A Study to Evaluate the Effects of YM872 on Stroke Lesion Volume in Acute Stroke Patients
Cerebrovascular Accident
About this trial
This is an interventional treatment trial for Cerebrovascular Accident focused on measuring ARTIST, Acute ischemic stroke
Eligibility Criteria
Inclusion Criteria: Patients who have suffered an acute ischemic stroke and can be evaluated and treatment initiated within 6 hours after the onset of symptoms (Onset is defined as the time that which the patient was last seen in a normal state, or bedtime for unwitnessed strokes occurring during the night). Patients who have a three dimensionally measurable lesion compatible with an acute ischemic stroke measured using MRI. Patients who have a National Institutes of Health Stroke Scale (NIHSS) score of at least 7 but not more than 23 and who are conscious. Patients who are able to provide written informed consent or have consent provided by a legally authorized representative. Patients who are at least 18 years of age. Other criteria as specified in the study protocol Exclusion Criteria: Patients who have received alteplase (t-PA) for the current stroke episode. It is assumed that all patients who are eligible will receive treatment with t-PA. Patients who have disability and functional limitations prior to the current stroke episode (e.g. deficit resulting from a prior stroke). Patients who have brain hemorrhage. Patients who have stroke of the brainstem or cerebellum. Patients who cannot be evaluated using MRI due to the presence of a pacemaker, claustrophobia, need for sedation, etc. Patients who have renal (kidney) disease or insufficiency. Patients who have active epilepsy or convulsions during the current stroke episode. Patients who are IV drug users or are inebriated. Patients who have a history of drug-related anaphylaxis. Patients who have taken sedatives, anticonvulsants, or any medication with sedating effects in the 10 days prior study enrollment. Patients who have taken more than 1.3 g of aspirin per day in the 2 days prior to enrollment. Patients who have a known vitamin hypersensitivity. Other exclusion criteria as specified by the study protocol.
Sites / Locations
- University of South Alabama Stroke Center
- Phoenix Neurology Associates (Good Samaritan Hospital)
- University of Arizona
- Providence St. Joseph's Medical Center
- Grossmont Hospital
- UCLA Emergency Medical Center
- Good Samaritan Hospital
- Santa Monica UCLA Medical Center
- John Muir Medical Center
- Bridgeport Hospital
- Bethesda Memorial Hospital
- Holmes Regional Medical Center
- University of Miami (Jackson Memorial Hospital)
- Florida Neurovascular Institute
- DNA Research (Dekalb Medical Center)
- OSF St. Francis Medical Center
- Parkview Hospital
- University of Kentucky
- Louisville Neuroscience Research Center
- Cullicchia Neurology Clinic, LLP
- Johns Hopkins Medical Institute
- Beth Israel Deaconess Medical Center
- New England Medical Center
- Wayne State University
- Michigan State University
- William Beaumont Hospital
- Field Neurosciences Institute (St. Mary's Hospital)
- Advanced Neurology Specialists (Benefis Healthcare Hospital)
- St. Patrick's Hospital & Health Sciences Center
- Washoe Comprehensive Stroke Center
- JFK Medical Center
- Neurology Group of Bergen County (Valley Hospital)
- University of New Mexico Hospital
- VA Medical Center
- Albany Medical Center
- Buffalo General Hospital
- North Shore University Hospital
- Long Island Jewish Medical Center
- St. Luke's Hospital
- Ellis Hospital
- Stony Brook Hospital
- All-Trials Clinical Research, LLC (Rowan Regional Medical Center)
- Metrohealth Medical Center
- Riverside Methodist Hospital
- Medical College of Ohio
- St. Elizabeth Health Center
- Hershey Medical Center
- University of Pittsburgh Medical Center Stroke Institute
- Chattanooga Neurology Associates (Erlanger Hospital)
- Chattanooga Neurology Associates (Memorial Hospital)
- St. Thomas Hospital
- Vanderbilt University Medical Center
- University of Texas (Houston Medical Center)
- Neurology Associates, Inc. (St. Mary's Hospital)
- Virginia Beach General Hospital
- Stevens Memorial Hospital
- Providence St. Peter Hospital
- Sacred Heart Medical Center
- St. Luke's Medical Center
- Theda Clark Medical Center
- Universitätsklinik Allgemeines
- Hopital Erasme
- Service de Neurologie, Cliniques Universitaires St.-Luc
- Dienst Neurologie UZ Gasthuisberg
- University of Alberta Hospital
- Royal Jubilee Hospital
- Toronto Western Hospital
- Universitätsklinikum Aachen, Neurologische Klinik
- University of Essen
- Neurologische Universitätsklinik, Albert-Ludwigs-University
- Universitätskrankenhaus Hamburg-Eppendorf Klinik für Neurologie
- Universitatklinikum Homburg, Neurologie Klinik und Poliklinik
- Friedrich-Schiller-University
- Universität zu Köln klinik und poliklinik fur neurology
- Universitatklinikum Leipzig
- Universitätsklinik Mainz
- Department of Neurology Klinikum
- Neurologische Klinik Klinikum Rechts der Isar der TU Munchen
- Neurologische Klinik Knappschafts - krankenhause
- Dr.-H.-Schmidt-Kliniken Ludwig-Erhar
- Muelmed Hospital
- Bloemfontein Medi-Clinic
- Groote Schuur Hospital
- St. Augustine's Hospital
- Sandton Medi-Clinic
- Pietermaritzburg Medi-Clinic
- Little Company of Mary Medical Centre
- Vergelegen Medi-Clinic
- Sunninghill Hospital