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A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205

Primary Purpose

Alzheimer's Disease

Status
Active
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Aducanumab
Sponsored by
Biogen
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Alzheimer's Disease

Eligibility Criteria

50 Years - 90 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Key Inclusion Criteria:

Core Treatment Period:

  • Participant was participating in an aducanumab clinical study at the time of the announcement of early termination (feeder studies).
  • Has one care partner who, in the Investigator's opinion, has adequate contact with the participant as to be able to provide accurate information about the participant's cognitive and functional abilities.

LTE Treatment Period:

  • Participant must have completed the Core study period (Week 102) and adequately tolerated 10 mg/kg of aducanumab during the Core study period in the opinion of the Investigator.
  • Has one informant/care partner who, in the Investigator's opinion, has frequent and sufficient contact with the participant as to be able to provide accurate information about the participant's cognitive and functional abilities.

Key Exclusion Criteria:

Core Treatment Period:

  • Any medical or neurological condition (other than Alzheimer's Disease) that might be a contributing cause of the participant's cognitive impairment.
  • Stroke or any unexplained loss of consciousness within 1 year prior to Screening.
  • Clinically significant unstable psychiatric illness in past 6 months.
  • History of unstable angina, myocardial infarction, advanced chronic heart failure, or clinically significant conduction abnormalities within 1 year prior to Screening.
  • A seizure event that occurred after the last visit of the feeder study and before Screening for this study.
  • Evidence of impaired liver function as shown by an abnormal liver function profile at Screening.
  • History of or known seropositivity for HIV.
  • Clinically significant systemic illness or serious infection within 30 days prior to or during Screening.
  • Contraindications to having a brain magnetic resonance imaging (MRI).

LTE Treatment Period:

  • Any medical or psychiatric contraindication or clinically significant abnormality that, in the opinion of the Investigator, will substantially increase the risk associated with the participant's enrollment in and completion of the study.

Note- Other protocol defined Inclusion/Exclusion criteria may apply.

