A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients
HIV Infections, Leukoencephalopathy, Progressive Multifocal
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Leukoencephalopathy, Progressive Multifocal, Probenecid, HIV-1, Central Nervous System Diseases, Acquired Immunodeficiency Syndrome, DNA, Viral, cidofovir, Anti-HIV Agents, Neurologic Examination, Renal Agents
Eligibility Criteria
Inclusion Criteria You may be eligible for this study if you: Are HIV-positive. Have had symptoms of PML for no more than 90 days before study entry, or have had abnormal neurological exams related to PML. Have negative tests for bacterial or fungal infections. Agree to practice abstinence or use effective methods of birth control during the study. Are at least 18 years old. Have a life expectancy of at least 6 months. Exclusion Criteria You will not be eligible for this study if you: Have a history of uveitis. Are allergic to sulfa drugs or probenecid. Have had active opportunistic infections other than Kaposi's sarcoma within 30 days before study entry. Have sickle cell anemia or trait. Are pregnant or breast-feeding.
Sites / Locations
- Univ of Alabama at Birmingham
- San Francisco AIDS Clinic / San Francisco Gen Hosp
- San Francisco Gen Hosp
- Univ of Colorado Health Sciences Ctr
- Howard Univ
- Northwestern Univ Med School
- Cook County Hosp
- Rush Presbyterian - Saint Luke's Med Ctr
- Louis A Weiss Memorial Hosp
- Johns Hopkins Hosp
- SUNY / Erie County Med Ctr at Buffalo
- Beth Israel Med Ctr
- Bellevue Hosp / New York Univ Med Ctr
- Mount Sinai Med Ctr
- Univ of Rochester Medical Center
- Univ of North Carolina
- Univ of Kentucky Lexington
- Julio Arroyo
- Univ of Washington