A Study to Evaluate the Safety and Efficacy of Zoledronic Acid in the Prevention or Delaying of Bone Metastasis in Patients With Stage IIIA and IIIB Non-small Cell Lung Cancer (NSCLC)
Non-Small-Cell Lung Cancer
About this trial
This is an interventional prevention trial for Non-Small-Cell Lung Cancer focused on measuring Non-Small-Cell Lung Cancer, Bisphosphonates, Zoledronic acid, Bone metastases, Prevention of bone metastases
Eligibility Criteria
Inclusion Criteria: Histologically or cytologically confirmed Non-small Cell Lung Cancer (NSCLC) Newly Diagnosed, Stage IIIA and Stage IIIB excluding patients with pleural effusion Patients must have received primary treatment for their disease and had no progression Exclusion Criteria: Diagnosed with NSCLC longer than 6 months ago Treatment with other bisphosphonates in past 12 months Presence of metastases Other protocol-defined inclusion and exclusion criteria may apply.
Sites / Locations
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Arms of the Study
Arm 1
Arm 2
Experimental
Other
Zoledronic acid
Control
Zoledronic acid 4 mg intravenous infusion over at least 15 minutes every 3 to 4 weeks for 24 months. Dosage was adjusted for participants with mild or moderate renal impairment.
No investigational treatment. If a participant developed bone metastases, treatment was started with Zoledronic acid 4 mg intravenous infusion over at least 15 minutes every 3 to 4 weeks until 24 months from the date of study entry had elapsed.