Sites / Locations

  • University of Alabama at Birmingham
  • Banner Alzheimer's Institute
  • Dignity Health
  • Banner Sun Health Research Institute
  • Center for Neurosciences
  • Neurology Center of North Orange County
  • UCI MIND
  • University of California San Diego Medical Center
  • Senior Clinical Trials, Inc.
  • USC Keck School of Medicine
  • Mary S. Easton Center for Alzheimer's Disease Research, UCLA
  • Pacific Neuroscience Medical Group
  • Stanford Hospital and Clinics
  • Anderson Clinical Research
  • Pacific Research Network, Inc
  • UCSF - Memory and Aging Center
  • Syrentis Clinical Research
  • California Neuroscience Research Medical Group Inc.
  • University of Colorado Denver
  • IMMUNOe International Research Centers
  • Yale University
  • Invicro
  • Yale University School Of Medicine
  • Research Center for Clinical Studies, Inc.
  • Georgetown University Clinical Research Unit (CRU)
  • JEM Research
  • Bradenton Research Center, Inc
  • Brain Matters Research
  • Neuropsychiatric Research Center of Southwest Florida
  • Infinity Clinical Research, LLC
  • Jacksonville Center for Clinical Research
  • Mayo Clinic in Florida
  • University of Miami
  • Miami Jewish Health System, Inc
  • Renstar Medical Research
  • Accelerated Enrollment Solutions (AES)
  • Clinical Neuroscience Solutions, Inc.
  • Accelerated Enrollment Solutions (AES)
  • Palm Beach Neurological Center
  • Quantum Laboratories Inc.
  • Axiom Clinical Research of Florida
  • Stedman Clinical Trials, LLC
  • USF Health Byrd Institute
  • Meridien Research
  • Premiere Research Institute
  • Cleveland Clinic Florida - Weston
  • Emory University Cognitive Neurology Clinic & ADRC
  • Medical Research Health and Education Foundation, Inc
  • NeuroStudies.net, LLC
  • Alexian Brothers Medical Center - Neuroscience Research Institute
  • Advocate Lutheran General Hospital
  • Fort Wayne Neurological Center
  • Indiana University School of Medicine
  • Josephson, Wallack, Munshower Neurology, P.C.
  • University of Kansas Medical Center Research Institute, Inc.
  • Ascension Via Christi Research, a division of Ascension Via Christi Hospitals Wichita, Inc.
  • Baptist Health Lexington
  • McLean Hospital
  • Beth Israel Deaconess Medical Center
  • Brigham and Women's Hospital Department of Neurology
  • ActivMed Practices & Research, Inc.
  • Boston Center for Memory
  • Donald S. Marks, M.D., P.C.
  • Mayo Clinic
  • Hattiesburg Clinic, PA
  • Washington University
  • Cleveland Clinic Lou Ruvo Center for Brain Health
  • Las Vegas Medical Research
  • ActivMed Practices & Research, Inc.
  • Advanced Memory Research Inst. of NJ, PC
  • Albany Medical College
  • Empire Neurology, PC
  • New York University Medical Center PRIME
  • Weill Cornell Medical College (WCMC) - Judith Jaffe Multiple Sclerosis Center (JJMSC)
  • Mount Sinai School of Medicine
  • University of Rochester
  • AMC Research, LLC
  • Raleigh Neurology Associates
  • Gastroenterology Associates of the Piedmont
  • Wake Forest Baptist Health
  • Cleveland Clinic Foundation
  • Ohio State University Wexner Medical Center
  • Lynn Health Science Institute
  • Lehigh Center for Clinical Research, LLC
  • The Clinical Trial Center, LLC
  • Penn Memory Center
  • University of Pittsburgh
  • Northeastern Pennsylvania Memory and Alzheimer's Center
  • Rhode Island Mood & Memory Research Institute
  • Rhode Island Hospital
  • Butler Hospital
  • Roper St. Francis Healthcare
  • Medical University of South Carolina (MUSC)
  • Neurology Clinic, PC
  • Senior Adult Specialty Research
  • UT Southwestern Medical Center
  • Baylor College of Medicine
  • Clinical Trial Network
  • University of Utah Health Sciences Center
  • The Memory Clinic
  • National Clinical Research Inc.-Richmond
  • University of Washington Medical Centre
  • Kingfisher Cooperative, LLC
  • Medical College of Wisconsin, Inc.
  • The Prince Charles Hospital
  • St Vincent's Hospital Sydney
  • Central Coast Neurosciences Research (Erina)
  • KaRa Institute of Neurological Diseases
  • Box Hill Hospital
  • Austin Health
  • Royal Melbourne Hospital
  • Australian Alzheimer's Research Foundation
  • LKH - Universitaetsklinikum Graz
  • Christian-Doppler-Klinik - Universitätsklinikum Salzburg
  • AKH - Medizinische Universität Wien
  • AZ Klina
  • AZ Sint-Jan
  • Universitair Ziekenhuis Brussel
  • Universitair Ziekenhuis Gent
  • AZ Groeninge
  • UZ Leuven
  • AZ Delta
  • University of Calgary - Heritage Medical Research Clinic
  • The Medical Arts Health Research Group
  • The Medical Arts Health Research Group
  • UBC Hospital
  • Medical Arts Health Research Group
  • True North Clinical Research - Halifax Inc.
  • True North Clinical Research
  • St. Joseph's HC- Parkwood Institute
  • Bruyere Continuing Care
  • Kawartha Centre - Redefining Healthy Aging
  • Toronto Memory Program (Neurology Research Inc.)
  • Toronto Sunnybrook Hospital
  • Toronto Western Hospital
  • Clinique de la Memoire de l'Outaouais
  • Institut et Clinique MoCA
  • Montreal Neurological Institute Clinical Research Unit
  • CHU de Quebec - Hôpital de l' Enfant Jésus
  • CCBR - Ålborg - DK
  • Danish Dementia Research Centre
  • CCBR - Vejle - DK
  • Terveystalo Ruoholahti
  • Itä-Suomen yliopisto, Aivotutkimusyksikkö
  • CRST, Clinical Research Services Turku
  • CHU Strasbourg - Hôpital Hautepierre
  • Hôpital de la Timone
  • Groupe Hospitalier Pellegrin - Hôpital Pellegrin
  • Hopital Purpan
  • Hôpital La Grave
  • Hopital Gui de Chauliac
  • CHU Rennes - Pontchaillou
  • CHU Nantes - Hopital Nord Laënnec
  • CHU Reims - Hôpital Maison Blanche
  • CHU Lille - Hopital Roger Salengro
  • Hôpital Lariboisière
  • CHU de Lyon - Hopital Neurologique Pierre Wertheimer
  • Hôpital des Chapennes
  • Groupe Hospitalier Pitie-Salpetriere
  • Hôpital Broca
  • Studienzentrum fur Neurologie und Psychiatrie
  • ISPG - Institut fuer Studien zur Psychischen Gesundheit
  • mind mvz GmbH
  • Neuropoint Studienzentrum
  • Universitaetsklinikum Ulm
  • Klinikum Bayreuth GmbH- Hohe Warte
  • Bezirkskrankenhaus Guenzburg
  • Klinikum rechts der Isar der TU Muenchen
  • Institut fuer Schlaganfall- und Demenzforschung (ISD)
  • Neuropraxis Muenchen Sued
  • Neuro Centrum Science GmbH, Geschaftführende Gesellschafterin Barbara Unsorg und Prüfarzt Dr. med. G
  • Neurologische Gemeinschaftspraxis Kassel
  • Klinische Forschung Hannover-Mitte GmbH
  • Universitaetsklinikum Aachen AOeR
  • Neurozentrum Bielefeld
  • Universitaetsklinikum Duesseldorf AoeR
  • Universitaetsklinikum Koeln
  • Zentrum f. Neurologisch- Psychiatrische Studien und Begutachtung
  • Klinikum Altenburger Land GmbH
  • Emovis GmbH
  • Neurologie im Tempelhofer Hafen
  • Charite Universitaetsmedizin Berlin - Campus Berlin Buch
  • Ospedale degli Infermi
  • Azienda Ospedaliera Card. G. Panico
  • ASST di Monza
  • Fondazione Istituto G.Giglio di Cefalù
  • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
  • Azienda Ospedaliero Universitaria San Martino
  • Ospedale San Raffaele
  • Fondazione IRCCS Istituto Neurologico Carlo Besta
  • AOU dell'Università degli studi della Campania Luigi Vanvitelli
  • Azienda Ospedaliera e Universitaria di Perugia
  • Azienda Ospedaliero Universitaria Pisana
  • Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza
  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS
  • Fondazione Santa Lucia IRCCS
  • Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona
  • A.O.U. Senese Policlinico Santa Maria alle Scotte
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  • Inha University Hospital
  • Seoul National University Bundang Hospital
  • Gachon University Gil Medical Center
  • Konkuk University Medical Center
  • Asan Medical Center
  • Samsung Medical Center
  • Brain Research Center
  • Amphia Ziekenhuis, Molengracht
  • Erasmus Medisch Centrum
  • Podlaskie Centrum Psychogeriatrii
  • PALLMED Sp. z o.o.
  • Klinika Psychiatrii Doroslych UCK
  • Novo-Med Zielinski i wspolnicy Sp. j.
  • SPZOZ Centralny Szpital Kliniczny UM w Lodzi
  • Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie
  • NZOZ "NEURO-KARD", "Ilkowski i Partnerzy" Sp. Partn. Lek.
  • Neuro-Care Gabriela Klodowska
  • Centrum Medyczne Senior
  • Osrodek Badan Klinicznych EUROMEDIS
  • Centrum Medyczne NeuroProtect
  • NZOZ Wroclawskie Centrum Alzheimerowskie
  • Hospital de Braga
  • Centro Hospitalar e Universitário de Coimbra E.P.E - Hospitais da Universidade de Coimbra
  • Hospital Beatriz Ângelo
  • CNS-Campus Neurologico Senior
  • Hospital General Universitario de Elche
  • Hospital Universitario Reina Sofia
  • Policlinica Gipuzkoa
  • Clinica Universidad de Navarra
  • CAE Oroitu
  • Hospital del Mar
  • Hospital de la Santa Creu i Sant Pau
  • Fundacio ACE
  • Hospital Clinic de Barcelona
  • Hospital Universitari de Santa Maria
  • Complejo Hospitalario Ruber Juan Bravo
  • Hospital Victoria Eugenia
  • Hospital Universitario Dr. Peset
  • Hospital Universitari i Politecnic La Fe
  • Skånes Universitetssjukhus
  • Sahlgrenska Universitetssjukhuset, Mölndal Sjukhus
  • Karolinska Universitetssjukhuset, Huddinge
  • Akademiska Sjukhuset
  • Spitalzentrum Biel
  • Hôpitaux Universitaires de Geneve- HUG
  • Centre Hospitalier Universitaire Vaudois
  • Ospedale Regionale di Lugano
  • Institut fur Regenerative Medizin-IREM Universitat Zurich, Campus Schlieren
  • Changhua Christian Medical Foundation Changhua Christian Hospital
  • Kaohsiung Chang Gung Memorial Hospital
  • National Cheng Kung University Hospital
  • Taipei Veterans General Hospital
  • Chang Gung Memorial Hospital, Linkou
  • Re:Cognition Health Ltd (London)
  • Charing Cross Hospital
  • The National Hospital for Neurology and Neurosurgery Centre
  • Manchester Royal Infirmary
  • The University of Edinburgh
  • The RICE Centre
  • Queen Elizabeth University Hospital Campus
  • Glasgow Memory Clinic Ltd
  • Ninewells Hospital
  • Newcastle University

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

Aducanumab

Arm Description

Participants will be administered aducanumab 10 milligrams per kilogram (mg/kg) by intravenous (IV) infusions every four weeks (Q4W) for a duration of 100 weeks during the Core Treatment Period. Eligible participants will continue to receive aducanumab 10 mg/kg IV infusion, Q4W, for 52 weeks during the Long-Term Extension (LTE) Treatment Period.

Outcomes

Primary Outcome Measures

Core Treatment Period: Number of Participants with Adverse Events (AEs) and Serious Adverse Events (SAEs)
An AE is any untoward medical occurrence in a participant or clinical investigation participant administered a pharmaceutical product and that does not necessarily have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not related to the medicinal (investigational) product. A SAE is any untoward medical occurrence that at any dose results in death, life-threatening event, requires inpatient hospitalization, significant disability/incapacity or congenital anomaly.
Core Treatment Period: Number of Participants with AEs Leading to Treatment Discontinuation or Study Withdrawal
An AE is any untoward medical occurrence in a participant or clinical investigation participant administered a pharmaceutical product and that does not necessarily have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not related to the medicinal (investigational) product.
Core Treatment Period: Number of Participants with Amyloid-related Imaging Abnormality-Edema (ARIA-E)
Magnetic resonance imaging (MRI) readings will be used to assess ARIA-E severity as mild, moderate and severe.
Core Treatment Period: Number of Participants with Amyloid-related Imaging Abnormality- Hemorrhage or Superficial Siderosis (ARIA-H)
MRI readings will be used to assess severity of ARIA-H microhemorrhages and superficial siderosis.
Core Treatment Period: Number of Participants With Antidrug Antibodies (ADAs) in Serum
Presence of serum ADAs will be determined using a validated assay.

