A Study to Compare the Safety and Effectiveness of 2 Doses of Levofloxacin Given for Different Time Periods in Patients With Pneumonia
Pneumonia
About this trial
This is an interventional treatment trial for Pneumonia focused on measuring respiratory tract diseases, pneumonia, levofloxacin, community-acquired pneumonia, lung diseases, quinolones
Eligibility Criteria
Inclusion Criteria: Diagnosis of community-acquired pneumonia as follows: clinical signs and symptoms of a lower respiratory tract infection and chest-x-ray findings consistent with pneumonia within 24 hours before entry into the study At least one of the following: abnormal temperature (high or low) or abnormal white blood cell count Previous antibiotic treatment <= 24 hours or, if the duration of treatment was >= 72 hours and that therapy failed based on at least 2 of the following: fever within 12 hours of entry into the study, chest x-ray findings have worsened compared to the initial chest-x-ray, white blood cell count is significantly increased, respiratory rate higher than at the start of treatment and >= 20 breaths per minute or need for supplemental oxygen if not previously needed Patients whose infection is acquired in the community or, if in a nursing home, who had been living there < 14 days Fine Class (rating scale used to assess patients' overall condition which includes information such as age, gender, other diseases, physical examination and laboratory findings) score <= 130 upon admission (patients with Fine Class scores > 70 but < = 130 must initially be hospitalized Patients with scores of <= 70 may be treated as outpatients or hospitalized at the discretion of the investigator) Exclusion Criteria: Pneumonia known or suspected to be due to a bacteria resistant to levofloxacin Previous allergic or serious reaction to or failed therapy with levofloxacin or similar drugs Life expectancy < 72 hours Hospitalized within 2 weeks before entry in the study or within 1 month before entry in the study if treated with antibiotics Pneumonia acquired in a hospital Cystic fibrosis or other lung disorders Receiving chronic steroid treatment Received assistance from a machine to breathe within the previous month