhachinaraj Hospital Renal Division; Dept of Medicine
City
Phitsanulok
ZIP/Postal Code
65000
Country
Thailand
Facility Name
Cukurova University School of Medicine; Nefrology Department
City
Adana
ZIP/Postal Code
01100
Country
Turkey
Facility Name
Baskent University Hospital; Transplantation
City
Ankara
ZIP/Postal Code
06490
Country
Turkey
Facility Name
Inonu Uni School of Medicine
City
Malatya
ZIP/Postal Code
44300
Country
Turkey
Facility Name
Ulster Hospital; Nephrology
City
Belfast
ZIP/Postal Code
BT16 1RH
Country
United Kingdom
Facility Name
Belfast City Hospital; Nephrology Unit
City
Belfast
ZIP/Postal Code
BT9 7LJ
Country
United Kingdom
Facility Name
St Luke'S Hospital; Renal Unit
City
Bradford
ZIP/Postal Code
BD5 0NA
Country
United Kingdom
Facility Name
University Hospital of Wales; Institute of Nephrology
City
Cardiff
ZIP/Postal Code
CF14 4XW
Country
United Kingdom
Facility Name
St Helier Hospital; Renal Unit
City
Carshalton
ZIP/Postal Code
SM5 1AA
Country
United Kingdom
Facility Name
University Hospital Coventry And Warwickshire Nhs Trust; Department Of Nephrology
City
Coventry
ZIP/Postal Code
CV2 2DX
Country
United Kingdom
Facility Name
Dorset County Hospital; Renal Unit
City
Dorchester
ZIP/Postal Code
DT1 1TS
Country
United Kingdom
Facility Name
Royal Devon & Exeter Hospital; Dept of Nephrology
City
Exeter
ZIP/Postal Code
EX2 5DW
Country
United Kingdom
Facility Name
Hull Royal Infirmary; Renal Medicine
City
Hull
ZIP/Postal Code
HU3 2JZ
Country
United Kingdom
Facility Name
The Ipswich Hospital Nhs Trust; The Renal Unit
City
Ipswich
ZIP/Postal Code
IP4 5PD
Country
United Kingdom
Facility Name
St James Uni Hospital; Renal Unit
City
Leeds
ZIP/Postal Code
LS9 7TF
Country
United Kingdom
Facility Name
Leicester General Hospital; Dept of Nephrology
City
Leicester
ZIP/Postal Code
LE5 4PW
Country
United Kingdom
Facility Name
Royal Free & University College Medical School; Centre for Nephrology
City
London
ZIP/Postal Code
NW3 2PF
Country
United Kingdom
Facility Name
James Cook Hospital; Nephrology
City
Middlesborough
ZIP/Postal Code
TS4 3BW
Country
United Kingdom
Facility Name
Freeman Hospital; Nephrology
City
Newcastle Upon Tyne
ZIP/Postal Code
NE7 7DN
Country
United Kingdom
Facility Name
The Churchill; Oxford Kidney Unit
City
Oxford
ZIP/Postal Code
OX3 7LJ
Country
United Kingdom
Facility Name
Derriford Hospital; Department Of Renal Medicine
City
Plymouth
ZIP/Postal Code
PL6 8DH
Country
United Kingdom
Facility Name
Royal Preston Hospital; Department of Renal Medicine
City
Preston
ZIP/Postal Code
PR2 9HT
Country
United Kingdom
Facility Name
Salford Royal Foundation Trust; Department Of Nephrology
City
Salford
ZIP/Postal Code
M6 8HD
Country
United Kingdom
Facility Name
Royal Shrewsbury Hospital
City
Shrewsbury
ZIP/Postal Code
SY3 8XQ
Country
United Kingdom
Facility Name
Morriston Hospital; Renal Medicine
City
Swansea
ZIP/Postal Code
SA6 6NL
Country
United Kingdom
Facility Name
Royal Cornwall Hospital; Renal Unit
City
Truro
ZIP/Postal Code
TR1 3LJ
Country
United Kingdom
Facility Name
Worthing Hospital; Renal Unit
City
West Sussex
ZIP/Postal Code
BN11 2DH
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
31420350
Citation
Locatelli F, Hannedouche T, Fishbane S, Morgan Z, Oguey D, White WB. Cardiovascular Safety and All-Cause Mortality of Methoxy Polyethylene Glycol-Epoetin Beta and Other Erythropoiesis-Stimulating Agents in Anemia of CKD: A Randomized Noninferiority Trial. Clin J Am Soc Nephrol. 2019 Dec 6;14(12):1701-1710. doi: 10.2215/CJN.01380219. Epub 2019 Aug 16.
Results Reference
derived

Learn more about this trial

A Study to Assess All-Cause Mortality and Cardiovascular Morbidity in Participants With Chronic Kidney Disease (CKD) on Dialysis and Those Not on Renal Replacement Therapy Receiving Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) or Reference Erythropoietin Stimulating Agents (ESAs)

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