Secondary Outcome Measures

Full Information

First Posted
January 22, 2020
Last Updated
April 13, 2023
Sponsor
Biogen
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1. Study Identification

Unique Protocol Identification Number
NCT04241068
Brief Title
A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205
Official Title
Phase 3b Open-Label, Multicenter, Safety Study of BIIB037 (Aducanumab) in Subjects With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205
Study Type
Interventional

2. Study Status

Record Verification Date
April 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
March 2, 2020 (Actual)
Primary Completion Date
October 20, 2023 (Anticipated)
Study Completion Date
February 3, 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Biogen

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Product Manufactured in and Exported from the U.S.
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The primary objective is to evaluate the safety and tolerability of aducanumab over 100 weeks of treatment after a wash-out period imposed by discontinuation of feeder studies in participants who had previously received aducanumab (i.e. previously treated participants) or who had previously received placebo (i.e. treatment-naïve participants).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Alzheimer's Disease

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
1696 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Aducanumab
Arm Type
Experimental
Arm Description
Participants will be administered aducanumab 10 milligrams per kilogram (mg/kg) by intravenous (IV) infusions every four weeks (Q4W) for a duration of 100 weeks during the Core Treatment Period. Eligible participants will continue to receive aducanumab 10 mg/kg IV infusion, Q4W, for 52 weeks during the Long-Term Extension (LTE) Treatment Period.
Intervention Type
Drug
Intervention Name(s)
Aducanumab
Other Intervention Name(s)
BIIB037
Intervention Description
Administered as specified in the treatment arm.
Primary Outcome Measure Information:
Title
Core Treatment Period: Number of Participants with Adverse Events (AEs) and Serious Adverse Events (SAEs)
Description
An AE is any untoward medical occurrence in a participant or clinical investigation participant administered a pharmaceutical product and that does not necessarily have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not related to the medicinal (investigational) product. A SAE is any untoward medical occurrence that at any dose results in death, life-threatening event, requires inpatient hospitalization, significant disability/incapacity or congenital anomaly.
Time Frame
Up to Week 100
Title
Core Treatment Period: Number of Participants with AEs Leading to Treatment Discontinuation or Study Withdrawal
Description
An AE is any untoward medical occurrence in a participant or clinical investigation participant administered a pharmaceutical product and that does not necessarily have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not related to the medicinal (investigational) product.
Time Frame
Up to Week 100
Title
Core Treatment Period: Number of Participants with Amyloid-related Imaging Abnormality-Edema (ARIA-E)
Description
Magnetic resonance imaging (MRI) readings will be used to assess ARIA-E severity as mild, moderate and severe.
Time Frame
Up to Week 100
Title
Core Treatment Period: Number of Participants with Amyloid-related Imaging Abnormality- Hemorrhage or Superficial Siderosis (ARIA-H)
Description
MRI readings will be used to assess severity of ARIA-H microhemorrhages and superficial siderosis.
Time Frame
Up to Week 100
Title
Core Treatment Period: Number of Participants With Antidrug Antibodies (ADAs) in Serum
Description
Presence of serum ADAs will be determined using a validated assay.
Time Frame
Up to Week 100

10. Eligibility

Sex
All
Minimum Age & Unit of Time
50 Years
Maximum Age & Unit of Time
90 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Key Inclusion Criteria: Core Treatment Period: Participant was participating in an aducanumab clinical study at the time of the announcement of early termination (feeder studies). Has one care partner who, in the Investigator's opinion, has adequate contact with the participant as to be able to provide accurate information about the participant's cognitive and functional abilities. LTE Treatment Period: Participant must have completed the Core study period (Week 102) and adequately tolerated 10 mg/kg of aducanumab during the Core study period in the opinion of the Investigator. Has one informant/care partner who, in the Investigator's opinion, has frequent and sufficient contact with the participant as to be able to provide accurate information about the participant's cognitive and functional abilities. Key Exclusion Criteria: Core Treatment Period: Any medical or neurological condition (other than Alzheimer's Disease) that might be a contributing cause of the participant's cognitive impairment. Stroke or any unexplained loss of consciousness within 1 year prior to Screening. Clinically significant unstable psychiatric illness in past 6 months. History of unstable angina, myocardial infarction, advanced chronic heart failure, or clinically significant conduction abnormalities within 1 year prior to Screening. A seizure event that occurred after the last visit of the feeder study and before Screening for this study. Evidence of impaired liver function as shown by an abnormal liver function profile at Screening. History of or known seropositivity for HIV. Clinically significant systemic illness or serious infection within 30 days prior to or during Screening. Contraindications to having a brain magnetic resonance imaging (MRI). LTE Treatment Period: Any medical or psychiatric contraindication or clinically significant abnormality that, in the opinion of the Investigator, will substantially increase the risk associated with the participant's enrollment in and completion of the study. Note- Other protocol defined Inclusion/Exclusion criteria may apply.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Medical Director
Organizational Affiliation
Biogen
Official's Role
Study Director
Facility Information:
Facility Name
University of Alabama at Birmingham
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35233
Country
United States
Facility Name
Banner Alzheimer's Institute
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85006
Country
United States
Facility Name
Dignity Health
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85013
Country
United States
Facility Name
Banner Sun Health Research Institute
City
Sun City
State/Province
Arizona
ZIP/Postal Code
85351
Country
United States
Facility Name
Center for Neurosciences
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85718
Country
United States
Facility Name
Neurology Center of North Orange County
City
Fullerton
State/Province
California
ZIP/Postal Code
92835
Country
United States
Facility Name
UCI MIND
City
Irvine
State/Province
California
ZIP/Postal Code
92607
Country
United States
Facility Name
University of California San Diego Medical Center
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Senior Clinical Trials, Inc.
City
Laguna Hills
State/Province
California
ZIP/Postal Code
92653
Country
United States
Facility Name
USC Keck School of Medicine
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
Mary S. Easton Center for Alzheimer's Disease Research, UCLA
City
Los Angeles
State/Province
California
ZIP/Postal Code
90095
Country
United States
Facility Name
Pacific Neuroscience Medical Group
City
Oxnard
State/Province
California
ZIP/Postal Code
93030
Country
United States
Facility Name
Stanford Hospital and Clinics
City
Palo Alto
State/Province
California
ZIP/Postal Code
94304
Country
United States
Facility Name
Anderson Clinical Research
City
Redlands
State/Province
California
ZIP/Postal Code
92374
Country
United States
Facility Name
Pacific Research Network, Inc
City
San Diego
State/Province
California
ZIP/Postal Code
92103
Country
United States
Facility Name
UCSF - Memory and Aging Center
City
San Francisco
State/Province
California
ZIP/Postal Code
94143
Country
United States
Facility Name
Syrentis Clinical Research
City
Santa Ana
State/Province
California
ZIP/Postal Code
92705
Country
United States
Facility Name
California Neuroscience Research Medical Group Inc.
City
Sherman Oaks
State/Province
California
ZIP/Postal Code
91403
Country
United States
Facility Name
University of Colorado Denver
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
IMMUNOe International Research Centers
City
Centennial
State/Province
Colorado
ZIP/Postal Code
80112
Country
United States
Facility Name
Yale University
City
Fairfield
State/Province
Connecticut
ZIP/Postal Code
06824
Country
United States
Facility Name
Invicro
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06510
Country
United States
Facility Name
Yale University School Of Medicine
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06510
Country
United States
Facility Name
Research Center for Clinical Studies, Inc.
City
Norwalk
State/Province
Connecticut
ZIP/Postal Code
06851
Country
United States
Facility Name
Georgetown University Clinical Research Unit (CRU)
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20007
Country
United States
Facility Name
JEM Research
City
Atlantis
State/Province
Florida
ZIP/Postal Code
33462
Country
United States
Facility Name
Bradenton Research Center, Inc
City
Bradenton
State/Province
Florida
ZIP/Postal Code
34205
Country
United States
Facility Name
Brain Matters Research
City
Delray Beach
State/Province
Florida
ZIP/Postal Code
334405
Country
United States
Facility Name
Neuropsychiatric Research Center of Southwest Florida
City
Fort Myers
State/Province
Florida
ZIP/Postal Code
33912
Country
United States
Facility Name
Infinity Clinical Research, LLC
City
Hollywood
State/Province
Florida
ZIP/Postal Code
33024
Country
United States
Facility Name
Jacksonville Center for Clinical Research
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Mayo Clinic in Florida
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
33462
Country
United States
Facility Name
University of Miami
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Facility Name
Miami Jewish Health System, Inc
City
Miami
State/Province
Florida
ZIP/Postal Code
33180
Country
United States
Facility Name
Renstar Medical Research
City
Ocala
State/Province
Florida
ZIP/Postal Code
34470
Country
United States
Facility Name
Accelerated Enrollment Solutions (AES)
City
Orlando
State/Province
Florida
ZIP/Postal Code
32162
Country
United States
Facility Name
Clinical Neuroscience Solutions, Inc.
City
Orlando
State/Province
Florida
ZIP/Postal Code
32801
Country
United States
Facility Name
Accelerated Enrollment Solutions (AES)
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Facility Name
Palm Beach Neurological Center
City
Palm Beach Gardens
State/Province
Florida
ZIP/Postal Code
33410
Country
United States
Facility Name
Quantum Laboratories Inc.
City
Pompano Beach
State/Province
Florida
ZIP/Postal Code
33064
Country
United States
Facility Name
Axiom Clinical Research of Florida
City
Tampa
State/Province
Florida
ZIP/Postal Code
33609
Country
United States
Facility Name
Stedman Clinical Trials, LLC
City
Tampa
State/Province
Florida
ZIP/Postal Code
33613
Country
United States
Facility Name
USF Health Byrd Institute
City
Tampa
State/Province
Florida
ZIP/Postal Code
33616
Country
United States
Facility Name
Meridien Research
City
Tampa
State/Province
Florida
ZIP/Postal Code
33634
Country
United States
Facility Name
Premiere Research Institute
City
West Palm Beach
State/Province
Florida
ZIP/Postal Code
33407
Country
United States
Facility Name
Cleveland Clinic Florida - Weston
City
Weston
State/Province
Florida
ZIP/Postal Code
33331
Country
United States
Facility Name
Emory University Cognitive Neurology Clinic & ADRC
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30329
Country
United States
Facility Name
Medical Research Health and Education Foundation, Inc
City
Columbus
State/Province
Georgia
ZIP/Postal Code
31909
Country
United States
Facility Name
NeuroStudies.net, LLC
City
Decatur
State/Province
Georgia
ZIP/Postal Code
30033
Country
United States
Facility Name
Alexian Brothers Medical Center - Neuroscience Research Institute
City
Elk Grove Village
State/Province
Illinois
ZIP/Postal Code
60007
Country
United States
Facility Name
Advocate Lutheran General Hospital
City
Park Ridge
State/Province
Illinois
ZIP/Postal Code
60068
Country
United States
Facility Name
Fort Wayne Neurological Center
City
Fort Wayne
State/Province
Indiana
ZIP/Postal Code
46804
Country
United States
Facility Name
Indiana University School of Medicine
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Facility Name
Josephson, Wallack, Munshower Neurology, P.C.
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46256
Country
United States
Facility Name
University of Kansas Medical Center Research Institute, Inc.
City
Fairway
State/Province
Kansas
ZIP/Postal Code
66205
Country
United States
Facility Name
Ascension Via Christi Research, a division of Ascension Via Christi Hospitals Wichita, Inc.
City
Wichita
State/Province
Kansas
ZIP/Postal Code
67214
Country
United States
Facility Name
Baptist Health Lexington
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40503
Country
United States
Facility Name
McLean Hospital
City
Belmont
State/Province
Massachusetts
ZIP/Postal Code
02474
Country
United States
Facility Name
Beth Israel Deaconess Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
Brigham and Women's Hospital Department of Neurology
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
ActivMed Practices & Research, Inc.
City
Methuen
State/Province
Massachusetts
ZIP/Postal Code
01844
Country
United States
Facility Name
Boston Center for Memory
City
Newton
State/Province
Massachusetts
ZIP/Postal Code
02459
Country
United States
Facility Name
Donald S. Marks, M.D., P.C.
City
Plymouth
State/Province
Massachusetts
ZIP/Postal Code
02360
Country
United States
Facility Name
Mayo Clinic
City
Rochester
State/Province
Michigan
ZIP/Postal Code
55902
Country
United States
Facility Name
Hattiesburg Clinic, PA
City
Hattiesburg
State/Province
Mississippi
ZIP/Postal Code
39401
Country
United States
Facility Name
Washington University
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63108
Country
United States
Facility Name
Cleveland Clinic Lou Ruvo Center for Brain Health
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89106
Country
United States
Facility Name
Las Vegas Medical Research
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89113
Country
United States
Facility Name
ActivMed Practices & Research, Inc.
City
Portsmouth
State/Province
New Hampshire
ZIP/Postal Code
03801
Country
United States
Facility Name
Advanced Memory Research Inst. of NJ, PC
City
Toms River
State/Province
New Jersey
ZIP/Postal Code
08755
Country
United States
Facility Name
Albany Medical College
City
Albany
State/Province
New York
ZIP/Postal Code
12208
Country
United States
Facility Name
Empire Neurology, PC
City
Latham
State/Province
New York
ZIP/Postal Code
12110
Country
United States
Facility Name
New York University Medical Center PRIME
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States
Facility Name
Weill Cornell Medical College (WCMC) - Judith Jaffe Multiple Sclerosis Center (JJMSC)
City
New York
State/Province
New York
ZIP/Postal Code
10021
Country
United States
Facility Name
Mount Sinai School of Medicine
City
New York
State/Province
New York
ZIP/Postal Code
10029
Country
United States
Facility Name
University of Rochester
City
Rochester
State/Province
New York
ZIP/Postal Code
14620
Country
United States
Facility Name
AMC Research, LLC
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28270
Country
United States
Facility Name
Raleigh Neurology Associates
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27607-6010
Country
United States
Facility Name
Gastroenterology Associates of the Piedmont
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
Wake Forest Baptist Health
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157-1207
Country
United States
Facility Name
Cleveland Clinic Foundation
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
Ohio State University Wexner Medical Center
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
Lynn Health Science Institute
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Lehigh Center for Clinical Research, LLC
City
Allentown
State/Province
Pennsylvania
ZIP/Postal Code
18104
Country
United States
Facility Name
The Clinical Trial Center, LLC
City
Jenkintown
State/Province
Pennsylvania
ZIP/Postal Code
19046
Country
United States
Facility Name
Penn Memory Center
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Facility Name
University of Pittsburgh
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15261
Country
United States
Facility Name
Northeastern Pennsylvania Memory and Alzheimer's Center
City
Wilkes-Barre
State/Province
Pennsylvania
ZIP/Postal Code
18705
Country
United States
Facility Name
Rhode Island Mood & Memory Research Institute
City
East Providence
State/Province
Rhode Island
ZIP/Postal Code
02914
Country
United States
Facility Name
Rhode Island Hospital
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02903
Country
United States
Facility Name
Butler Hospital
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02906
Country
United States
Facility Name
Roper St. Francis Healthcare
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29401
Country
United States
Facility Name
Medical University of South Carolina (MUSC)
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Facility Name
Neurology Clinic, PC
City
Cordova
State/Province
Tennessee
ZIP/Postal Code
38018
Country
United States
Facility Name
Senior Adult Specialty Research
City
Austin
State/Province
Texas
ZIP/Postal Code
33410
Country
United States
Facility Name
UT Southwestern Medical Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390-9129
Country
United States
Facility Name
Baylor College of Medicine
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Clinical Trial Network
City
Houston
State/Province
Texas
ZIP/Postal Code
77074
Country
United States
Facility Name
University of Utah Health Sciences Center
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84108
Country
United States
Facility Name
The Memory Clinic
City
Bennington
State/Province
Vermont
ZIP/Postal Code
05201
Country
United States
Facility Name
National Clinical Research Inc.-Richmond
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23294
Country
United States
Facility Name
University of Washington Medical Centre
City
Seattle
State/Province
Washington
ZIP/Postal Code
98104-2499
Country
United States
Facility Name
Kingfisher Cooperative, LLC
City
Spokane
State/Province
Washington
ZIP/Postal Code
99202
Country
United States
Facility Name
Medical College of Wisconsin, Inc.
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226
Country
United States
Facility Name
The Prince Charles Hospital
City
Chermside
State/Province
New South Wales
ZIP/Postal Code
4032
Country
Australia
Facility Name
St Vincent's Hospital Sydney
City
Darlinghurst
State/Province
New South Wales
ZIP/Postal Code
2010
Country
Australia
Facility Name
Central Coast Neurosciences Research (Erina)
City
Erina
State/Province
New South Wales
ZIP/Postal Code
2250
Country
Australia
Facility Name
KaRa Institute of Neurological Diseases
City
Macquarie Park
State/Province
New South Wales
ZIP/Postal Code
2113
Country
Australia
Facility Name
Box Hill Hospital
City
Box Hill
State/Province
Victoria
ZIP/Postal Code
3128
Country
Australia
Facility Name
Austin Health
City
Heidelberg West
State/Province
Victoria
ZIP/Postal Code
3081
Country
Australia
Facility Name
Royal Melbourne Hospital
City
Parkville
State/Province
Victoria
ZIP/Postal Code
3050
Country
Australia
Facility Name
Australian Alzheimer's Research Foundation
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
Facility Name
LKH - Universitaetsklinikum Graz
City
Graz
ZIP/Postal Code
8036
Country
Austria
Facility Name
Christian-Doppler-Klinik - Universitätsklinikum Salzburg
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
Facility Name
AKH - Medizinische Universität Wien
City
Vienna
ZIP/Postal Code
1090
Country
Austria
Facility Name
AZ Klina
City
Brasschaat
ZIP/Postal Code
2930
Country
Belgium
Facility Name
AZ Sint-Jan
City
Brugge
ZIP/Postal Code
8000
Country
Belgium
Facility Name
Universitair Ziekenhuis Brussel
City
Brussel
ZIP/Postal Code
1090
Country
Belgium
Facility Name
Universitair Ziekenhuis Gent
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
AZ Groeninge
City
Kortrijk
ZIP/Postal Code
8500
Country
Belgium
Facility Name
UZ Leuven
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
AZ Delta
City
Roeselare
ZIP/Postal Code
8800
Country
Belgium
Facility Name
University of Calgary - Heritage Medical Research Clinic
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N4Z6
Country
Canada
Facility Name
The Medical Arts Health Research Group
City
Kamloops
State/Province
British Columbia
ZIP/Postal Code
V2C 5T1
Country
Canada
Facility Name
The Medical Arts Health Research Group
City
Penticton
State/Province
British Columbia
ZIP/Postal Code
V2A 5L5
Country
Canada
Facility Name
UBC Hospital
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V6T 1Z3
Country
Canada
Facility Name
Medical Arts Health Research Group
City
West Vancouver
State/Province
British Columbia
ZIP/Postal Code
V7T 1C5
Country
Canada
Facility Name
True North Clinical Research - Halifax Inc.
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3S 1M7
Country
Canada
Facility Name
True North Clinical Research
City
Kentville
State/Province
Nova Scotia
ZIP/Postal Code
MB3 2S7
Country
Canada
Facility Name
St. Joseph's HC- Parkwood Institute
City
London
State/Province
Ontario
ZIP/Postal Code
N6C OA7
Country
Canada
Facility Name
Bruyere Continuing Care
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1N 5C8
Country
Canada
Facility Name
Kawartha Centre - Redefining Healthy Aging
City
Peterborough
State/Province
Ontario
ZIP/Postal Code
K9H 2P4
Country
Canada
Facility Name
Toronto Memory Program (Neurology Research Inc.)
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M3B 2S7
Country
Canada
Facility Name
Toronto Sunnybrook Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N 3M5
Country
Canada
Facility Name
Toronto Western Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5T 2S8
Country
Canada
Facility Name
Clinique de la Memoire de l'Outaouais
City
Gatineau
State/Province
Quebec
ZIP/Postal Code
J8T 8J1
Country
Canada
Facility Name
Institut et Clinique MoCA
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2J2
Country
Canada
Facility Name
Montreal Neurological Institute Clinical Research Unit
City
Montréal
State/Province
Quebec
ZIP/Postal Code
H3A 2B4
Country
Canada
Facility Name
CHU de Quebec - Hôpital de l' Enfant Jésus
City
Quebec
ZIP/Postal Code
G1J 1Z4
Country
Canada
Facility Name
CCBR - Ålborg - DK
City
Aalborg
ZIP/Postal Code
9000
Country
Denmark
Facility Name
Danish Dementia Research Centre
City
København
ZIP/Postal Code
2100
Country
Denmark
Facility Name
CCBR - Vejle - DK
City
Vejle
ZIP/Postal Code
7100
Country
Denmark
Facility Name
Terveystalo Ruoholahti
City
Helsinki
ZIP/Postal Code
00180
Country
Finland
Facility Name
Itä-Suomen yliopisto, Aivotutkimusyksikkö
City
Kuopio
ZIP/Postal Code
70210
Country
Finland
Facility Name
CRST, Clinical Research Services Turku
City
Turku
ZIP/Postal Code
20520
Country
Finland
Facility Name
CHU Strasbourg - Hôpital Hautepierre
City
Strasbourg Cedex
State/Province
Bas Rhin
ZIP/Postal Code
67098
Country
France
Facility Name
Hôpital de la Timone
City
Marseille cedex 05
State/Province
Bouches-du-Rhône
ZIP/Postal Code
13385
Country
France
Facility Name
Groupe Hospitalier Pellegrin - Hôpital Pellegrin
City
Bordeaux Cedex
State/Province
Gironde
ZIP/Postal Code
33076
Country
France
Facility Name
Hopital Purpan
City
Toulouse cedex 9
State/Province
Haute Garonne
ZIP/Postal Code
31059
Country
France
Facility Name
Hôpital La Grave
City
Toulouse Cedex 9
State/Province
Haute Garonne
ZIP/Postal Code
31059
Country
France
Facility Name
Hopital Gui de Chauliac
City
Montpellier
State/Province
Herault
ZIP/Postal Code
34295
Country
France
Facility Name
CHU Rennes - Pontchaillou
City
Rennes cedex 9
State/Province
Ille Et Vilaine
ZIP/Postal Code
35033
Country
France
Facility Name
CHU Nantes - Hopital Nord Laënnec
City
Nantes cedex 1
State/Province
Loire Atlantique
ZIP/Postal Code
44093
Country
France
Facility Name
CHU Reims - Hôpital Maison Blanche
City
Reims
State/Province
Marne
ZIP/Postal Code
51092
Country
France
Facility Name
CHU Lille - Hopital Roger Salengro
City
Lille Cedex
State/Province
Nord
ZIP/Postal Code
59037
Country
France
Facility Name
Hôpital Lariboisière
City
Paris cedex 10
State/Province
Paris
ZIP/Postal Code
75010
Country
France
Facility Name
CHU de Lyon - Hopital Neurologique Pierre Wertheimer
City
Bron Cedex
State/Province
Rhone
ZIP/Postal Code
69677
Country
France
Facility Name
Hôpital des Chapennes
City
Villeurbanne
State/Province
Rhone
ZIP/Postal Code
69100
Country
France
Facility Name
Groupe Hospitalier Pitie-Salpetriere
City
Paris
ZIP/Postal Code
75013
Country
France
Facility Name
Hôpital Broca
City
Paris
ZIP/Postal Code
75013
Country
France
Facility Name
Studienzentrum fur Neurologie und Psychiatrie
City
Böblingen
State/Province
Baden Wuerttemberg
ZIP/Postal Code
71034
Country
Germany
Facility Name
ISPG - Institut fuer Studien zur Psychischen Gesundheit
City
Mannheim
State/Province
Baden Wuerttemberg
ZIP/Postal Code
68165
Country
Germany
Facility Name
mind mvz GmbH
City
Stuttgart
State/Province
Baden Wuerttemberg
ZIP/Postal Code
70182
Country
Germany
Facility Name
Neuropoint Studienzentrum
City
Ulm
State/Province
Baden Wuerttemberg
ZIP/Postal Code
89073
Country
Germany
Facility Name
Universitaetsklinikum Ulm
City
Ulm
State/Province
Baden Wuerttemberg
ZIP/Postal Code
89081
Country
Germany
Facility Name
Klinikum Bayreuth GmbH- Hohe Warte
City
Bayreuth
State/Province
Bayern
ZIP/Postal Code
95445
Country
Germany
Facility Name
Bezirkskrankenhaus Guenzburg
City
Günzburg
State/Province
Bayern
ZIP/Postal Code
89312
Country
Germany
Facility Name
Klinikum rechts der Isar der TU Muenchen
City
Munich
State/Province
Bayern
ZIP/Postal Code
81675
Country
Germany
Facility Name
Institut fuer Schlaganfall- und Demenzforschung (ISD)
City
München
State/Province
Bayern
ZIP/Postal Code
81377
Country
Germany
Facility Name
Neuropraxis Muenchen Sued
City
Unterhaching
State/Province
Bayern
ZIP/Postal Code
82008
Country
Germany
Facility Name
Neuro Centrum Science GmbH, Geschaftführende Gesellschafterin Barbara Unsorg und Prüfarzt Dr. med. G
City
Erbach
State/Province
Hessen
ZIP/Postal Code
64711
Country
Germany
Facility Name
Neurologische Gemeinschaftspraxis Kassel
City
Kassel
State/Province
Hessen
ZIP/Postal Code
34121
Country
Germany
Facility Name
Klinische Forschung Hannover-Mitte GmbH
City
Hannover
State/Province
Niedersachsen
ZIP/Postal Code
30159
Country
Germany
Facility Name
Universitaetsklinikum Aachen AOeR
City
Aachen
State/Province
Nordrhein Westfalen
ZIP/Postal Code
52074
Country
Germany
Facility Name
Neurozentrum Bielefeld
City
Bielefeld
State/Province
Nordrhein Westfalen
ZIP/Postal Code
33647
Country
Germany
Facility Name
Universitaetsklinikum Duesseldorf AoeR
City
Duesseldorf
State/Province
Nordrhein Westfalen
ZIP/Postal Code
40225
Country
Germany
Facility Name
Universitaetsklinikum Koeln
City
Koeln
State/Province
Nordrhein Westfalen
ZIP/Postal Code
50937
Country
Germany
Facility Name
Zentrum f. Neurologisch- Psychiatrische Studien und Begutachtung
City
Siegen
State/Province
Nordrhein Westfalen
ZIP/Postal Code
57076
Country
Germany
Facility Name
Klinikum Altenburger Land GmbH
City
Altenburg
State/Province
Thueringen
ZIP/Postal Code
04600
Country
Germany
Facility Name
Emovis GmbH
City
Berlin
ZIP/Postal Code
10629
Country
Germany
Facility Name
Neurologie im Tempelhofer Hafen
City
Berlin
ZIP/Postal Code
12099
Country
Germany
Facility Name
Charite Universitaetsmedizin Berlin - Campus Berlin Buch
City
Berlin
ZIP/Postal Code
13125
Country
Germany
Facility Name
Ospedale degli Infermi
City
Ponderano
State/Province
Biella
ZIP/Postal Code
13875
Country
Italy
Facility Name
Azienda Ospedaliera Card. G. Panico
City
Tricase
State/Province
Lecce
ZIP/Postal Code
73039
Country
Italy
Facility Name
ASST di Monza
City
Monza
State/Province
Milano
ZIP/Postal Code
20052
Country
Italy
Facility Name
Fondazione Istituto G.Giglio di Cefalù
City
Cefalù
State/Province
Palermo
ZIP/Postal Code
90015
Country
Italy
Facility Name
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
City
Brescia
ZIP/Postal Code
25123
Country
Italy
Facility Name
Azienda Ospedaliero Universitaria San Martino
City
Genova
ZIP/Postal Code
16132
Country
Italy
Facility Name
Ospedale San Raffaele
City
Milano
ZIP/Postal Code
20132
Country
Italy
Facility Name
Fondazione IRCCS Istituto Neurologico Carlo Besta
City
Milano
ZIP/Postal Code
20133
Country
Italy
Facility Name
AOU dell'Università degli studi della Campania Luigi Vanvitelli
City
Napoli
ZIP/Postal Code
80138
Country
Italy
Facility Name
Azienda Ospedaliera e Universitaria di Perugia
City
Perugia
ZIP/Postal Code
06156
Country
Italy
Facility Name
Azienda Ospedaliero Universitaria Pisana
City
Pisa
ZIP/Postal Code
56126
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza
City
Roma
ZIP/Postal Code
00161
Country
Italy
Facility Name
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
City
Roma
ZIP/Postal Code
00168
Country
Italy
Facility Name
Fondazione Santa Lucia IRCCS
City
Roma
ZIP/Postal Code
179
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona
City
Salerno
ZIP/Postal Code
84131
Country
Italy
Facility Name
A.O.U. Senese Policlinico Santa Maria alle Scotte
City
Siena
ZIP/Postal Code
53100
Country
Italy
Facility Name
Research Site
City
Obu-shi
State/Province
Aichi-Ken
ZIP/Postal Code
474-8511
Country
Japan
Facility Name
Research Site
City
Chiba-shi
State/Province
Chiba-Ken
ZIP/Postal Code
260-8656
Country
Japan
Facility Name
Research Site
City
Chiba-shi
State/Province
Chiba-Ken
ZIP/Postal Code
263-0043
Country
Japan
Facility Name
Research Site
City
Inzai-shi
State/Province
Chiba-Ken
ZIP/Postal Code
270-1694
Country
Japan
Facility Name
Research Site
City
Toon-shi
State/Province
Ehime-Ken
ZIP/Postal Code
791-0295
Country
Japan
Facility Name
Research Site
City
Fukuoka-shi
State/Province
Fukuoka-Ken
ZIP/Postal Code
814-0180
Country
Japan
Facility Name
Research Site
City
Kurume-shi
State/Province
Fukuoka-Ken
ZIP/Postal Code
830-0011
Country
Japan
Facility Name
Research Site
City
Aizu-Wakamatsu
State/Province
Fukushima-Ken
ZIP/Postal Code
965-8585
Country
Japan
Facility Name
Research Site
City
Otake-shi
State/Province
Hiroshima-Ken
ZIP/Postal Code
739-0696
Country
Japan
Facility Name
Research Site
City
Asahikawa-shi
State/Province
Hokkaido
ZIP/Postal Code
070-8644
Country
Japan
Facility Name
Research Site
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
064-8570
Country
Japan
Facility Name
Research Site
City
Amagasaki-shi
State/Province
Hyogo-Ken
ZIP/Postal Code
660-8511
Country
Japan
Facility Name
Research Site
City
Himeji-shi
State/Province
Hyogo-Ken
ZIP/Postal Code
670-0981
Country
Japan
Facility Name
Research Site
City
Himeji-shi
State/Province
Hyogo-Ken
ZIP/Postal Code
672-8043
Country
Japan
Facility Name
Research Site
City
Kobe-shi
State/Province
Hyogo-Ken
ZIP/Postal Code
650-0047
Country
Japan
Facility Name
Research Site
City
Kita-gun
State/Province
Kagawa-Ken
ZIP/Postal Code
761-0793
Country
Japan
Facility Name
Research Site
City
Kamakura-shi
State/Province
Kanagawa-Ken
ZIP/Postal Code
247-8533
Country
Japan
Facility Name
Research Site
City
Kyoto-shi
State/Province
Kyoto-Fu
ZIP/Postal Code
607-8113
Country
Japan
Facility Name
Research Site
City
Kyoto-shi
State/Province
Kyoto-Fu
ZIP/Postal Code
616-8255
Country
Japan
Facility Name
Research Site
City
Tsu-shi
State/Province
Mie-Ken
ZIP/Postal Code
514-8507
Country
Japan
Facility Name
Research Site
City
Togitsu
State/Province
Nagasaki-Ken
ZIP/Postal Code
851-2103
Country
Japan
Facility Name
Research Site
City
Nagaoka-shi
State/Province
Niigata-Ken
ZIP/Postal Code
940-2081
Country
Japan
Facility Name
Research Site
City
Yufu-shi
State/Province
Oita-Ken
ZIP/Postal Code
879-5593
Country
Japan
Facility Name
Research Site
City
Kurashiki-shi
State/Province
Okayama-Ken
ZIP/Postal Code
247-8533
Country
Japan
Facility Name
Research Site
City
Okayama-shi
State/Province
Okayama-Ken
ZIP/Postal Code
703-8265
Country
Japan
Facility Name
Research Site
City
Tsukuba
State/Province
Okayama-Ken
ZIP/Postal Code
701-0304
Country
Japan
Facility Name
Research Site
City
Osaka-shi
State/Province
Osaka-Fu
ZIP/Postal Code
545-8586
Country
Japan
Facility Name
Research Site
City
Suita-shi
State/Province
Osaka-Fu
ZIP/Postal Code
565-0871
Country
Japan
Facility Name
Research Site
City
Iruma-gun
State/Province
Saitama-Ken
ZIP/Postal Code
350-0495
Country
Japan
Facility Name
Research Site
City
Kasukabe-shi
State/Province
Saitama-Ken
ZIP/Postal Code
344-0036
Country
Japan
Facility Name
Research Site
City
Shizuka-shi
State/Province
Shizuoka-Ken
ZIP/Postal Code
424-8636
Country
Japan
Facility Name
Research Site
City
Shizuoka-shi
State/Province
Shizuoka-Ken
ZIP/Postal Code
420-8688
Country
Japan
Facility Name
Research Site
City
Bunkyo-ku
State/Province
Tokyo-To
ZIP/Postal Code
113-0034
Country
Japan
Facility Name
Research Site
City
Kiyose-shi
State/Province
Tokyo-To
ZIP/Postal Code
204-8585
Country
Japan
Facility Name
Research Site
City
Kodaira-shi
State/Province
Tokyo-To
ZIP/Postal Code
187-8551
Country
Japan
Facility Name
Research Site
City
Yamagata-shi
State/Province
Yamagata-Ken
ZIP/Postal Code
990-0834
Country
Japan
Facility Name
Inha University Hospital
City
Incheon
State/Province
Gyeonggi-do
ZIP/Postal Code
22332
Country
Korea, Republic of
Facility Name
Seoul National University Bundang Hospital
City
Seongnam
State/Province
Gyeonggi-do
ZIP/Postal Code
13620
Country
Korea, Republic of
Facility Name
Gachon University Gil Medical Center
City
Incheon
ZIP/Postal Code
405-760
Country
Korea, Republic of
Facility Name
Konkuk University Medical Center
City
Seoul
ZIP/Postal Code
05030
Country
Korea, Republic of
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Facility Name
Samsung Medical Center
City
Seoul
ZIP/Postal Code
135-710
Country
Korea, Republic of
Facility Name
Brain Research Center
City
Amsterdam
ZIP/Postal Code
1081 GN
Country
Netherlands
Facility Name
Amphia Ziekenhuis, Molengracht
City
Breda
ZIP/Postal Code
4818 CK
Country
Netherlands
Facility Name
Erasmus Medisch Centrum
City
Rotterdam
ZIP/Postal Code
3015 AA
Country
Netherlands
Facility Name
Podlaskie Centrum Psychogeriatrii
City
Bialystok
ZIP/Postal Code
15-756
Country
Poland
Facility Name
PALLMED Sp. z o.o.
City
Bydgoszcz
ZIP/Postal Code
85-023
Country
Poland
Facility Name
Klinika Psychiatrii Doroslych UCK
City
Gdansk
ZIP/Postal Code
80-952
Country
Poland
Facility Name
Novo-Med Zielinski i wspolnicy Sp. j.
City
Katowice
ZIP/Postal Code
40-650
Country
Poland
Facility Name
SPZOZ Centralny Szpital Kliniczny UM w Lodzi
City
Lodz
ZIP/Postal Code
92-216
Country
Poland
Facility Name
Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie
City
Lublin
ZIP/Postal Code
20-954
Country
Poland
Facility Name
NZOZ "NEURO-KARD", "Ilkowski i Partnerzy" Sp. Partn. Lek.
City
Poznan
ZIP/Postal Code
61-853
Country
Poland
Facility Name
Neuro-Care Gabriela Klodowska
City
Siemianowice Slaskie
ZIP/Postal Code
41-100
Country
Poland
Facility Name
Centrum Medyczne Senior
City
Sopot
ZIP/Postal Code
81-855
Country
Poland
Facility Name
Osrodek Badan Klinicznych EUROMEDIS
City
Szczecin
ZIP/Postal Code
70-111
Country
Poland
Facility Name
Centrum Medyczne NeuroProtect
City
Warszawa
ZIP/Postal Code
01-684
Country
Poland
Facility Name
NZOZ Wroclawskie Centrum Alzheimerowskie
City
Wroclaw
ZIP/Postal Code
53659
Country
Poland
Facility Name
Hospital de Braga
City
Braga
ZIP/Postal Code
4710-243
Country
Portugal
Facility Name
Centro Hospitalar e Universitário de Coimbra E.P.E - Hospitais da Universidade de Coimbra
City
Coimbra
ZIP/Postal Code
3040-278
Country
Portugal
Facility Name
Hospital Beatriz Ângelo
City
Loures
ZIP/Postal Code
2674-514
Country
Portugal
Facility Name
CNS-Campus Neurologico Senior
City
Torres Vedras
ZIP/Postal Code
2560-280
Country
Portugal
Facility Name
Hospital General Universitario de Elche
City
Elche
State/Province
Alicante
ZIP/Postal Code
03203
Country
Spain
Facility Name
Hospital Universitario Reina Sofia
City
Cordoba
State/Province
Córdoba
ZIP/Postal Code
14011
Country
Spain
Facility Name
Policlinica Gipuzkoa
City
San Sebastian
State/Province
Guipuzcoa
ZIP/Postal Code
20009
Country
Spain
Facility Name
Clinica Universidad de Navarra
City
Pamplona
State/Province
Navarra
ZIP/Postal Code
31008
Country
Spain
Facility Name
CAE Oroitu
City
Getxo
State/Province
Vizcaya
ZIP/Postal Code
48993
Country
Spain
Facility Name
Hospital del Mar
City
Barcelona
ZIP/Postal Code
08003
Country
Spain
Facility Name
Hospital de la Santa Creu i Sant Pau
City
Barcelona
ZIP/Postal Code
08025
Country
Spain
Facility Name
Fundacio ACE
City
Barcelona
ZIP/Postal Code
08028
Country
Spain
Facility Name
Hospital Clinic de Barcelona
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Facility Name
Hospital Universitari de Santa Maria
City
Lleida
ZIP/Postal Code
25198
Country
Spain
Facility Name
Complejo Hospitalario Ruber Juan Bravo
City
Madrid
ZIP/Postal Code
28006
Country
Spain
Facility Name
Hospital Victoria Eugenia
City
Sevilla
ZIP/Postal Code
41009
Country
Spain
Facility Name
Hospital Universitario Dr. Peset
City
Valencia
ZIP/Postal Code
46017
Country
Spain
Facility Name
Hospital Universitari i Politecnic La Fe
City
Valencia
ZIP/Postal Code
46026
Country
Spain
Facility Name
Skånes Universitetssjukhus
City
Malmö
ZIP/Postal Code
205 02
Country
Sweden
Facility Name
Sahlgrenska Universitetssjukhuset, Mölndal Sjukhus
City
Mölndal
ZIP/Postal Code
205 02
Country
Sweden
Facility Name
Karolinska Universitetssjukhuset, Huddinge
City
Stockholm
ZIP/Postal Code
141 86
Country
Sweden
Facility Name
Akademiska Sjukhuset
City
Uppsala
ZIP/Postal Code
75185
Country
Sweden
Facility Name
Spitalzentrum Biel
City
Biel/Bienne
ZIP/Postal Code
2501
Country
Switzerland
Facility Name
Hôpitaux Universitaires de Geneve- HUG
City
Genève
ZIP/Postal Code
1205
Country
Switzerland
Facility Name
Centre Hospitalier Universitaire Vaudois
City
Lausanne
ZIP/Postal Code
1011
Country
Switzerland
Facility Name
Ospedale Regionale di Lugano
City
Lugano
ZIP/Postal Code
6900
Country
Switzerland
Facility Name
Institut fur Regenerative Medizin-IREM Universitat Zurich, Campus Schlieren
City
Schlieren
ZIP/Postal Code
8952
Country
Switzerland
Facility Name
Changhua Christian Medical Foundation Changhua Christian Hospital
City
Changhua
ZIP/Postal Code
50004
Country
Taiwan
Facility Name
Kaohsiung Chang Gung Memorial Hospital
City
Kaohsiung
ZIP/Postal Code
833
Country
Taiwan
Facility Name
National Cheng Kung University Hospital
City
Tainan
ZIP/Postal Code
704
Country
Taiwan
Facility Name
Taipei Veterans General Hospital
City
Taipei
ZIP/Postal Code
11217
Country
Taiwan
Facility Name
Chang Gung Memorial Hospital, Linkou
City
Taoyuan City
ZIP/Postal Code
333
Country
Taiwan
Facility Name
Re:Cognition Health Ltd (London)
City
London
State/Province
Greater London
ZIP/Postal Code
W1G 9JF
Country
United Kingdom
Facility Name
Charing Cross Hospital
City
London
State/Province
Greater London
ZIP/Postal Code
W6 8RF
Country
United Kingdom
Facility Name
The National Hospital for Neurology and Neurosurgery Centre
City
London
State/Province
Greater London
ZIP/Postal Code
WC1N 3BG
Country
United Kingdom
Facility Name
Manchester Royal Infirmary
City
Manchester
State/Province
Greater Manchester
ZIP/Postal Code
M13 9WL
Country
United Kingdom
Facility Name
The University of Edinburgh
City
Edinburgh
State/Province
Lothian Region
ZIP/Postal Code
EH10 5HF
Country
United Kingdom
Facility Name
The RICE Centre
City
Bath
State/Province
Somerset
ZIP/Postal Code
BA1 3NG
Country
United Kingdom
Facility Name
Queen Elizabeth University Hospital Campus
City
Glasgow
State/Province
Strathclyde
ZIP/Postal Code
G21 3UW
Country
United Kingdom
Facility Name
Glasgow Memory Clinic Ltd
City
Motherwell
State/Province
Strathclyde
ZIP/Postal Code
ML1 4UF
Country
United Kingdom
Facility Name
Ninewells Hospital
City
Dundee
State/Province
Tayside Region
ZIP/Postal Code
DD1 9SY
Country
United Kingdom
Facility Name
Newcastle University
City
Newcastle upon Tyne
State/Province
Tyne & Wear
ZIP/Postal Code
NE4 5PL
Country
United Kingdom

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
In accordance with Biogen's Clinical Trial Transparency and Data Sharing Policy on https://www.biogentrialtransparency.com/
IPD Sharing URL
https://vivli.org/

Learn more about this trial

A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205

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